P. Belfrage

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P. Strålfors, H. Olsson, P. Belfrage, 1987 .

Identification of the Site in the cGMP-inhibited Phosphodiesterase Phosphorylated in Adipocytes in Response to Insulin and Isoproterenol (*)

C. Wernstedt, L. Rönnstrand, E. Degerman, 1996, The Journal of Biological Chemistry.

Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family).

E. Degerman, V. Manganiello, P. Belfrage, 1995, Cellular signalling.

Essential role of phosphatidylinositol 3‐kinase in insulin‐induced activation and phosphorylation of the cGMP‐inhibited cAMP phosphodiesterase in rat adipocytes studies using the selective inhibitor wortmannin

M. Ridderstråle, E. Degerman, V. Manganiello, 1994, FEBS letters.

Expression of biologically active hormone‐sensitive lipase in mammalian (COS) cells

P. Belfrage, G. Fredrikson, C. Holm, 1991, FEBS letters.

Synthesis of 14C-labeled alkyl polyoxyethylene detergents.

P. Belfrage, G. Fredrikson, L. Krabisch, 1982, Journal of lipid research.

Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.

P. Strålfors, P. Belfrage, G. Fredrikson, 1981, The Journal of biological chemistry.

Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides.

P. Belfrage, M. Vaughan, 1969, Journal of lipid research.

Positional specificity of purified milk lipoprotein lipase.

P. Nilsson-ehle, P. Belfrage, T. Olivecrona, 1973, The Journal of biological chemistry.

Rapid Effects on Lipoprotein Lipase Activity in Adipose Tissue of Humans after Carbohydrate and Lipid Intake Time Course and Relation to Plasma Glycerol, Triglyceride, and Insulin Levels

P. Nilsson-ehle, P. Belfrage, S. Carlström, 1975 .

Use of protein G for preparation and characterization of rabbit antibodies against rat adipose tissue hormone-sensitive lipase.

L. Björck, H. Olsson, P. Belfrage, 1987, Journal of immunological methods.

Characteristics of the lipolytic β-adrenergic receptors in hamster adipocytes

P. Belfrage, P. Björgell, 1982 .

Hormone‐sensitive lipase of rat adipose tissue: Identification and some properties of the enzyme protein

P. Strålfors, P. Belfrage, H. Tornqvist, 1977, FEBS letters.

Regulation of Protein Kinase B in Rat Adipocytes by Insulin, Vanadate, and Peroxovanadate

E. Degerman, V. Manganiello, L. S. Holst, 1997, The Journal of Biological Chemistry.

Determination of protein in adipose tissue extracts.

P. Belfrage, H. Tornqvist, 1976, Journal of lipid research.

Alterations of lipid metabolism in healthy volunteers during long‐term ethanol intake

P. Nilsson-ehle, P. Belfrage, H. Tornqvist, 1977, European journal of clinical investigation.

Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B.

E. Degerman, V. Manganiello, F. Ahmad, 1998, Methods.

Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 Kinase.

E. Degerman, V. Manganiello, P. Belfrage, 1998, Endocrinology.

Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin.

M. Ridderstråle, E. Degerman, V. Manganiello, 1995, Biochimica et biophysica acta.

cAMP-dependent protein kinase activation mediated by beta 3-adrenergic receptors parallels lipolysis in rat adipocytes.

M. Ridderstråle, P. Belfrage, D. Langin, 1992, Biochimica et biophysica acta.

Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand.

A. Newman, E. Degerman, V. Manganiello, 1987, The Journal of biological chemistry.

Continuous monitoring of free fatty acid release from adipocytes by pH-stat titration.

P. Belfrage, N. Ö. Nilsson, 1979, Journal of lipid research.

Enzymes catalyzing the hydrolysis of long-chain monoacyglycerols in rat adipose tissue.

P. Nilsson-ehle, P. Belfrage, H. Tornqvist, 1978, Biochimica et biophysica acta.

Effects of acetate, acetaldehyde, and ethanol on lipolysis in isolated rat adipocytes.

P. Belfrage, N. Ö. Nilsson, 1978, Journal of lipid research.

Molecular mechanisms involved in the antilipolytic action of insulin: phosphorylation and activation of a particulate adipocyte cAMP phosphodiesterase.

