C. Lange

发表

Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer.

D. Yee, C. Lange, Douglas Yee, 2011, Endocrine-related cancer.

Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors.

C. Lange, Emily J. Faivre, A. R. Daniel, 2008, Molecular endocrinology.

Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells.

J. Ostrander, C. Lange, A. R. Daniel, 2007, Cancer research.

Pathway-based discovery of genetic interactions in breast cancer

C. Myers, Charles Boone, M. Costanzo, 2017, PLoS genetics.

Met Receptors Induce Sam68-dependent Cell Migration by Activation of Alternate Extracellular Signal-regulated Kinase Family Members*

C. Lange, A. Locatelli, Carol A Lange, 2011, The Journal of Biological Chemistry.

ck2-Dependent Phosphorylation of Progesterone Receptors (PR) on Ser81 Regulates PR-B Isoform-Specific Target Gene Expression in Breast Cancer Cells

C. Lange, Gwen E. Dressing, C. Hagan, 2011, Molecular and Cellular Biology.

Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals.

C. Lange, J. Richer, K. Horwitz, 1999, Molecular endocrinology.

Progesterone regulation of tissue factor depends on MEK1/2 activation and requires the proline-rich site on progesterone receptor

M. Cuello, C. Lange, M. Pinto, 2015, Endocrine.

Progesterone receptor action: defining a role in breast cancer

C. Lange, A. R. Daniel, C. Hagan, 2011, Expert review of endocrinology & metabolism.

Progesterone and Breast Cancer

D. Yee, C. Lange, 2008, Women's health.

Policy decisions on endocrine disruptors should be based on science across disciplines

Adrian V. Lee, P. Hof, D. Carpenter, 2013, European journal of endocrinology.

Progesterone receptor variants found in breast cells repress transcription by wild-type receptors

K. Horwitz, C. Lange, J. Richer, 1998, Breast Cancer Research and Treatment.

Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells.

C. Lange, Emily J. Faivre, A. R. Daniel, 2007, Molecular endocrinology.

Challenges to defining a role for progesterone in breast cancer

C. Lange, 2008, Steroids.

Histone Methylation and Epigenetic Silencing in Breast Cancer

J. Simon, C. Lange, 2008 .

Roles of the EZH2 histone methyltransferase in cancer epigenetics.

J. Simon, C. Lange, 2008, Mutation research.

Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs

G. Raj, N. Brady, Shihong Ma, 2017, Journal of Hematology & Oncology.

2-Methoxyestradiol Inhibits Progesterone-Dependent Tissue Factor Expression and Activity in Breast Cancer Cells

J. Brosens, M. Cuello, C. Lange, 2010, Hormones & cancer.

Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming

Caroline H. Diep, C. Lange, T. Knutson, 2015, Molecular Cancer Research.

Role of phosphorylation in progesterone receptor signaling and specificity

C. Lange, A. R. Daniel, Gwen E. Dressing, 2012, Molecular and Cellular Endocrinology.

Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.

K. Horwitz, C. Lange, Emily J. Faivre, 2003, Molecular endocrinology.

Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

Yan Peng, G. Raj, J. Cidlowski, 2018, Molecular Cancer Research.

Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells

C. Lange, Nancy E. Castro, 2010, Breast Cancer Research.

Integration of progesterone receptor action with rapid signaling events in breast cancer models

C. Lange, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Convergence of Progesterone with Growth Factor and Cytokine Signaling in Breast Cancer

K. Horwitz, C. Lange, N. Manning, 1998, The Journal of Biological Chemistry.

Differential Expression of the A and B Isoforms of Progesterone Receptor in Human Endometrial Cancer Cells

K. Horwitz, K. Leslie, C. Lange, 1997, Annals of the New York Academy of Sciences.

3C. 3-Ketosteroid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

D. Edwards, Sean M. Hartig, J. Cidlowski, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association

C. Lange, M. Qiu, 2003, The Journal of Steroid Biochemistry and Molecular Biology.

Transcriptional Hyperactivity of Human Progesterone Receptors Is Coupled to Their Ligand-Dependent Down-Regulation by Mitogen-Activated Protein Kinase-Dependent Phosphorylation of Serine 294

K. Horwitz, C. Lange, T. Shen, 2001, Molecular and Cellular Biology.

Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals.

