A. Scheer

发表

Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1.

Barbara Kappes, Didier Leroy, Matthias K Schwarz, 2009, Biochemistry.

Cellular imaging in drug discovery

K. Yeow, A. Scheer, Paul Lang, 2006, Nature Reviews Drug Discovery.

Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.

S. Nwaka, A. Scheer, K. Georgi, 2013, ACS medicinal chemistry letters.

Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy

Timothy N C Wells, M. Gelb, F. Buckner, 2008, Antimicrobial Agents and Chemotherapy.

A cellular assay for measuring the modulation of glucose production in H4IIE cells.

K. Yeow, A. Scheer, Paul Lang, 2006, Assay and drug development technologies.

Functional Characterization of Atherosclerosis-Associated Ser128Arg and Leu554Phe E-Selectin Mutations

G. Baumann, S. Felix, A. Scheer, 1999, Biological chemistry.

Abstracts, Poster Session

A. Zlotta, O. Rampin, J. Sullivan, 1999, European Urology.

Pharmacology of (2S,4Z)-N-[(2S)-2-Hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2′-methyl[1,1′-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a New Potent and Selective Nonpeptide Antagonist of the Oxytocin Receptor

C. Giachetti, M. Schwarz, A. Scheer, 2003, Journal of Pharmacology and Experimental Therapeutics.

S-prenylated cysteine analogues inhibit receptor-mediated G protein activation in native human granulocyte and reconstituted bovine retinal rod outer segment membranes.

A. Scheer, P. Gierschik, 1995, Biochemistry.

Arrest of preterm labor in rat and mouse by an oral and selective nonprostanoid antagonist of the prostaglandin F2alpha receptor (FP).

M. Schwarz, A. Scheer, A. Chollet, 2007, American journal of obstetrics and gynecology.

Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.

M. Caron, A. Scheer, S. Mhaouty-Kodja, 1999, Molecular pharmacology.

Molecular mechanisms involved in the activation and regulation of the alpha 1-adrenergic receptor subtypes.

A. Scheer, F. Fanelli, P. D. De Benedetti, 1998, Farmaco.

Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.

G. Bernardinelli, Y. Filinchuk, C. Giachetti, 2008, Journal of medicinal chemistry.

Future trends in screening technology for drug discovery

A. Scheer, 2006, Expert opinion on drug discovery.

The DRY motif as a molecular switch of the human oxytocin receptor.

C. Rommel, A. Scheer, F. Fanelli, 2005, Biochemistry.

Overcoming the hurdle of fluorescent compounds in kinase screening: a case study.

A. Scheer, C. Frémaux, D. Perrin, 2006, Assay and drug development technologies.

Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists.

C. Giachetti, M. Schwarz, A. Scheer, 2005, Journal of medicinal chemistry.

Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits.

M. Camps, P. Parker, P. Schnabel, 1992, Nature.

Glycosaminoglycan analogs as a novel anti-inflammatory strategy

M. Teixeira, J. Shaw, M. Schwarz, 2012, Front. Immun..

Constitutively active mutants of the alpha 1B‐adrenergic receptor: role of highly conserved polar amino acids in receptor activation.

A. Scheer, F. Fanelli, P. D. De Benedetti, 1996, The EMBO journal.

A Look at Receptor Efficacy. From the Signalling Network of the Cell to the Intramolecular Motion of the Receptor

A. Scheer, Alexander Scheer, T. Costa, 2000 .

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

M. Camps, P. Parker, P. Schnabel, 1992, Nature.

G Protein-Coupled Receptor-Mediated ERK1/2 Phosphorylation: Towards a Generic Sensor of GPCR Activation

C. Waltzinger, A. Scheer, D. Leroy, 2007, Journal of receptor and signal transduction research.

Assay Development and Screening of a Serine/Threonine Kinase in an On-Chip Mode Using Caliper Nanofluidics Technology

A. Scheer, Alexander Scheer, Dominique Perrin, 2006, Journal of biomolecular screening.

Survivin expression pattern in the intestine of normoxic and ischemic rats

A. Scheer, S. Knauer, Rabea Verhaegh, 2017, BMC Gastroenterology.

Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation.

A. Scheer, S. Cotecchia, Susanna Cotecchia, 1997, Journal of receptor and signal transduction research.

Structure-Function Relationships of the α1b-Adrenergic Receptor

A. Scheer, F. Fanelli, P. D. De Benedetti, 1999, European Urology.

Constitutively active α1B-adrenergic receptor mutants: Potential mechanisms underlying receptor activation

A. Scheer, F. Fanelli, T. Costa, 1997 .

A cellular assay for measuring the inhibition of glycogen synthase kinase-3 via the accumulation of beta-catenin in Chinese hamster ovary clone K1 cells.

K. Yeow, A. Scheer, Paul Lang, 2006, Assay and drug development technologies.

The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate.

A. Scheer, F. Fanelli, P. D. De Benedetti, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A Microfluidics-Based Mobility Shift Assay to Discover New Tyrosine Phosphatase Inhibitors

Wolfgang H. B. Sauer, A. Scheer, Alexander Scheer, 2006, Journal of biomolecular screening.

Ab initio modeling and molecular dynamics simulation of the alpha 1b-adrenergic receptor activation.

A. Scheer, F. Fanelli, P. D. De Benedetti, 1998, Methods.

Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.

A. Scheer, S. Mhaouty-Kodja, F. Fanelli, 2000, Molecular pharmacology.

Studies on G-protein alpha.betagamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit.

Y. Henis, Y. Kloog, A. Scheer, 2003, The Biochemical journal.

Expression of the alpha 1b-adrenergic receptor and G protein subunits in mammalian cell lines using the Semliki Forest virus expression system.

K. Lundstrom, A. Scheer, S. Cotecchia, 1999, Journal of receptor and signal transduction research.

Theoretical study of the electrostatically driven step of receptor‐G protein recognition

A. Scheer, F. Fanelli, P. D. De Benedetti, 1999, Proteins.

Theoretical study on receptor-G protein recognition: new insights into the mechanism of the α1b-adrenergic receptor activation

A. Scheer, F. Fanelli, P. Benedetti, 1999 .

Building a disease knowledge environment to lay the foundations for in silico drug discovery and translational medicine

Alexander Scheer, Caroline S Kant, Mark R Ibberson, 2010, Expert opinion on drug discovery.

Farnesylcysteine analogues inhibit chemotactic peptide receptor‐mediated G‐protein activation in human HL‐60 granulocyte membranes

A. Scheer, P. Gierschik, 1993, FEBS letters.

Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling.

A. Scheer, F. Fanelli, L. Abuin, 2001, The Journal of biological chemistry.

Characterization of Chemokine Receptors

A. Scheer, A. Proudfoot, A. Scheer, 2001, Current protocols in pharmacology.

A Homogeneous 384-Well High-Throughput Binding Assay for a TNF Receptor Using Alphascreen Technology

A. Scheer, C. Rossi, C. Frémaux, 2003, Journal of biomolecular screening.