A. Molinolo

A. Molinolo, M. Itoiz, A. Raimondi, 2006, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

E. Hirsch, J. Gutkind, R. Wetzker, 2011, Cancer cell.

p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas.

A. Efeyan, C. Conti, A. Molinolo, 2002, Carcinogenesis.

Natural and Synthetic Progestins Accelerate 7,12-Dimethylbenz[a]Anthracene-Initiated Mammary Tumors and Increase Angiogenesis in Sprague-Dawley Rats

M. Ellersieck, A. Molinolo, C. Besch-Williford, 2006, Clinical Cancer Research.

Expression and Genetic Loss of Function Analysis of the HAT/DESC Cluster Proteases TMPRSS11A and HAT

J. P. Hobson, A. Molinolo, T. Bugge, 2011, PloS one.

Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

J. Grandis, J. Califano, M. Gilardi, 2021, Nature Communications.

Induction of mammary adenocarcinomas by medroxyprogesterone acetate in BALB/c female mice.

A. Molinolo, C. Pasqualini, C. Lanari, 1986, Cancer letters.

Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters

B. Jacobsen, A. Molinolo, P. Rojas, 2015, International journal of cancer.

Combined estrogen-progestogen menopausal therapy

V. Beral, K. Straif, S. Shapiro, 2007 .

The common analgesic paracetamol enhances the anti-tumour activity of decitabine through exacerbation of oxidative stress

F. Khanim, M. Wiench, J. S. Gutkind, 2020, bioRxiv.

The common analgesic paracetamol enhances the anti-tumour activity of decitabine through exacerbation of oxidative stress

F. Khanim, M. Wiench, J. S. Gutkind, 2020, bioRxiv.

Phenotypic and Genotypic Characterization and Treatment of a Cohort With Familial Tumoral Calcinosis/Hyperostosis‐Hyperphosphatemia Syndrome

K. White, M. Econs, Marcus Y. Chen, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Breast Cancer Mortality in Older and Younger Patients in California

James D. Murphy, S. Gomez, R. Schwab, 2018, Cancer Epidemiology, Biomarkers & Prevention.

Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene

J. S. Gutkind, D. Martin, A. Molinolo, 2014, Oncogene.

Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis.

S. Leppla, A. Molinolo, T. Bugge, 2012, Biochemical and biophysical research communications.

Animal Model Allows Targeted Delivery of Polyoma MiddleTOncogene toVascular Endothelial Progenitors In vivo and Results in Hemangioma Development

J. S. Gutkind, A. Molinolo, J. Frampton, 2008 .

RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors In vivo and Results in Hemangioma Development

J. S. Gutkind, A. Molinolo, J. Frampton, 2008, Clinical Cancer Research.

Potent Inhibition and Global Co-localization Implicate the Transmembrane Kunitz-type Serine Protease Inhibitor Hepatocyte Growth Factor Activator Inhibitor-2 in the Regulation of Epithelial Matriptase Activity*

J. P. Hobson, A. Molinolo, Chen-Yong Lin, 2008, Journal of Biological Chemistry.

Five novel hormone-responsive cell lines derived from murine mammary ductal carcinomas: in vivo and in vitro effects of estrogens and progestins.

A. Molinolo, N. Sanjuán, I. Lüthy, 2001, Cancer research.

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype

S. Thorgeirsson, F. Elloumi, M. Heikenwalder, 2016, Hepatology.

Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes.

D. Leroith, A. Rowzee, T. Wood, 2010, Cancer research.

Liver damage and senescence increases in patients developing hepatocellular carcinoma

L. Terracciano, C. Quintavalle, A. Molinolo, 2017, Journal of gastroenterology and hepatology.

Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition.

J. Gutkind, A. Molinolo, John H. Lee, 2013, Neoplasia.

James D. Murphy, S. Gomez, R. Schwab, 2019, BMC Cancer.

Effects of denosumab treatment and discontinuation on human growth plates.

