S. Gujar

发表

TRPM2 Silencing Causes G2/M Arrest and Apoptosis in Lung Cancer Cells via Increasing Intracellular ROS and RNS Levels and Activating the JNK Pathway.

Shekoufeh Almasi, C. Y. Long, A. Sterea, 2019, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies.

G. Kroemer, Patrick W. Lee, S. Gujar, 2017, Trends in immunology.

Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages

S. Gygi, J. Paulo, Patrick W. Lee, 2017, Journal of proteome research.

Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response

Patrick W. Lee, T. Sharif, K. Chisholm, 2015, Cell cycle.

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors

L. Zitvogel, L. Galluzzi, G. Kroemer, 2018, Oncoimmunology.

Newly Recruited CD11b+, GR-1+, Ly6Chigh Myeloid Cells Augment Tumor-Associated Immunosuppression Immediately following the Therapeutic Administration of Oncolytic Reovirus

Patrick W. Lee, P. Marcato, C. Dean, 2015, The Journal of Immunology.

Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis

Patrick W. Lee, P. Marcato, C. Dean, 2011, Stem cells.

Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling

J. Mackey, Patrick W. Lee, P. Marcato, 2015, Molecular oncology.

Core Needle Biopsy of Breast Cancer Tumors Increases Distant Metastases in a Mouse Model12

Patrick W. Lee, P. Marcato, C. Dean, 2014, Neoplasia.

Core Needle Biopsy of Breast Cancer Tumors Increases Distant

P. Marcato, C. Giacomantonio, Nova Scotia, 2014 .

Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma

Colin G. Cameron, R. Thummel, S. Gujar, 2020, Chemical science.

Therapy-Induced MHC I Ligands Shape Neo-Antitumor CD8 T Cell Responses during Oncolytic Virus-Based Cancer Immunotherapy.

S. Gygi, S. Stevanović, J. Paulo, 2019, Journal of proteome research.

All that glitters is not gold: the need to consider desirable and undesirable immune aspects of oncolytic virus therapy

D. Clements, S. Gujar, Youra Kim, 2016, Oncoimmunology.

Reovirus the Therapeutic Administration of Oncolytic Immunosuppression Immediately following Myeloid Cells Augment Tumor-Associated high , Ly 6 C + , GR-1 + Newly Recruited CD 11 b

P. Marcato, C. Dean, T. Sharif, 2015 .

Two is better than one

D. Clements, S. Gujar, Patrick Lee, 2014, Oncoimmunology.

Elicit Sterilizing Antiviral Immunity Can Protect from Hepatitis but Does Not Core and Gamma Interferon DNA Vaccine Bicistronic Woodchuck Hepatitis Virus

S. Gujar, L. Cova, Jinguo Wang, 2013 .

Primary Occult Hepadnavirus Infection Induces Virus-Specific T-Cell and Aberrant Cytokine Responses in the Absence of Antiviral Antibody Reactivity in the Woodchuck Model of Hepatitis B Virus Infection

S. Gujar, T. Michalak, 2009, Journal of Virology.

Bicistronic Woodchuck Hepatitis Virus Core and Gamma Interferon DNA Vaccine Can Protect from Hepatitis but Does Not Elicit Sterilizing Antiviral Immunity

S. Gujar, L. Cova, T. Michalak, 2006, Journal of Virology.

Flow Cytometric Quantification of T Cell Proliferation and Division Kinetics in Woodchuck Model of Hepatitis B

S. Gujar, T. Michalak, 2005, Immunological investigations.

Photodynamic therapy of melanoma with new, structurally similar, NIR-absorbing ruthenium (II) complexes promotes tumor growth control via distinct hallmarks of immunogenic cell death.

Colin G. Cameron, S. Gujar, L. M. Lifshits, 2022, American journal of cancer research.

Pre-acute hepadnaviral infection is associated with activation-induced apoptotic death of lymphocytes in the woodchuck (Marmota monax) model of hepatitis B.

