Weifang Tang

发表

Discovery of N-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)quinazolin-7-amine as a Novel, Potent, and Oral Cyclin-Dependent Kinase Inhibitor against Haematological Malignancies.

Yanmin Zhang, T. Lu, Yadong Chen, 2021, Journal of medicinal chemistry.

Potent Pan-Raf and Receptor Tyrosine Kinase Inhibitors Based on a Cyclopropyl Formamide Fragment Overcome Resistance

Yanmin Zhang, T. Lu, Yadong Chen, 2017, J. Chem. Inf. Model..

Transition-metal-free base catalyzed intramolecular cyclization of 2-ynylphenols for efficient and facile synthesis of 2-substituted benzo[b]furans

T. Lu, Weifang Tang, Jian Gao, 2018, RSC advances.

Discovery of a Potent FLT3 Inhibitor (LT-850-166) with the Capacity of Overcoming a Variety of FLT3 Mutations.

Shuai Lu, T. Lu, Yadong Chen, 2021, Journal of medicinal chemistry.

Protein–ligand interaction-guided discovery of novel VEGFR-2 inhibitors

Haichun Liu, Yanmin Zhang, T. Lu, 2020, Journal of biomolecular structure & dynamics.

Design, synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

Haichun Liu, Yanmin Zhang, T. Lu, 2014 .

Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.

T. Lu, Yadong Chen, Weifang Tang, 2017, European journal of medicinal chemistry.

Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance.

Yanmin Zhang, T. Lu, Weifang Tang, 2017, Organic & biomolecular chemistry.

Discovery of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and selective CDK9 inhibitors that enable transient target engagement for the treatment of hematologic malignancies.

Yadong Chen, Jianhang Huang, Xinren Wang, 2022, European journal of medicinal chemistry.

An Integrated Tumor Microenvironment Responsive Polymeric Micelle for Smart Drug Delivery and Effective Drug Release.

Weifang Tang, Jun Luo, Tao Lu, 2021, Bioconjugate chemistry.

The discovery of quinoline derivatives, as NF-κB inducing kinase (NIK) inhibitors with anti-inflammatory effects in vitro, low toxicities against T cell growth.

Jianing Song, Yanmin Zhang, T. Lu, 2020, Bioorganic & medicinal chemistry.

Redox-Neutral Borylation of Aryl Sulfonium Salts via C-S Activation Enabled by Light.

T. Lu, Weifang Tang, Ding Du, 2019, Organic letters.

Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.

Yanmin Zhang, T. Lu, Weifang Tang, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase.

Haichun Liu, T. Lu, Yadong Chen, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of urea-based benzamides derivatives as HDAC inhibitors

T. Ran, T. Lu, Weifang Tang, 2017, Medicinal Chemistry Research.

Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors

T. Lu, Yadong Chen, Weifang Tang, 2012, Archives of Pharmacal Research.

Dendritic polyethylene glycol-modified folate–nickel nanotubes as an efficient antitumor nano-metal medicine

Weifang Tang, Jun Luo, Yue Wang, 2022, Journal of Materials Science.

Discovery of 2-Amino-7-sulfonyl-7H-pyrrolo[2,3-d]pyrimidine Derivatives as Potent Reversible FGFR Inhibitors with Gatekeeper Mutation Tolerance: Design, Synthesis, and Biological Evaluation.

M. Wang, Yanmin Zhang, Yadong Chen, 2022, Journal of medicinal chemistry.

A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines

Jian Wang, T. Lu, Weifang Tang, 2010, Molecules.

An efficient one-pot synthesis of 1,4-disubstituted 3-amino-2-pyridone derivatives via three-component reactions of alkynyl aldehydes and amines with ethyl 2-((diphenylmethylene)amino)acetate

T. Lu, Weifang Tang, Qingfa Zhou, 2012 .

DMAP-promoted in situ activation of bromoacetic acid as a 2-carbon synthon for facile synthesis of pyridines and fused pyridin-2-ones

T. Lu, Weifang Tang, Ding Du, 2016 .

β-Functionalization of Indolin-2-one-Derived Aliphatic Acids for the Divergent Synthesis of Spirooxindole γ-Butyrolactones.

Weifang Tang, Jing Cao, Ding Du, 2017, The Journal of organic chemistry.

A convenient synthesis of polysubstituted 2-amino-4,5-dihydrofuran-3-nitriles from benzoins or benzaldehydes

T. Lu, Weifang Tang, Ding Du, 2012 .

N-Heterocyclic carbene-catalyzed three-component domino reaction of alkynyl aldehydes with oxindoles.

T. Lu, Weifang Tang, Ding Du, 2012, Organic letters.

Cooperative N-heterocyclic carbene (NHC)-Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins.

T. Lu, Weifang Tang, Ding Du, 2014, Organic & biomolecular chemistry.

Access to Spiro and Fused Indole Derivatives from α,β-Unsaturated Aldehydes Enabled by N-Heterocyclic Carbene Catalysis.

