S. Awasthi

发表

Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane.

Y. Awasthi, S. Jaiswal, M. Sahu, 2012, Free radical biology & medicine.

Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice

M. Boerma, Se-Ran Jun, A. Cheema, 2020, Microorganisms.

Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin.

Y. Awasthi, S. Awasthi, S. Pikula, 2000, Biochemistry.

Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse.

D. Gaddy, Y. Awasthi, S. Awasthi, 2004, Toxicology and applied pharmacology.

Role of Glutathione S-Transferases in Protection against Lipid Peroxidation

Y. Awasthi, S. Awasthi, J. Cheng, 2001, The Journal of Biological Chemistry.

COH-SR4 Reduces Body Weight, Improves Glycemic Control and Prevents Hepatic Steatosis in High Fat Diet-Induced Obese Mice

S. Awasthi, S. Rahbar, S. Singhal, 2013, PloS one.

Novel Anti-cancer Compounds for Developing Combinatorial Therapies to Target Anoikis-Resistant Tumors

S. Awasthi, S. Singhal, L. Nagaprashantha, 2011, Pharmaceutical Research.

RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma

S. Awasthi, S. Singhal, P. Singhal, 2017, Pharmaceutical Research.

Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling.

R. Vatsyayan, L. Prokai, Y. Awasthi, 2010, Biochemistry.

Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal.

Shaheen Dhanani, Y. Awasthi, Abha Sharma, 2006, Biochemistry.

RLIP76, a non-ABC transporter, and drug resistance in epilepsy

Y. Awasthi, S. Awasthi, D. Janigro, 2005, BMC Neuroscience.

Topical 2′-Hydroxyflavanone for Cutaneous Melanoma

V. Tonk, Jihyun Lee, S. Awasthi, 2019, Cancers.

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment.

S. Awasthi, S. Singhal, Shireen Chikara, 2018, Cancer letters.

Prevention of mammary carcinogenesis in MMTV‐neu mice by targeting RLIP

Prakash Kulkarni, R. Salgia, S. Awasthi, 2021, Molecular carcinogenesis.

The determination of glutathione-4-hydroxynonenal (GSHNE), E-4-hydroxynonenal (HNE), and E-1-hydroxynon-2-en-4-one (HNO) in mouse liver tissue by LC-ESI-MS

D. Armstrong, S. Awasthi, Eranda Wanigasekara, 2008, Analytical and bioanalytical chemistry.

Metastasis of breast tumor cells to brain is suppressed by targeting RLIP alone and in combination with 2'-Hydroxyflavanone.

R. Salgia, S. Awasthi, S. Singhal, 2018, Cancer letters.

2′‐Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76

R. Salgia, S. Awasthi, S. Singhal, 2018, Molecular carcinogenesis.

The sensors and regulators of cell–matrix surveillance in anoikis resistance of tumors

R. Vatsyayan, S. Awasthi, S. Singhal, 2011, International journal of cancer.

Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines.

E. Frenkel, S. Awasthi, R. Sharma, 1993, Cancer letters.

Role of RLIP76 in doxorubicin resistance in lung cancer.

R. Vatsyayan, Y. Awasthi, P. Chaudhary, 2009, International journal of oncology.

Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): A novel link between G‐protein and tyrosine kinase signaling and drug resistance

Y. Awasthi, Rajendra K. Sharma, S. Awasthi, 2003, International journal of cancer.

Differential carcinogenicity of benzo[a]pyrene in male and female CD-1 mouse lung.

Y. Awasthi, S. Awasthi, A. Haque, 1997, Journal of toxicology and environmental health.

Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression.

J. Li, M. Sinha, B. Luxon, 2005, Biochemical and biophysical research communications.

LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells

S. Awasthi, S. Rahbar, S. Singhal, 2014, Apoptosis.

S. Srivastava, Y. Awasthi, S. Awasthi, 1998, Cancer letters.

1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma.

R. Jove, S. Awasthi, S. Rahbar, 2012, Biochemical pharmacology.

RLIP76 in AED drug resistance

Y. Awasthi, Rajendra K. Sharma, S. Awasthi, 2007, Epilepsia.

Metabolic fate of glutathione conjugate of benzo[a]pyrene-(7R,8S)-diol (9S,10R)-epoxide in human liver.

S. Srivastava, S. Amin, S. Awasthi, 1999, Archives of biochemistry and biophysics.

Bilateral breast MALT lymphoma: a case report and review of the literature

S. Awasthi, M. Elghetany, S. Gopal, 2000, Annals of Hematology.

RLIP76, a Glutathione-Conjugate Transporter, Plays a Major Role in the Pathogenesis of Metabolic Syndrome

R. Vatsyayan, S. Awasthi, S. Singhal, 2011, PloS one.

The expression and function of Vascular Endothelial Growth Factor in Retinal Pigment Epithelial (RPE) cells is regulated by4-Hydroxynonenal (HNE) and Glutathione s-transferase4-4

R. Vatsyayan, Surinder Kumar, Y. Awasthi, 2012 .

GENETIC ASSOCIATION OF GLUTATHIONE-S-TRANSFERASE GENE POLYMORPHISMS IN BRONCHIAL ASTHMA PATIENTS: A STUDY IN NORTHERN INDIA

S. Awasthi, S. Kant, S. Bhattacharya, 2012 .

Multi-omic analysis reveals the anti-aging impact of sulforaphane on the microbiome and metabolome

M. Boerma, A. Cheema, S. Awasthi, 2020 .

RLIP76: a target for kidney cancer therapy.

