Ningyu Wang

发表

A novel benzothiazole derivative SKLB826 inhibits human hepatocellular carcinoma growth via inducing G2/M phase arrest and apoptosis

Xiaowei Liu, Q. Lei, Lidan Zhang, 2015 .

Preclinical Evaluation of Amphihevir, a First-in-Class Clinical Hepatitis C Virus NS4B Inhibitor

Z. Gu, Ningyu Wang, Luoting Yu, 2019, Antimicrobial Agents and Chemotherapy.

SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo.

Yuquan Wei, Q. Lei, Yong Xia, 2014, Cancer letters.

Identification of a new series of benzothiazinone derivatives with excellent antitubercular activity and improved pharmacokinetic profiles

Yuquan Wei, Q. Lei, Ningyu Wang, 2018 .

BRD4 inhibition sensitizes aggressive non-Hodgkin lymphomas to PI3Kδ inhibitors by suppressing PI3K reactivation and c-MYC expression.

Yong Xia, Yongxia Zhu, Ningyu Wang, 2021, American journal of cancer research.

Structure–Function Relationship of Aminopeptidase P from Pseudomonas aeruginosa

Q. Lei, Yong Xia, Ningyu Wang, 2017, Front. Microbiol..

Discovery of novel N-(5-(tert-butyl)isoxazol-3-yl)-N'-phenylurea analogs as potent FLT3 inhibitors and evaluation of their activity against acute myeloid leukemia in vitro and in vivo.

Q. Lei, Lidan Zhang, Yong Xia, 2015, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships evaluation of benzothiazinone derivatives as potential anti-tubercular agents.

Yuquan Wei, Lidan Zhang, Yong Xia, 2013, Bioorganic & medicinal chemistry letters.

Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.

Ningyu Wang, Ying Xu, Weiqiong Zuo, 2021, European journal of medicinal chemistry.

Benzothiazinethione is a potent preclinical candidate for the treatment of drug-resistant tuberculosis

Yuquan Wei, Lidan Zhang, Yongxia Zhu, 2016, Scientific Reports.

Synthesis and antitubercular evaluation of 4-carbonyl piperazine substituted 1,3-benzothiazin-4-one derivatives.

Q. Lei, Lidan Zhang, Yongxia Zhu, 2015, Bioorganic & medicinal chemistry letters.

THE NEW CONVENIENT SYNTHESIS OF 6-FLUOROPURINE AND ITS 7-/9-UNSUBSTITUTED ANALOGUES

Ningyu Wang, Luoting Yu, Mei Deng, 2012 .

Selective and efficient synthesis of trans-arylvinylboronates and trans-hetarylvinylboronates using palladium catalyzed cross-coupling

Ningyu Wang, Luoting Yu, L. Xiong, 2017 .

Synthesis and biological evaluation of N-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)benzenesulfonamide derivatives as new BET bromodomain inhibitors for anti-hematologic malignancies activities

Tinghong Ye, Yongxia Zhu, Ningyu Wang, 2017, Molecular Diversity.

Design, synthesis and biological evaluation of 3,5-dimethylisoxazole and pyridone derivatives as BRD4 inhibitors.

Ningyu Wang, Ying Xu, Luoting Yu, 2019, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors.

Yongxia Zhu, Ningyu Wang, Ying Xu, 2020, European journal of medicinal chemistry.

Pharmacokinetic studies of a novel multikinase inhibitor for treating cancer by HPLC-UV.

Sheng-yong Yang, Ningyu Wang, Luoting Yu, 2013, Journal of chromatographic science.

The discovery of SKLB-0335 as a paralog-selective EZH2 covalent inhibitor.

Lidan Zhang, Yongxia Zhu, Ningyu Wang, 2021, Chemical communications.

Mannosylated liposomes improve therapeutic effects of paclitaxel in colon cancer models

Q. Lei, Lidan Zhang, Yong Xia, 2017, Journal of microencapsulation.

Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis.