Weifang Tang, Ding Du, 2016, Chemical record.

N‐Heterocyclic Carbene‐Catalyzed Umpolung Formal [3+3] Cycloaddition of Enals with Isatogens: Access to Fused Indolin‐3‐ones with a Tetrasubstituted Carbon Stereocenter

T. Lu, Junyu Xu, Weifang Tang, 2015 .

N-Heterocyclic Carbene-Catalyzed Formal [3 + 2] Annulation of α-Bromoenals with 3-Aminooxindoles: A Stereoselective Synthesis of Spirooxindole γ-Butyrolactams.

T. Lu, Weifang Tang, Ding Du, 2015, The Journal of organic chemistry.

Alkynyl Acylammoniums as Electrophilic 3C Synthons in a Formal [3 + 3] Annulation: Access to Functionalized 4H-Pyran-4-ones.

T. Lu, Weifang Tang, Chao Fang, 2016, Organic letters.

N-Heterocyclic carbene-catalyzed annulation of cyclic β-enamino esters with enals: access to functionalized indolo[2,3-a]quinolizidines.

T. Lu, Weifang Tang, Ding Du, 2015, Organic & biomolecular chemistry.

N-Heterocyclic Carbene-Catalyzed Annulations of Enals and Ynals with Indolin-3-ones: Synthesis of 3,4-Dihydropyrano[3,2-b]indol-2-ones

T. Lu, Weifang Tang, Ding Du, 2013 .

Discovery of coumarin derivatives as potent and selective cyclin-dependent kinase 9 (CDK9) inhibitors with high antitumour activity.

Yanmin Zhang, T. Lu, Yadong Chen, 2020, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine scaffold as DFG-out B-Raf kinase inhibitors.

T. Lu, Yadong Chen, Weifang Tang, 2015, European journal of medicinal chemistry.

Tributylphosphine-catalyzed reaction of ethanethiol with alkynyl ketones

T. Lu, Weifang Tang, Qingfa Zhou, 2011 .

BF3·Et2O promoted conjugate addition of ethanethiol to electron-deficient alkynes

T. Lu, Weifang Tang, Qingfa Zhou, 2012 .

N-Heterocyclic carbene-catalyzed hydroacylation of isatins with aldehydes: access to 3-acyloxy-1,3-dihydro-2H-indol-2-ones

T. Lu, Weifang Tang, Ding Du, 2011 .

Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents.

Yanmin Zhang, B. Xin, Weifang Tang, 2015, European journal of medicinal chemistry.

Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy.

T. Ran, T. Lu, Yadong Chen, 2021, European journal of medicinal chemistry.

Uptake, Translocation, and Fate of Carcinogenic Aristolochic Acid in Typical Vegetables in Soil−Plant Systems

Weifang Tang, Jing Sun, Xi-kui Wang, 2022, Molecules.

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.

T. Ran, Yanmin Zhang, T. Lu, 2016, Bioorganic & medicinal chemistry letters.

A Facile Synthesis of 1-Substituted β-Carboline Derivatives via Minisci-Reaction

Jian Wang, T. Lu, Weifang Tang, 2011 .

Discovery of 3-(1H-benzo[d]imidazole-2-yl)-1H-pyrazol-4 -amine derivatives as novel and potent syk inhibitors for the treatment of hematological malignancies.

Yadong Chen, Hongmei Li, Weifang Tang, 2023, European journal of medicinal chemistry.

Alkynyl Acylammoniums as Electrophilic 3C Synthons in a Formal [3 + 3] Annulation: Access to Functionalized 4H-Pyran-4-ones.

T. Lu, Weifang Tang, Chao Fang, 2016, Organic letters.

Investigation on the isoform selectivity of histone deacetylase inhibitors using chemical feature based pharmacophore and docking approaches.

Shuai Lu, T. Lu, Huifang Li, 2010, European journal of medicinal chemistry.

Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors

Yadong Chen, Weifang Tang, Xin Chen, 2012, Archives of pharmacal research.

Review and prospects of targeted therapies for Spleen tyrosine kinase (SYK).

Weifang Tang, Yong Zhu, Zhaozhao Wang, 2023, Bioorganic & medicinal chemistry.

A Convenient Synthesis of Polysubstituted 2‐Amino‐4,5‐dihydrofuran‐3‐nitriles from Benzoins or Benzaldehydes.

T. Lu, Weifang Tang, Ding Du, 2012 .

N‐Heterocyclic Carbene‐Catalyzed Hydroacylation of Isatins with Aldehydes: Access to 3‐Acyloxy‐1,3‐dihydro‐2H‐indol‐2‐ones.

T. Lu, Weifang Tang, Ding Du, 2011 .

Michael Addition―Lactonization Reaction of Electron-Deficient Alkynes with N-(Diphenylmethylene)glycinates: An Efficient Synthesis of 3-Amino-2-pyrone Derivatives

T. Lu, Weifang Tang, Qingfa Zhou, 2010 .