A. Fry

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Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

Otto Hudecz, Karl Mechtler, Andrea Musacchio, 2011, Science Signaling.

Cell Cycle Regulation of the Activity and Subcellular Localization of Plk1, a Human Protein Kinase Implicated in Mitotic Spindle Function Finally, Genetic Studies Performed with Fungi and Flies Have Identified Multiple Protein Kinases

E. Nigg, A. Fry, R. Golsteyn, 1995 .

Structure and Regulation of the Human Nek2 Centrosomal Kinase*

Stefan Knapp, Andrew M Fry, Oleg Fedorov, 2007, Journal of Biological Chemistry.

The Centrosomal Kinase Nek2 Displays Elevated Levels of Protein Expression in Human Breast Cancer

Andrew M Fry, Iain M Hagan, M. R. Pillai, 2004, Cancer Research.

Protein kinases in the control of mitosis: focus on nucleocytoplasmic trafficking

E. Nigg, A. Fry, P. Gallant, 1995, Journal of Cell Science.

Regulating centrosomes by protein phosphorylation.

T. Mayor, E. Nigg, A. Fry, 2000, Current topics in developmental biology.

Cell Cycle: The NIMA kinase joins forces with Cdc2

E. Nigg, A. Fry, 1995, Current Biology.

The NIMA kinase joins forces with Cdc2 The NIMA and Cdc2 protein kinases cooperate to regulate mitosis in Aspergillus nidulans. NIMA-related pathways have now begun to emerge in higher eukaryotes.

E. Nigg, A. Fry, 1995 .

In vitro assembly of a functional human CDK7‐cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.

E. Nigg, S. Frutiger, G. Hughes, 1995, The EMBO journal.

BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma

A. Mansfield, D. Fennell, P. Baas, 2020, Molecular Cancer Therapeutics.

Alternative Splicing Controls Nuclear Translocation of the Cell Cycle-regulated Nek2 Kinase*

E. F. da Cruz e Silva, M. Fardilha, A. Knebel, 2007, Journal of Biological Chemistry.

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators

P. Meraldi, E. Nigg, A. Fry, 1998, The EMBO journal.

Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles.

A. Fry, A. J. Faragher, 2003, Molecular biology of the cell.

The structural mechanisms that underpin mitotic kinase activation.

R. Bayliss, C. Dodson, A. Fry, 2013, Biochemical Society transactions.

Structure-guided design of purine-based probes for selective Nek2 inhibition

I. Hardcastle, R. Griffin, B. Golding, 2016, Oncotarget.

Identification by High-Throughput Screening of Viridin Analogs as Biochemical and Cell-Based Inhibitors of the Cell Cycle–Regulated Nek2 Kinase

P. Workman, L. Pickard, W. Aherne, 2010, Journal of biomolecular screening.

Mitotic phosphorylation by NEK 6 and NEK 7 reduces microtubule affinity of EML 4 to promote chromosome congression

R. Bayliss, C. Moores, J. Atherton, 2019 .

Sealed with a Kiz: How Plk1 ensures spindle pole integrity.

A. Fry, Joanne E. Baxter, 2006, Developmental cell.

Characterization of mammalian NIMA-related kinases.

E. Nigg, A. Fry, 1997, Methods in enzymology.

OFD1 and Flotillins Are Integral Components of a Ciliary Signaling Protein Complex Organized by Polycystins in Renal Epithelia and Odontoblasts

A. Wandinger-Ness, H. Ward, A. Fry, 2014, PloS one.

EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity

Jene Choi, R. Bayliss, A. Fry, 2022, Molecular cancer research : MCR.

Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas

R. Franco, P. Chieffi, C. Sette, 2009, The Journal of pathology.

Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C

L. Lanier, A. Weiss, A. Fry, 1996, The Journal of experimental medicine.

Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells.

M. Dyer, R. Bayliss, A. Fry, 2017, Cancer research.

An Undecided Coiled Coil

S. Smerdon, D. Scott, F. Muskett, 2011, The Journal of Biological Chemistry.

EGF-induced centrosome separation promotes mitotic progression and cell survival.

J. Ellenberg, A. Krämer, A. Fry, 2013, Developmental cell.

E. Nigg, A. Fry, P. Descombes, 2000, Journal of cell science.

Faculty Opinions recommendation of Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro.

