K. Uoto

发表

Discovery of novel Thieno[2,3-d]pyrimidin-4-yl hydrazone-based cyclin-dependent kinase 4 inhibitors: synthesis, biological evaluation and structure-activity relationships.

T. Horiuchi, Y. Takeda, N. Haginoya, 2011, Chemical & pharmaceutical bulletin.

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: synthesis, biological evaluation, and structure-activity relationships.

T. Horiuchi, K. Uoto, J. Chiba, 2009, Bioorganic & medicinal chemistry letters.

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation and structure-activity relationships. Part 2.

T. Horiuchi, M. Nagata, Mayumi Kitagawa, 2009, Bioorganic & medicinal chemistry.

Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.

K. Uoto, Makoto Suzuki, A. Mochizuki, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological activity of piperidine diamine derivatives as factor Xa inhibitor.

K. Uoto, Yumi Nakamoto, A. Mochizuki, 2008, Bioorganic & medicinal chemistry letters.

A New Water‐soluble Camptothecin Derivative, DX‐8951f, Exhibits Potent Antitumor Activity against Human Tumors in vitro and in vivo

K. Uoto, M. Sugimori, E. Kumazawa, 1995, Japanese journal of cancer research : Gann.

Design, synthesis, and optimization of a series of 2-azaspiro[3.3]heptane derivatives as orally bioavailable fetal hemoglobin inducers.

K. Uoto, T. Makino, Hiroaki Maeda, 2020, Bioorganic & medicinal chemistry letters.

Preparation of large macrocyclic tetra-amines consisting of a methylene backbone and a cyclophane type skeleton

K. Uoto, H. Okuno, T. Tomohiro, 1990 .

Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase.

K. Uoto, Y. Ishii, M. Hata, 2010, Medical mycology.

Synthesis of large macrocyclic tetraaza compounds with a methylene backbone: Cyclo[‐NH‐ (CH2)n‐]4, (n = 6, 7, 8, 9 and 10). The formation of 28‐, 32‐, 36‐, 40‐ and 44‐membered rings

K. Uoto, H. Okuno, T. Tomohiro, 1990 .

Synthesis of tetranuclear iron–sulphur protein analogues with tetrathiol ligands attached to macrocycles which provide intramolecular hydrophobic domains

K. Uoto, H. Okuno, T. Tomohiro, 1990 .

Synthesis of tetra-aza macrocycles with remarkably high efficiency

K. Uoto, H. Okuno, T. Tomohiro, 1988 .

Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel.

K. Uoto, T. Soga, S. Iimura, 1997, Chemical & pharmaceutical bulletin.

Synthesis and evaluation of water-soluble non-prodrug analogs of docetaxel bearing sec-aminoethyl group at the C-10 position.

K. Uoto, T. Soga, T. Yoshino, 1998, Chemical & pharmaceutical bulletin.

New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 4.

T. Horiuchi, Y. Takeda, K. Uoto, 2003, Bioorganic & medicinal chemistry.

Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs.

K. Uoto, T. Soga, K. Nakayama, 1998, Bioorganic & medicinal chemistry letters.

Antitumor agents. 7. Synthesis and antitumor activity of novel hexacyclic camptothecin analogues.

K. Uoto, H. Tagawa, M. Sugimori, 1994, Journal of medicinal chemistry.

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 2

K. Uoto, J. Chiba, T. Soga, 2002 .

A Useful Method for Deprotection of the Protective Allyl Group at the Anomeric Oxygen of Carbohydrate Moieties Using Tetrakis(triphenylphosphine)palladium

K. Uoto, T. Soga, T. Kusama, 1992 .

Facile Total Synthesis of Carbonolides by Witting-Hoener Macro-Cyclization and Stereoselective Epoxidation

N. Nakajima, K. Uoto, T. Hata, 1991 .

A srereocontrolled synthesis of the 16-membered ring macrolide aglycones, niddanolide, carbonolide B, and platenonolide W1

N. Nakajima, K. Uoto, O. Yonemitsu, 1990 .

Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor.

Masaki Miyazaki, Mayumi Kitagawa, K. Uoto, 2015, Bioorganic & medicinal chemistry.

Synthesis and biological activities of lipid A analogs: modification of a glycosidically bound group with chemically stable polar acidic groups and lipophilic groups on the disaccharide backbone with tetradecanoyl or N-dodecanoylglycyl groups.

K. Uoto, T. Soga, T. Kusama, 1991, Chemical & pharmaceutical bulletin.

Zinc triflate-promoted glycosidation: synthesis of lipid A disaccharide intermediates.

K. Uoto, T. Soga, T. Kusama, 1992, Chemical & pharmaceutical bulletin.

Electrochemical reduction of carbon dioxide catalysed by macrocyclic Fe4S4 iron–sulphur clusters

K. Uoto, H. Okuno, T. Tomohiro, 1990 .

Orally active docetaxel analogue: synthesis of 10-deoxy-10-C-morpholinoethyl docetaxel analogues.

K. Uoto, J. Chiba, T. Soga, 2001, Bioorganic & medicinal chemistry letters.

AN ASYMMETRIC SYNTHESIS OF FULLY FUNCTIONALIZED B RING SYSTEM OF TAXOL

K. Uoto, Isamu Shiina, N. Mori, 1995 .

An Asymmetric Synthesis of Fully Functionalized B Ring System of Taxol.

K. Uoto, Isamu Shiina, N. Mori, 1995 .

Synthesis and Antitumor Activity of Non-Prodrug Water-soluble Taxoid: 10-C-Aminoalkylated Docetaxel Analogs

K. Uoto, J. Chiba, T. Soga, 2000 .

New entry to tetranuclear clusters with tetrathiol ligands anchored to hydrophobic macrocycles in iron–sulphur protein analogues; Fe4S4{cyclo-(XN[CH2]8)4}2– and Fe4S4{cyclo-(XN[CH2]8NX–p-C6H4–p-CH2C6H4)2}2–(X =p-SC6H4CO)

K. Uoto, O. Yonemitsu, T. Tomohiro, 1987 .

A Convenient Method for the Synthesis of C-10 Alkylated Docetaxel Analogs Using Tris-(trimethylsilyl)silane as a Radical Mediator

K. Uoto, T. Soga, K. Nakayama, 2000 .

First synthesis and cytotoxic activity of novel docetaxel analogs modified at the C18-position

K. Uoto, T. Soga, I. Mitsui, 1997 .

Macrocyclic tetranuclear clusters with 28-, 32-, 36-, 40-, and 44-membered rings as high-potential iron–sulphur protein analogues

K. Uoto, H. Okuno, T. Tomohiro, 1990 .

Macrocyclic Tetranuclear Clusters with 28-, 32-, 36-, 40-, and 44-Membered Rings as High-Potential Iron-Sulfur Protein Analogues.

K. Uoto, H. Okuno, T. Tomohiro, 1990 .

Preparation of Fe4S4 iron-sulphur protein analogues with hydrophobic macrocyclic tetrathiol ligand anchored to a 38-membered cyclophane type skeleton

K. Uoto, H. Okuno, T. Tomohiro, 1990 .

Stabilising effects on the 4Fe–4S core analogues for high-potential iron–sulphur proteins with a hydrophobic environment provided by macrocycles

K. Uoto, O. Yonemitsu, T. Tomohiro, 1987 .

A new method for synthesis of 7-deoxytaxane analogues by hydrogenation of delta(6,7)-taxane derivatives.

Y. Takeda, K. Uoto, T. Soga, 2002, Chemical & pharmaceutical bulletin.