B. Ksander

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Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

G. Merlino, J. Vaqué, J. Gutkind, 2014, Cancer cell.

Uveal melanomas contain antigenically specific and non-specific infiltrating lymphocytes.

B. Ksander, M. Salgaller, D. C. Geer, 1998, Current eye research.

Reprogramming to recover youthful epigenetic information and restore vision

Margarita V. Meer, M. Levine, S. Horvath, 2020, Nature.

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

Margarita V. Meer, S. Horvath, G. Church, 2019, bioRxiv.

MHC class II-transduced tumor cells originating in the immune-privileged eye prime and boost CD4(+) T lymphocytes that cross-react with primary and metastatic uveal melanoma cells.

M. Lotem, B. Ksander, S. Ostrand-Rosenberg, 2007, Cancer research.

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice.

B. Ksander, C. Cursiefen, L. Heindl, 2015, Investigative ophthalmology & visual science.

Immunity causing blindness: five different paths to herpes stromal keratitis.

M. Dana, B. Ksander, J. Streilein, 1997, Immunology today.

Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma

B. Ksander, Jinfeng Cao, M. Jager, 2015, Ocular Oncology and Pathology.

A Murine Model for Metastatic Conjunctival Melanoma.

E. Jordanova, B. Ksander, Jinfeng Cao, 2015, Investigative ophthalmology & visual science.

αB-Crystallin Protects Retinal Tissue during Staphylococcus aureus- Induced Endophthalmitis

E. Wawrousek, B. Ksander, M. Gilmore, 2008, Infection and Immunity.

A novel treatment for ocular tumors using membrane FasL vesicles to activate innate immunity and terminate immune privilege.

S. Mukai, B. Ksander, A. Marshak‐Rothstein, 2005, Investigative ophthalmology & visual science.

Immunology of Uveal Melanoma: Adaptive Antitumor Immunity and the Basis for Immunotherapy

B. Ksander, J. Bosch, 2003 .

Uveal Melanoma Cell Lines: Where do they come from? (An American Ophthalmological Society Thesis).

Sander R. Dubovy, B. Ksander, M. Jager, 2016, Transactions of the American Ophthalmological Society.

Opposing Roles for Membrane Bound and Soluble Fas Ligand in Glaucoma-Associated Retinal Ganglion Cell Death

D. Chen, B. Ksander, A. Giani, 2011, PloS one.

Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference

David J. Wilson, Justine R. Smith, J. O'Brien, 2019, Translational vision science & technology.

Tumor Cell Programmed Death Ligand 1-Mediated T Cell Suppression Is Overcome by Coexpression of CD80

B. Ksander, S. Ostrand-Rosenberg, M. Srivastava, 2011, The Journal of Immunology.

by Coexpression of CD80 1-Mediated T Cell Suppression Is Overcome Tumor Cell Programmed Death Ligand

B. Ksander, S. Ostrand-Rosenberg, J. Bosch, 2011 .

Immune privilege, tumors, and the eye.

B. Ksander, P. Chen, P. Chen, 1999, Chemical immunology.

IMMUNOTHERAPY AND GENE THERAPY OF UVEAL MELANOMA

Peter W. Chen, B. Ksander, 1999 .

Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines

C. Roskelley, B. Ksander, J. Mills, 2015, Cell cycle.

2 M UTATION ANALYSIS OF THE PTEN GENE IN UVEAL MELANOMA CELL LINES

N. Naus, B. Ksander, A. Klein, 2005 .

Mutation analysis of the PTEN gene in uveal melanoma cell lines

N. Naus, B. Ksander, A. Klein, 2000, International journal of cancer.

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment

Joan W. Miller, H. Weiner, B. Ksander, 2018, Proceedings of the National Academy of Sciences.

Membrane Fas Ligand Activates Innate Immunity and Terminates Ocular Immune Privilege1

B. Ksander, A. Marshak‐Rothstein, R. Saff, 2002, The Journal of Immunology.

Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase.

