S. Pyne

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The sphingosine kinase inhibitor N,N‐dimethylsphingosine inhibits neointimal hyperplasia

R. Mcdonald, S. Pyne, N. Pyne, 2010, British journal of pharmacology.

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

Kevin R. Lynch, Gabor Tigyi, J. Chun, 2002, Pharmacological Reviews.

Interaction between anandamide and sphingosine‐1‐phosphate in mediating vasorelaxation in rat coronary artery

S. Pyne, N. Pyne, E. Robinson, 2010, British journal of pharmacology.

The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells.

S. Pyne, N. Pyne, M. Ahmad, 2006, Prostaglandins & other lipid mediators.

Sphingosine 1-Phosphate and Platelet-derived Growth Factor (PDGF) Act via PDGFβ Receptor-Sphingosine 1-Phosphate Receptor Complexes in Airway Smooth Muscle Cells*

S. Pyne, N. Pyne, C. Waters, 2003, The Journal of Biological Chemistry.

Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.

S. Pyne, N. Pyne, R. Bittman, 2014, Cellular signalling.

Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.

S. Pyne, N. Pyne, 2013, Cancer cell.

(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.

S. Pyne, N. Pyne, R. Bittman, 2011, Cellular signalling.

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

S. Pyne, N. Pyne, R. Bittman, 2010, Cellular signalling.

The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division.

S. Pyne, N. Pyne, N. Ktistakis, 2009, Cellular signalling.

The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids.

S. Pyne, T. Mavlyutov, A. Ruoho, 2009, European journal of pharmacology.

Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

J. Garcia, Yutong Zhao, V. Natarajan, 2011, PloS one.

Dihydroceramide Desaturase Functions as an Inducer and Rectifier of Apoptosis: Effect of Retinol Derivatives, Antioxidants and Phenolic Compounds

S. Pyne, N. Pyne, F. Torta, 2021, Cell Biochemistry and Biophysics.

Sphingosine 1-phosphate and cancer.

S. Pyne, N. Pyne, D. Adams, 2017, Advances in biological regulation.

Targeting sphingosine-1-phosphate signalling for cardioprotection.

S. Pyne, N. Pyne, K. Kane, 2009, Current opinion in pharmacology.

Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival

A. Merrill, S. Pyne, N. Pyne, 2018, Molecular and Cellular Biology.

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

R. Schiff, J. Edwards, V. Natarajan, 2010, Molecular and Cellular Biology.

P112 Discovery of a Novel, High Affinity, Small Molecule αvβ6 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis

D. Flint, R. Chambers, S. Pyne, 2016 .

Effect of sphingosine kinase modulators on interleukin‐1β release, sphingosine 1‐phosphate receptor 1 expression and experimental autoimmune encephalomyelitis

S. Pyne, N. Pyne, Hui-Rong Jiang, 2017, British journal of pharmacology.

Short-Term Local Delivery of an Inhibitor of Ras Farnesyltransferase Prevents Neointima Formation In Vivo After Porcine Coronary Balloon Angioplasty

S. Pyne, N. Pyne, C. Wainwright, 2001, Circulation.

Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms: out of the shadow?

S. Pyne, N. Pyne, 2011, Trends in pharmacological sciences.

The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction.

S. Pyne, N. Pyne, C. Waters, 2004, Seminars in cell & developmental biology.

Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis.

S. Pyne, N. Pyne, G. Dubois, 2013, Biochimica et biophysica acta.

A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes

S. Pyne, N. Pyne, D. Adams, 2020, International journal of molecular sciences.

Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1

Noah Dephoure, C. Mai, S. Pyne, 2020, Cells.

Sphingosine Kinase 1 Is an Intracellular Effector of Phosphatidic Acid*

S. Pyne, N. Ktistakis, M. Manifava, 2004, Journal of Biological Chemistry.

Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination.

S. Pyne, N. Pyne, 2008, Biochimica et biophysica acta.

Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases.

S. Pyne, N. Pyne, D. Adams, 2020, Cellular signalling.

New perspectives on the role of sphingosine 1-phosphate in cancer.

S. Pyne, N. Pyne, 2013, Handbook of experimental pharmacology.

Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells.

S. Pyne, N. Pyne, R. Bittman, 2013, MedChemComm.

Lysophospholipid receptor signalling platforms: the receptor tyrosine kinase-G-protein coupled receptor signaling complex

S. Pyne, N. Pyne, 2012 .

Bradykinin stimulates phospholipase D in primary cultures of guinea-pig tracheal smooth muscle.

