Jeffrey R. Moore

发表

Probing the Stochastic, Motor-Driven Properties of the Cytoplasm Using Force Spectrum Microscopy

Ming Guo, Robert D. Goldman, David A. Weitz, 2014, Cell.

Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

David M. Warshaw, L. Leinwand, Jeffrey R. Moore, 2012, Circulation research.

Myosin V exhibits a high duty cycle and large unitary displacement

David M. Warshaw, E. Krementsova, K. Trybus, 2001, The Journal of cell biology.

Robust mechanobiological behavior emerges in heterogeneous myosin systems

C. Schunn, D. Weitz, J. Cagan, 2017, Proceedings of the National Academy of Sciences.

Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling

Jeffrey R. Moore, W. Lehman, S. Campbell, 2016, Front. Physiol..

Direct observation of tropomyosin binding to actin filaments

Jeffrey R. Moore, W. Lehman, William M. Schmidt, 2015, Cytoskeleton.

Energy landscapes reveal the myopathic effects of tropomyosin mutations.

Marek Orzechowski, Stefan Fischer, Jeffrey R. Moore, 2014, Archives of biochemistry and biophysics.

Germinal center‐specific protein human germinal center associated lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin

I. Lossos, D. Helfman, D. Szczesna‐Cordary, 2011, The FEBS journal.

Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

S. Fischer, M. Rynkiewicz, K. Trybus, 2017, Biophysical journal.

Tropomyosin diffusion over actin subunits facilitates thin filament assembly

Stefan Fischer, M. Rynkiewicz, Jeffrey R. Moore, 2016, Structural dynamics.

A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity.

Jeffrey R. Moore, E. Ostap, M. Greenberg, 2011, Biochemistry.

The Focal Adhesion: A Regulated Component of Aortic Stiffness

Robert J. Saphirstein, M. H. Jensen, Jeffrey R. Moore, 2013, PloS one.

to conditions that simulate fatigue Response of compressed skinned skeletal muscle fibers

R. Cooke, D. Szczesna‐Cordary, K. Myburgh, 2015 .

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Journal of Muscle Research and Cell Motility.

Mechanism of calponin stabilization of cross-linked actin networks.

D. Weitz, M. H. Jensen, Jeffrey R. Moore, 2014, Biophysical journal.

Effects of basic calponin on the flexural mechanics and stability of F‐actin

T. Angelini, W. Lehman, M. H. Jensen, 2012, Cytoskeleton.

The direct molecular effects of fatigue and myosin regulatory light chain phosphorylation on the actomyosin contractile apparatus.

D. Szczesna‐Cordary, Jeffrey R. Moore, T. Mealy, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

The molecular effects of skeletal muscle myosin regulatory light chain phosphorylation.

D. Szczesna‐Cordary, Jeffrey R. Moore, T. Mealy, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Cell volume change through water efflux impacts cell stiffness and stem cell fate

David J Mooney, David A Weitz, Jennifer Lippincott-Schwartz, 2017, Proceedings of the National Academy of Sciences.

Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2021, The Journal of general physiology.

Myosin regulatory light chain phosphorylation enhances cardiac β-myosin in vitro motility under load.

D. Szczesna‐Cordary, Jeffrey R. Moore, A. Karabina, 2015, Archives of biochemistry and biophysics.

In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.

D. Szczesna‐Cordary, Jeffrey R. Moore, Jingsheng Liang, 2014, Archives of biochemistry and biophysics.

Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry

D. Szczesna‐Cordary, Jeffrey R. Moore, M. Greenberg, 2010, Proceedings of the National Academy of Sciences.

The role of vimentin intermediate filaments in cortical and cytoplasmic mechanics.

David A Weitz, Allen J Ehrlicher, Jeffrey J Fredberg, 2013, Biophysical journal.

Structural implications of conserved aspartate residues located in tropomyosin’s coiled-coil core

Jasmine A. Nirody, Stefan Fischer, J. Nirody, 2011, Bioarchitecture.

Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments.

M. Regnier, M. Rynkiewicz, Jeffrey R. Moore, 2020, Biophysical journal.

Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting.

S. Fischer, M. Rynkiewicz, Jeffrey R. Moore, 2018, Biophysical journal.

Novel collective mechanics of actively driven DNA networks

M. H. Jensen, Jeffrey R. Moore, M. Kilfoil, 2015 .

Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity.

