A. Conejo-García

发表

New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine.

H. Boulaiz, J. Marchal, A. Ramirez, 2011, European journal of medicinal chemistry.

Choline kinase inhibition and docking studies of a series of 6-(benzylthio)-9H-purin-9-yl-pyridinium derivatives

A. Conejo-García, Belén Rubio-Ruiz, C. Marco, 2017, Medicinal Chemistry Research.

Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4-benzoxaheteroin-2-ylmethyl)-9H-purines.

J. Marchal, A. Ramirez, A. Aránega, 2011, European journal of medicinal chemistry.

Latest advances on regiospecific microwave-assisted synthesis of novel purine derivatives as antitumor agents

J. Campos, A. Conejo-García, M. Gallo, 2008 .

Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines.

J. Marchal, A. Aránega, J. Campos, 2008, European journal of medicinal chemistry.

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.

A. Conejo-García, C. Schofield, K. Hewitson, 2010, Bioorganic & medicinal chemistry letters.

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.

P. Ratcliffe, N. Oldham, A. Conejo-García, 2008, Chemical communications.

The selective cytotoxic activity in breast cancer cells by an anthranilic alcohol-derived acyclic 5-fluorouracil O,N-acetal is mediated by endoplasmic reticulum stress-induced apoptosis.

A. Martínez-Amat, P. Álvarez, J. Marchal, 2012, European journal of medicinal chemistry.

Determination of Potential Scaffolds for Human Choline Kinase α1 by Chemical Deconvolution Studies

A. Velázquez‐Campoy, A. Conejo-García, Belén Rubio-Ruiz, 2013, Chembiochem : a European journal of chemical biology.

Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition

A. Conejo-García, R. Hurtado-Guerrero, B. Rubio-Ruiz, 2020, Medicinal research reviews.

1H and 13C spectral assignment of symmetrical bis[(4‐aminosubstituted)quinolinium] derivatives

J. Campos, A. Conejo-García, O. Cruz-López, 2005, Magnetic resonance in chemistry : MRC.

Benzo-Fused Seven- and Six-Membered Derivatives Linked to Pyrimidines or Purines Induce Apoptosis of Human Metastatic Breast Cancer MCF-7 Cells In Vitro

J. Campos, A. Conejo-García, O. Cruz-López, 2011 .

Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides.

J. Lacal, J. Campos, A. Conejo-García, 2003, European journal of medicinal chemistry.

NMR spectroscopic characterization of new nonsymmetrical bispyridinium choline kinase inhibitors

A. Conejo-García, A. Espinosa, A. Entrena Guadix, 2014, Magnetic resonance in chemistry : MRC.

Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence

J. Marchal, M. Perán, A. Ramirez, 2013, Drug design, development and therapy.

Synthesis and Anticancer Activity of the (R,S)‐Benzofused 1,5‐Oxathiepine Moiety Tethered to Purines through Alkylidenoxy Linkers

J. Marchal, A. Ramirez, A. Aránega, 2011, ChemMedChem.

Anti-proliferative activity of 2,6-dichloro-9- or 7-(ethoxycarbonylmethyl)-9H- or 7H-purines against several human solid tumour cell lines.

J. Marchal, A. Ramirez, J. Campos, 2014, European journal of medicinal chemistry.

Novel substituted quinazolines for potent EGFR tyrosine kinase inhibitors.

M. E. García-Rubiño, A. Conejo-García, O. Cruz-López, 2011, Current medicinal chemistry.

Symmetrical bis-quinolinium compounds: new human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line.

J. Lacal, J. Campos, A. Conejo-García, 2005, Journal of medicinal chemistry.

Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells.

J. Marchal, A. Ramirez, J. Campos, 2017, Future medicinal chemistry.

A prodrug system for hydroxylamines based on esterase catalysis.

A. Conejo-García, C. Schofield, 2005, Bioorganic & medicinal chemistry letters.

Bis-quinolinium cyclophanes: highly potent and selective non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel.

J. Campos, A. Conejo-García, 2008, Current medicinal chemistry.

Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines

H. Gutiérrez‐de‐Terán, H. Boulaiz, J. Marchal, 2021, Journal of enzyme inhibition and medicinal chemistry.

Chromatographic Enantioresolution of Six Purine Derivatives Endowed with Anti-Human Breast Cancer Activity

J. Campos, M. E. García-Rubiño, A. Conejo-García, 2013, Chromatographia.

Homochiral drugs: a demanding tendency of the pharmaceutical industry.

J. Campos, M. E. García-Rubiño, A. Conejo-García, 2009, Current medicinal chemistry.

Synthesis and Anticancer Activity of (R,S)‐9‐(2,3‐Dihydro‐1,4‐Benzoxathiin‐3‐ylmethyl)‐9H‐Purines

J. Marchal, A. Aránega, J. Campos, 2008, ChemMedChem.

From 5-fluorouracil acyclonucleosides to benzo-fused six- and seven-membered rings linked to pyrimidine and purine bases: the shift from differentiating anticancer agents to apoptotic inducers

J. Campos, A. Conejo-García, O. Cruz-López, 2008, Expert opinion on drug discovery.

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.

