Jianmei Wu

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Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry

N. Sanai, X. Bao, Jianmei Wu, 2019, Journal of pharmaceutical and biomedical analysis.

Implications of Plasma Protein Binding for Pharmacokinetics and Pharmacodynamics of the γ-Secretase Inhibitor RO4929097

P. LoRusso, Jianmei Wu, Jing Li, 2012, Clinical Cancer Research.

Tissue-specific and glucose-responsive expression of the pancreatic derived factor (PANDER) promoter.

B. Wolf, B. Burkhardt, Jichun Yang, 2005, Biochimica et biophysica acta.

Targeted Disruption of Pancreatic-Derived Factor (PANDER, FAM3B) Impairs Pancreatic β-Cell Function

B. Wolf, B. Burkhardt, Jichun Yang, 2010, Diabetes.

Quantitative evaluation of monocyte transmigration into the brain following chemical opening of the blood–brain barrier in mice

Jianmei Wu, Yuanan Lu, L. Zeng, 2006, Brain Research.

Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors

M. Romero, Christina Cherian, Jianmei Wu, 2010, Molecular Pharmacology.

Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.

Christina Cherian, Jianmei Wu, L. Matherly, 2009, Journal of medicinal chemistry.

Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood–Brain Barrier in Glioblastoma Patients Using an IVIVE–PBPK Modeling Approach

N. Sanai, A. Sparreboom, X. Bao, 2017, Clinical Cancer Research.

Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.

Christina Cherian, Jianmei Wu, L. Matherly, 2010, Journal of medicinal chemistry.

A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

N. Sanai, X. Bao, Jianmei Wu, 2017, Journal of pharmaceutical analysis.

Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking

Christina Cherian, Jianmei Wu, L. Matherly, 2010, The Biochemical journal.

Liver-specific overexpression of pancreatic-derived factor (PANDER) induces fasting hyperglycemia in mice.

B. Wolf, B. Burkhardt, Jianmei Wu, 2010, Endocrinology.

Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells.

B. Wolf, B. Burkhardt, Jichun Yang, 2005, Diabetes.

Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood–Brain Barrier of Human Brain and Glioblastoma

N. Sanai, S. Mittal, X. Bao, 2020, Clinical pharmacology and therapeutics.

Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase

A. Shields, P. LoRusso, T. Mangner, 2016, Journal of clinical pharmacology.

Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer

N. Sanai, X. Bao, Jianmei Wu, 2021, Clinical and translational science.

Identification of the Minimal Functional Unit of the Homo-oligomeric Human Reduced Folate Carrier*

Christina Cherian, Jianmei Wu, L. Matherly, 2009, The Journal of Biological Chemistry.

Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry

B. Shuch, P. LoRusso, R. Bindra, 2019, Scientific Reports.

Staphylococcus aureus induces mammary gland fibrosis through activating the TLR/NF-κB and TLR/AP-1 signaling pathways in mice.

Jianmei Wu, Z. Miao, Yulin Ding, 2020, Microbial pathogenesis.

Role of Lysine 411 in Substrate Carboxyl Group Binding to the Human Reduced Folate Carrier, as Determined by Site-Directed Mutagenesis and Affinity Inhibition

Christina Cherian, Jianmei Wu, L. Matherly, 2008, Molecular Pharmacology.

Liposomal coencapsulated fludarabine and mitoxantrone for lymphoproliferative disorder treatment.

J. Byrd, Jianmei Wu, Robert J. Lee, 2008, Journal of pharmaceutical sciences.

Impaired β-cell function in PANDER

B. Wolf, B. Burkhardt, Jichun Yang, 2010 .

Interferon-γ-induced regulation of the pancreatic derived cytokine FAM3B in islets and insulin-secreting βTC3 cells

B. Wolf, Jianmei Wu, Zhiyong Gao, 2005, Molecular and Cellular Endocrinology.

A liquid chromatography with tandem mass spectrometry method for simultaneous determination of UTL-5g and its metabolites in human plasma.

J. Shaw, F. Valeriote, X. Bao, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simultaneous determination of ABT-888, a poly (ADP-ribose) polymerase inhibitor, and its metabolite in human plasma by liquid chromatography/tandem mass spectrometry.