E. Degerman, V. Manganiello, P. Belfrage, 1991, Advances in experimental medicine and biology.

Hormone-sensitive lipase in brown adipose tissue: Identification and effect of cold exposure

P. Belfrage, G. Fredrikson, C. Holm, 1987, Bioscience reports.

Rapid determination of lipoprotein lipase activity in human adipose tissue

P. Nilsson-ehle, P. Belfrage, H. Tornqvist, 1972 .

Methods for the determination in the nanomole range of lipids in liver fine-needle aspiration biopsies.

P. Belfrage, A. Lundquist, T. Wiebe, 1970, Scandinavian journal of clinical and laboratory investigation.

cGMP-inhibited phosphodiesterases (PDE3 gene family).

E. Degerman, V. Manganiello, P. Belfrage, 1996, Biochemical Society transactions.

Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol.

P. Belfrage, H. Tornqvist, G. Fredrikson, 1986, Biochimica et biophysica acta.

Relaxant effects of the selective phosphodiesterase inhibitors milrinone and OPC 3911 on isolated human mesenteric vessels.

E. Degerman, V. Manganiello, P. Belfrage, 1989, Pharmacology & toxicology.

6 – cGMP-Inhibited Phosphodiesterases (PDE3)

E. Degerman, V. Manganiello, P. Belfrage, 1996 .

Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.

V. Manganiello, J. Calvo, P. Belfrage, 1993, The Journal of biological chemistry.

Regulation of hormone-sensitive lipase activity in adipose tissue.

E. Degerman, V. Manganiello, P. Belfrage, 1997, Methods in enzymology.

Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue.

P. Belfrage, H. Tornqvist, 1976, The Journal of biological chemistry.

Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation.

E. Degerman, V. Manganiello, P. Belfrage, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of adipose tissue lipolysis: effects of noradrenaline and insulin on phosphorylation of hormone‐sensitive lipase and on lipolysis in intact rat adipocytes

P. Strålfors, P. Belfrage, G. Fredrikson, 1980, FEBS letters.

Purification and characterization of guanosine 3',5'-monophosphate-inhibited low K(m) adenosine 3',5'-monophosphate phosphodiesterase from human placental cytosolic fractions.

V. Manganiello, P. Belfrage, J. Kasuya, 1992, Endocrinology.

The regulatory and basal phosphorylation sites of hormone-sensitive lipase are dephosphorylated by protein phosphatase-1, 2A and 2C but not by protein phosphatase-2B.

H. Olsson, P. Belfrage, 1987, European journal of biochemistry.

Metabolism of chyle triglycerides in the liver. I. Studies on the mechanisms for liver uptake of intravenously injected, glycerol- and fatty acid-labeled chyle in the carbohydrate-fed rat.

P. Belfrage, 1966, Biochimica et biophysica acta.

Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin.

P. Strålfors, P. Belfrage, P. Björgell, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Prolonged administration of ethanol to young, healthy volunteers: effects on biochemical, morphological and neurophysiological parameters.

P. Nilsson-ehle, P. Belfrage, T. Cronholm, 1973, Acta medica Scandinavica. Supplementum.

Nucleotide sequence of rat adipose hormone sensitive lipase cDNA.

K. Svenson, T. Kirchgessner, P. Belfrage, 1988, Nucleic acids research.

Hormone-sensitive lipase: structure, function, evolution and overproduction in insect cells using the baculovirus expression system.

P. Belfrage, D. Langin, C. Holm, 1994, Protein engineering.

MECHANISMS FOR REMOVAL OF CHYLE TRIGLYCERIDE FROM THE CIRCULATING BLOOD AS STUDIED WITH (14C)GLYCEROL AND (3H)PALMITIC ACID- LABELED CHYLE.

P. Belfrage, T. Olivecrona, 1965, Biochimica et biophysica acta.

Hormonal control of lipid degradation

P. Belfrage, 1985 .

Removal of nonionic detergent from proteins fractionated by electrofocusing.

P. Strålfors, P. Belfrage, H. Tornqvist, 1978, Biochimica et biophysica acta.

Rapid assay for hormone-sensitive lipase activity of adipose tissue.

P. Belfrage, H. Tornqvist, L. Krabisch, 1972, Journal of lipid research.

Identification and some characteristics of the enzyme protein of the hormone-sensitive lipase from rat adipose tissue.