S. Pyne, N. Pyne, 1993, Biochemical pharmacology.

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation.

A. Martelli, S. Pyne, N. Pyne, 2016, Advances in biological regulation.

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

T. Palmer, S. Pyne, N. Pyne, 2013, Cell Death and Disease.

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies

A. Martelli, J. Barata, S. Pyne, 2016, Leukemia.

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor negative breast cancer

E. Mallon, S. Pyne, N. Pyne, 2012, British Journal of Cancer.

Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1‐phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor‐positive breast cancer

E. Mallon, J. Edwards, S. Pyne, 2013, International journal of cancer.

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

J. McCubrey, A. Martelli, A. Pession, 2014, Oncotarget.

Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase.

S. Pyne, N. Pyne, A. Conway, 1999, The Biochemical journal.

New aspects of sphingosine 1-phosphate signaling in mammalian cells.

S. Pyne, N. Pyne, Suechin Lee, 2009, Advances in enzyme regulation.

Targeting sphingosine kinase 1 in cancer.

J. Edwards, S. Pyne, N. Pyne, 2012, Advances in biological regulation.

Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease.

S. Pyne, N. Pyne, Suechin Lee, 2009, Cellular signalling.

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle

S. Pyne, N. Pyne, R. Tate, 1999 .

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase.

S. Pyne, N. Pyne, R. Tate, 1999, The Biochemical journal.

Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.

S. Pyne, N. Pyne, 2000, Pharmacology & therapeutics.

Sphingosine 1-phosphate and cancer.

S. Pyne, N. Pyne, D. Adams, 2017, Advances in biological regulation.

The sphingosine kinase inhibitor 2‐(p‐hyroxyanilino)‐4‐(p‐chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress‐dependent mechanism

S. Pyne, N. Pyne, R. Bittman, 2013, British journal of pharmacology.

Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors.

S. Pyne, N. Pyne, D. Adams, 2017, Trends in pharmacological sciences.

Cellular signal pathways in tracheal smooth muscle.

S. Pyne, N. Pyne, 1993, Cellular signalling.

Differential effects of B2 receptor antagonists upon bradykinin‐stimulated phospholipase C and D in guinea‐pig cultured tracheal smooth muscle

S. Pyne, N. Pyne, 1993, British journal of pharmacology.

G-Proteins in Airways Smooth Muscle

S. Pyne, N. Pyne, 1994 .

Muscarinic blockade of β‐adrenoceptor‐stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine‐nucleotide binding regulatory proteins (Gs and Gi)

I. Rodger, S. Pyne, N. Pyne, 1992, British journal of pharmacology.

Translational aspects of sphingosine 1-phosphate biology.

S. Pyne, N. Pyne, 2011, Trends in molecular medicine.

Chapter 4 – Lysolipids: Sphingosine 1-phosphate and lysophosphatidic acid

S. Pyne, 2012 .

Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases.

S. Pyne, K. Kong, P. Darroch, 2004, Seminars in cell & developmental biology.

PKC-dependent activation of the type II adenylate cyclase in airway smooth muscle limits the bradykinin-stimulated ERK-2 pathway.

S. Pyne, N. Pyne, N. Moughal, 1995, Biochemical Society transactions.

Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors.

S. Pyne, N. Pyne, 2002, Biochimica et biophysica acta.

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

M. Ballantyne, S. Pyne, N. Pyne, 2019, European journal of pharmacology.

The functional PDGFβ receptor–S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor

V. Natarajan, S. Pyne, N. Pyne, 2006 .

Receptor tyrosine kinase-GPCR signal complexes.

S. Pyne, N. Pyne, C. Waters, 2003, Biochemical Society transactions.

Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.

S. Pyne, N. Pyne, D. Tolan, 1997, The Biochemical journal.

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells.

A. Merrill, S. Pyne, N. Pyne, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Does the Sphingosine 1-Phosphate Receptor-1 Provide a Better or Worse Prognostic Outcome for Breast Cancer Patients?

S. Pyne, N. Pyne, 2018, Front. Oncol..

Sphingosine Kinases as Druggable Targets.