A. Molinolo, M. Collins, R. Gafni, 2014, The Journal of clinical endocrinology and metabolism.

Toxicological Studies of 212Pb Intravenously or Intraperitoneally Injected into Mice for a Phase 1 Trial

M. Brechbiel, A. Molinolo, D. Milenic, 2015, Pharmaceuticals.

Studies concerning the effect of external irradiation on localization of radiolabeled monoclonal antibody B72.3 to human colon carcinoma xenografts.

P. Hand, J. Schlom, A. Molinolo, 1989, International journal of radiation oncology, biology, physics.

Co‐localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase

J. P. Hobson, A. Molinolo, T. Bugge, 2007, Journal of cellular physiology.

Autosomal Ichthyosis with Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice*

J. Segre, B. Cravatt, A. Molinolo, 2007, Journal of Biological Chemistry.

Denosumab treatment for fibrous dysplasia

N. Bhattacharyya, A. Molinolo, M. Collins, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy

Dina V. Hingorani, S. Adams, J. S. Gutkind, 2022, Nature Communications.

Progesterone receptors in estrogen-induced fibromatosis of guinea pigs.

A. Molinolo, E. Kordon, C. Lanari, 1990, Cancer letters.

TAG-72 as a Tumor Marker

M. Kuroki, P. Hand, A. Thor, 1992 .

Tumor-induced osteomalacia

A. Molinolo, Clara C. Chen, M. Collins, 2017, Bone reports.

Progressive Tumor Formation in Mice with Conditional Deletion of TGF- B Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway Molecular Biology, Pathobiology, and

L. Wakefield, K. Flanders, A. Kulkarni, 2009 .

Regulation of cell growth of a progestin-dependent murine mammary carcinoma in vitro: progesterone receptor involvement in serum or growth factor-induced cell proliferation

A. Molinolo, M. Simian, C. Lamb, 1999, The Journal of Steroid Biochemistry and Molecular Biology.

TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition.

A. Molinolo, T. Bugge, D. H. Madsen, 2014, The Biochemical journal.

A pilot, single arm, prospective trial using neoadjuvant rapamycin prior to definitive therapy in head and neck squamous cell carcinoma.

E. Szabo, C. Waes, J. S. Gutkind, 2015 .

of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in and

J. Grandis, J. Califano, M. Gilardi, 2021 .

Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter.

J. S. Gutkind, A. Molinolo, Panomwat Amornphimoltham, 2006, The American journal of pathology.

Immune Consequences of Decreasing Tumor Vasculature with Antiangiogenic Tyrosine Kinase Inhibitors in Combination with Therapeutic Vaccines

A. Molinolo, R. Donahue, J. Hodge, 2014, Cancer Immunology Research.

ActivationofthemTORPathwayinPrimaryMedullaryThyroid Carcinoma and Lymph Node Metastases

M. Raffeld, M. Santoro, J. S. Gutkind, 2012 .

Phase 1 dose‐finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer

V. Takiar, J. S. Gutkind, A. Molinolo, 2020, Cancer.

Medroxyprogesterone acetate enhances in vivo and in vitro antibody production

A. Molinolo, J. Geffner, R. Gamberale, 2001, Immunology.

Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development

A. Molinolo, T. Bugge, K. List, 2007, Oncogene.

Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity

I. Frahm, A. Molinolo, A. Iribarren, 2004, Oncogene.

Cellular systems for studying human oral squamous cell carcinomas.

J. S. Gutkind, V. Patel, R. Iglesias-Bartolome, 2011, Advances in experimental medicine and biology.

Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden

N. Bhattacharyya, A. Molinolo, M. Collins, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Human Cancer Biology Activationof themTORPathway inPrimaryMedullary Thyroid Carcinoma and Lymph Node Metastases

M. Raffeld, M. Santoro, J. S. Gutkind, 2012 .

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation.

S. Leppla, A. Molinolo, M. Ploug, 2010, Blood.

Novel, Low Cost, Highly Effective, Handmade Steroid Pellets for Experimental Studies

A. Molinolo, M. May, V. Wargon, 2013, PloS one.

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

James B. Mitchell, Vyomesh Patel, J. Gutkind, 2012, Cell stem cell.