C. Lange, J. Richer, K. Horwitz, 1999, Molecular endocrinology.

Integrated actions of PR and cell cycle machinery regulate breast cancer cell proliferation

C. Lange, Gwen E. Dressing, 2016 .

Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation

C. Lange, Gwen E. Dressing, 2009, Steroids.

Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models.

C. Lange, A. R. Daniel, T. Knutson, 2009, Endocrine-related cancer.

Membrane progesterone receptor expression in mammalian tissues: A review of regulation and physiological implications

C. Lange, K. Schwertfeger, Gwen E. Dressing, 2011, Steroids.

A functional signal profiling test for identifying a subset of HER2-negative breast cancers with abnormally amplified HER2 signaling activity

Lance G. Laing, C. Lange, I. Macneil, 2016, Oncotarget.

The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention.

C. Lange, A. R. Daniel, Christopher J Hillard, 2010, Molecular endocrinology.

Bi-directional Regulation of Human Progesterone Receptors and the Mitogen Activated Protein Kinase Pathway in Breast Cancer Cell Models

C. Lange, Emily J. Faivre, M. Qiu, 2005 .

Scaffolding actions of membrane-associated progesterone receptors

C. Lange, Emily J. Faivre, C. Hagan, 2009, Steroids.

Making sense of cross-talk between steroid hormone receptors and intracellular signaling pathways: who will have the last word?

C. Lange, 2004, Molecular endocrinology.

Tumour and cellular distribution of activated forms of PR in breast cancers: a novel immunohistochemical analysis of a large clinical cohort

S. Fuqua, J. Bonneterre, J. Bosq, 2016, ESMO Open.

PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER+ breast cancer

J. Ostrander, B. Welm, Camila O. dos Santos, 2021, Oncogene.

PELP1/SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer

J. Ostrander, B. Welm, C. Lange, 2020, bioRxiv.

Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

Lance G. Laing, C. Lange, I. Macneil, 2017, BMC Cancer.

Breast cancer and pregnancy.

K. Leslie, C. Lange, 2005 .

Minireview: Deciphering the Cellular Functions of PELP1.

G. Raj, C. Lange, P. Ravindranathan, 2015, Molecular endocrinology.

PELP1: A review of PELP1 interactions, signaling, and biology

J. Ostrander, C. Lange, A. R. Daniel, 2014, Molecular and Cellular Endocrinology.

Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes

Caroline H. Diep, C. Lange, Hannah D. Ahrendt, 2016, Steroids.

Modifications to glucocorticoid and progesterone receptors alter cell fate in breast cancer.

J. Ostrander, C. Lange, A. R. Daniel, 2016, Journal of molecular endocrinology.

Dynamic regulation of steroid hormone receptor transcriptional activity by reversible SUMOylation.

C. Lange, T. Knutson, 2013, Vitamins and hormones.

Steroid Receptors as MAPK Signaling Sensors in Breast Cancer: Let the Fates Decide.

J. Ostrander, C. Lange, Thu H. Truong, 2020, Journal of molecular endocrinology.

Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

S. Fuqua, K. Covington, K. Silverstein, 2012, Breast Cancer Research.

Progesterone Receptors Upregulate Wnt-1 To Induce Epidermal Growth Factor Receptor Transactivation and c-Src-Dependent Sustained Activation of Erk1/2 Mitogen-Activated Protein Kinase in Breast Cancer Cells

C. Lange, Emily J. Faivre, Carol A. Lange, 2006, Molecular and Cellular Biology.

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

J. Sarkaria, Liewei Wang, Minetta C. Liu, 2018, Breast cancer research : BCR.

Crosstalk Between Estrogen Receptors and Growth Factor Signaling

D. Yee, C. Lange, 2002 .

Convergence of Progesterone and Epidermal Growth Factor Signaling in Breast Cancer

K. Horwitz, C. Lange, J. Richer, 1998, The Journal of Biological Chemistry.

Progesterone Receptors Promote Quiescence & Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models.