P. Strålfors, P. Belfrage, H. Tornqvist, 1978, Advances in experimental medicine and biology.

Activation of hormone-sensitive lipase in extracts of adipose tissue.

S. Tsai, P. Belfrage, M. Vaughan, 1970, Journal of lipid research.

Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation.

E. Degerman, V. Manganiello, P. Belfrage, 1991, The Journal of biological chemistry.

Phosphorylation and dephosphorylation of hormone‐sensitive lipase Interactions between the regulatory and basal phosphorylation sites

H. Olsson, P. Belfrage, 1988, FEBS letters.

Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue.

P. Belfrage, G. Fredrikson, C. Holm, 1987, Biochemical and biophysical research communications.

Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase.

E. Degerman, V. Manganiello, P. Belfrage, 1994, Biochimica et biophysica acta.

Rapid purification of detergent-solubilized bovine hormone-sensitive lipase by high performance hydrophobic interaction chromatography.

P. Belfrage, C. Holm, S. Nilsson, 1989, Biomedical chromatography : BMC.

Effects of insulin on lipolysis and lipogenesis in hamster white adipocytes with high sensitivity to hormones.

P. Belfrage, N. Ö. Nilsson, P. Björgell, 1981, Biochimica et biophysica acta.

Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase.

E. Degerman, V. Manganiello, P. Belfrage, 1998, Endocrinology.

Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets.

E. Degerman, V. Manganiello, P. Belfrage, 1992, Biochemical and biophysical research communications.

Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.

E. Degerman, V. Manganiello, P. Belfrage, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium.

L. S. Holst, P. Belfrage, D. Langin, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation of the basal site of hormone‐sensitive lipase by glycogen synthase kinase‐4

P. Strålfors, H. Olsson, P. Belfrage, 1986, FEBS letters.

Phosphorylation of hormone‐sensitive lipase by cyclic GMP‐dependent protein kinase

P. Strålfors, P. Belfrage, 1985, FEBS letters.

Positional specificity of hormone-sensitive lipase from rat adipose tissue.

P. Belfrage, G. Fredrikson, 1983, The Journal of biological chemistry.

The antilipolytic, insulin-like effect of growth hormone is caused by a net decrease of hormone-sensitive lipase phosphorylation.

P. Belfrage, O. Isaksson, S. Rosberg, 1984, Endocrinology.

Continuous measurement of free fatty acid release from intact adipocytes by pH-Stat titration.

P. Belfrage, N. Ö. Nilsson, 1981, Methods in enzymology.

Metabolism of chyle triglycerides in the liver. II. Distribution of radioactivity between subcellular components after the intravenous injection of glyceroland fatty acid-labelled chyle into the carbohydrate-fed rat.

P. Belfrage, 1968, Biochimica et biophysica acta.

Hormone-sensitive lipase: quantitation of enzyme activity and mRNA level in small biopsies of human adipose tissue.

P. Belfrage, D. Langin, K. Frayn, 1993, Clinica chimica acta; international journal of clinical chemistry.

Human adipose tissue hormone-sensitive lipase: identification and comparison with other species.

P. Belfrage, G. Fredrikson, C. Holm, 1989, Biochimica et biophysica acta.

Phosphorylation of hormone-sensitive lipase by cyclic AMP-dependent protein kinase.

P. Strålfors, P. Belfrage, 1983, The Journal of biological chemistry.

Mechanisms for activation of the rat adipocyte particulate cyclic-GMP-inhibited cyclic AMP phosphodiesterase and its importance in the antilipolytic action of insulin.

E. Degerman, V. Manganiello, P. Belfrage, 1992, Advances in second messenger and phosphoprotein research.

Hormonal regulation of adipocyte particulate "low Km" cAMP phosphodiesterase.

A. Newman, E. Degerman, V. Manganiello, 1986, Journal of cyclic nucleotide and protein phosphorylation research.

Regulation of adipose-tissue lipolysis by phosphorylation of hormone-sensitive lipase.

P. Strålfors, P. Belfrage, G. Fredrikson, 1981, International journal of obesity.

Regulation of adipose tissue lipolysis: phosphorylation of hormone‐sensitive lipase in intact rat adipocytes

P. Strålfors, P. Belfrage, G. Fredrikson, 1980, FEBS letters.

[74] Hormone-sensitive lipase from adipose tissue of rat

P. Strålfors, P. Belfrage, G. Fredrikson, 1981 .

Time-course of liver fat accumulation in man after a single load of ethanol.