Y. Awasthi, M. Sahu, S. Awasthi, 2009, Cancer research.

A novel glutathione S-transferase isozyme similar to GST 8-8 of rat and mGSTA4-4 (GST 5.7) of mouse is selectively expressed in human tissues.

S. Srivastava, Y. Awasthi, S. Awasthi, 1994, Biochimica et biophysica acta.

Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1.

G. Ansari, V. Thiviyanathan, Y. Awasthi, 2000, Chemico-biological interactions.

Modulation of doxorubicin cytotoxicity by ethacrynic acid

S. Srivastava, Shivendra V. Singh, Y. Awasthi, 1996, International journal of cancer.

Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein.

S. Srivastava, E. Frenkel, M. Saxena, 1994, The Journal of clinical investigation.

Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells.

Shivendra V. Singh, Y. Awasthi, Abha Sharma, 2004, European journal of biochemistry.

Activity of allelic variants of Pi class human glutathione S-transferase toward chlorambucil.

S. Srivastava, Y. Awasthi, S. Awasthi, 2000, Biochemical and biophysical research communications.

Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.

S. Awasthi, Sharda P. Singh, S. Singhal, 2015, Toxicology and applied pharmacology.

Inhibition of mercapturic acid pathway-mediated disposal of 4-hydroxynonenal causes complete and sustained remission of human cancer xenografts in nude mice.

Y. Awasthi, M. Sahu, Rajendra K. Sharma, 2011, Indian journal of experimental biology.

Glutathione-Conjugate Transport by RLIP76 Is Required for Clathrin-Dependent Endocytosis and Chemical Carcinogenesis

Sumihiro Suzuki, R. Vatsyayan, Y. Awasthi, 2011, Molecular Cancer Therapeutics.

Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases.

G. Ansari, Y. Awasthi, S. Awasthi, 2005, Methods in enzymology.

Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases.

Y. Awasthi, Abha Sharma, S. Awasthi, 2004, Free radical biology & medicine.

Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2004, Antioxidants & redox signaling.

Membrane Association of Glutathione S-Transferase mGSTA4-4, an Enzyme That Metabolizes Lipid Peroxidation Products*

S. Srivastava, Y. Awasthi, S. Awasthi, 2002, The Journal of Biological Chemistry.

Two distinct 4-hydroxynonenal metabolizing glutathione S-transferase isozymes are differentially expressed in human tissues.

Y. Awasthi, S. Awasthi, Sharda P. Singh, 2001, Biochemical and biophysical research communications.

Role of glutathione S-transferase 8-8 in allylamine resistance of vascular smooth muscle cells in vitro.

P. Boor, T. Zhao, S. Awasthi, 1999, Toxicology and applied pharmacology.

The role of human glutathione S-transferases hGSTA1-1 and hGSTA2-2 in protection against oxidative stress.

T. Zhao, Y. Awasthi, S. Awasthi, 1999, Archives of biochemistry and biophysics.

A Scientific Basis for Cancer Prevention

S. Awasthi, Sanjay K. Srivastawa, 1998 .

Rat GST 8-8 is expressed predominantly in myeloid origin cells infiltrating the gravid uterus.

C. Yallampalli, Y. Awasthi, S. Awasthi, 1997, The international journal of biochemistry & cell biology.

Active Site Architecture of Polymorphic Forms of Human GlutathioneS-Transferase P1-1 Accounts for Their Enantioselectivity and Disparate Activity in the Glutathione Conjugation of 7β,8α-Dihydroxy-9α, 10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

S. Srivastava, X. Ji, Shivendra V. Singh, 1997 .

Induction of glutathione S‐transferase π as a bioassay for the evaluation of potency of inhibitors of benzo(a)pyrene‐induced cancer in a murine model

S. Srivastava, Shivendra V. Singh, Y. Awasthi, 1997, International journal of cancer.

Multiple transport proteins involved in the detoxification of endo- and xenobiotics.

Y. Awasthi, S. Awasthi, P. Zimniak, 1997, Frontiers in bioscience : a journal and virtual library.

Purification and characterization of glutathione S-transferases of rat uterus.

C. Yallampalli, S. Awasthi, S. Singhal, 1996, The international journal of biochemistry & cell biology.

Purification and characterization of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme from bovine pulmonary microvessel endothelial cells.