Yong Xia, Tinghong Ye, Xuejiao Song, 2019, European journal of medicinal chemistry.

Discovery of imidazo[2,1-b]thiazole HCV NS4B inhibitors exhibiting synergistic effect with other direct-acting antiviral agents.

Yuquan Wei, Hong Tang, Q. Lei, 2015, Journal of medicinal chemistry.

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors.

Yuquan Wei, Sheng-yong Yang, Lidan Zhang, 2014, Bioorganic & medicinal chemistry letters.

A Novel Small-Molecule YLT205 Induces Apoptosis in Human Colorectal Cells via Mitochondrial Apoptosis Pathway In Vitro and Inhibits Tumor Growth In Vivo

Yong Xia, Tinghong Ye, Yongxia Zhu, 2014, Cellular Physiology and Biochemistry.

Correction: Synthesis and biological evaluation of N -(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents

Lidan Zhang, Tinghong Ye, Yongxia Zhu, 2015 .

Small Molecule TH-39 Potentially Targets Hec1/Nek2 Interaction and Exhibits Antitumor Efficacy in K562 Cells via G0/G1 Cell Cycle Arrest and Apoptosis Induction

Lidan Zhang, Tinghong Ye, Yongxia Zhu, 2016, Cellular Physiology and Biochemistry.

YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect

Q. Lei, Yong Xia, Tinghong Ye, 2018, Cell Death & Disease.

Design, synthesis and biological evaluation of novel 1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolins as potential EZH2 inhibitors

Lidan Zhang, Xuejiao Song, Ningyu Wang, 2015 .

Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis

Yuquan Wei, Sheng-yong Yang, Q. Lei, 2017, Cell Death & Disease.

Synthesis and biological evaluation of (E)-4-(3-arylvinyl-1H-indazol-6-yl)pyrimidin-2-amine derivatives as PLK4 inhibitors for the treatment of breast cancer

Q. Lei, Tinghong Ye, Ningyu Wang, 2017 .

Design and Synthesis of EZH2-Based PROTACs to Degrade the Complex for Targeting the Noncatalytic Activity of EZH2.

Xiuli Wu, Tinghong Ye, Yongxia Zhu, 2021, Journal of medicinal chemistry.

Selective inhibition of EZH2 by ZLD1039 blocks H3K27methylation and leads to potent anti-tumor activity in breast cancer

Yuquan Wei, Q. Lei, Lidan Zhang, 2016, Scientific Reports.

Design, synthesis and biological evaluations of a series of Pyrido[1,2-a]pyrimidinone derivatives as novel selective FGFR inhibitors.

Ningyu Wang, Luoting Yu, J. Zeng, 2021, European journal of medicinal chemistry.

A Novel Cinnamide YLT26 Induces Breast Cancer Cells Apoptosis via ROS-Mitochondrial Apoptotic Pathway in Vitro and Inhibits Lung Metastasis in Vivo

Yuquan Wei, Mengyao Wang, Yong Xia, 2014, Cellular Physiology and Biochemistry.

Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis

Ningyu Wang, Luoting Yu, Lihui He, 2018, Scientific Reports.

A novel small-molecule YLT256 inhibits proliferation and induces apoptosis both in vitro and in vivo in solid tumors.

Lidan Zhang, Yong Xia, Tinghong Ye, 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer.

Ningyu Wang, Luoting Yu, Lifeng Zhao, 2022, Journal of medicinal chemistry.

Novel Dual BET and PLK1 Inhibitor WNY0824 Exerts Potent Antitumor Effects in CRPC by Inhibiting Transcription Factor Function and Inducing Mitotic Abnormality

Xuejiao Song, Ningyu Wang, Ying Xu, 2020, Molecular Cancer Therapeutics.

Identification of a new series of benzothiazinone derivatives with excellent antitubercular activity and improved pharmacokinetic profiles

Yuquan Wei, Q. Lei, Ningyu Wang, 2018, RSC advances.

A novel benzothiazinethione analogue SKLB-TB1001 displays potent antimycobacterial activities in a series of murine models.

