D. Loiselle

发表

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

S. Landas, W. Stetler-Stevenson, L. Neckers, 2015, Cell reports.

Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90

W. Linehan, L. Schmidt, T. Haystead, 2019, Cell reports.

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target.

Philip F. Hughes, T. Haystead, S. Vasudevan, 2016, Antiviral research.

Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.

V. Arshavsky, N. Skiba, D. Loiselle, 2016, Biochemistry.

Transcription factor–driven alternative localization of Cryptococcus neoformans superoxide dismutase

D. Thiele, D. Loiselle, T. Haystead, 2021, The Journal of biological chemistry.

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

Philip F. Hughes, L. Schmidt, T. Haystead, 2016, Nature Communications.

ROCK1 Phosphorylates and Activates Zipper-interacting Protein Kinase*

Matthew H. Brush, T. Haystead, D. Loiselle, 2007, Journal of Biological Chemistry.

Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.

Philip F. Hughes, T. Haystead, L. Neckers, 2013, Chemistry & biology.

A highly selective Hsp90 affinity chromatography resin with a cleavable linker.

Philip F. Hughes, T. Haystead, L. Rund, 2012, Bioorganic & medicinal chemistry.

Improved protein identification through the use of unstained gels.

C. Borchers, D. Loiselle, W. Thelin, 2005, Journal of proteome research.

Smoothelin-like 1 Protein Regulates Myosin Phosphatase-targeting Subunit 1 Expression during Sexual Development and Pregnancy*

T. Haystead, D. Zheng, D. Loiselle, 2010, The Journal of Biological Chemistry.

Smoothelin-like 1 Protein Is a Bifunctional Regulator of the Progesterone Receptor during Pregnancy*

D. Loiselle, T. Haystead, S. Lengyel, 2011, The Journal of Biological Chemistry.

Tethered Hsp90 Inhibitors Carrying Optical or Radioiodinated Probes Reveal Selective Internalization of Ectopic Hsp90 in Malignant Breast Tumor Cells

Philip F. Hughes, L. Neckers, N. Ramanujam, 2013 .

Expression of membrane Hsp90 is a molecular signature of T cell activation

Philip F. Hughes, B. Haynes, D. Roy, 2022, Scientific Reports.

Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease

Philip F. Hughes, B. Haynes, D. Roy, 2021, bioRxiv.

Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

D. Loiselle, J. Niles, E. Derbyshire, 2020, bioRxiv.

Identiﬁcation of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

Philip F. Hughes, D. Thiele, David B. Darr, 2014 .

Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice*

T. Haystead, D. Zheng, D. Loiselle, 2015, The Journal of Biological Chemistry.

Cellular fatty acid synthase is required for late stages of HIV-1 replication

Philip F. Hughes, T. Haystead, D. Loiselle, 2017, Retrovirology.

Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.

Andrew W. Truman, Timothy A. J. Haystead, Mehdi Mollapour, 2017, Cell reports.

Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.

Timothy A J Haystead, Laura G. Dubois, Philip F. Hughes, 2016, Cell chemical biology.

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

Philip F. Hughes, D. Thiele, Jiaoti Huang, 2020, Science Translational Medicine.

Efficient detection of RNA–protein interactions using tethered RNAs

T. Haystead, I. Macara, D. Loiselle, 2011, Nucleic acids research.

Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.

David C. Lee, S. Sunnarborg, C. Hinkle, 2004, The Journal of biological chemistry.

The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect

W. Linehan, L. Schmidt, W. Stetler-Stevenson, 2021, Nature Structural & Molecular Biology.

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Philip F. Hughes, D. Thiele, David B. Darr, 2014, Chemistry & biology.

Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.

Timothy A J Haystead, Asim K Bera, Philip F. Hughes, 2017, Cell chemical biology.

Identification of components of protein complexes.

Christoph H Borchers, Carol E Parker, C. Borchers, 2005, Methods in molecular biology.

The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules

T. Haystead, S. Mili, I. Macara, 2013, The Journal of cell biology.

A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo.

Philip F. Hughes, David B. Darr, T. Haystead, 2017, ACS chemical biology.

Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion

Philip F. Hughes, D. Loiselle, T. Haystead, 2018, Scientific Reports.

Selective Roles for Tumor Necrosis Factor α-converting Enzyme/ADAM17 in the Shedding of the Epidermal Growth Factor Receptor Ligand Family

David C. Lee, S. Sunnarborg, C. Hinkle, 2004, Journal of Biological Chemistry.

Human Cytidine Triphosphate Synthetase 1 Interacting Proteins

T. Haystead, L. Graves, D. Loiselle, 2008, Nucleosides, nucleotides & nucleic acids.

Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion

Philip F. Hughes, D. Loiselle, T. Haystead, 2018, Scientific Reports.

Copine A Interacts with Actin Filaments and Plays a Role in Chemotaxis and Adhesion

D. Loiselle, T. Haystead, Min Han, 2019, Cells.

A bioorthogonal chemical reporter for fatty acid synthase–dependent protein acylation

T. Haystead, D. Loiselle, J. Yount, 2021, bioRxiv.