A. Fry, 2017 .

Alternative Treatment Options to ALK Inhibitor Monotherapy for EML4-ALK-Driven Lung Cancer

R. Bayliss, A. Fry, Laura O'Regan, 2022, Cancers.

Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain

D. Fennell, R. Bayliss, A. Fry, 2014, Proceedings of the National Academy of Sciences.

Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

A. Fry, E. Schiebel, Joanne E. Baxter, 2010, Nature Cell Biology.

Cell Cycle Phase-specific Phosphorylation of Human Topoisomerase IIα

N. J. Wells, I. Hickson, C. Norbury, 1995, The Journal of Biological Chemistry.

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog.

J. Chin, R. Bayliss, A. Kazlauskaite, 2015, Nature chemical biology.

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release

J. Chin, A. Zhuravleva, R. Bayliss, 2018 .

Polo-like Kinase-2 Is Required for Centriole Duplication in Mammalian Cells

U. Hoffmann‐Rohrer, I. Hoffmann, A. Fry, 2004, Current Biology.

- of the Cell Cycle Identification by High-Throughput Screening of Viridin Analogs as Biochemical and Cell-Based Inhibitors

L. Pickard, W. Aherne, I. Collins, 2013 .

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression

R. Bayliss, A. Knebel, A. Fry, 2015, The Journal of cell biology.

JCB_201409151 1..10

R. Bayliss, A. Knebel, A. Fry, 2015 .

Casein Kinase II Stabilizes the Activity of Human Topoisomerase IIα in a Phosphorylation-independent Manner*

N. J. Wells, I. Hickson, A. Fry, 1998, The Journal of Biological Chemistry.

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs

D. Fennell, Jene Choi, R. Bayliss, 2016, Cellular and Molecular Life Sciences.

Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines.

A. Harris, C. Chresta, J. Masters, 1991, Cancer research.

Nek2B stimulates zygotic centrosome assembly in Xenopus laevis in a kinase-independent manner.

M. R. Pillai, A. Fry, Joanne E. Baxter, 2004, Developmental biology.

BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms

D. Fennell, A. Fry, A. Nakas, 2022, Oncogene.

2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase

I. Hardcastle, R. Griffin, B. Golding, 2020, RSC medicinal chemistry.

Nek2 kinase in chromosome instability and cancer.

A. Fry, D. Hayward, 2006, Cancer letters.

Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

Andrew M. Fry, Yuu Kimata, A. Fry, 2006, Nature Cell Biology.

Cell cycle regulation by the NEK family of protein kinases

R. Bayliss, A. Fry, Laura O'Regan, 2012, Journal of Cell Science.

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

O. Dovey, S. Cowley, J. Schwabe, 2014, Proceedings of the National Academy of Sciences.

On the molecular mechanisms of mitotic kinase activation

R. Bayliss, A. Fry, S. Yeoh, 2012, Open Biology.

SUN1 Interacts with Nuclear Lamin A and Cytoplasmic Nesprins To Provide a Physical Connection between the Nuclear Lamina and the Cytoskeleton

R. Trembath, A. Fry, C. Shanahan, 2006, Molecular and Cellular Biology.

Construction of a human hTERT RPE-1 cell line with inducible Cre for editing of endogenous genes

K. Hirota, A. Fry, Masato T. Kanemaki, 2022, Biology open.

Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation

Jene Choi, R. Bayliss, A. Fry, 2021, EMBO reports.

Phase-separation of EML4-ALK variant 3 is dependent upon an active ALK conformation

Jene Choi, R. Bayliss, A. Fry, 2020, bioRxiv.

Mitotic Regulation by NEK Kinase Networks

R. Bayliss, J. Roig, A. Fry, 2017, Front. Cell Dev. Biol..

Fluorescence imaging of the centrosome cycle in mammalian cells.

A. Fry, S. Prosser, 2009, Methods in molecular biology.

The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion

T. Mayor, E. Nigg, A. Fry, 2000, The Journal of cell biology.

Protein kinases in control of the centrosome cycle

P. Meraldi, T. Mayor, E. Nigg, 1999, FEBS letters.

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A

Jiri Bartek, Andrew M. Fry, Erich A. Nigg, 1999, Nature Cell Biology.

An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9

R. Bayliss, A. Fry, S. Hoelder, 2009, Molecular cell.

The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

A. Fry, Laura O'Regan, 2009, Molecular and Cellular Biology.

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

Mark W. Richards, Andrew M. Fry, Richard Bayliss, 2009, Journal of molecular biology.

The Centrosomal Kinase Nek 2 Displays Elevated Levels of Protein Expression in Human Breast Cancer

M. R. Pillai, A. Fry, R. Clarke, 2004 .

Identification of centrosome kinases.

A. Fry, A. J. Faragher, 2001, Methods in cell biology.

Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity.