Yuquan Wei, Lidan Zhang, Ningyu Wang, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Identification of a potent and selective phosphatidylinositol 3-kinase δ inhibitor for the treatment of non-Hodgkin's lymphoma.

Yongxia Zhu, Ningyu Wang, Ying Xu, 2020, Bioorganic chemistry.

Reductions in Myeloid-Derived Suppressor Cells and Lung Metastases using AZD4547 Treatment of a Metastatic Murine Breast Tumor Model

Yuquan Wei, Yong Xia, Yongxia Zhu, 2014, Cellular Physiology and Biochemistry.

ZLD1122, a novel EZH2 and EZH1 small molecular inhibitor, blocks H3K27 methylation and diffuse large B cell lymphoma cell growth

Q. Lei, Lidan Zhang, Yong Xia, 2016 .

Inhibition of FGFR signaling by PD173074 improves antitumor immunity and impairs breast cancer metastasis

Yuquan Wei, Yong Xia, Tinghong Ye, 2014, Breast Cancer Research and Treatment.

Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer.

Tinghong Ye, Yongxia Zhu, Ningyu Wang, 2021, European journal of medicinal chemistry.

The Anthelmintic Drug Niclosamide Induces Apoptosis, Impairs Metastasis and Reduces Immunosuppressive Cells in Breast Cancer Model

Yuquan Wei, Lidan Zhang, Yong Xia, 2014, PloS one.

A new series of HCV inhibitors based on a 2-(thieno[2,3b]pyridin-2-yl)-1,3,4-oxadiazole scaffold

Hong Tang, Lidan Zhang, Yongxia Zhu, 2016 .

Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma

Yuquan Wei, Q. Lei, Lidan Zhang, 2016, Scientific Reports.

Design, Synthesis and Structure-Activity Relationship Study of Piperazinone-Containing Thieno[3,2-d]pyrimidine Derivatives as New PI3Kδ Inhibitors.

Yongxia Zhu, Ningyu Wang, Ying Xu, 2020, Bioorganic & medicinal chemistry letters.

Structural characterization of a Δ3, Δ2-enoyl-CoA isomerase from Pseudomonas aeruginosa: implications for its involvement in unsaturated fatty acid metabolism

Ningyu Wang, Lihui He, Tao Li, 2018, Journal of biomolecular structure & dynamics.

Correction: Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis

Yuquan Wei, Sheng-yong Yang, Q. Lei, 2019, Cell Death and Disease.

Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants.

Ningyu Wang, Lifeng Zhao, Zhihao Liu, 2023, European journal of medicinal chemistry.

Covalent inhibitors of EZH2: Design, synthesis and evaluation.

Ningyu Wang, Lu Li, Qiangsheng Zhang, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Discovery of a Novel Covalent EZH2 Inhibitor Based on Tazemetostat Scaffold for the Treatment of Ovarian Cancer.

Yongxia Zhu, Ningyu Wang, Hongtao Xiao, 2023, Journal of medicinal chemistry.

Corrigendum: Selective inhibition of EZH2 by ZLD1039 blocks H3K27methylation and leads to potent anti-tumor activity in breast cancer

Yuquan Wei, Lidan Zhang, Yong Xia, 2016, Scientific Reports.

A Novel Benzothiazole Derivative YLT322 Induces Apoptosis via the Mitochondrial Apoptosis Pathway In Vitro with Anti-Tumor Activity in Solid Malignancies

Tinghong Ye, Yongxia Zhu, Xuejiao Song, 2013, PloS one.

Metabolism of SKLB-TB1001, a Potent Antituberculosis Agent, in Animals

Ningyu Wang, Juan Rong, Xin Tao, 2018, Antimicrobial Agents and Chemotherapy.

Discovery of imidazo[2,1-b]thiazole HCV NS4B inhibitors exhibiting synergistic effect with other direct-acting antiviral agents.

Yuquan Wei, Hong Tang, Lidan Zhang, 2015, Journal of medicinal chemistry.