X. Bao

发表

Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry

N. Sanai, X. Bao, Jianmei Wu, 2019, Journal of pharmaceutical and biomedical analysis.

Krebs Cycle-Deficient Hereditary Cancer Syndromes are Defined by Homologous Recombination DNA Repair Defects

B. Shuch, P. Glazer, R. Bindra, 2018, Nature Genetics.

Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer

Benjamin L. Kidder, J. Saxton, P. Shaw, 2018, Clinical Cancer Research.

Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood–Brain Barrier in Glioblastoma Patients Using an IVIVE–PBPK Modeling Approach

N. Sanai, A. Sparreboom, X. Bao, 2017, Clinical Cancer Research.

A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

N. Sanai, X. Bao, Jianmei Wu, 2017, Journal of pharmaceutical analysis.

Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization.

M. Shekhar, X. Bao, Jing Li, 2016, Nanomedicine : nanotechnology, biology, and medicine.

Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood–Brain Barrier of Human Brain and Glioblastoma

N. Sanai, S. Mittal, X. Bao, 2020, Clinical pharmacology and therapeutics.

Amino acid-linked platinum(II) analogues have altered specificity for RNA compared to cisplatin.

X. Bao, C. Chow, K. Rijal, 2014, Chemical communications.

Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer

N. Sanai, X. Bao, Jianmei Wu, 2021, Clinical and translational science.

Amino acid-linked platinum(II) compounds: non-canonical nucleoside preferences and influence on glycosidic bond stabilities

M. Rodgers, X. Bao, Zhihua Yang, 2019, JBIC Journal of Biological Inorganic Chemistry.

Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry

B. Shuch, P. LoRusso, R. Bindra, 2019, Scientific Reports.

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy

B. Shuch, R. Bindra, Amrita Sule, 2022, Oncotarget.

A liquid chromatography with tandem mass spectrometry method for simultaneous determination of UTL-5g and its metabolites in human plasma.

J. Shaw, F. Valeriote, X. Bao, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evaluation of Hybrid Theoretical Approaches for Structural Determination of a Glycine-Linked Cisplatin Derivative via Infrared Multiple Photon Dissociation (IRMPD) Action Spectroscopy.

G. Berden, J. Oomens, M. Rodgers, 2015, The journal of physical chemistry. A.

Nano-delivery of RAD6/Translesion Synthesis Inhibitor SMI#9 for Triple-negative Breast Cancer Therapy

M. Shekhar, P. Nangia-Makker, X. Bao, 2018, Molecular Cancer Therapeutics.

ACTR-45. PHASE 0/2 STUDY OF RIBOCICLIB IN PATIENTS WITH RECURRENT GLIOBLASTOMA

N. Sanai, X. Bao, Jing Li, 2018, Neuro-Oncology.

Oncometabolites suppress DNA repair by disrupting local chromatin signaling

B. Shuch, P. Glazer, R. Bindra, 2020, Nature.

A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort

Nader Sanai, Jing Li, Shwetal Mehta, 2019, Clinical Cancer Research.

Physiologically Based Pharmacokinetic Modeling of Central Nervous System Pharmacokinetics of CDK4/6 Inhibitors to Guide Selection of Drug and Dosing Regimen for Brain Cancer Treatment

N. Sanai, X. Bao, Jianmei Wu, 2020, Clinical pharmacology and therapeutics.

Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

J. Rabinowitz, C. Dann, X. Bao, 2019, Molecular Cancer Therapeutics.

Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients

P. LoRusso, X. Bao, Jianmei Wu, 2018, Journal of clinical pharmacology.

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.

C. Dann, G. Garcia, X. Bao, 2021, Bioorganic & medicinal chemistry.

Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

B. Shuch, P. Glazer, R. Bindra, 2018, Nature Genetics.

An aqueous normal-phase chromatography coupled with tandem mass spectrometry method for determining unbound brain-to-plasma concentration ratio of AZD1775, a Wee1 kinase inhibitor, in patients with glioblastoma.

P. LoRusso, N. Sanai, X. Bao, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evaluation and correction of injection order effects in LC-MS/MS based targeted metabolomics.

X. Bao, Jing Li, Jun Jiang, 2022, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Oncometabolites suppress DNA repair by disrupting local chromatin signalling

P. Glazer, R. Bindra, X. Bao, 2020, Nature.

Co-targeting of HDAC, PI3K, and Bcl-2 Results in Metabolic and Transcriptional Reprogramming and Decreased Mitochondrial Function in Acute Myeloid Leukemia.

A. Dombkowski, X. Bao, J. Taub, 2022, Biochemical pharmacology.

Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis

M. Konopleva, S. Wiley, X. Bao, 2023, Research square.

A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma

R. Fiorelli, N. Sanai, X. Bao, 2021, Clinical Cancer Research.

Acquired Resistance to Venetoclax plus Azacitidine in Acute Myeloid Leukemia: in vitro Models and Mechanisms.

X. Bao, J. Taub, M. Hüttemann, 2023, Biochemical pharmacology.

Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism.

X. Bao, Jing Li, L. Matherly, 2023, ACS pharmacology & translational science.