Joan W. Miller, E. Gragoudas, D. Vavvas, 2014, Investigative ophthalmology & visual science.

Gene transfer of the CD80 costimulatory molecule into ocular melanoma cells using a novel episomal vector.

B. Ksander, E. Podack, T. Murray, 1997, Investigative ophthalmology & visual science.

Activation of Tumor-specific CD4+ T Lymphocytes by Major Histocompatibility Complex Class II Tumor Cell Vaccines

Peter W. Chen, B. Ksander, S. Ostrand-Rosenberg, 2004, Cancer Research.

Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma

B. Ksander, A. Marshak‐Rothstein, M. Gregory-Ksander, 2016, The Journal of Immunology.

Murine orthotopic corneal transplantation in high-risk eyes. Rejection is dictated primarily by weak rather than strong alloantigens.

B. Ksander, J. Streilein, Y. Sano, 1997, Investigative ophthalmology & visual science.

Studies of tumor-infiltrating lymphocytes from a human choroidal melanoma.

B. Ksander, S. Cousins, P. Rubsamen, 1991, Investigative ophthalmology & visual science.

In vivo gene delivery and visualization of corneal stromal cells using an adenoviral vector and keratocyte-specific promoter.

Eric C. Carlson, Chia-Yang Liu, B. Ksander, 2004, Investigative ophthalmology & visual science.

Failure of infiltrating precursor cytotoxic T cells to acquire direct cytotoxic function in immunologically privileged sites.

B. Ksander, J. Streilein, 1990, Journal of immunology.

Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation

C. Lian, F. Hildebrandt, B. Ksander, 2022, Cell reports.

Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium

Y. Murakami, D. Vavvas, B. Ksander, 2015, Cell Death and Disease.

Expression of angiogenic factors Cyr61 and tissue factor in uveal melanoma.

D. Albert, B. Ksander, L. Subramanian, 2002, Archives of ophthalmology.

Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease

Peter W. Chen, B. Ksander, M. Salgaller, 1997, Clinical & Experimental Metastasis.

Immunotherapy of uveal melanoma.

B. Ksander, P. Chen, P. Chen, 1999, Developments in ophthalmology.

Process Development and Safety Evaluation of ABCB5+ Limbal Stem Cells as Advanced-therapy Medicinal Product to Treat Limbal Stem Cell De ciency

B. Ksander, M. Frank, G. Auffarth, 2020 .

Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells.

Santa Jeremy Ono, B. Ksander, J. Gorga, 2004, Investigative ophthalmology & visual science.

PrivilegeImmunity and Terminates Ocular Immune Membrane Fas Ligand Activates Innate

B. Ksander, A. Marshak‐Rothstein, R. Saff, 2002 .

Anterior chamber-associated immune deviation, ocular immune privilege, and orthotopic corneal allografts.

M. Dana, B. Ksander, J. Streilein, 1999, Transplantation proceedings.

Spontaneous bacterial keratitis in CD36 knockout mice.

J. Zieske, B. Ksander, M. Gilmore, 2011, Investigative ophthalmology & visual science.

Increased Resistance to Staphylococcus aureus Endophthalmitis in BALB/c Mice: Fas Ligand Is Required for Resolution of Inflammation but Not for Bacterial Clearance

B. Ksander, E. Whiston, M. Gregory, 2013, Infection and Immunity.

Anterior chamber‐associated immune deviation‐inducing cells activate T cells, and rescue them from antigen‐induced apoptosis

B. Ksander, M. Takeuchi, J. Streilein, 1999, Immunology.

Characterization of specific T helper cell activity in mice bearing alloantigenic tumors in the anterior chamber of the eye

B. Ksander, J. Streilein, Y. Bando, 1991, European journal of immunology.

Cytotoxic T cells play no essential role in acute rejection of orthotopic corneal allografts in mice.