Y. Awasthi, S. Awasthi, P. Zimniak, 1996, Biochimica et biophysica acta.

Several closely related glutathione S-transferase isozymes catalyzing conjugation of 4-hydroxynonenal are differentially expressed in human tissues.

D. Petersen, Y. Awasthi, S. Awasthi, 1994, Archives of biochemistry and biophysics.

Estimation of genomic complexity, heterologous expression, and enzymatic characterization of mouse glutathione S-transferase mGSTA4-4 (GST 5.7).

S. Srivastava, Y. Awasthi, S. Awasthi, 1994, The Journal of biological chemistry.

Glutathione S-transferases of human skin: qualitative and quantitative differences in men and women.

H. Mukhtar, M. Saxena, Y. Awasthi, 1993, Biochimica et biophysica acta.

M. Saxena, Y. Awasthi, S. Awasthi, 1994, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

Phase I study of a 3-drug regimen of gemcitabine/cisplatin/pemetrexed in patients with metastatic transitional cell carcinoma of the urothelium

S. Awasthi, W. Berry, Thomas E. Hutson, 2008, Investigational New Drugs.

4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2008, Biochemistry.

Targeting p 53-Null Neuroblastomas through RLIP 76

R. Vatsyayan, S. Awasthi, S. Singhal, 2011 .

Targeting p53-Null Neuroblastomas through RLIP76

R. Vatsyayan, S. Awasthi, S. Singhal, 2011, Cancer Prevention Research.

A Central Role of RLIP76 in Regulation of Glycemic Control

R. Vatsyayan, Y. Awasthi, S. Awasthi, 2009, Diabetes.

A flow cell assay for evaluation of whole cell drug efflux kinetics: analysis of paclitaxel efflux in CCRF-CEM leukemia cells overexpressing P-glycoprotein.

S. Awasthi, R. Sharma, J. Lin, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2002, Acta biochimica Polonica.

Cells Preconditioned with Mild, Transient UVA Irradiation Acquire Resistance to Oxidative Stress and UVA-induced Apoptosis

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2003, Journal of Biological Chemistry.

Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling

M. Boerma, Preeti Singh, Se-Ran Jun, 2020, Aging cell.

Accelerated Metabolism and Exclusion of 4-Hydroxynonenal through Induction of RLIP76 and hGST5.8 Is an Early Adaptive Response of Cells to Heat and Oxidative Stress*

Shivendra V. Singh, Y. Awasthi, Abha Sharma, 2001, The Journal of Biological Chemistry.

Synergistic efficacy of RLIP inhibition and 2′‐hydroxyflavanone against DMBA‐induced mammary carcinogenesis in SENCAR mice

R. Salgia, S. Awasthi, S. Vonderfecht, 2019, Molecular carcinogenesis.

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model

M. Boerma, Rajendra K. Sharma, S. Awasthi, 2018, PloS one.

Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells

S. Awasthi, C. Bose, P. Palade, 2021, Cancers.

Novel human ocular glutathione S-transferases with high activity toward 4-hydroxynonenal.

Y. Awasthi, S. Awasthi, N. Ansari, 1995, Investigative ophthalmology & visual science.

Glutathione S-transferases as antioxidant enzymes: small cell lung cancer (H69) cells transfected with hGSTA1 resist doxorubicin-induced apoptosis.

J. Li, Y. Awasthi, Abha Sharma, 2006, Archives of biochemistry and biophysics.

RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer.

D. Stuckler, Y. Awasthi, S. Awasthi, 2005, Cancer research.

RLIP 76 Transports Vinorelbine and Mediates Drug Resistance in Non – Small Cell Lung Cancer

D. Stuckler, Y. Awasthi, S. Awasthi, 2005 .

Effects of mGST A4 transfection on 4-hydroxynonenal-mediated apoptosis and differentiation of K562 human erythroleukemia cells.

F. V. van Kuijk, Y. Awasthi, S. Awasthi, 1999, Archives of biochemistry and biophysics.

Transfection of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme, mouse GSTA4-4, confers doxorubicin resistance to Chinese hamster ovary cells.

S. Srivastava, Y. Awasthi, S. Awasthi, 1996, Archives of biochemistry and biophysics.

Determinants of differential doxorubicin sensitivity between SCLC and NSCLC

Y. Awasthi, S. Awasthi, S. Singhal, 2006, FEBS letters.

Modulation of cisplatin cytotoxicity by sulphasalazine.

Y. Awasthi, S. Awasthi, R. Sharma, 1994, British Journal of Cancer.

RLIP: A necessary transporter protein for translating oxidative stress into pro-obesity and pro-carcinogenic signaling.