S. Gujar, T. Michalak, S. Macparland, 2010, Developmental and comparative immunology.

Repeated Exposure to Trace Amounts of Woodchuck Hepadnavirus Induces Molecularly Evident Infection and Virus-Specific T Cell Response in the Absence of Serological Infection Markers and Hepatitis

S. Gujar, P. M. Mulrooney-Cousins, T. Michalak, 2012, Journal of Virology.

Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

Colin G. Cameron, S. Gujar, L. M. Lifshits, 2020, Oncoimmunology.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Gemcitabine enhances the efficacy of reovirus-based oncotherapy through anti-tumour immunological mechanisms

P. Marcato, P. C. Lee, D. Clements, 2013, British Journal of Cancer.

Repurposing CD8+ T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?

G. Kroemer, S. Gujar, Jonathan G. Pol, 2020, Oncoimmunology.

Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies

G. Kroemer, S. Gujar, Jonathan G. Pol, 2018, Oncoimmunology.

A Qualitative Evaluation of Program Budgeting and Marginal Analysis in a Canadian Pediatric Tertiary Care Institution

C. Mitton, S. Gujar, N. Smith, 2016, Applied Health Economics and Health Policy.

Characterization of bioactive recombinant woodchuck interleukin-2 amplified by RLM-RACE and produced in eukaryotic expression system.

S. Gujar, T. Michalak, 2006, Veterinary immunology and immunopathology.

The NAD+ salvage pathway modulates cancer cell viability via p73

M. Kwak, P. Marcato, C. Dean, 2015, Cell Death and Differentiation.

Multiplexed Relative Quantitation with Isobaric Tagging Mass Spectrometry Reveals Class I Major Histocompatibility Complex Ligand Dynamics in Response to Doxorubicin.

S. Gygi, S. Stevanović, J. Paulo, 2019, Analytical chemistry.

Reovirus Variants with Mutations in Genome Segments S1 and L2 Exhibit Enhanced Virion Infectivity and Superior Oncolysis

S. Gujar, M. Shmulevitz, D. Ahn, 2012, Journal of Virology.

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433.

Colin G. Cameron, L. Lilge, R. Thummel, 2018, Chemical reviews.

IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression

S. Gujar, V. K, S. Damodar, 2021, Heliyon.

Reovirus Virotherapy Overrides Tumor Antigen Presentation Evasion and Promotes Protective Antitumor Immunity

P. Marcato, S. Gujar, D. Pan, 2010, Molecular Cancer Therapeutics.

After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism

S. Gygi, J. Paulo, D. Clements, 2023, Frontiers in Immunology.

Aberrant Lymphocyte Activation Precedes Delayed Virus-Specific T-Cell Response after both Primary Infection and Secondary Exposure to Hepadnavirus in the Woodchuck Model of Hepatitis B Virus Infection

S. Gujar, T. Michalak, Jinguo Wang, 2008, Journal of Virology.

Single Amino Acid Differences between Closely Related Reovirus T3D Lab Strains Alter Oncolytic Potency In Vitro and In Vivo

D. Clements, S. Gujar, M. Shmulevitz, 2019, Journal of Virology.

Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus Strains

D. Clements, S. Gujar, M. Shmulevitz, 2019, bioRxiv.

TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway

Shekoufeh Almasi, A. Sterea, S. Gujar, 2018, The Journal of Biological Chemistry.

Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy

P. Marcato, S. Gujar, Jonathan G. Pol, 2018, Front. Immunol..

Autophagic homeostasis is required for the pluripotency of cancer stem cells

T. Sharif, D. Clements, S. Gujar, 2017, Autophagy.

Hide-and-seek: the interplay between cancer stem cells and the immune system

P. Marcato, S. Gujar, K. Coyle, 2017, Carcinogenesis.

Dendritic Cells in Oncolytic Virus-Based Anti-Cancer Therapy

A. Sterea, D. Clements, S. Gujar, 2015, Viruses.

Reovirus in cancer therapy: an evidence-based review

D. Clements, S. Gujar, E. Helson, 2014, Oncolytic virotherapy.

Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells

S. Shirasawa, T. Sasazuki, S. Gujar, 2018, Autophagy.

Epigenetic Silencing of TAP1 in Aldefluor+ Breast Cancer Stem Cells Contributes to Their Enhanced Immune Evasion

I. Weaver, P. Marcato, C. Dean, 2018, Stem cells.

Metabolite profiling reveals a connection between aldehyde dehydrogenase 1A3 and GABA metabolism in breast cancer metastasis

P. Marcato, C. Dean, Devanand M. Pinto, 2022, Metabolomics : Official journal of the Metabolomic Society.

ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells

P. Marcato, C. Dean, S. Gujar, 2019, Cell Death & Differentiation.

Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma

P. Opolon, L. Zitvogel, M. Maiuri, 2021, The Journal of experimental medicine.

The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis.