B. Ksander, J. Streilein, J. Yamada, 2001, Investigative ophthalmology & visual science.

ANALYSIS OF PRIMED DONOR-SPECIFIC T CELLS IN RECIPIENT MICE BEARING ORTHOTOPIC CORNEAL ALLOGRAFTS1

B. Ksander, J. Streilein, Y. Sano, 2000, Transplantation.

Langerhans cells, orthotopic corneal allografts, and direct and indirect pathways of T-cell allorecognition.

B. Ksander, J. Streilein, Y. Sano, 2000, Investigative ophthalmology & visual science.

Detection of minor alloantigen-specific cytotoxic T cells after rejection of murine orthotopic corneal allografts: evidence that graft antigens are recognized exclusively via the "indirect pathway".

B. Ksander, J. Streilein, Y. Sano, 1999, Transplantation.

Melanomas that develop within the eye inhibit lymphocyte proliferation

B. Ksander, T. Murray, D. Verbik, 1997, International journal of cancer.

Blood-borne signals that induce anterior chamber-associated immune deviation after intracameral injection of antigen.

B. Ksander, J. Streilein, S. Okamoto, 1997, Investigative ophthalmology & visual science.

Immune deviation in relation to ocular immune privilege.

B. Ksander, J. Streilein, A. Taylor, 1997, Journal of immunology.

Opposing Roles of Blood-Borne Monocytes and Tissue-Resident Macrophages in Limbal Stem Cell Damage after Ocular Injury

R. Dana, D. Vavvas, B. Ksander, 2021, bioRxiv.

By Altering Ocular Immune Privilege, Bone Marrow–derived Cells Pathogenically Contribute to DBA/2J Pigmentary Glaucoma

Michael G. Anderson, Richard S. Smith, B. Ksander, 2003, The Journal of experimental medicine.

Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency

S. Sel, B. Ksander, J. Chodosh, 2020, Stem cell research & therapy.

Epigenetic Regulation of Corneal Epithelial Differentiation by TET2

Catherine A. Lee, B. Ksander, M. Frank, 2023, International journal of molecular sciences.

High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells

Catherine A. Lee, B. Ksander, M. Frank, 2021, The Ocular Surface.

Investigation of factors associated with ABCB5-positive limbal stem cell isolation yields from human donors.

B. Ksander, M. Frank, Naoko Sasamoto, 2020, The ocular surface.

In vitro expanded human purified ABCB5-positive limbal stem cells for treatment of limbal stem cell deficiency.

B. Ksander, M. Frank, Ekaterina Korobkina, 2018 .

Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies

B. Ksander, M. Frank, N. Frank, 2018, Expert opinion on biological therapy.

Limbal stem cells: identity, developmental origin, and therapeutic potential

B. Ksander, M. Frank, N. Frank, 2018, Wiley interdisciplinary reviews. Developmental biology.

ABCB5 is a limbal stem cell gene required for corneal development and repair

Charles P. Lin, W. Kao, J. Zieske, 2014, Nature.

Fate of orthotopic corneal allografts in eyes that cannot support anterior chamber-associated immune deviation induction.

B. Ksander, J. Streilein, Y. Sano, 1995, Investigative ophthalmology & visual science.

Characterization of cell-mediated immune responses elicited by orthotopic corneal allografts in mice.

B. Ksander, J. Streilein, Y. Sonoda, 1995, Investigative ophthalmology & visual science.

Minor H, rather than MHC, alloantigens offer the greater barrier to successful orthotopic corneal transplantation in mice.

B. Ksander, J. Streilein, Y. Sano, 1996, Transplant immunology.

Role of donor-specific cytotoxic T cells in rejection of corneal allografts in normal and high-risk eyes.

B. Ksander, J. Streilein, Y. Sano, 1996, Transplant immunology.

Midkine promotes metastasis and therapeutic resistance via mTOR/RPS6 in uveal melanoma.