P. LoRusso, Jianmei Wu, Jing Li, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Phase 0 Trial of AZD1775 in First-Recurrence Glioblastoma Patients

Jing Li, Nader Sanai, Shwetal Mehta, 2018, Clinical Cancer Research.

Effects of overexpression of pancreatic derived factor (FAM3B) in isolated mouse islets and insulin-secreting betaTC3 cells.

B. Wolf, B. Burkhardt, Jichun Yang, 2005, American journal of physiology. Endocrinology and metabolism.

Staphylococcus aureus induces TGF-β1 and bFGF expression through the activation of AP-1 and NF-κB transcription factors in bovine mammary epithelial cells.

Jianmei Wu, Yulin Ding, Jinling Wang, 2016, Microbial pathogenesis.

A stable isotope-labeled internal standard is essential for correcting for the interindividual variability in the recovery of lapatinib from cancer patient plasma in quantitative LC-MS/MS analysis.

P. LoRusso, Jianmei Wu, Jing Li, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma by liquid chromatography/tandem mass spectrometry.

A. Shields, P. LoRusso, Jianmei Wu, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

In Vitro Metabolism and Drug-Drug Interaction Potential of UTL-5g, a Novel Chemo- and Radioprotective Agent

J. Shaw, F. Valeriote, Jianmei Wu, 2014, Drug Metabolism and Disposition.

Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells.

B. Wolf, Jichun Yang, J. Markmann, 2006, Diabetes.

Reactivation of Estrogen Receptor α by Vorinostat Sensitizes Mesenchymal-Like Triple-Negative Breast Cancer to Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor

Jianmei Wu, Jing Li, A. Burger, 2013, PloS one.

Physiologically Based Pharmacokinetic Modeling of Central Nervous System Pharmacokinetics of CDK4/6 Inhibitors to Guide Selection of Drug and Dosing Regimen for Brain Cancer Treatment

N. Sanai, X. Bao, Jianmei Wu, 2020, Clinical pharmacology and therapeutics.

Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replication.

Jianguo Wu, Ying Zhu, Y. Mu, 2008, Immunology letters.

Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice.

Nathan R. Qi, L. Yin, X. Tong, 2018, Gastroenterology.

Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients

P. LoRusso, X. Bao, Jianmei Wu, 2018, Journal of clinical pharmacology.

An aqueous normal-phase chromatography coupled with tandem mass spectrometry method for determining unbound brain-to-plasma concentration ratio of AZD1775, a Wee1 kinase inhibitor, in patients with glioblastoma.

P. LoRusso, N. Sanai, X. Bao, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Leucine Culture Reveals That ATP Synthase Functions as a Fuel Sensor in Pancreatic β-Cells*

B. Wolf, J. Moibi, Jichun Yang, 2004, Journal of Biological Chemistry.

Complex Disease–, Gene–, and Drug–Drug Interactions: Impacts of Renal Function, CYP2D6 Phenotype, and OCT2 Activity on Veliparib Pharmacokinetics

P. LoRusso, Jianmei Wu, Jing Li, 2014, Clinical Cancer Research.

PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).

B. Wolf, K. Kaestner, B. Burkhardt, 2006, Gene.

Structure−Function Studies of PANDER, an Islet Specific Cytokine Inducing Cell Death of Insulin-Secreting β Cells†

B. Wolf, B. Burkhardt, Jichun Yang, 2005 .

Validation and implementation of a liquid chromatography/tandem mass spectrometry assay for quantitation of the total and unbound RO4929097, a γ-secretase inhibitor targeting Notch signaling, in human plasma.

P. LoRusso, Jianmei Wu, Jing Li, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate aminoflavone (NSC 686288) in human plasma.

E. Heath, P. LoRusso, Jianmei Wu, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Characterization of the expression, localization, and secretion of PANDER in α-cells

B. Wolf, B. Burkhardt, Jianmei Wu, 2010, Molecular and Cellular Endocrinology.

Phase 0 Trial of AZD1775 in First-Recurrence Glioblastoma Patients

P. LoRusso, N. Sanai, Harshil Dhruv, 2018, Clinical Cancer Research.

Quantitative analysis of intracellular nucleoside triphosphates and other polar metabolites using ion pair reversed-phase liquid chromatography coupled with tandem mass spectrometry.

G. Bepler, Yingtao Zhang, Jianmei Wu, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.