Proliferative and Nonproliferative Lesions of the Rat and Mouse Mammary, Zymbal’s, Preputial, and Clitoral Glands

R. Cardiff, A. Molinolo, S. Treumann, 2012, Toxicologic pathology.

Progesterone induction of mammary carcinomas in BALB/c female mice

A. Molinolo, G. Dran, C. Pasqualini, 1993, Breast Cancer Research and Treatment.

Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice.

A. Molinolo, C. Lanari, P. Pazos, 2001, Leukemia research.

A role for p38 MAPK in head and neck cancer cell growth and tumor‐induced angiogenesis and lymphangiogenesis

J. Gutkind, A. Molinolo, J. Basile, 2014, Molecular oncology.

Precancer in Mice: Animal Models Used to Understand, Prevent, and Treat Human Precancers

R. Cardiff, G. Boivin, J. Ward, 2006, Toxicologic pathology.

Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma

Jaime Rodriguez-Canales, Stephen M Hewitt, Catherine M Conway, 2013, Pigment cell & melanoma research.

Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth

A. Molinolo, S. Vanzulli, A. Sahores, 2010, BMC Cancer.

Cholecystokinin Receptor Antagonist Halts Progression of Pancreatic Cancer Precursor Lesions and Fibrosis in Mice

Christopher O. McGovern, J. S. Gutkind, A. Molinolo, 2014, Pancreas.

Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays

J Silvio Gutkind, Vyomesh Patel, Apiwat Mutirangura, 2004, Clinical Cancer Research.

Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary

J. Gillespie, J. S. Gutkind, V. Patel, 2004 .

Transcriptional signature primes human oral mucosa for rapid wound healing

Marie-Liesse Asselin-Labat, Maria I. Morasso, Stephen R. Brooks, 2018, Science Translational Medicine.

Pathogenesis of Ductal and Lobular Progestin-Induced Mammary Carcinomas in BALB/c Mice

A. Molinolo, G. Dran, C. Pasqualini, 1996 .

Effect of sialoadenectomy on medroxyprogesterone‐acetate‐induced mammary carcinogenesis in BALB/c mice. Correlation between histology and epidermal‐growth‐factor receptor content

A. Molinolo, G. Dran, C. Pasqualini, 1994, International journal of cancer.

Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies

Kai Hung Tiong, Pei San Yee, A. Tan, 2016, Oncotarget.

Antiprogestins in breast cancer treatment: are we ready?

A. Molinolo, P. Rojas, V. Wargon, 2012, Endocrine-related cancer.

Head and Neck Cancer and the PI3K/Akt/mTOR Signaling Network: Novel Molecular Targeted Therapies

J. Gutkind, V. Patel, A. Molinolo, 2011 .

A Synthetic Biology Approach Reveals a CXCR4-G13-Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells

Michel Bouvier, Hiroshi Yagi, J Silvio Gutkind, 2011, Science Signaling.

Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC

J. Mesirov, S. Schokrpur, B. Fox, 2022, Nature Communications.

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

L. Alexandrov, M. Gilardi, Zhiyong Wang, 2019, Nature Communications.

PTEN deficiency contributes to the development and progression of head and neck cancer.

M. Lingen, J. S. Gutkind, A. Molinolo, 2013, Neoplasia.

Metformin Prevents the Development of Oral Squamous Cell Carcinomas from Carcinogen-Induced Premalignant Lesions

J. S. Gutkind, V. Patel, A. Schneider, 2012, Cancer Prevention Research.

Dysregulated molecular networks in head and neck carcinogenesis.

J. Gutkind, V. Patel, A. Molinolo, 2009, Oral oncology.

Proteomic Analysis of Laser-Captured Paraffin-Embedded Tissues: A Molecular Portrait of Head and Neck Cancer Progression

Timothy D. Veenstra, J. Silvio Gutkind, Thomas P. Conrads, 2008, Clinical Cancer Research.

The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.