S. Pyne, N. Pyne, D. Adams, 2018, Handbook of experimental pharmacology.

1 ROLE OF SPHINGOSINE 1-PHOSPHATE RECEPTORS , SPHINGOSINE KINASES AND SPHINGOSINE IN CANCER AND INFLAMMATION

A. Martelli, S. Pyne, N. Pyne, 2017 .

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells

S. Pyne, N. Pyne, S. Pitson, 2016, Oncotarget.

Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?

S. Pyne, N. Pyne, 2011, Front. Pharmacol..

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells*

Y. Fujiwara, J. Edwards, S. Pyne, 2010, The Journal of Biological Chemistry.

De novo synthesis of ceramide involves a pathway in which serine and palmitoyl CoA undergo

A. Merrill, S. Pyne, N. Pyne, 2018 .

Lipid phosphate phosphatases and lipid phosphate signalling.

S. Pyne, N. Pyne, N. Ktistakis, 2005, Biochemical Society transactions.

Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools.

S. Pyne, N. Pyne, N. Ktistakis, 2005, The Biochemical journal.

norpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5)- trisphosphate receptor in Drosophila melanogaster renal function

G. Hasan, S. Pyne, S. Davies, 2003, Journal of Experimental Biology.

Recent advances in the role of sphingosine 1‐phosphate in cancer

S. Pyne, N. Pyne, 2020, FEBS letters.

Sphingosine Kinases: Emerging Structure-Function Insights.

S. Pyne, N. Pyne, D. Adams, 2016, Trends in biochemical sciences.

Supplemental Information Sphingosine kinases : emerging structure-function insights

S. Pyne, N. Pyne, D. Adams, 2016 .

Structure–Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors

S. Pyne, N. Pyne, R. Bittman, 2013, Journal of medicinal chemistry.

The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells

V. Natarajan, S. Pyne, N. Pyne, 2013, Biomolecules.

Synthesis of selective inhibitors of sphingosine kinase 1.

S. Pyne, N. Pyne, R. Bittman, 2013, Chemical communications.

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.

S. Pyne, N. Pyne, R. Bittman, 2012, The international journal of biochemistry & cell biology.

Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.

S. Pyne, N. Pyne, R. Bittman, 2011, Cancer research.

FTY720 Analogues as Sphingosine Kinase 1 Inhibitors

S. Pyne, N. Pyne, R. Bittman, 2011, The Journal of Biological Chemistry.

Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells.

S. Pyne, N. Pyne, A. Conway, 2000, Cellular signalling.

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells

S. Pyne, N. Pyne, 2017, Molecules.

Extracellular actions of sphingosine I-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis.

S. Pyne, N. Pyne, R. Tate, 1999, Biochemical Society transactions.

Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model.

S. Pyne, N. Pyne, A. Conway, 1999, Cellular signalling.

Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway

L. Johannes, S. Pyne, Enric Gutiérrez-Martínez, 2013, Journal of Cell Science.

Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.

S. Pyne, N. Pyne, J. Long, 2008, The Biochemical journal.

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration.

S. Pyne, N. Pyne, G. Tigyi, 2006, The Biochemical journal.

The role of sphingosine 1-phosphate in inflammation and cancer.

S. Pyne, N. Pyne, R. Bittman, 2014, Advances in biological regulation.

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer

E. Mallon, J. Edwards, S. Pyne, 2012, British Journal of Cancer.

Adenylyl cyclase in lung from hypersensitive guinea pig displays increased responsiveness to guanine nucleotides and isoprenaline: the role of the G proteins Gs and Gi.

S. Pyne, N. Pyne, P. Stevens, 1993, Biochimica et biophysica acta.

Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis.

J. Pfeilschifter, S. Schwalm, A. Huwiler, 2020, Cellular signalling.

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells*

V. Natarajan, S. Pyne, N. Pyne, 2010, The Journal of Biological Chemistry.

Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis.

S. Pyne, N. Pyne, Hui-Rong Jiang, 2016, Chemistry and physics of lipids.

The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor.

V. Natarajan, S. Pyne, N. Pyne, 2006, Prostaglandins & other lipid mediators.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

Stephen P. H. Alexander, C. Southan, D. Fabbro, 2021, British journal of pharmacology.

Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases

I. Charles, D. Stammers, A. Hawkins, 2007, Proteins.

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.