S. Awasthi, R. Garg, S. Singhal, 2022, Biochimica et biophysica acta. Reviews on cancer.

Role of Glutathione S-Transferases in Protection against Lipid Peroxidation OVEREXPRESSION OF hGSTA2-2 IN K562 CELLS PROTECTS AGAINST HYDROGEN PEROXIDE-INDUCED APOPTOSIS AND INHIBITS JNK AND CASPASE 3 ACTIVATION*

Y. Awasthi, S. Awasthi, S. Singhal, 2001 .

Didymin Induces Apoptosis by Inhibiting N-Myc and Upregulating RKIP in Neuroblastoma

Ashutosh, R. Vatsyayan, S. Awasthi, 2011, Cancer Prevention Research.

Protein oxidation biomarkers in hyperoxic lung injury in rats: effects of U-74389.

C. V. Smith, S. Awasthi, S. Welty, 1998, Toxicology letters.

RLIP76 and Cancer

Y. Awasthi, S. Awasthi, A. Frankel, 2008, Clinical Cancer Research.

RLIP76 Knockdown Attenuates Obesity Due to High-Fat Diet*

R. Natarajan, S. Awasthi, S. Singhal, 2013 .

Induction of glutathione S-transferase hGST 5.8 is an early response to oxidative stress in RPE cells.

B. Godley, Y. Awasthi, S. Awasthi, 1999, Investigative ophthalmology & visual science.

Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2.

U. Andley, Y. Awasthi, Rajendra K. Sharma, 2002, Investigative ophthalmology & visual science.

Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76

M. Sahu, S. Awasthi, S. Singhal, 2008, FEBS letters.

Hsf-1 and POB1 Induce Drug Sensitivity and Apoptosis by Inhibiting Ralbp1*

S. Awasthi, S. Singhal, Sushma Yadav, 2008, Journal of Biological Chemistry.

RLIP76 (RALBP1)‐mediated transport of leukotriene C4 (LTC4) in cancer cells: Implications in drug resistance

Y. Awasthi, Rajendra K. Sharma, S. Awasthi, 2004, International journal of cancer.

Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling.

Y. Awasthi, S. Awasthi, A. Sharma, 2001, Archives of biochemistry and biophysics.

A Central Role of RLIP 76 in Regulation of Glycemic Control Running Title : Mechanisms of Insulin Resistance

R. Vatsyayan, Y. Awasthi, S. Awasthi, 2009 .

Attenuation of 4-hydroxynonenal-induced cataractogenesis in rat lens by butylated hydroxytoluene.

Y. Awasthi, S. Awasthi, N. Ansari, 1996, Current eye research.

Rlip Protein: A Potential Target for COVID-19

S. Awasthi, C. Bose, Sharda P. Singh, 2022, Journal of community hospital internal medicine perspectives.

ATP-dependent transport of glutathione conjugate of 7 b ,8 a -dihydroxy-9 a ,10 a -oxy-7,8,9,10-tetrahydrobenzo[ a ]pyrene in murine hepatic canalicular plasma membrane vesicles

S. Srivastava, Shivendra V. Singh, S. Awasthi, 1998 .

Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo(a)pyrene.

S. Srivastava, X. Ji, B. Nanduri, 1997, Biochemical and biophysical research communications.

Mixed hepatocellular carcinoma-neuroendocrine carcinoma—A diagnostic and therapeutic challenge

S. Awasthi, E. Onkendi, Irfan Warraich, 2020 .

Glutathione S-transferase 8-8 is localized in smooth muscle cells of rat aorta and is induced in an experimental model of atherosclerosis.

S. Srivastava, P. Boor, Y. Awasthi, 1995, Toxicology and applied pharmacology.

Regression of Lung Cancer by Hypoxia-Sensitizing Ruthenium Polypyridyl Complexes

S. Awasthi, S. Singhal, F. MacDonnell, 2013, Molecular Cancer Therapeutics.

Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver.

Y. Awasthi, S. Awasthi, S. Singhal, 1998, The international journal of biochemistry & cell biology.

Prognostic significance of natural products against multidrug tumor resistance.

S. Awasthi, R. Garg, S. Singhal, 2023, Cancer letters.

The effect of curcumin on glutathione-linked enzymes in K562 human leukemia cells.

Y. Awasthi, S. Awasthi, J. Cheng, 1999, Toxicology letters.

Dietary curcumin prevents ocular toxicity of naphthalene in rats.

G F Jin, B. Godley, Y. Awasthi, 2000, Toxicology letters.

Mechanism of differential catalytic efficiency of two polymorphic forms of human glutathione S-transferase P1-1 in the glutathione conjugation of carcinogenic diol epoxide of chrysene.

S. Srivastava, X. Ji, S. Srivastava, 1997, Archives of biochemistry and biophysics.

Therapeutic resistance in lung cancer

S. Awasthi, S. Singhal, Ewa Zając, 2006, Expert opinion on drug metabolism & toxicology.

Rlip Depletion Suppresses Growth of Breast Cancer

S. Rehman, Jihyun Lee, S. Awasthi, 2020, Cancers.

Targeting RLIP with CRISPR/Cas9 controls tumor growth.