E. Sausville, B. Manning, J. Gutkind, 2006, Cancer cell.

Association of estrogen receptor-α and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment

V. Patel, A. Molinolo, S. Vanzulli, 2007, Breast Cancer Research.

Inactivating Mutations in GNA13 and RHOA in Burkitt’s Lymphoma and Diffuse Large B cell Lymphoma: A Tumor Suppressor Function for the Gα13/RhoA Axis in B Cells

Khalid W. Kalim, I. Kufareva, J. Gutkind, 2015, Oncogene.

Tumor-induced osteomalacia.

A. Molinolo, Clara C. Chen, M. Collins, 2011, Endocrine-related cancer.

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

A. Kulkarni, C. Waes, Y. Bian, 2012, Oncogene.

Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells

S. Millar, J. Gutkind, V. Patel, 2007, Oncogene.

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma

E. H. Margulies, Jimmy Lin, Xiaomu Wei, 2011, Nature Genetics.

Mutational and Functional Analysis Reveals ADAMTS18 Metalloproteinase as a Novel Driver in Melanoma

Jimmy Lin, C. López-Otín, Xiaomu Wei, 2010, Molecular Cancer Research.

Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis

A. Molinolo, T. Bugge, P. Kósa, 2011, Oncogene.

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

Chenwei Wang, S. Davis, A. Weeraratna, 2009, Nature Genetics.

SDF‐1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis

J. Gutkind, Zhiyong Wang, R. Weigert, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas

S. Hewitt, T. Seiwert, J. S. Gutkind, 2012, Clinical Cancer Research.

Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice.

R. Leapman, J. S. Gutkind, V. Patel, 2010, Nanomedicine.

Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer

P. Hegde, M. Taketo, A. Molinolo, 2020, Proceedings of the National Academy of Sciences.

Conditional Expression of K-ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis

J. S. Gutkind, A. Molinolo, Panomwat Amornphimoltham, 2004, Cancer Research.

Promote Squamous Cell Carcinogenesis Compartment that Includes the Stem Cells Is Sufficient to in an Epithelial ras Conditional Expression of K-Updated

J. S. Gutkind, A. Molinolo, Panomwat Amornphimoltham, 2004 .

Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression.

A. Molinolo, M. Simian, C. Lanari, 2006, The American journal of pathology.

Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.

E. Sausville, J. S. Gutkind, V. Patel, 2005, Cancer research.

mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations

Zhiyong Wang, J. S. Gutkind, V. Patel, 2014, Journal of the National Cancer Institute.

Accumulated Chromosomal Instability in Murine Bone Marrow Mesenchymal Stem Cells Leads to Malignant Transformation

Baojin Fu, T. Ried, V. Patel, 2006, Stem cells.

Abstract OT1-04-02: Mifepristone treatment for breast cancer patients expressing levels of progesterone receptor isoform A (PRA) higher than those of isoform B (PRB)

A. Molinolo, P. Rojas, A. Castets, 2018 .

Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia.

A. Molinolo, V. Wargon, A. Sahores, 2010, Medicina.

Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.

L. Wakefield, K. Flanders, A. Kulkarni, 2009, Cancer research.

TGFβ Receptor I Conditional Knockout Mice Develop Spontaneous Squamous Cell Carcinoma

R. Puri, A. Kulkarni, S. Karlsson, 2007, Cell cycle.

Targeting matriptase in breast cancer abrogates tumor progression via impairment of stromal-epithelial growth factor signaling

R. Leduc, A. Molinolo, Christopher Bergum, 2015, Nature Communications.

Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas

M. Vanoni, M. Gilardi, Zhiyong Wang, 2020, Molecular Cancer Therapeutics.

Intraperitoneal administration of interferon-gamma to carcinoma patients enhances expression of tumor-associated glycoprotein-72 and carcinoembryonic antigen on malignant ascites cells.

F. Guadagni, J. Schlom, E. Borden, 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Emerging Cancer Biomarkers for HNSCC Detection and Therapeutic Intervention

Zhiyong Wang, J. S. Gutkind, V. Patel, 2017 .

MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements

Jason I. Herschkowitz, C. Perou, J. Gutkind, 2011, Breast Cancer Research and Treatment.