S. Pyne, N. Pyne, R. Bittman, 2013, Bioorganic & medicinal chemistry.

Characterization of an extract from the leaves of Cissampelos sympodialis Eichl. on the spontaneous tone of isolated trachea

S. Pyne, N. Pyne, G. Thomas, 1997 .

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

S. Pyne, N. Pyne, S. Mackay, 2014, Archives of Toxicology.

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

S. Pyne, N. Pyne, A. I. Gray, 2012, British journal of pharmacology.

Sphingosine 1-phosphate signalling in mammalian cells

S. Pyne, N. Pyne, 2000 .

Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.

S. Pyne, N. Pyne, D. Adams, 2019, Journal of medicinal chemistry.

Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells.

S. Pyne, N. Pyne, J. Long, 2009, Stem cells and development.

Cellular signaling by sphingosine and sphingosine 1-phosphate. Their opposing roles in apoptosis.

S. Pyne, 2002, Sub-cellular biochemistry.

Sphingosine 1-phosphate and cancer

S. Pyne, N. Pyne, 2010, Nature Reviews Cancer.

Crystal Structure of Sphingosine Kinase 1 with PF-543.

S. Knapp, J. Elkins, S. Pyne, 2014, ACS medicinal chemistry letters.

Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances.

S. Pyne, N. Pyne, D. Adams, 2016, Progress in lipid research.

Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells.

Yutong Zhao, V. Natarajan, S. Pyne, 2006, The Biochemical journal.

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

J. Edwards, S. Pyne, N. Pyne, 2012, Front. Oncol..

Protean agonism of the lysophosphatidic acid receptor‐1 with Ki16425 reduces nerve growth factor‐induced neurite outgrowth in pheochromocytoma 12 cells

S. Pyne, N. Pyne, G. Tigyi, 2006, Journal of neurochemistry.

Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells.

S. Pyne, N. Pyne, C. Waters, 2004, Cellular signalling.

Experimental systems for studying the role of G-protein-coupled receptors in receptor tyrosine kinase signal transduction.

S. Pyne, N. Pyne, C. Waters, 2004, Methods in enzymology.

The platelet-derived growth factor receptor stimulation of p42/p44 mitogen-activated protein kinase in airway smooth muscle involves a G-protein-mediated tyrosine phosphorylation of Gab1.

S. Pyne, N. Pyne, S. Rakhit, 2000, Molecular pharmacology.

Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells.

S. Pyne, N. Pyne, G. Tigyi, 2007, Advances in enzyme regulation.

Gabor Tigyi, Y. Fujiwara, V. Natarajan, 2022 .

c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells.

S. Pyne, N. Pyne, C. Waters, 2005, Cellular signalling.

Assessment of agonism at G‐protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

S. Pyne, N. Pyne, R. Tate, 2001, British journal of pharmacology.

Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.

T. Palmer, S. Pyne, N. Pyne, 2001, The Journal of biological chemistry.

Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing.

S. Pyne, N. Pyne, S. Rakhit, 2001, Molecular pharmacology.

G-protein-coupled Receptor Stimulation of the p42/p44 Mitogen-activated Protein Kinase Pathway Is Attenuated by Lipid Phosphate Phosphatases 1, 1a, and 2 in Human Embryonic Kidney 293 Cells*

S. Pyne, N. Pyne, B. Sambi, 2001, The Journal of Biological Chemistry.

PDGF-stimulated cyclic AMP formation in airway smooth muscle: assessment of the roles of MAP kinase, cytosolic phospholipase A2, and arachidonate metabolites.

S. Pyne, N. Pyne, 1998, Cellular signalling.

The Platelet-Derived Growth Factor Receptor Stimulation of p 42 / p 44 Mitogen-Activated Protein Kinase in Airway Smooth Muscle Involves a G-Protein-Mediated Tyrosine Phosphorylation of Gab 1

S. Pyne, N. Pyne, S. Rakhit, 2000 .

Sphingosine 1-phosphate signalling in mammalian cells.

S. Pyne, N. Pyne, 2000, The Biochemical journal.

Phosphorylation of the recombinant spliced variants of the alpha-sub-unit of the stimulatory guanine-nucleotide binding regulatory protein (Gs) by the catalytic sub-unit of protein kinase A.

S. Pyne, N. Pyne, M. Freissmuth, 1992, Biochemical and biophysical research communications.

Inhibition of non-Ras protein farnesylation reduces in-stent restenosis.