A. Mackensen, B. Ksander, L. Heindl, 2022, Molecular cancer research : MCR.

Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities

K. Nishida, A. Quantock, R. Hayashi, 2021, iScience.

Local Treatment With Alpha-Melanocyte Stimulating Hormone Reduces Corneal Allorejection

Z. Haskova, M. Dana, B. Ksander, 2009, Transplantation.

Limbal Stem Cells and the Treatment of Limbal Stem Cell Deficiency

B. Ksander, M. Frank, N. Frank, 2018 .

Inhibition of lymphocyte proliferation by aqueous humor.

B. Ksander, J. Streilein, C. J. Kaiser, 1989, Regional immunology.

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status.

E. Jordanova, F. Claas, M. Heemskerk, 2018, Investigative ophthalmology & visual science.

Requirement of CD80+ costimulation for rejection of ocular tumors and termination of immune privilege.

Peter W. Chen, B. Ksander, T. Uno, 2006, Experimental eye research.

Cell-mediated immune tolerance to HSV-1 antigens associated with reduced susceptibility to HSV-1 corneal lesions.

B. Ksander, R. Hendricks, 1987, Investigative ophthalmology & visual science.

Control of ocular tumor growth and metastatic spread by soluble and membrane Fas ligand.

B. Ksander, A. Marshak‐Rothstein, R. Saff, 2007, Cancer research.

Immune privilege is extended, then withdrawn, from allogeneic tumor cell grafts placed in the subretinal space.

B. Ksander, J. Streilein, H. Wenkel, 1999, Investigative ophthalmology & visual science.

Analysis of cytotoxic T cell responses to intracameral allogeneic tumors.

B. Ksander, J. Streilein, B R Ksander, 1989, Investigative ophthalmology & visual science.

Imposing deviant immunity on the presensitized state.

B. Ksander, J. Streilein, T. Shimizu, 1994, Journal of immunology.

In vitro efficacy of carboplatin and hyperthermia in a murine retinoblastoma cell line.

J. O'Brien, W. Feuer, W. Mieler, 1997, Investigative ophthalmology & visual science.

The absence of invariant chain in MHC II cancer vaccines enhances the activation of tumor-reactive type 1 CD4+ T lymphocytes

B. Ksander, S. Ostrand-Rosenberg, Suzanne Ostrand-Rosenberg, 2008, Cancer Immunology, Immunotherapy.

Loss of epigenetic information as a cause of mammalian aging

Andreas R. Pfenning, Brendan L. O’Connell, Margarita V. Meer, 2023, Cell.

Characterization of complex chromosomal abnormalities in uveal melanoma by fluorescence in situ hybridization, spectral karyotyping, and comparative genomic hybridization

N. Naus, A. de Klein, B. Ksander, 2001, Genes, chromosomes & cancer.

Tumor cells transduced with the MHC class II Transactivator and CD80 activate tumor-specific CD4+ T cells whether or not they are silenced for invariant chain.

B. Ksander, K. Knutson, M. Disis, 2006, Cancer research.

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

David J. Forsthoefel, A. Debant, M. Seeger, 2013, Molecular cell.

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing GPCR-initiated mitogenic signals

David J. Forsthoefel, A. Debant, M. Seeger, 2013 .

Lung cancer patients’ CD4+ T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells

M. Edelman, B. Ksander, S. Ostrand-Rosenberg, 2008, Cancer Immunology, Immunotherapy.

Endomucin prevents leukocyte–endothelial cell adhesion and has a critical role under resting and inflammatory conditions

F. Luscinskas, B. Ksander, A. Zahr, 2016, Nature Communications.

Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development.

S. Pavey, B. Ksander, N. Gruis, 2004, International journal of cancer.

Uveal melanoma cell-based vaccines express MHC II molecules that traffic via the endocytic and secretory pathways and activate CD8+ cytotoxic, tumor-specific T cells

M. Lotem, B. Ksander, S. Reid, 2009, Cancer Immunology, Immunotherapy.

NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration.

B. Ksander, K. Lashkari, K. Kinnunen, 2013, Investigative ophthalmology & visual science.

Immunology of ocular tumours.