Caroline H. Diep, L. Litovchick, R. Drapkin, 2021, The Journal of clinical endocrinology and metabolism.

Progesterone action in breast, uterine, and ovarian cancers.

Caroline H. Diep, C. Lange, A. R. Daniel, 2015, Journal of molecular endocrinology.

Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases.

C. Lange, Andrew Skildum, Emily J. Faivre, 2005, Molecular endocrinology.

Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1).

K. Horwitz, S. Groshong, R. Sclafani, 1997, Molecular endocrinology.

Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells

Caroline H. Diep, S. Kalloger, C. Lange, 2013, Cell cycle.

Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers

C. Lange, Thu H. Truong, 2018, Endocrinology.

Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes

J. Ostrander, N. Brady, C. Lange, 2018, Molecular Cancer Research.

Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes

D. Yee, Yan Peng, G. Raj, 2014, Oncogene.

Tracking progesterone receptor-mediated actions in breast cancer.

C. Lange, T. Knutson, 2014, Pharmacology & therapeutics.

Abstract 3572: Unliganded progesterone receptors augment estrogen-induced growth of breast cancer cells via co-regulation of estrogen receptor target genes.

D. Yee, J. Ostrander, C. Lange, 2013 .

Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.

R. Wenger, C. Lange, A. R. Daniel, 2013, Cancer research.

A Bright Future for Hormones and Cancer: Farewell Comments of Dr. Carol A. Lange, Recent Past Editor-in-Chief

C. Lange, 2015, Hormones and Cancer.

Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1.

J. Brosens, Marius C. Jones, M. Cuello, 2012, The Journal of endocrinology.

Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

S. Fuqua, K. Covington, K. Silverstein, 2012, Breast Cancer Research.

Hormones and Cancer: a Bright Future

C. Lange, 2012, Hormones & cancer.

Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.

C. Lange, K. Horwitz, T. Shen, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK

J. Ostrander, C. Lange, Kristopher A. Lofgren, 2011, Breast Cancer Research.

Brk/PTK6 signaling in normal and cancer cell models.

J. Ostrander, C. Lange, A. R. Daniel, 2010, Current opinion in pharmacology.

Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.

G. Raj, J. Cidlowski, Shihong Ma, 2016, Cancer research.

Tumor and Stem Cell Biology Breast Tumor Kinase ( Brk / PTK 6 ) Is a Mediator of Hypoxia-Associated Breast Cancer Progression

R. Wenger, C. Lange, A. R. Daniel, 2013 .

Mechanisms of HGF/Met Signaling to Brk and Sam68 in Breast Cancer Progression

C. Lange, A. R. Daniel, Kristopher A. Lofgren, 2011, Hormones and Cancer.

Regulated Association of Protein Kinase B/Akt with Breast Tumor Kinase*

J. Ostrander, C. Lange, Emily J. Faivre, 2005, Journal of Biological Chemistry.

Molecular genomics of progestin actions

C. Lange, M. Tetel, 2009 .

Stress sensing within the breast tumor microenvironment: how glucocorticoid receptors live in the moment.

J. Ostrander, C. Lange, Thu H. Truong, 2021, Essays in biochemistry.

Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling

B. Moriarity, C. Lange, B. Smeester, 2020, Molecular Cancer Research.

Molecular determinants of context-dependent progesterone receptor action in breast cancer

C. Lange, C. Hagan, 2014, BMC Medicine.

A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells

C. Lange, T. Knutson, C. Hagan, 2013, Nucleic acids research.

Progesterone receptor action: translating studies in breast cancer models to clinical insights.

K. Horwitz, M. Spillman, B. Jacobsen, 2008, Advances in experimental medicine and biology.

Linkage of progestin and epidermal growth factor signaling: Phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth

J. Ostrander, C. Lange, Andrew Skildum, 2007, Steroids.

Phosphorylation of Progesterone Receptor Serine 400 Mediates Ligand-Independent Transcriptional Activity in Response to Activation of Cyclin-Dependent Protein Kinase 2

C. Lange, L. Pierson-Mullany, 2004, Molecular and Cellular Biology.

Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells

S. Byron, D. Yee, C. Lange, 2006, British Journal of Cancer.

Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer.