P. Ratcliffe, A. Conejo-García, C. Pugh, 2013, ACS chemical biology.

Enhancement of Tumor Cell Death by Combining gef Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells

H. Boulaiz, J. Marchal, A. Ramirez, 2018, Front. Pharmacol..

HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib

H. Boulaiz, J. Marchal, M. Perán, 2014, Oncotarget.

Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum

D. Wirth, J. Clardy, N. Philip, 2017, Cell.

Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.

J. Campos, A. Conejo-García, F. Leonetti, 2011, Journal of medicinal chemistry.

Edinburgh Research Explorer Plasmodium Falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death

Terry K. Smith, A. Conejo-García, L. Izquierdo, 2022 .

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.

N. Oldham, A. Conejo-García, C. Schofield, 2005, Chemical communications.

Bozepinib: A Promising Selective Derivative Targeting Breast Cancer Stem Cells

J. Campos, A. Conejo-García, O. Cruz-López, 2020, Translational Research in Cancer.

New insights into cytotoxic mechanisms of bozepinib against glioblastoma.

F. Figueiró, J. Campos, A. Conejo-García, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Bispyridinium cyclophanes: novel templates for human choline kinase inhibitors.

J. Campos, A. Conejo-García, R. Sánchez-Martín, 2003, Journal of medicinal chemistry.

1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds.

J. Marchal, A. Ramirez, J. Campos, 2017, Future medicinal chemistry.

Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives.

A. Conejo-García, Fermín Capitán-Cañadas, M. P. Carrasco, 2014, Journal of medicinal chemistry.

QSAR-derived choline kinase inhibitors: how rational can antiproliferative drug design be?

J. Lacal, A. Conejo-García, R. Sánchez-Martín, 2003, Current medicinal chemistry.

The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor.

A. Velázquez‐Campoy, F. Gervasio, G. Saladino, 2013, Angewandte Chemie.

Antiproliferative Activity, Cell Cycle, and Apoptosis Studies of a Series of 6‐Substituted 9H‐Purin‐9‐yl‐pyridinium Derivatives on a Human Cervical Carcinoma Cell Line

A. Conejo-García, R. Sánchez-Martín, Fermín Capitán-Cañadas, 2013, ChemMedChem.

Towards a model for the inhibition of choline kinase by a new type of inhibitor.

J. Campos, A. Conejo-García, R. Sánchez-Martín, 2005, European journal of medicinal chemistry.

1H and 13C NMR spectral assignments of pyridinium salts linked to a N‐9 or N‐3 adenine moiety

A. Conejo-García, M. Gallo, A. Espinosa, 2012, Magnetic resonance in chemistry : MRC.

Design, synthesis, theoretical calculations and biological evaluation of new non-symmetrical choline kinase inhibitors.

A. Conejo-García, J. Segovia, C. Marco, 2012, European journal of medicinal chemistry.

Influence of the linker in bispyridium compounds on the inhibition of human choline kinase.

A. Ramírez de Molina, J. Lacal, J. Campos, 2004, Journal of medicinal chemistry.

Syntheses of 2,3-Dihydro-1,4-Benzodioxins and Bioisosteres as Structural Motifs for Biologically Active Compounds

J. Campos, A. Conejo-García, O. Cruz-López, 2011 .

Enantiospecific synthesis of heterocycles linked to purines: different apoptosis modulation of enantiomers in breast cancer cells.

J. Marchal, J. García‐Ruiz, E. Carrasco, 2013, Current Medicinal Chemistry.

Syntheses of 2,3‐Dihydro‐1,4‐benzodioxins and Bioisosteres as Structural Motifs for Biologically Active Compounds

J. Campos, A. Conejo-García, O. Cruz-López, 2011 .

Design, synthesis and anticancer activity against the MCF-7 cell line of benzo-fused 1,4-dihetero seven- and six-membered tethered pyrimidines and purines.

J. Campos, A. Conejo-García, O. Cruz-López, 2008, Current medicinal chemistry.

Selective Anticancer Therapy Based on a HA-CD44 Interaction Inhibitor Loaded on Polymeric Nanoparticles

C. Domene, A. Conejo-García, O. Cruz-López, 2022, Pharmaceutics.

N-aryltetrahydroisoquinoline derivatives as HA-CD44 interaction inhibitors: Design, synthesis, computational studies, and antitumor effect.

C. Domene, A. Conejo-García, O. Cruz-López, 2023, European journal of medicinal chemistry.

p-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents

J. Marchal, A. Ramirez, J. Campos, 2015 .

1H and 13C NMR spectral data of p‐nitrobenzenesulfonamides and dansylsulfonamides derived from N‐alkylated o‐(purinemethyl)anilines

J. Campos, A. Conejo-García, F. Morales, 2016, Magnetic resonance in chemistry : MRC.

Synthesis of Purine Derivatives as Scaffolds for a Diversity of Biological Activities

J. Campos, M. E. García-Rubiño, A. Conejo-García, 2010 .

Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death

A. Conejo-García, A. Entrena, Borja López-Gutiérrez, 2016, Scientific Reports.

Hydroxytyrosyl punicate: A first overview of a novel phenolipid with antiproliferative and antitrypanosomal activity

A. Conejo-García, M. Caboni, V. Verardo, 2024, Journal of Functional Foods.

Synthesis and Anti-Diabetic Activity of an 8-Purine Derivative as a Novel DPP-4 Inhibitor in Obese Diabetic Zücker Rats

A. Conejo-García, Amjad Al-shdaifat, Meriem Chayah, 2024, Drug design, development and therapy.