R. Salgia, S. Awasthi, S. Singhal, 2020, Carcinogenesis.

SOX9: The Master Regulator of Cell Fate in Breast Cancer.

R. Salgia, S. Awasthi, S. Singhal, 2020, Biochemical pharmacology.

Didymin: an orally active citrus flavonoid for targeting neuroblastoma

David Horne, Sanjay Awasthi, S. Awasthi, 2017, Oncotarget.

Notch Signaling in Breast Cancer: From Pathway Analysis to Therapy.

R. Salgia, S. Awasthi, S. Singhal, 2019, Cancer letters.

2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer

R. Salgia, S. Awasthi, Hongzhi Li, 2018, Oncotarget.

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells.

K. Ramana, S. Srivastava, R. Tammali, 2006, Cancer research.

Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer.

S. Awasthi, D. Jain, S. Singhal, 2017, Biochimica et biophysica acta. Reviews on cancer.

Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer.

R. Roby, R. Vatsyayan, S. Awasthi, 2011, Biochemical pharmacology.

RALBP1/RLIP76 mediates multidrug resistance.

S. Awasthi, S. Singhal, Sushma Yadav, 2007, International journal of oncology.

Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonenal in human lens epithelial cells.

P. Boor, Y. Awasthi, Abha Sharma, 2003, Investigative ophthalmology & visual science.

Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2008, Free radical biology & medicine.

Chromosomal alterations of pediatric malignancy in a West Texas population

V. Tonk, S. Awasthi, C. Bose, 2020 .

Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2003, Acta biochimica Polonica.

Ral-Binding Protein is Required for the Maturation and Function of Dendritic Cells

Y. Awasthi, M. Sahu, S. Awasthi, 2010 .

Novel Anti-cancer Compounds for Developing Combinatorial Therapies to Target Anoikis-Resistant Tumors

S. Awasthi, S. Singhal, L. Nagaprashantha, 2012, Pharmaceutical Research.

Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76).

Shivendra V. Singh, Y. Awasthi, Rajendra K. Sharma, 2002, Acta biochimica Polonica.

ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter.

Y. Awasthi, S. Awasthi, P. Zimniak, 1999, Toxicology and applied pharmacology.

Translational opportunities for broad‐spectrum natural phytochemicals and targeted agent combinations in breast cancer

S. Awasthi, S. Singhal, Shireen Chikara, 2018, International journal of cancer.

Therapeutic targeting of miRNA-216b in cancer.

R. Salgia, S. Awasthi, S. Singhal, 2020, Cancer letters.

Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal Cancer

S. Awasthi, A. Dwivedi, A. Philipovskiy, 2022, Frontiers in Oncology.

Glutathione S-transferases of rabbit lung macrophages.

S. Awasthi, A. Bidani, T. Heming, 1998, Toxicology and applied pharmacology.

Haploinsufficiency Interactions of RALBP1 and TP53 in Carcinogenesis

S. Awasthi, 2021, Cancers.

Rlip depletion prevents spontaneous neoplasia in TP53 null mice

Zheng Liu, Meenakshi Awasthi, Sanjay Awasthi, 2018, Proceedings of the National Academy of Sciences.

Inhibition of aldose reductase prevents colon cancer metastasis.

K. Ramana, S. Srivastava, A. Saxena, 2011, Carcinogenesis.

Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression.

S. Awasthi, S. Rahbar, S. Singhal, 2013, Biochemical pharmacology.

RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis.

R. Salgia, S. Awasthi, S. Singhal, 2020, Biochimica et biophysica acta. Reviews on cancer.

2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention.

A. Riggs, S. Awasthi, S. Singhal, 2015, Biochemical pharmacology.

RLIP76 Targeted Therapy for Kidney Cancer

S. Awasthi, S. Singhal, J. Figarola, 2015, Pharmaceutical Research.

4-Hydroxynonenal Induces G2/M Phase Cell Cycle Arrest by Activation of the Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR)/Checkpoint Kinase 1 (Chk1) Signaling Pathway*

J. Vishwanatha, Y. Awasthi, M. Sahu, 2013, The Journal of Biological Chemistry.

RLIP Depletion Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells.

Prakash Kulkarni, R. Salgia, S. Awasthi, 2021, Carcinogenesis.

Regression of prostate cancer xenografts by RLIP76 depletion.

S. Awasthi, S. Singhal, Kathryn L. Leake, 2009, Biochemical pharmacology.

Glutathione-Conjugate Transport and Stress-Response Signaling: Role of RLIP76

S. Awasthi, S. Singhal, 2006 .

Nutlin‐3 enhances sorafenib efficacy in renal cell carcinoma

R. Vatsyayan, S. Awasthi, S. Singhal, 2013, Molecular carcinogenesis.

Role of 4-hydroxynonenal in stress-mediated apoptosis signaling.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2003, Molecular aspects of medicine.

4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells.