S. Pyne, C. Wainwright, R. Wadsworth, 2008, Atherosclerosis.

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

D. Flint, R. Chambers, S. Pyne, 2020, Nature Communications.

High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.

E. Mallon, J. Edwards, L. Mcglynn, 2010, The American journal of pathology.

The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells.

D. Siderovski, S. Pyne, N. Pyne, 2006, Cellular signalling.

Ceramide and sphingosine 1-phosphate in adipose dysfunction.

S. Pyne, N. Pyne, Zijian Fang, 2019, Progress in lipid research.

Ceramide and sphingosine 1-phosphate in adipose dysfunction.

S. Pyne, N. Pyne, Zijian Fang, 2019, Progress in lipid research.

Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2

D. Flint, S. Pyne, J. Marshall, 2016, Pharmacology.

Sphingosine 1-phosphate signalling in cancer.

J. Edwards, S. Pyne, N. Pyne, 2012, Biochemical Society transactions.

Sphingosine 1-phosphate and lysophosphatidic acid

S. Pyne, 2004 .

A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells

S. Pyne, N. Pyne, F. Torta, 2021, The Journal of biological chemistry.

Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle.

S. Pyne, N. Pyne, A. Conway, 1997, The American journal of physiology.

Bradykinin-stimulated phosphatidate and 1,2-diacylglycerol accumulation in guinea-pig airway smooth muscle: evidence for regulation 'down-stream' of phospholipases.

S. Pyne, N. Pyne, 1994, Cellular signalling.

Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle.

S. Pyne, N. Pyne, J. Chapman, 1996, European journal of biochemistry.

The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts

S. Pyne, N. Pyne, D. Adams, 2018, Oncotarget.

Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatases from airway smooth muscle.

S. Pyne, R. Tate, D. Tolan, 1999, Cellular signalling.

The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation

M. Loda, L. Chirieac, M. Freeman, 2013, Oncogene.

Protein kinase C-dependent cyclic AMP formation in airway smooth muscle: the role of type II adenylate cyclase and the blockade of extracellular-signal-regulated kinase-2 (ERK-2) activation.

S. Pyne, N. Pyne, N. Moughal, 1994, The Biochemical journal.

Platelet-derived growth factor activates a mammalian Ste20 coupled mitogen-activated protein kinase in airway smooth muscle.

S. Pyne, N. Pyne, 1997, Cellular signalling.

Adenylate cyclase, cyclic AMP and extracellular-signal-regulated kinase-2 in airway smooth muscle: modulation by protein kinase C and growth serum.

S. Pyne, N. Pyne, N. Moughal, 1995, Biochemical Journal.

Bradykinin-dependent activation of adenylate cyclase activity and cyclic AMP accumulation in tracheal smooth muscle occurs via protein kinase C-dependent and -independent pathways.

S. Pyne, N. Pyne, P. Stevens, 1994, The Biochemical journal.

The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle.

S. Pyne, N. Pyne, 1996, The Biochemical journal.

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension

S. Pyne, N. Pyne, Giora Volpert, 2016, Cellular signalling.

Platelet-derived-growth-factor stimulation of the p 42 / p 44 mitogen-activated protein kinase pathway in airway smooth muscle : role of pertussis-toxin-sensitive G-proteins , cSrc tyrosine kinases and phosphoinositide 3-kinase

S. Pyne, N. Pyne, A. Conway, 1999 .

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor negative breast cancer

E. Mallon, S. Pyne, N. Pyne, 2012, British Journal of Cancer.

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

Vasco M. Barreto, Chunxu Qu, C. Mullighan, 2021, Nature Communications.

Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?

S. Pyne, N. Pyne, 2017, Trends in molecular medicine.

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.

S. Pyne, N. Pyne, R. Bittman, 2013, Cellular signalling.

Prevention of Restenosis

S. Pyne, N. Pyne, C. Wainwright, 2001 .

Sphingosine 1-phosphate turnover in GtoPdb v.2023.1

S. Pyne, N. Pyne, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

Short Periods of Hypoxia Upregulate Sphingosine Kinase 1 and Increase Vasodilation of Arteries to Sphingosine 1-Phosphate (S1P) via S1P3

S. Pyne, N. Pyne, C. Daly, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Characterization of an extract from the leaves of Cissampelos sympodialis Eichl. on the spontaneous tone of isolated trachea

S. Pyne, N. Pyne, G. Thomas, 1997 .

Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis

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