Carcinoma‐associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF‐2/FGFR‐2 axis

A. Molinolo, A. Baldi, V. Fabris, 2008, International journal of cancer.

Mammary carcinoma associated fibroblasts as key players in the acquisition of hormone independence interaction between progesterone receptors and fibroblast growth factor receptor 2

A. Molinolo, V. Wargon, V. Fabris, 2007 .

Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer.

B. Jacobsen, A. Molinolo, V. Fabris, 2018, Endocrine-related cancer.

Targeting progesterone receptors in breast cancer.

A. Molinolo, Sebastián Giulianelli, C. Lanari, 2013, Vitamins and hormones.

Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells

A. Kornblihtt, I. Frahm, A. Molinolo, 2005, Molecular and Cellular Biology.

The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer.

A. Molinolo, V. Wargon, L. Helguero, 2009, Endocrine-related cancer.

Mouse mammary tumors induced by medroxyprogesterone acetate: immunohistochemistry and hormonal receptors.

A. Molinolo, N. Sanjuán, C. Pasqualini, 1987, Journal of the National Cancer Institute.

Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial

O. Harismendy, S. Lippman, E. Szabo, 2018, Clinical Cancer Research.

Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice.

A. Molinolo, P. Elizalde, C. Lanari, 1998, Carcinogenesis.

Plasma cell granuloma of the bladder: a case report.

A. Molinolo, R. Meiss, R. Jufe, 1984, The Journal of urology.

Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis

J. Sicklick, O. Harismendy, R. DeMatteo, 2021, Oncogene.

Increased High Molecular Weight FGF2 in Endocrine-Resistant Breast Cancer

S. Hewitt, B. Jacobsen, A. Molinolo, 2018, Hormones and Cancer.

Associated expressions of FGFR-2 and FGFR-3: from mouse mammary gland physiology to human breast cancer

S. Hewitt, A. Molinolo, S. Vanzulli, 2012, Breast Cancer Research and Treatment.

Mutational and Functional Analysis Reveals ADAMTS 18 Metalloproteinase as a Novel Oncogene in Melanoma

Jimmy Lin, C. López-Otín, Xiaomu Wei, 2011 .

Molecular Cancer esearch cer Genes and Genomics ational and Functional Analysis Reveals ADAMTS 18 R alloproteinase as a Novel Driver in Melanoma

Jimmy Lin, C. López-Otín, S. Rosenberg, 2010 .

alloproteinase as a Novel Driver in Melanoma

Jimmy Lin, C. López-Otín, S. Rosenberg, 2010 .

SHORT COMMUNICATION Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice

A. Molinolo, P. Elizalde, C. Lanari, 1998 .

Activation of the mTOR Pathway in Primary Medullary Thyroid Carcinoma and Lymph Node Metastases

M. Raffeld, M. Santoro, A. Molinolo, 2012, Clinical Cancer Research.

Progesterone Receptor Expression in Medroxyprogesterone Acetate-Induced Murine Mammary Carcinomas and Response to Endocrine Treatment

A. Asaithamby, A. Molinolo, G. Shyamala, 2003, Breast Cancer Research and Treatment.

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.

B. Nielsen, J. Gutkind, A. Molinolo, 2005, Genes & development.

Efficient Targeting of Head and Neck Squamous Cell Carcinoma by Systemic Administration of a Dual uPA and MMP-Activated Engineered Anthrax Toxin

S. Leppla, A. Molinolo, T. Bugge, 2011, PloS one.

Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography.

B. Nielsen, J. Myers, J. Ensley, 2004, Oral oncology.

A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation.

A. Molinolo, C. Squarize, A. Abrahão, 2010, Oral oncology.

Demonstration of cytokeratins by immunoperoxidase staining in prostatic tissue.

A. Molinolo, R. Meiss, P. Leo, 1985, The Journal of urology.

Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta?