P. Belfrage, A. Lundquist, T. Wiebe, 1971, Scandinavian journal of clinical and laboratory investigation.

Purification and properties of the cGMP-inhibited cAMP phosphodiesterase from bovine aortic smooth muscle.

E. Degerman, V. Manganiello, P. Belfrage, 1992, Biochimica et biophysica acta.

Purification of a cGMP-inhibited cAMP Phosphodiesterase from Vascular Smooth Muscle

A. Newman, E. Degerman, V. Manganiello, 1990 .

Direct evidence that cholesterol ester hydrolase from adrenal cortex is the same enzyme as hormone-sensitive lipase from adipose tissue.

K. G. Cook, P. Strålfors, P. Belfrage, 1982, European journal of biochemistry.

Effects of ethanol intake on lipoprotein lipase activity in adipose tissue of fasting subjects

P. Nilsson-ehle, P. Belfrage, S. Carlstrom, 1978, Lipids.

Protein kinase A-dependent activation of PDE4 (cAMP-specific cyclic nucleotide phosphodiesterase) in cultured bovine vascular smooth muscle cells.

E. Degerman, V. Manganiello, P. Belfrage, 1997, Biochimica et biophysica acta.

Properties and purification of the catalytic subunit of cyclic AMP-dependent protein kinase of adipose tissue.

P. Strålfors, P. Belfrage, 1982, Biochimica et biophysica acta.

Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.

M. Taira, E. Degerman, V. Manganiello, 1994, The Journal of biological chemistry.

Monoacylmonoalkylglycerol as a substrate for diacylglycerol hydrolase activity in adipose tissue.

P. Belfrage, H. Tornqvist, L. Krabisch, 1978, Journal of lipid research.

Regulation of adipose tissue lipolysis through reversible phosphorylation of hormone-sensitive lipase.

P. Strålfors, H. Olsson, P. Belfrage, 1984, Advances in cyclic nucleotide and protein phosphorylation research.

Demonstration of the amphiphilic character of hormone-sensitive lipase by temperature-induced phase separation in Triton X-114 and charge-shift electrophoresis.

P. Belfrage, G. Fredrikson, C. Holm, 1986, The Journal of biological chemistry.

Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol.

C. Wernstedt, L. Rönnstrand, E. Degerman, 2009, The Journal of biological chemistry.

Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)*

E. Degerman, V. Manganiello, P. Belfrage, 1997, The Journal of Biological Chemistry.

Diversity in cyclic nucleotide phosphodiesterase isoenzyme families.

E. Degerman, V. Manganiello, P. Belfrage, 1995, Archives of biochemistry and biophysics.

Mechanism for Dual Regulation of the Particulate cGMP-Inhibited cAMP Phosphodiesterase in Rat Adipocytes by Isoproterenol and Insulin

E. Degerman, V. Manganiello, P. Belfrage, 1990 .

Type III cyclic nucleotide phosphodiesterases and insulin action.

E. Degerman, V. Manganiello, P. Belfrage, 1996, Current topics in cellular regulation.

Increased Sensitivity to the Muscle‐Relaxing Effect of Succinylcholine in Irradiated Rabbits

P. Belfrage, B. Schildt, 1967, Acta anaesthesiologica Scandinavica.

A monoglyceride-splitting enzyme of rat and hog liver.

P. Belfrage, 1965, Biochimica et biophysica acta.

Identification of the cGMP-mhifoited low Km cAMP phosphodiesterase in rat aortic smooth muscle

E. Degerman, P. Belfrage, K. Andersson, 1990 .

Micromethods for analysis of lipids in endomyocardial biopsy specimens.

P. Belfrage, B. Johansson, B. Åkesson, 2009, Acta medica Scandinavica.

Hormone-sensitive lipase from adipose tissue of rat.

P. Strålfors, P. Belfrage, G. Fredrikson, 1981, Methods in enzymology.

THE TISSUE DISTRIBUTION AND METABOLISM IN THE RAT OF INTRAVENOUSLY INJECTED LABELED FAT EMULSIONS.