S. Gygi, R. Everley, J. Paulo, 2018, Cell reports.

Gemcitabine-mediated tumour regression and p53-dependent gene expression: implications for colon and pancreatic cancer therapy

C. Giacomantonio, P. Madureira, D. Waisman, 2013, Cell Death and Disease.

TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway

P. Marcato, D. Hoskin, Shekoufeh Almasi, 2019, Scientific Reports.

Role of Myeloid Cells in Oncolytic Reovirus-Based Cancer Therapy

S. Gujar, Michael A Giacomantonio, Vishnupriyan Kumar, 2021, Viruses.

Potentiating prostate cancer immunotherapy with oncolytic viruses

S. Gujar, Patrick Lee, 2018, Nature Reviews Urology.

Cytokines in oncolytic virotherapy.

G. Kroemer, S. Gujar, S. Workenhe, 2020, Cytokine & growth factor reviews.

Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1

Amos S Hundert, I. Weaver, P. Marcato, 2016, Oncotarget.

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells

I. Weaver, T. Sharif, S. Gujar, 2018, Cell Death & Disease.

The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways.

W. Zong, Shekoufeh Almasi, A. Sterea, 2019, Cell calcium.

RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers.

Isabel R Schlaepfer, D. Clements, S. Gujar, 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

S. Gujar, M. Shmulevitz, Heather E Eaton, 2020, PLoS pathogens.

TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway

P. Marcato, D. Hoskin, Shekoufeh Almasi, 2019, Scientific Reports.

REOVIRUS ONCOLYSIS: A BRIEF INSIGHT ON MOLECULAR MECHANISM AND IMMUNOLOGICAL ASPECT

S. Gujar, Lee P.W.K., Gujar S.A. et.al, 2007 .

Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines

S. Gujar, Youra Kim, Namit Holay, 2017, Front. Immunol..

IL-6 and IL-10 as predictors of disease severity in COVID 19 patients: Results from Meta-analysis and Regression

S. Gujar, V. K, S. Damodar, 2020, medRxiv.

Activation of p53 by Chemotherapeutic Agents Enhances Reovirus Oncolysis

P. Marcato, S. Gujar, M. Shmulevitz, 2013, PloS one.

HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells

C. Giacomantonio, T. Sharif, S. Gujar, 2018, Autophagy.

TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem–Like Cells in a Redox-Sensitive Manner

P. Marcato, C. Giacomantonio, T. Sharif, 2018, Clinical Cancer Research.

The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target

T. Sharif, D. Clements, S. Gujar, 2014, Cell cycle.

Oncolytic Virus-Mediated Reversal of Impaired Tumor Antigen Presentation

S. Gujar, Patrick Lee, 2014, Front. Oncol..

Inhibition of pyruvate dehydrogenase kinase enhances the antitumor efficacy of oncolytic reovirus.

D. Clements, S. Gujar, Yassine El Hiani, 2019, Cancer research.

NAD+ salvage pathway in cancer metabolism and therapy.

T. Sharif, S. Gujar, Youra Kim, 2016, Pharmacological research.

Oncolytic Virus-initiated Protective Immunity Against Prostate Cancer.

P. Marcato, S. Gujar, D. Pan, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

MHC-I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T-Cell Immunotherapies.

Morten Nielsen, Prathyusha Konda, Shashi Gujar, 2017, Journal of proteome research.

Improving MHC-I Ligand Identification by Incorporating Targeted Searches of Mass Spectrometry Data.

S. Gujar, J. Murphy, Prathyusha Konda, 2020, Methods in molecular biology.

Regulation of Cancer and Cancer-Related Genes via NAD.

T. Sharif, S. Gujar, Barry E. Kennedy, 2018, Antioxidants & redox signaling.

Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF and M-CSF-Differentiated Bone Marrow-Derived Cells.

S. Gygi, J. Paulo, C. Giacomantonio, 2019, Journal of proteome research.

Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis

D. Hoskin, A. Easton, D. Clements, 2018, Acta neuropathologica communications.

Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.