A. Molinolo, V. Wargon, S. Vanzulli, 2010, Breast Cancer Research and Treatment.

IARC MONOGRAPHS PROGRAMME ON THE EVALUATION OF CARelNOGENIC RISKS TO HUMANS'

V. Beral, K. Straif, S. Shapiro, 2008 .

Involvement of EGF in medroxyprogesterone acetate (MPA)-induced mammary gland hyperplasia and its role in MPA-induced mammary tumors in BALB/c mice.

A. Molinolo, S. Vanzulli, M. Simian, 1998, Cancer letters.

Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas

A. Molinolo, P. Rojas, V. Wargon, 2009, Breast Cancer Research and Treatment.

Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas.

M. M. Facchinetti, V. Patel, A. Molinolo, 2012, Experimental and molecular pathology.

Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.

J. Gutkind, A. Molinolo, M. Lionakis, 2015, Cancer research.

Establishment of Two Hormone-responsive Mouse Mammary Carcinoma Cell Lines Derived from a Metastatic Mammary Tumor

A. Efeyan, A. Molinolo, V. Fabris, 2004, Breast Cancer Research and Treatment.

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.

S. Lippman, N. Sonenberg, J. Califano, 2019, Cancer research.

Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma

E. Sausville, C. Conti, J. Gutkind, 2004, Clinical Cancer Research.

Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness

C. Perou, Xiaping He, S. Hewitt, 2017, Journal of the National Cancer Institute.

Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects

O. Pignataro, J. Calvo, A. Molinolo, 2011, Breast Cancer Research and Treatment.

Progesterone receptors - animal models and cell signalling in breast cancer: Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer

A. Molinolo, C. Lanari, 2002, Breast Cancer Research.

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

P. Tamayo, S. Lippman, Y. Samuels, 2018, Nature Communications.

Increased Expression of the Collagen Internalization Receptor uPARAP/Endo180 in the Stroma of Head and Neck Cancer

A. Molinolo, N. Behrendt, T. Bugge, 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

J. Gutkind, A. Molinolo, T. Bugge, 2010, Oncogene.

Progesterone promotes immunomodulation and tumor development in the murine mammary gland

Howard H. Yang, Ying Hu, K. Hunter, 2021, Journal for ImmunoTherapy of Cancer.

Determining the molecular landscape and impact on prognosis in HPV-associated head and neck cancer

V. Takiar, A. Molinolo, T. Wise-Draper, 2020, Cancers of the Head & Neck.

Progesterone receptor involvement in independent tumor growth in MPA-induced murine mammary adenocarcinomas

A. Molinolo, S. Vanzulli, C. Lamb, 1999, The Journal of Steroid Biochemistry and Molecular Biology.

Abstract 351: mTOR-ERK co-targeting strategies for head and neck cancer therapy

R. Iglesias-Bartolome, A. Molinolo, Qianming Chen, 2017 .

Isoform specificity of progesterone receptor antibodies

B. Jacobsen, M. Lombès, A. Molinolo, 2017, The journal of pathology. Clinical research.

Germline Genetic Variation Modulates Tumor Progression and Metastasis in a Mouse Model of Neuroendocrine Prostate Carcinoma

N. Crawford, A. Molinolo, Shashank J. Patel, 2013, PloS one.

Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model

V. Patel, A. Molinolo, Panomwat Amornphimoltham, 2009, Cancer Prevention Research.

Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer.

A. Molinolo, P. Rojas, M. May, 2016, Experimental and molecular pathology.

Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes

A. Molinolo, S. Offermanns, Karina K. Hansen, 2017, PloS one.

Cryopreservation of Viable Human Tissues: Renewable Resource for Viable Tissue, Cell Lines, and Organoid Development.

J. Sicklick, M. Rose, A. Molinolo, 2020, Biopreservation and biobanking.

Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer.

J Silvio Gutkind, Vyomesh Patel, Roberto Weigert, 2011, Cancer research.

Future directions and treatment strategies for head and neck squamous cell carcinomas.

A. Molinolo, K. Wikenheiser-Brokamp, T. Wise-Draper, 2012, Translational research : the journal of laboratory and clinical medicine.

Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis

S. Teo, S. Cheong, R. Zain, 2014, OncoTarget.

The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer

A. Molinolo, P. Rojas, M. May, 2014, Oncotarget.

Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions

V. Patel, A. Molinolo, Panomwat Amornphimoltham, 2008, Clinical Cancer Research.

Matrix Metalloproteinase-activated Anthrax Lethal Toxin Demonstrates High Potency in Targeting Tumor Vasculature*

Alfredo Molinolo, Shihui Liu, S. Leppla, 2008, Journal of Biological Chemistry.

Therapeutic advantage of high-affinity anticarcinoma radioimmunoconjugates.

J. Schlom, A. Molinolo, D. Houchens, 1992, Cancer research.

WISP1/CCN4: A Potential Target for Inhibiting Prostate Cancer Growth and Spread to Bone

N. Crawford, A. Molinolo, M. Young, 2013, PloS one.

Reversal of estrogen‐resistance in murine mammary adenocarcinomas

A. Molinolo, C. Lanari, M. F. Montecchia, 1999, Breast Cancer Research and Treatment.

Phase II multi-site investigation of neoadjuvant pembrolizumab and adjuvant concurrent radiation and pembrolizumab with or without cisplatin in resected head and neck squamous cell carcinoma.

V. Takiar, A. Molinolo, N. Dunlap, 2018 .

HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers

Alexander V. Favorov, Daria A. Gaykalova, T. Ideker, 2020, Oncogene.

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

B. Győrffy, J. Heino, D. Schlaepfer, 2019, bioRxiv.

Progesterone receptor isoform ratio dictates antiprogestin/progestin effects on breast cancer growth and metastases: A role for NDRG1

C. Sartorius, A. Molinolo, P. Rojas, 2021, International journal of cancer.

Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance

Susan S. Taylor, R. Iglesias-Bartolome, A. Molinolo, 2017, Proceedings of the National Academy of Sciences.

Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3

V. Steele, A. Bode, I. Stijleman, 2015, Cancer Prevention Research.

mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.

J. Califano, R. Iglesias-Bartolome, A. Molinolo, 2016, Carcinogenesis.

Real-Time Temperature Mapping in Ultra-Low Freezers as a Standard Quality Assessment.

Sharmeela Kaushal, Samantha Powell, Alfredo Molinolo, 2019, Biopreservation and biobanking.

Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry.

W. Hancock, J. Myers, J. Ensley, 2005, Oral oncology.

Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer

R. Weigert, V. Patel, A. Molinolo, 2013, Clinical Cancer Research.

Inactivation of a Gαs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

Susan S. Taylor, Min Chen, L. Weinstein, 2015, Nature Cell Biology.

Inhibitory effect of medroxyprogesterone acetate on foreign body tumorigenesis in mice.

A. Molinolo, C. Pasqualini, C. Lanari, 1986, Journal of the National Cancer Institute.

Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression.

A. Molinolo, S. Vanzulli, L. Colombo, 2005, Carcinogenesis.

Differential Effects of Raloxifene, Tamoxifen and Fulvestrant on a Murine Mammary Carcinoma

A. Molinolo, L. Helguero, L. Colombo, 2003, Breast Cancer Research and Treatment.

Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative

D. Wong, S. Hewitt, D. Saranath, 2007, Clinical Cancer Research.

Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands.

A. Kulkarni, S. Karlsson, A. Molinolo, 2007, Arthritis and rheumatism.

The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs

W. ElShamy, A. Molinolo, Eman Sami, 2021, Cancer Gene Therapy.

Positive Surgical Margins in the 10 Most Common Solid Cancers

S. Lippman, James D. Murphy, C. Kane, 2018, Scientific Reports.

Human Cancer Biology Rab 25 Regulates Invasion and Metastasis in Head and Neck Cancer

R. Weigert, V. Patel, A. Molinolo, 2013 .

Rab 25 in head and neck cancer metastasis 1 Rab 25 regulates invasion and metastasis in head and neck cancer

R. Weigert, V. Patel, A. Molinolo, 2012 .

Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model.

A. Molinolo, A. Raimondi, J. Gutkind, 2009, Cancer research.

Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data.

