S. Betzi

发表

Discovery of a potential allosteric ligand binding site in CDK2.

Huijong Han, E. Schönbrunn, Mathew P. Martin, 2011, ACS chemical biology.

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.

S. Knapp, P. Roche, T. Roux, 2016, Journal of medicinal chemistry.

A Novel Approach to the Discovery of Small‐Molecule Ligands of CDK2

E. Schönbrunn, Mathew P. Martin, S. Betzi, 2012, Chembiochem : a European journal of chemical biology.

Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)*

S. Olesen, Huijong Han, E. Schönbrunn, 2012, The Journal of Biological Chemistry.

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.

D. Horvath, A. Varnek, P. Roche, 2018, Journal of medicinal chemistry.

Protein–protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

F. Guerlesquin, S. Arold, I. Parrot, 2007, Proceedings of the National Academy of Sciences.

Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

Christian Drosten, Xavier Morelli, Stéphane Betzi, 2014, The Journal of Biological Chemistry.

Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery.

S. Knapp, S. Müller, P. Roche, 2016, ACS chemical biology.

Stability of the Human Hsp90-p50Cdc37 Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2

S. Olesen, E. Schönbrunn, Mathew P. Martin, 2015, Molecules.

Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions

C. Schiff, F. Guerlesquin, S. Betzi, 2015, Nature Communications.

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

E. Pasquier, P. Tsvetkov, S. Betzi, 2020, Molecular oncology.

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

E. Pasquier, P. Tsvetkov, S. Betzi, 2020, bioRxiv.

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.

S. Betzi, J. Neyts, J. Haiech, 2009, Antiviral research.

Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer

Ruedi Aebersold, Stéphane Betzi, Matthias Peter, 2014, PloS one.

CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation.

E. Pasquier, P. Roche, S. Betzi, 2022, Journal of medicinal chemistry.

CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation

E. Pasquier, P. Roche, S. Betzi, 2021, bioRxiv.

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.

A. Becker, C. Cubitt, Huijong Han, 2013, Journal of medicinal chemistry.

Stereoselective synthesis of original spirolactams displaying promising folded structures.

Jean Martínez, I. Parrot, P. Roche, 2013, Organic & biomolecular chemistry.

The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .

S. Olesen, A. Becker, Huijong Han, 2010, Biochemistry.

Prevalence, Specificity and Determinants of Lipid-Interacting PDZ Domains from an In-Cell Screen and In Vitro Binding Experiments

J. Reboul, J. Borg, Y. Ivarsson, 2013, PloS one.

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology

S. Betzi, P. Dubreuil, L. Gros, 2017, Nature Communications.

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis

A. Sergé, B. Durand, J. Borg, 2017, PLoS genetics.

Discovery of small molecule inhibitors of the PTK7/β-catenin inter-action targeting the Wnt signaling pathway in colorectal cancer

J. Borg, P. Roche, S. Betzi, 2021, bioRxiv.

Molecular Mapping of the RNA Cap 2′-O-Methyltransferase Activation Interface between Severe Acute Respiratory Syndrome Coronavirus nsp10 and nsp16*

E. Decroly, P. Lécine, Aurélie Hermant, 2010, The Journal of Biological Chemistry.

Crystal Structure of the Vaccinia Virus DNA Polymerase Holoenzyme Subunit D4 in Complex with the A20 N-Terminal Domain

S. Betzi, N. Tarbouriech, X. Morelli, 2014, PLoS pathogens.

Antimicrobial and cytotoxic effects of marine sponge extracts Agelas clathrodes, Desmapsamma anchorata and Verongula rigida from a Caribbean Island

S. Betzi, A. Restouin, R. Castellano, 2022, PeerJ.

Revisiting the Molecular Interactions between the Tumor Protein TCTP and the Drugs Sertraline/Thioridazine

E. Jacquet, S. Betzi, E. Lescop, 2021, ChemMedChem.

Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets.

Xavier Morelli, Stéphane Betzi, Françoise Guerlesquin, 2009, Combinatorial chemistry & high throughput screening.

Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

D. Normanno, S. Betzi, M. Modesti, 2017, eLife.

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

Huan Yang, J. Cheng, E. Schönbrunn, 2010, Cell Death and Differentiation.

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG‐2‐interacting protein X (Alix)

Mingdong Huang, Xavier Morelli, Isabelle Parrot, 2012, FEBS letters.

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.

Philippe Roche, Xu Zhang, Xavier Morelli, 2014, Future medicinal chemistry.

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity.

H. Lashuel, S. Betzi, A. Lugari, 2010, Bioorganic & medicinal chemistry.

Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo

D. Kovalskyy, P. Roche, S. Betzi, 2020, Journal of extracellular vesicles.

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions

Philippe Roche, Xavier Morelli, Marie Jeanne Basse, 2016, Database J. Biol. Databases Curation.

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia

P. Roche, S. Betzi, P. Dubreuil, 2023, Nature communications.

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology

S. Betzi, P. Dubreuil, L. Gros, 2017, Nature Communications.

2P2Idb: a structural database dedicated to orthosteric modulation of protein–protein interactions

Philippe Roche, Xavier Morelli, Raphaël Bourgeas, 2012, Nucleic Acids Res..

Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.

P. Roche, S. Betzi, Avais M. Daulat, 2023, Journal of medicinal chemistry.

Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer.

J. Borg, P. Roche, S. Betzi, 2022, ACS chemical biology.

Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex

M. Nilges, D. Byrne, R. Pellarin, 2021, mBio.

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.

S. Betzi, J. Neyts, J. Haiech, 2009, Antiviral research.

GFscore: A General Nonlinear Consensus Scoring Function for High-Throughput Docking

Xavier Morelli, Stéphane Betzi, Karsten Suhre, 2006, J. Chem. Inf. Model..