S. Hammes, C. Lange, P. Marker, 2007, Annual review of physiology.

Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates.

Caroline H. Diep, C. Lange, Thu H. Truong, 2018, Endocrinology.

Progesterone promotes immunomodulation and tumor development in the murine mammary gland

Howard H. Yang, Ying Hu, K. Hunter, 2021, Journal for ImmunoTherapy of Cancer.

Leveraging Antiprogestins in the Treatment of Metastatic Breast Cancer.

H. Rui, D. Yee, K. Wisinski, 2021, Endocrinology.

Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models

C. Lange, Thu H. Truong, Katherine A. Leehy, 2018, The Journal of Steroid Biochemistry and Molecular Biology.

Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: Role of mitogen-activated protein kinases and cell cycle regulators

C. Lange, Andrew Skildum, Emily J. Faivre, 2005, Steroids.

Signaling inputs to progesterone receptor gene regulation and promoter selectivity

C. Lange, A. R. Daniel, T. Knutson, 2009, Molecular and Cellular Endocrinology.

Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer

Caroline H. Diep, J. Cidlowski, C. Lange, 2020, Breast Cancer Research.

Expression of Membrane Progesterone Receptors (mPR/PAQR) in Ovarian Cancer Cells: Implications for Progesterone-Induced Signaling Events

C. Lange, P. Thomas, N. Charles, 2010, Hormones & cancer.

Progesterone and Breast Cancer: an NCI Workshop Report

C. Lange, N. Sathyamoorthy, 2020, Hormones and Cancer.

Lost in Translation: Can We Afford to Miss the Trees for the Forest?

S. Hammes, C. Lange, 2014, Hormones and Cancer.

Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells

C. Lange, A. R. Daniel, Andrea R Daniel, 2009, Proceedings of the National Academy of Sciences.

Mechanisms of Hormone Action

S. Hammes, C. Lange, M. McPhaul, 2006 .

Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease

E. Levin, C. Lange, F. Mauvais-Jarvis, 2021, Endocrine reviews.

Commentary: Killing The Second Messenger: Targeting Loss of Cell Cycle Control in Endocrine Resistant Breast Cancer Running Title: Targeting Cell Cycle Control in Breast Cancer

D. Yee, C. Lange, 2011 .

Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells.

Caroline H. Diep, K. Knudsen, C. Lange, 2014, Molecular endocrinology.

Steadying the boat: integrating mechanisms of membrane and nuclear‐steroid‐receptor signalling

C. Lange, C. Watson, 2005, EMBO reports.

Abstract 2107: Aurora A kinase and progesterone receptor cross talk in breast cancer

C. Lange, A. R. Daniel, A. D’Assoro, 2014 .

Identification of the activated form of the progesterone receptor (PR) in breast cancer (BC).

S. Fuqua, J. Bonneterre, J. Bosq, 2013 .

Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells

A. Degnim, J. Ingle, J. McCubrey, 2014, PloS one.

Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer

P. Kabos, C. Sartorius, C. Lange, 2020, British journal of cancer.

Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer

Caroline H. Diep, J. Cidlowski, C. Lange, 2020, Breast Cancer Research.

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

J. Sarkaria, Liewei Wang, Minetta C. Liu, 2018, Breast Cancer Research.

Steroid Receptors as MAPK Signaling Sensors in Breast Cancer: Let the Fates Decide.

J. Ostrander, C. Lange, Thu H. Truong, 2020, Journal of molecular endocrinology.

Review of: Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity

C. Lange, 2006 .

Glucocorticoid receptors drive breast cancer cell migration and metabolic reprograming via PDK4.

J. Cidlowski, C. Lange, C. Liddle, 2023, Endocrinology.

Challenges to defining a role for progesterone in breast cancer

C. Lange, 2008, Steroids.