E. Nigg, A. Schmidt, A. Fry, 2005, Genes & development.

C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2

P. Meraldi, T. Mayor, E. Nigg, 1998, The Journal of cell biology.

Mitotic phosphorylation of SUN1 loosens its connection with the nuclear lamina while the LINC complex remains intact

A. Fry, A. Bottrill, S. Prosser, 2014, Nucleus.

APC/C‐mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A‐type D‐box

A. Fry, Samantha L. Wattam, H. Yamano, 2001, The EMBO journal.

EML4–ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7

D. Fennell, P. Muller, Jene Choi, 2020, Journal of Cell Science.

Overexpression of the Nek2 kinase in colorectal cancer correlates with beta‐catenin relocalization and shortened cancer‐specific survival

A. Fry, D. Berry, M. Manson, 2014, Journal of surgical oncology.

Molecular Dissection of the Centrosome Overduplication Pathway in S-Phase-Arrested Cells

A. Fry, S. Prosser, K. Straatman, 2009, Molecular and Cellular Biology.

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

R. Bayliss, C. Moores, J. Atherton, 2019, Science Signaling.

EML4-ALK V3 drives cell migration through NEK9 and NEK7 kinases in non-small-cell lung cancer

D. Fennell, P. Muller, Jene Choi, 2019, bioRxiv.

Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression

R. Bayliss, C. Moores, J. Atherton, 2018, bioRxiv.

EML proteins in microtubule regulation and human disease.

R. Bayliss, A. Fry, Laura O'Regan, 2016, Biochemical Society transactions.

Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis

A. Holder, D. Ferguson, D. Brady, 2018, Scientific Reports.

Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis.

Rebecca S Hames, Andrew M Fry, A. Fry, 2002, The Biochemical journal.

Phosphorylation of the human topoisomerase II protein

A. Fry, 1992 .

Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1

Andrew M Fry, A. Woolf, A. Fry, 2011, Journal of Cell Science.

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization

D. Reverter, R. Bayliss, J. Roig, 2015, Nature Communications.

The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation

A. Munnich, J. García-Verdugo, A. Mégarbané, 2014, Nature Genetics.

Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.

A. Merdes, A. Fry, A. J. Faragher, 2005, Molecular biology of the cell.

Poc1A and Poc1B act together in human cells to ensure centriole integrity

A. Fry, H. Woodland, K. Straatman, 2013, Journal of Cell Science.

OFD1 is a centrosomal/basal body protein expressed during mesenchymal-epithelial transition in human nephrogenesis.

A. Woolf, P. Winyard, S. Malcolm, 2004, Journal of the American Society of Nephrology : JASN.

Activity of the Human Centrosomal Kinase, Nek2, Depends on an Unusual Leucine Zipper Dimerization Motif*

E. Nigg, A. Fry, L. Arnaud, 1999, The Journal of Biological Chemistry.

C-Nap 1 , a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle – regulated Protein Kinase Nek 2

P. Meraldi, T. Mayor, E. Nigg, 1998 .

The primary cilium

R. Bayliss, A. Fry, Michelle J Leaper, 2014, Organogenesis.

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

Kyle L. Morris, A. Roseman, S. Cowley, 2020, Nature Communications.

Substrate Specificity and Cell Cycle Regulation of the Nek2 Protein Kinase, a Potential Human Homolog of the Mitotic Regulator NIMA of Aspergillus nidulans(*)

J. Bartek, E. Nigg, A. Fry, 1995, The Journal of Biological Chemistry.

Mitotic regulation by NIMA-related kinases

A. Fry, Laura O'Regan, Joelle Blot, 2007, Cell Division.

Coordinate Regulation of the Mother Centriole Component Nlp by Nek2 and Plk1 Protein Kinases

Andrew M. Fry, Erich A. Nigg, P. Meraldi, 2005, Molecular and Cellular Biology.

The Nek2 protein kinase: a novel regulator of centrosome structure

A. Fry, 2002, Oncogene.

RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin.

A. Swaroop, U. Wolfrum, A. Lennon, 2005, Human molecular genetics.

Recent advances in pericentriolar material organization: ordered layers and scaffolding gels

A. Fry, S. Shackleton, Josephina Sampson, 2017, F1000Research.

APC/C-Mediated Degradation in Early Mitosis: How to Avoid Spindle Assembly Checkpoint Inhibition

A. Fry, H. Yamano, 2006, Cell cycle.

Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.