P. Belfrage, T. Olivecrona, B. Edgren, 1964, Acta physiologica Scandinavica.

Purified human lipoprotein lipase: positional specificity.

P. Nilsson-ehle, P. Belfrage, B. Borgström, 1971, Biochimica et biophysica acta.

A monoglyceride hydrolyzing enzyme in human postheparin plasma.

P. Nilsson-ehle, P. Belfrage, 1972, Biochimica et Biophysica Acta.

Simple assay for monoacylglycerol hydrolase activity of rat adipose tissue.

P. Belfrage, H. Tornqvist, L. Krabisch, 1974, Journal of lipid research.

Monoglyceride-protein interaction. The binding of monoolein to native human serum albumin.

P. Belfrage, E. Arvidsson, 1969, Acta chemica Scandinavica.

Stimulation by insulin of a serine kinase in human platelets that phosphorylates and activates the cGMP-inhibited cAMP phosphodiesterase.

E. Degerman, V. Manganiello, P. Belfrage, 1993, Biochemical and biophysical research communications.

Human liver lipids: representativity of determinations on material obtained by fine-needle aspiration biopsy.

P. Belfrage, T. Wiebe, 1971, Scandinavian journal of clinical and laboratory investigation.

4. EFFECTS ON LIVER LIPIDS AND LIPOPROTEIN LIPASE ACTIVITY OF ADIPOSE TISSUE IN RELATION TO DIETARY LIPIDS

P. Nilsson-ehle, P. Belfrage, T. Wiebe, 2009 .

Liver lipid content in alcoholics.

P. Belfrage, A. Lundquist, T. Wiebe, 2009, Acta Medica Scandinavica.

Lipoprotein lipase and hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy.

P. Belfrage, C. Holm, M. Schotz, 1994, The American journal of physiology.

Purification of hormone-sensitive lipase by high-performance ion exchange chromatography.

P. Belfrage, S. Nilsson, 1986, Analytical Biochemistry.

Incorporation of hormone-sensitive lipase into phosphatidylcholine vesicles

P. Belfrage, G. Fredrikson, C. Holm, 1990, Lipids.

Dispersion of viable pig liver cells with collagenase.

P. Belfrage, A. Nilsson, I. Hägerstrand, 1975, Life sciences.

Metabolism in the rat of chyle obtained after feeding hydrogenated coconut oil labeled with stearic acid.

P. Belfrage, T. Olivecrona, J. Elovson, 1965, Biochimica et Biophysica Acta.

Radioactivity in blood and liver partial glycerides, and liver phospholipids after intravenous administration to carbohydrate-fed rats of chyle containing double-labeled triglycerides.

P. Belfrage, T. Olivecrona, J. Elovson, 1965, Biochimica et biophysica acta.

The tissue distribution of radioactivity following the injection of varying levels of fatty acid labeled chylomicrons in the rat.

P. Belfrage, B. Borgstrom, T. Olivercrona, 1963, Acta Physiologica Scandinavica.

The acute GH action in rat adipocytes is associated with enhanced phosphorylation of a 46 kDa plasma membrane protein enriched by GH‐Sepharose

P. Belfrage, H. Eriksson, J. Donnér, 1986, FEBS letters.

Direct evidence for protein phosphatase-catalyzed dephosphorylation/deactivation of hormone-sensitive lipase from adipose tissue.

P. Strålfors, H. Olsson, P. Belfrage, 1984, Biochimica et biophysica acta.

Electrophoretic elution of proteins from polyacrylamide gel slices.

P. Strålfors, P. Belfrage, 1983, Analytical biochemistry.

Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 Kinase.

E. Degerman, V. Manganiello, P. Belfrage, 1998, Endocrinology.

Monoacylglycerol lipase from rat adipose tissue.

P. Belfrage, H. Tornqvist, 1981, Methods in enzymology.

Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation.

E. Degerman, P. Belfrage, Carolyn J. Smith, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Effects of ethanol on fatty acid esterification and oxidation in isolated rat hepatocytes.

P. Belfrage, T. Wiebe, 1980, Journal of studies on alcohol.

Rapid effect on lipoprotein lipase activity in adipose tissue of humans after carbohydrate and lipid intake.

P. Belfrage, S. Carlström, P. Nilsson‐Ehle, 1975, Scandinavian journal of clinical and laboratory investigation.