S. Hewitt, J. Gutkind, M. M. Facchinetti, 2012, Lung cancer.

Isolation of a stromal cell line from an early passage of a mouse mammary tumor line: A model for stromal parenchymal interactions

A. Efeyan, A. Molinolo, N. Sanjuán, 2005, Journal of cellular physiology.

Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides.

Dina V. Hingorani, R. Tsien, A. Molinolo, 2017, Oral oncology.

The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress

F. Khanim, M. Wiench, Joanna L. Parish, 2020, Cancer letters.

Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin

S. Leppla, A. Molinolo, T. Bugge, 2005, Nature Biotechnology.

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays.

James F Rusling, J Silvio Gutkind, Vyomesh Patel, 2013, Oral oncology.

Estrogen inhibition of MPA‐Induced mouse mammary tumor transplants

A. Molinolo, C. Pasqualini, P. Elizalde, 1991, International journal of cancer.

Evidence for two progesterone receptor binding sites in murine mammary carcinomas

A. Molinolo, L. Helguero, C. Lamb, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

Dissecting theAkt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer TissueArray Initiative

John, D. Wong, D. Saranath, 2007 .

and Neck Cancer Increased Expression of the Collagen Internalization Receptor uPARAP/Endo180 in the Stroma of Head

A. Molinolo, N. Behrendt, T. Bugge, 2013 .

Chemical Carcinogenesis Models for Evaluating Molecular-Targeted Prevention and Treatment of Oral Cancer

V. Patel, A. Molinolo, Panomwat Amornphimoltham, 2009, Cancer Prevention Research.

A comprehensive list of studies using 4 NQO as an oral carcinogen in mice , either by local ( oral cavity brushing ) or systemic ( drinking water ) delivery

V. Patel, A. Molinolo, Panomwat Amornphimoltham, 2009 .

Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals.

R. Weigert, A. Molinolo, L. Parente, 2009, American journal of physiology. Cell physiology.

Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4

L. Alexandrov, M. Gilardi, Zhiyong Wang, 2019, bioRxiv.

Tumor-induced osteomalacia.

A. Molinolo, Clara C. Chen, M. Collins, 2011, Endocrine-related cancer.

The head and neck cancer cell oncogenome : a platform for the development of precision molecular therapies

Y. Samuels, A. Molinolo, M. Abba, 2014 .

Direct reprogramming of oral epithelial progenitor cells to cancer stem cells at single cell resolution in vivo

Kyle B. Jones, O. Klein, J. Califano, 2023, bioRxiv.

Progesterone receptors - animal models and cell signalling in breast cancer: Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer

A. Molinolo, C. Lanari, 2002, Breast Cancer Research.

The head and neck cancer cell oncogenome: A platform for the development of precision molecular therapies

A. Molinolo, M. Abba, Daniel Martin, 2014 .

Metformin Prevents the Development of Oral Squamous Cell Carcinomas from Carcinogen-Induced Premalignant Lesions

V. Patel, A. Schneider, A. Molinolo, 2012, Cancer Prevention Research.

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype

S. Thorgeirsson, M. Heikenwalder, V. Factor, 2016, Hepatology.

Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes.

D. Leroith, A. Rowzee, T. Wood, 2010, Cancer research.

A phase I study of everolimus in combination with cetuximab and cisplatin as first-line therapy in recurrent and metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).

C. Chung, J. Gutkind, A. Molinolo, 2012 .

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

V. Patel, R. Iglesias-Bartolome, A. Molinolo, 2012, Cell stem cell.

Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer.

B. Jacobsen, A. Molinolo, V. Fabris, 2018, Endocrine-related cancer.

A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal

S. Rosenthal, A. Molinolo, K. Fisch, 2023, Cancers.

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

A. Molinolo, D. Swaney, M. Ceribelli, 2023, Cell reports. Medicine.

TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition.

A. Molinolo, T. Bugge, D. H. Madsen, 2014, The Biochemical journal.

A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death.

A. Molinolo, J. Watrous, Xingyu Wu, 2024, Cancer letters.