T. Ried, E. Nigg, C. Sütterlin, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction

A. Fry, Joanne E. Baxter, S. Prosser, 2014, Journal of Cell Science.

Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis

L. Pelletier, A. Fry, N. K. Sahota, 2015, The Journal of cell biology.

Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis

L. Pelletier, A. Fry, N. K. Sahota, 2015, The Journal of cell biology.

Chemosensitivity in Human Tumor Cell Lines Relationship between Topoisomerase II Level and Updated Version

A. Harris, I. Hickson, Christine, 2006 .

Studies on the molecular pharmacology of GR63178A. A novel pentacyclic pyrolloquinone anticancer drug.

I. Hickson, J. Cummings, J. Smyth, 1992, Biochemical pharmacology.

Pix Proteins and the Evolution of Centrioles

A. Fry, H. Woodland, 2008, PloS one.

Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification

A. Fry, Joanne E. Baxter, C. Morrison, 2012, Journal of Cell Science.

Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

R. Bayliss, A. Fry, M. Richards, 2015, The Biochemical journal.

Mutation of POC1B in a Severe Syndromic Retinal Ciliopathy

Yang Wang, Monte Westerfield, Carsten Bergmann, 2014, Human mutation.

Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells.

A. Fry, H. Woodland, U. Euteneuer, 2008, Experimental cell research.

Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface

Daniel W. Udwary, Andrew T Rajczewski, R. Klausner, 2020, Proceedings of the National Academy of Sciences.

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase

A. Tobin, R. Griffin, B. Golding, 2016, Malaria Journal.

Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity.

K. Boxall, G. Aherne, R. Bayliss, 2012, Journal of medicinal chemistry.

Regulation of the Centrosome Cycle by Protein Degradation

A. Fry, S. Prosser, 2012 .

Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: SAR, structural biology and cellular activity

Swen, K. Boxall, G. Aherne, 2012 .

Solving the centriole disengagement puzzle

A. Fry, 2014, Nature Cell Biology.

Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro.

N. J. Wells, A. Fry, R. Ganapathi, 1994, The Journal of biological chemistry.

Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions

A. Fry, A. Bottrill, Cyril Dominguez, 2022, bioRxiv.

Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents

A. Fry, N. K. Sahota, George D.D. Jones, 2015, PloS one.

Under arrest in mitosis: Cdc20 dies twice

A. Fry, H. Yamano, 2008, Nature Cell Biology.

Hsp70 proteins in mitosis and disease

A. Fry, Laura O'Regan, Josephina Sampson, 2015, Oncotarget.

Novel insights into the mechanisms of mitotic spindle assembly by NEK kinases

A. Fry, S. Prosser, Laura O'Regan, 2016, Molecular & cellular oncology.

A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment.

A. Fry, Joanne E. Baxter, H. Yamano, 2008, Molecular cell.

A Polytherapy Strategy Using Vincristine and ALK Inhibitors to Sensitise EML4-ALK-Positive NSCLC

Jene Choi, R. Bayliss, A. Fry, 2022, Cancers.

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release

J. Chin, A. Zhuravleva, R. Bayliss, 2018, Science Signaling.

A role for Nek6 kinase activity in preventing senescence?

A. Fry, 2011, Cell cycle.

Baade-Wesselink Analysis of Magellanic Cloud Cepheids

B. Carney, W. Gieren, A. Fry, 2000 .

The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis

R. Bayliss, A. Fry, D. Zalli, 2011, Human molecular genetics.

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression

R. Bayliss, A. Knebel, A. Fry, 2015, The Journal of cell biology.

Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation

A. Merdes, A. Fry, A. J. Faragher, 2005 .

Nek5: a new regulator of centrosome integrity

A. Fry, S. Prosser, 2015, Oncotarget.

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs

D. Fennell, Jene Choi, R. Bayliss, 2016, Cellular and Molecular Life Sciences.

Cdc20 turnover rate: A key determinant in cancer patient response to anti‐mitotic therapies?

A. Fry, 2013, BioEssays : news and reviews in molecular, cellular and developmental biology.

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

E. Nigg, A. Fry, R. Golsteyn, 1995, The Journal of cell biology.

Abstract 1808: Loss of BAP1/BRCA1 counteracts spindle assembly checkpoint activation by the anti-mesothelin antibody drug-conjugate anetumab ravtansine

D. Fennell, A. Sommer, A. Fry, 2020 .

The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation

A. Munnich, J. García-Verdugo, A. Mégarbané, 2014, Nature Genetics.

Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas

R. Franco, P. Chieffi, C. Sette, 2009, Journal of Pathology.

Overexpression of the Nek2 kinase in colorectal cancer correlates with beta‐catenin relocalization and shortened cancer‐specific survival

A. Fry, D. Berry, M. Manson, 2014, Journal of surgical oncology.