R. Vatsyayan, Y. Awasthi, Abha Sharma, 2008, Archives of biochemistry and biophysics.

Apoptosis and Differentiation of K562 Cells by Targeting GST-O1 to Inhibit 4-HNE Metabolism

S. Awasthi, S. Singhal, Kathryn L. Leake, 2014 .

Phase III detoxification system.

Y. Awasthi, S. Awasthi, P. Zimniak, 1993, Trends in biochemical sciences.

Role of SMC1 in Overcoming Drug Resistance in Triple Negative Breast Cancer

R. Hickey, Y. Awasthi, S. Awasthi, 2013, PloS one.

Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells

W. Gmeiner, S. Awasthi, Chinnadurai Mani, 2019, Breast Cancer Research.

NCI 8628: A randomized phase 2 study of ziv‐aflibercept and high‐dose interleukin 2 or high‐dose interleukin 2 alone for inoperable stage III or IV melanoma

J. Kirkwood, A. Chen, H. Tawbi, 2018, Cancer.

2'-hydroxyflavanone inhibits proliferation, tumor vascularization and promotes normal differentiation in VHL-mutant renal cell carcinoma.

R. Vatsyayan, L. Prokai, S. Awasthi, 2011, Carcinogenesis.

Iron-induced lipid peroxidation in rat liver is accompanied by preferential induction of glutathione S-transferase 8-8 isozyme.

G. Ansari, S. Srivastava, D. Petersen, 1995, Toxicology and applied pharmacology.

The Framingham Study on Cardiovascular Disease Risk and Stress-Defenses: A Historical Review

S. Awasthi, S. Shurmur, Mostafa M Abohelwa, 2023, Journal of Vascular Diseases.

RLIP76 in defense of radiation poisoning.

Sumihiro Suzuki, D. Armstrong, P. Dent, 2008, International journal of radiation oncology, biology, physics.

Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters

S. Awasthi, S. Singhal, Sushma Yadav, 2007, Cancer and Metastasis Reviews.

RLIP76 is a major determinant of radiation sensitivity.

P. Dent, A. Yacoub, P. Boor, 2005, Cancer research.

RLIP76 Regulates PI3K/Akt Signaling and Chemo-Radiotherapy Resistance in Pancreatic Cancer

S. Awasthi, S. Singhal, Kathryn L. Leake, 2012, PloS one.

Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer

R. Vatsyayan, M. Sahu, S. Awasthi, 2009, International journal of cancer.

Physiological and Pharmacological Significance of Glutathione-Conjugate Transport

R. Vatsyayan, Y. Awasthi, Abha Sharma, 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics.

Y. Awasthi, Rajendra K. Sharma, S. Awasthi, 2002, Drug metabolism and disposition: the biological fate of chemicals.

RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes.

Y. Awasthi, S. Awasthi, R. Sharma, 2001, Archives of biochemistry and biophysics.

Transport of glutathione-conjugates in human erythrocytes.

Y. Awasthi, S. Awasthi, R. Sharma, 2000, Acta biochimica Polonica.

Role of RLIP 76 in doxorubicin resistance in lung cancer ( Review )

R. Vatsyayan, Y. Awasthi, P. Chaudhary, 2022 .

Doxorubicin transport by RALBP 1 and ABCG 2 in lung and breast cancer

Y. Awasthi, S. Awasthi, A. Lacko, 2022 .

Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity.

K. Ramana, S. Srivastava, Y. Awasthi, 2017, Free radical biology & medicine.

RLIP: An existential requirement for breast carcinogenesis.

R. Salgia, S. Awasthi, S. Singhal, 2019, Biochimica et biophysica acta. Reviews on cancer.

Activating p53 function by targeting RLIP.

R. Salgia, S. Awasthi, S. Singhal, 2021, Biochimica et biophysica acta. Reviews on cancer.

Association of TGF-β1 Polymorphisms with Breast Cancer Risk: A Meta-Analysis of Case–Control Studies †

R. Salgia, S. Awasthi, S. Singhal, 2020, Cancers.

P300 regulates the human RLIP76 promoter activity and gene expression.

Y. Awasthi, S. Awasthi, A. Basu, 2013, Biochemical pharmacology.

Activity of melphalan in combination with the glutathione transferase inhibitor sulfasalazine

Bing-he Xu, M. Levitt, Shivendra V. Singh, 2004, Cancer Chemotherapy and Pharmacology.

2'-Hydroxyflavanone: A novel strategy for targeting breast cancer

S. Awasthi, S. Singhal, Shireen Chikara, 2017, Oncotarget.

The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4.

R. Vatsyayan, Y. Awasthi, P. Chaudhary, 2012, Biochemical and biophysical research communications.

Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent.

R. Vatsyayan, Shivendra V. Singh, Y. Awasthi, 2010, Biochemistry.

Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1).

P. Boor, Y. Awasthi, S. Awasthi, 2007, Cancer research.

Mitogenic Responses of Vascular Smooth Muscle Cells to Lipid Peroxidation-derived Aldehyde 4-Hydroxy-trans-2-nonenal (HNE)

K. Ramana, S. Srivastava, Y. Awasthi, 2006, Journal of Biological Chemistry.

Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties.

