Qian Zhang

发表

Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells

C. Tse, W. N. Pappano, Qian Zhang, 2014, BMC Cancer.

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605

S. Davidsen, Eric F. Johnson, N. Soni, 2009, BMC Cancer.

Molecular Dynamics Simulations of A27S and K120A Mutated PTP1B Reveals Selective Binding of the Bidentate Inhibitor

Qiang Gan, Qian Zhang, Changgen Feng, 2019, BioMed research international.

Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor

Qian Zhang, L. Tucker, Jieyi Wang, 2008, Proceedings of the National Academy of Sciences.

Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases.

S. Davidsen, Eric F. Johnson, J. Wilsbacher, 2010, Bioorganic & medicinal chemistry letters.

Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR).

S. Davidsen, Eric F. Johnson, J. Wilsbacher, 2007, Bioorganic & medicinal chemistry letters.

ABBV-399, a c-Met Antibody–Drug Conjugate that Targets Both MET–Amplified and c-Met–Overexpressing Tumors, Irrespective of MET Pathway Dependence

Kedar S Vaidya, L. Naumovski, Mark G. Anderson, 2016, Clinical Cancer Research.

Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

Kedar S Vaidya, L. Naumovski, P. Ansell, 2016, BMC Cancer.

Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.

S. Fesik, Qian Zhang, L. Tucker, 2007, Cancer research.

Beyond the Canonical Function of Receptor Tyrosine Kinase: New Perspectives for ERBB2 (HER2) Signaling Control Across the Cell Membrane

Qian Zhang, 2014 .

Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.

Scott A. Erickson, S. Davidsen, K. Swinger, 2010, Bioorganic & medicinal chemistry letters.

ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition

P. Ansell, Mark G. Anderson, Qian Zhang, 2021, BMC Cancer.

A “Prozone-Like” Effect Influences the Efficacy of the Monoclonal Antibody ABT-700 against the Hepatocyte Growth Factor Receptor

Kedar S Vaidya, Mark G. Anderson, W. N. Pappano, 2017, Pharmacology.

Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

Kedar S Vaidya, L. Naumovski, P. Ansell, 2016, BMC Cancer.

ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution.

S. Bass, M. Whitlow, Qian Zhang, 2016, Protein engineering, design & selection : PEDS.

Insulin-like Growth Factor-1 Receptor and ErbB Kinase Inhibitor Combinations Block Proliferation and Induce Apoptosis through Cyclin D1 Reduction and Bax Activation*

S. Davidsen, J. Wilsbacher, Gary T. Wang, 2008, Journal of Biological Chemistry.

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling

R. Landgraf, Qian Zhang, Kian Kani, 2012, Proceedings of the National Academy of Sciences.

Discovery and study of novel protein tyrosine phosphatase 1B inhibitors

Xi Chen, Changgen Feng, Qian Zhang, 2017 .

Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.

Scott A. Erickson, S. Davidsen, Eric F. Johnson, 2009, Bioorganic & medicinal chemistry letters.

Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition.

S. Davidsen, P. Richardson, Qian Zhang, 2008, Journal of proteome research.

Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation

S. Davidsen, Qian Zhang, L. Tucker, 2008, Oncogene.

Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor

Qian Zhang, L. Tucker, Jieyi Wang, 2008, Proceedings of the National Academy of Sciences.