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Biophysical journal.

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.

Marek Orzechowski, M. Rynkiewicz, Jeffrey R. Moore, 2018, Archives of biochemistry and biophysics.

Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation

C. Yengo, M. Rynkiewicz, Jeffrey R. Moore, 2022, The Journal of general physiology.

Tropomyosin movement on F-actin during muscle activation explained by energy landscapes.

Marek Orzechowski, S. Fischer, Jeffrey R. Moore, 2014, Archives of biochemistry and biophysics.

The Conformational State of Actin Filaments Regulates Branching by Actin-related Protein 2/3 (Arp2/3) Complex*♦

D. Weitz, R. Dominguez, M. H. Jensen, 2012, The Journal of Biological Chemistry.

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics.

D. Szczesna‐Cordary, Jeffrey R. Moore, M. Greenberg, 2009, Journal of molecular and cellular cardiology.

The Drosophila projectin mutant, bentD, has reduced stretch activation and altered indirect flight muscle kinetics

J. Vigoreaux, D. Maughan, Jeffrey R. Moore, 1999, Journal of Muscle Research & Cell Motility.

Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.

T. Abraham, D. Szczesna‐Cordary, Jeffrey R. Moore, 2014, Journal of molecular and cellular cardiology.

Calcium increases titin N2A binding to F-actin and regulated thin filaments

K. Nishikawa, M. Gage, Jeffrey R. Moore, 2018, Scientific Reports.

Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain.

Stefan Fischer, M. Regnier, Jeffrey R. Moore, 2015, Archives of biochemistry and biophysics.

The D3 Methodology: Bridging Science and Design for Bio-Based Product Development

Jonathan Cagan, Christian D. Schunn, Paul Egan, 2016 .

Tropomyosin-based Effects Of Acidosis On Thin-filament Regulation During Muscle Fatigue

E. Debold, Jeffrey R. Moore, M. Woodward, 2019, Medicine & Science in Sports & Exercise.

Emergent Systems Energy Laws for Predicting Myosin Ensemble Processivity

Jonathan Cagan, Christian D. Schunn, Paul Egan, 2015, PLoS Comput. Biol..

The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors

Jeffrey R. Moore, M. Greenberg, 2010, Cytoskeleton.

Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2023, PNAS nexus.

The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time.

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Biophysical journal.

Structural determinants of muscle thin filament cooperativity.

Stuart G Campbell, Jeffrey R. Moore, W. Lehman, 2016, Archives of biochemistry and biophysics.

Does the myosin V neck region act as a lever?

E. Krementsova, K. Trybus, Jeffrey R. Moore, 2004, Journal of Muscle Research & Cell Motility.

Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.

J B Patlak, J. Schmitt, J. Seidman, 2007, American journal of physiology. Heart and circulatory physiology.

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.

K. Ocorr, R. Bodmer, D. Swank, 2016, Journal of molecular biology.

Cardiomyopathies: Classification, Clinical Characterization, and Functional Phenotypes

A. Gomes, D. Szczesna‐Cordary, Jeffrey R. Moore, 2012, Biochemistry research international.

Cell volume change through water efflux impacts cell stiffness and stem cell fate

Angelo S. Mao, J. Lippincott-Schwartz, J. Fredberg, 2017, Proceedings of the National Academy of Sciences.

Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics.

D. Szczesna‐Cordary, Jeffrey R. Moore, Gerrie P. Farman, 2014, Journal of applied physiology.

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics.

D. Szczesna‐Cordary, Jeffrey R. Moore, M. Greenberg, 2009, Journal of molecular and cellular cardiology.

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2019, Journal of Muscle Research and Cell Motility.

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

C. Yengo, M. Rynkiewicz, Jeffrey R. Moore, 2022, bioRxiv.

Modulation of actin mechanics by caldesmon and tropomyosin.

J. Moore, Jeffrey R. Moore, W. Lehman, 2008, Cell motility and the cytoskeleton.

Calcium increases titin N2A binding to F-actin and regulated thin filaments

K. Nishikawa, M. Gage, J. Moore, 2018, Scientific Reports.

M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end

M. Rynkiewicz, Jeffrey R. Moore, W. Lehman, 2020, The Journal of Biological Chemistry.