S. Srivastava, S. Srivastava, B. Nanduri, 1994, European journal of biochemistry.

Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses.

Y. Awasthi, S. Awasthi, S. Singhal, 1996, The American journal of clinical nutrition.

hSET1: a novel approach for colon cancer therapy.

S. Awasthi, S. Singhal, Sushma Yadav, 2009, Biochemical pharmacology.

LR-90 prevents methylglyoxal-induced oxidative stress and apoptosis in human endothelial cells

S. Awasthi, S. Rahbar, S. Singhal, 2014, Apoptosis.

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

K. Ramana, S. Awasthi, P. Pal, 2017, Scientific Reports.

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

K. Ramana, S. Srivastava, S. Awasthi, 2017, Scientific Reports.

Phase IIIb safety results from an expanded-access protocol of talimogene laherparepvec for patients with unresected, stage IIIB–IVM1c melanoma

G. Linette, J. Nemunaitis, L. Hutchins, 2018, Melanoma research.

2'-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells.

R. Salgia, S. Awasthi, S. Singhal, 2019, Journal of proteomics.

Attenuation of galactose cataract by low levels of dietary curcumin

B. Godley, Y. Awasthi, S. Awasthi, 2000 .

Association of rash with outcomes in a randomized phase II trial evaluating cetuximab in combination with mitoxantrone plus prednisone after docetaxel for metastatic castration-resistant prostate cancer.

G. Sonpavde, M. Galsky, D. Martincic, 2012, Clinical genitourinary cancer.

Depletion of RLIP76 sensitizes lung cancer cells to doxorubicin.

Y. Awasthi, S. Awasthi, S. Singhal, 2005, Biochemical pharmacology.

Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels

P. Reddy, S. Awasthi, C. Bose, 2022, Cancers.

RLIP76: a versatile transporter and an emerging target for cancer therapy.

R. Vatsyayan, S. Awasthi, S. Singhal, 2010, Biochemical pharmacology.

Functional reassembly of ATP-dependent xenobiotic transport by the N- and C-terminal domains of RLIP76 and identification of ATP binding sequences.

Y. Awasthi, S. Awasthi, R. Sharma, 2001, Biochemistry.

Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease

Hafiz M. R. Khan, P. Reddy, S. Awasthi, 2021, bioRxiv.

Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis

Yate-Ching Yuan, Jihyun Lee, S. Awasthi, 2021, Cancers.

Anticancer activity of 2’-hydroxyflavanone towards lung cancer

Yate-Ching Yuan, V. Tonk, Y. Awasthi, 2018, Oncotarget.

RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.

S. Awasthi, Seunghyung Lee, L. Goldfinger, 2012, Cancer research.

Mitogenic and drug-resistance mediating effects of PKCα require RLIP76

Y. Awasthi, S. Awasthi, S. Singhal, 2006 .

Regression of melanoma in a murine model by RLIP76 depletion.

Y. Awasthi, S. Awasthi, S. Singhal, 2006, Cancer research.

The role of PKCα and RLIP76 in transport‐mediated doxorubicin‐resistance in lung cancer

Y. Awasthi, S. Awasthi, S. Singhal, 2005, FEBS letters.

POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis.

Y. Awasthi, S. Awasthi, S. Singhal, 2005, Biochemical and biophysical research communications.

Is a Major Determinant of Radiation Sensitivity

P. Dent, A. Yacoub, P. Boor, 2005 .

Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes.

Y. Awasthi, S. Awasthi, R. Sharma, 2001, Acta biochimica Polonica.

Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2α Expression

R. Vatsyayan, Jia Guo, L. Prokai, 2013, PloS one.

Retreatment with yttrium-90 ibritumomab tiuxetan in patients with B-cell non-Hodgkin's lymphoma

S. Shen, A. Forero, S. Awasthi, 2007, Leukemia & lymphoma.

2 Role of oxidative stress in the severity of SARS-COV-2 infection

S. Awasthi, C. Bose, Sharda P. Singh, 2023, COVID-19 in Alzheimer's Disease and Dementia.

The relationship of doxorubicin binding to membrane lipids with drug resistance.

J A Belli, E P Frenkel, J. Belli, 1992, Cancer letters.

Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway.

Preeti Singh, S. Awasthi, E. Børsheim, 2021, The Journal of nutritional biochemistry.

SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells*

A. Riggs, S. Awasthi, G. Rogers, 2015, The Journal of Biological Chemistry.

Interactions of melphalan with glutathione and the role of glutathione S-transferase.

G. Ansari, Y. Awasthi, S. Awasthi, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Rabbit aorta glutathione S-transferases and their role in bioactivation of trinitroglycerin.

Y. Awasthi, S. Awasthi, S. Singhal, 1996, Toxicology and applied pharmacology.

Targeting the mercapturic acid pathway for the treatment of melanoma.