P. Marcato, D. Clements, S. Gujar, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

NAD+ depletion enhances reovirus-induced oncolysis in multiple myeloma

S. Gygi, G. Kroemer, J. Paulo, 2022, Molecular therapy oncolytics.

Targeted Metabolic Reprogramming to Improve the Efficacy of Oncolytic Virus Therapy.

S. Gujar, Barry E. Kennedy, Maryanne Sadek, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

UNDERSTANDING THE PERSPECTIVES OF THE DECISION MAKERS REGARDING THE SUCCESS OF AN EVIDENCE-BASED RESOURCE ALLOCATION PROCESS

S. Gujar, 2015 .

SnapShot: Cancer Immunotherapy with Oncolytic Viruses

J. Diallo, S. Gujar, J. Bell, 2019, Cell.

Immune Checkpoint Blockade Augments Changes Within Oncolytic Virus-induced Cancer MHC-I Peptidome, Creating Novel Antitumor CD8 T Cell Reactivities

S. Gygi, J. Paulo, S. Gujar, 2021, Molecular & cellular proteomics : MCP.

Introducing New Priority Setting and Resource Allocation Processes in a Canadian Healthcare Organization: A Case Study Analysis Informed by Multiple Streams Theory

C. Mitton, S. Gujar, N. Smith, 2015, International journal of health policy and management.

Targeting NAD+ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma.

S. Gujar, Barry E. Kennedy, M. Elnenaei, 2020, Trends in cancer.

Regulation of the proline regulatory axis and autophagy modulates stemness in TP73/p73 deficient cancer stem-like cells

T. Sharif, S. Gujar, Sheila K. Singh, 2019, Autophagy.

Neuronal mitochondrial calcium uniporter deficiency exacerbates axonal injury and suppresses remyelination in mice subjected to experimental autoimmune encephalomyelitis

G. Robertson, S. Gujar, Barry E. Kennedy, 2020, Experimental Neurology.

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells

I. Weaver, S. Gujar, Sheila K. Singh, 2018, Cell Death & Disease.

De novo infection and propagation of wild-type Hepatitis C virus in human T lymphocytes in vitro.

S. Gujar, T. Pham, T. Michalak, 2006, The Journal of general virology.

Pre-acute hepadnaviral infection is associated with activation-induced apoptotic death of lymphocytes in the woodchuck (Marmota monax) model of hepatitis B.

S. Gujar, T. Michalak, S. Macparland, 2010, Developmental and comparative immunology.

Reovirus Variants with Mutations in Genome Segments S1 and L2 Exhibit Enhanced Virion Infectivity and Superior Oncolysis

S. Gujar, M. Shmulevitz, Adil Mohamed, 2012, Journal of Virology.

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433.

Colin G. Cameron, L. Lilge, R. Thummel, 2018, Chemical reviews.

TRPM2 Silencing Causes G2/M Arrest and Apoptosis in Lung Cancer Cells via Increasing Intracellular ROS and RNS Levels and Activating the JNK Pathway.

Shekoufeh Almasi, A. Sterea, D. Clements, 2019, Cellular Physiology and Biochemistry.

MHC-I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T-Cell Immunotherapies.

S. Stevanović, M. Nielsen, D. Clements, 2017, Journal of proteome research.

Enhancing Mass Spectrometry-Based MHC-I Peptide Identification Through a Targeted Database Search Approach.

M. Nielsen, S. Gujar, Prathyusha Konda, 2019, Methods in molecular biology.

Repeated Exposure to Trace Amounts of Woodchuck Hepadnavirus Induces Molecularly Evident Infection and Virus-Specific T Cell Response in the Absence of Serological Infection Markers and Hepatitis

S. Gujar, P. M. Mulrooney-Cousins, T. Michalak, 2012, Journal of Virology.

Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.

P. Marcato, D. Clements, S. Gujar, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy.

S. Gujar, Jonathan G. Pol, Prathyusha Konda, 2024, Nature protocols.

DMG26: A Targeted Sequencing Panel for Mutation Profiling to Address Gaps in the Prognostication of Multiple Myeloma.

Clinton J. V. Campbell, M. A. El Hassan, J. Boudreau, 2021, The Journal of molecular diagnostics : JMD.