D. Ruiter, B. Ksander, M. Jager, 1999, Immunology today.

Retinal microglia initiate neuroinflammation in ocular autoimmunity

R. Dana, B. Ksander, O. Butovsky, 2019, Proceedings of the National Academy of Sciences.

Modeling of human uveal melanoma in zebrafish xenograft embryos.

A. Jochemsen, B. Snaar-Jagalska, A. Teunisse, 2014, Investigative ophthalmology & visual science.

Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development

S. Pavey, B. Ksander, N. Gruis, 2003, International journal of cancer.

Tumor Escape Mutants Develop within an Immune-Privileged Environment in the Absence of T Cell Selection

Peter W. Chen, B. Ksander, T. Uno, 2006, The Journal of Immunology.

Influence of immune surveillance and immune privilege on formation of intraocular tumors.

Peter W. Chen, B. Ksander, 2007, Chemical immunology and allergy.

Complete elimination ('cure') of progressively growing intraocular tumors by local injection of tumor-specific CD8+ T lymphocytes.

B. Ksander, J. Streilein, S. Miki, 1993, Investigative ophthalmology & visual science.

Termination of Systemic Immunity in the Presence of Intraocular Tumors: Influence of Ocular Immune Privilege on Tumor Vaccines

Peter W. Chen, B. Ksander, 2006 .

Local T helper cell signals by lymphocytes infiltrating intraocular tumors.

B. Ksander, J. Streilein, J. Acevedo, 1992, Journal of immunology.

Recovery of Activated Cytotoxic T Cells from Minor H Incompatible Tumor Graft Rejection Sites

B. Ksander, J. Streilein, 1989, Journal of immunology.

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

L. Pasquale, B. Ksander, Emmanuel S. Buys, 2014, Front. Mol. Neurosci..

Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma

Douglas J. Rhee, Janey L. Wiggs, Rajeev Malhotra, 2013, PloS one.

Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP‐dependent kinase

Joan W. Miller, E. Gragoudas, M. Kayama, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

J. Seidman, S. Bonasera, K. Tsubota, 2019, bioRxiv.

Soluble Fas ligand blocks destructive corneal inflammation in mouse models of corneal epithelial debridement and LPS induced keratitis

B. Ksander, V. Perez, A. Marshak‐Rothstein, 2019, Experimental eye research.

Incomplete activation of lymphokine-producing T cells by alloantigenic intraocular tumours in anterior chamber-associated immune deviation.

B. Ksander, Y. Bando, J. Streilein, 1993, Immunology.

IL-12 ABROGATES IMMUNE PRIVILEGE IN THE ANTERIOR CHAMBER OF THE EYE

B. Ksander, S. Miki, D. Bradley, 1994 .

Infiltration and accumulation of precursor cytotoxic T-cells increase with time in progressively growing ocular tumors.

B. Ksander, Y. Bando, Jorge Acevedo, 1991, Cancer research.

ABCB5+ Limbal Epithelial Stem Cells Inhibit Developmental but Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal Inflammation

B. Ksander, M. Frank, N. Frank, 2023, Cells.

Regulation of the immune response within privileged sites.

B. Ksander, J. Streilein, 1994, Chemical immunology.

Evidence that active suppression contributes to the success of H-2-incompatible orthotopic corneal allografts in mice.

B. Ksander, J. Streilein, Y. Sonoda, 1993, Transplantation Proceedings.

IMMUNE PRIVILEGE TO MHC‐DISPARATE TUMOR GRAFTS IN THE ANTERIOR CHAMBER OF THE EYE: I. QUANTITATIVE ANALYSIS OF INTRAOCULAR TUMOR GROWTH AND THE CORRESPONDING DELAYED HYPERSENSITIVITY RESPONSE

B. Ksander, J. Streilein, 1989, Transplantation.

RB116: An RB1+ retinoblastoma cell line expressing primitive markers

J. O'Brien, G. Seigel, B. Ksander, 2012, Molecular vision.