R. Salgia, S. Awasthi, T. Mirzapoiazova, 2021, Cancer letters.

Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells

W. Gmeiner, S. Awasthi, Chinnadurai Mani, 2019, Breast Cancer Research.

Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells.

Shivendra V. Singh, Y. Awasthi, Rajendra K. Sharma, 2003, International journal of oncology.

Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells.

R. Vatsyayan, Y. Awasthi, Abha Sharma, 2011, Experimental eye research.

Case report of recurrent fibromatosis with laryngeal involvement: Treatment based on network analyses of NGS data

S. Awasthi, J. Cordero, J. Kopel, 2022, Molecular and clinical oncology.

RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma

S. Awasthi, S. Singhal, P. Singhal, 2017, Pharmaceutical Research.

Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis.

R. Vatsyayan, P. Chaudhary, S. Awasthi, 2009, Cancer letters.

Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer.

Y. Awasthi, S. Awasthi, A. Lacko, 2007, International journal of oncology.

Functional reconstitution of RLIP76 catalyzing ATP-dependent transport of glutathione-conjugates.

M. Sahu, S. Awasthi, S. Singhal, 2009, International journal of oncology.

RLIP76 Protein Knockdown Attenuates Obesity Due to a High-fat Diet*

R. Natarajan, S. Awasthi, S. Singhal, 2013, The Journal of Biological Chemistry.

M. Saxena, Y. Awasthi, S. Awasthi, 1992, Biochimica et biophysica acta.

RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease

Hafiz M. R. Khan, P. Reddy, S. Awasthi, 2021, Cells.

RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.

S. Awasthi, Seunghyung Lee, M. Ginsberg, 2015, Biochemical and biophysical research communications.

On the diversity of biological therapeutics

S. Awasthi, 2007, Biologics : targets & therapy.

Phase I trial of intravenous fenretinide (4-HPR) plus safingol in advanced malignancies

D. Gerber, S. Awasthi, Min H. Kang, 2023, Cancer Chemotherapy and Pharmacology.

Increased resistance to oxidative stress in transfected cultured cells overexpressing glutathione S-transferase mGSTA4-4.

S. Srivastava, S. Awasthi, P. Zimniak, 1997, Toxicology and applied pharmacology.

Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia.

Y. Awasthi, M. Sahu, Rajendra K. Sharma, 2014, Experimental eye research.

The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2007, Current drug metabolism.

RLIP76 Targeted Therapy for Kidney Cancer

S. Awasthi, S. Singhal, J. Figarola, 2015, Pharmaceutical Research.

1 RALBP 1 / RLIP 76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization . Running title : RLIP 76 is essential for tumor angiogenesis

S. Awasthi, Seunghyung Lee, S. Singhal, 2012 .

Dinitrophenyl S-glutathione ATPase purified from human muscle catalyzes ATP hydrolysis in the presence of leukotrienes.

M. Saxena, Y. Awasthi, S. Awasthi, 1992, Archives of biochemistry and biophysics.

ATP-Dependent human erythrocyte glutathione-conjugate transporter. I. Purification, photoaffinity labeling, and kinetic characteristics of ATPase activity.

S. Srivastava, Y. Awasthi, S. Awasthi, 1998, Biochemistry.

ATP-Dependent human erythrocyte glutathione-conjugate transporter. II. Functional reconstitution of transport activity.

S. Srivastava, Y. Awasthi, S. Awasthi, 1998, Biochemistry.

Identification of membrane-anchoring domains of RLIP76 using deletion mutant analyses.

T. Albrecht, Y. Awasthi, S. Awasthi, 2004, Biochemistry.

Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity.

Y. Awasthi, S. Awasthi, P. Zimniak, 2003, International journal of oncology.

Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76.

Y. Awasthi, S. Awasthi, P. Zimniak, 2003, International journal of oncology.

Glutathione S-transferases of human lung: characterization and evaluation of the protective role of the alpha-class isozymes against lipid peroxidation.

M. Saxena, Y. Awasthi, S. Awasthi, 1992, Archives of biochemistry and biophysics.

Oxidative stress in intensive care unit patients: a review of glutathione linked metabolism and lipid peroxidation

S. Awasthi, P. Palade, Sharda P. Singh, 2019, The Southwest Respiratory and Critical Care Chronicles.

Interactions of glutathione S-transferase-pi with ethacrynic acid and its glutathione conjugate.

S. Srivastava, G. Ansari, S. Srivastava, 1993, Biochimica et biophysica acta.

Journal of Community Hospital Internal Medicine Perspectives Journal of Community Hospital Internal Medicine Perspectives

S. Awasthi, C. Bose, Sharda P. Singh, 2022 .

Energy dependent transport of xenobiotics and its relevance to multidrug resistance.

Y. Awasthi, Abha Sharma, Rajendra K. Sharma, 2003, Current cancer drug targets.