N. Pyne

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The sphingosine kinase inhibitor N,N‐dimethylsphingosine inhibits neointimal hyperplasia

R. Mcdonald, S. Pyne, N. Pyne, 2010, British journal of pharmacology.

Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism.

B. Furman, J. Parratt, N. Pyne, 2002, European journal of pharmacology.

Interaction between anandamide and sphingosine‐1‐phosphate in mediating vasorelaxation in rat coronary artery

S. Pyne, N. Pyne, E. Robinson, 2010, British journal of pharmacology.

The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells.

S. Pyne, N. Pyne, M. Ahmad, 2006, Prostaglandins & other lipid mediators.

Sphingosine 1-Phosphate and Platelet-derived Growth Factor (PDGF) Act via PDGFβ Receptor-Sphingosine 1-Phosphate Receptor Complexes in Airway Smooth Muscle Cells*

S. Pyne, N. Pyne, C. Waters, 2003, The Journal of Biological Chemistry.

The Concise Guide to Pharmacology 2013/14: Overview

Adam J Pawson, Stephen P. H. Alexander, A. A. Khan, 2013, British journal of pharmacology.

Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.

S. Pyne, N. Pyne, R. Bittman, 2014, Cellular signalling.

Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.

S. Pyne, N. Pyne, 2013, Cancer cell.

(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.

S. Pyne, N. Pyne, R. Bittman, 2011, Cellular signalling.

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

S. Pyne, N. Pyne, R. Bittman, 2010, Cellular signalling.

The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division.

S. Pyne, N. Pyne, N. Ktistakis, 2009, Cellular signalling.

Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

J. Garcia, Yutong Zhao, V. Natarajan, 2011, PloS one.

Dihydroceramide Desaturase Functions as an Inducer and Rectifier of Apoptosis: Effect of Retinol Derivatives, Antioxidants and Phenolic Compounds

S. Pyne, N. Pyne, F. Torta, 2021, Cell Biochemistry and Biophysics.

Sphingosine 1-phosphate and cancer.

S. Pyne, N. Pyne, D. Adams, 2017, Advances in biological regulation.

Targeting sphingosine-1-phosphate signalling for cardioprotection.

S. Pyne, N. Pyne, K. Kane, 2009, Current opinion in pharmacology.

Ischaemic preconditioning in the rat heart: The role of G-proteins and adrenergic stimulation

J. Parratt, N. Pyne, T. Ravingerová, 1995, Molecular and Cellular Biochemistry.

Increased expression of the cGMP‐inhibited cAMP‐specific (PDE3) and cGMP binding cGMP‐specific (PDE5) phosphodiesterases in models of pulmonary hypertension

M. Maclean, N. Pyne, F. Murray, 2002, British journal of pharmacology.

Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival

A. Merrill, S. Pyne, N. Pyne, 2018, Molecular and Cellular Biology.

Changes in the phosphorylation state of the inhibitory guanine-nucleotide-binding protein Gi-2 in hepatocytes from lean (Fa/Fa) and obese (fa/fa) Zucker rats.

M. Houslay, N. Pyne, M. Bushfield, 1990, European journal of biochemistry.

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

R. Schiff, J. Edwards, V. Natarajan, 2010, Molecular and Cellular Biology.

Effect of sphingosine kinase modulators on interleukin‐1β release, sphingosine 1‐phosphate receptor 1 expression and experimental autoimmune encephalomyelitis

S. Pyne, N. Pyne, Hui-Rong Jiang, 2017, British journal of pharmacology.

Short-Term Local Delivery of an Inhibitor of Ras Farnesyltransferase Prevents Neointima Formation In Vivo After Porcine Coronary Balloon Angioplasty

S. Pyne, N. Pyne, C. Wainwright, 2001, Circulation.

Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms: out of the shadow?

S. Pyne, N. Pyne, 2011, Trends in pharmacological sciences.

The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction.

S. Pyne, N. Pyne, C. Waters, 2004, Seminars in cell & developmental biology.

Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis.

S. Pyne, N. Pyne, G. Dubois, 2013, Biochimica et biophysica acta.

A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes

S. Pyne, N. Pyne, D. Adams, 2020, International journal of molecular sciences.

Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1

Noah Dephoure, C. Mai, S. Pyne, 2020, Cells.

Targeting β‐cell cyclic 3′5′adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review

B. Furman, N. Pyne, P. Flatt, 2004, The Journal of pharmacy and pharmacology.

Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination.

S. Pyne, N. Pyne, 2008, Biochimica et biophysica acta.

Ryanodine receptors of pancreatic β‐cells mediate a distinct context‐dependent signal for insulin secretion

H. Westerblad, B. Furman, N. Pyne, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases.

S. Pyne, N. Pyne, D. Adams, 2020, Cellular signalling.

New perspectives on the role of sphingosine 1-phosphate in cancer.

S. Pyne, N. Pyne, 2013, Handbook of experimental pharmacology.

Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells.

S. Pyne, N. Pyne, R. Bittman, 2013, MedChemComm.

Chapter 13 Cyclic AMP Signalling in Pancreatic Islets

B. Furman, N. Pyne, W. Ong, 2018 .

Cyclic AMP signaling in pancreatic islets.

B. Furman, N. Pyne, W. Ong, 2010, Advances in experimental medicine and biology.

Cyclic AMP Signalling in Pancreatic Islets

B. Furman, N. Pyne, W. Ong, 2010 .

Lysophospholipid receptor signalling platforms: the receptor tyrosine kinase-G-protein coupled receptor signaling complex

S. Pyne, N. Pyne, 2012 .

Bradykinin stimulates phospholipase D in primary cultures of guinea-pig tracheal smooth muscle.

S. Pyne, N. Pyne, 1993, Biochemical pharmacology.

A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research.

N. Pyne, G. Tigyi, 2016, Progress in lipid research.

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation.

A. Martelli, S. Pyne, N. Pyne, 2016, Advances in biological regulation.

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

T. Palmer, S. Pyne, N. Pyne, 2013, Cell Death and Disease.

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies

A. Martelli, J. Barata, S. Pyne, 2016, Leukemia.

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor negative breast cancer

E. Mallon, S. Pyne, N. Pyne, 2012, British Journal of Cancer.

Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1‐phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor‐positive breast cancer

E. Mallon, J. Edwards, S. Pyne, 2013, International journal of cancer.

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

J. McCubrey, A. Martelli, A. Pession, 2014, Oncotarget.

Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase.

S. Pyne, N. Pyne, A. Conway, 1999, The Biochemical journal.

New aspects of sphingosine 1-phosphate signaling in mammalian cells.

S. Pyne, N. Pyne, Suechin Lee, 2009, Advances in enzyme regulation.

Targeting sphingosine kinase 1 in cancer.

J. Edwards, S. Pyne, N. Pyne, 2012, Advances in biological regulation.

Molecular determinants in pulmonary hypertension: the role of PDE5

M. Maclean, N. Pyne, F. Murray, 2006 .

Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease.

S. Pyne, N. Pyne, Suechin Lee, 2009, Cellular signalling.

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle

S. Pyne, N. Pyne, R. Tate, 1999 .

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase.

S. Pyne, N. Pyne, R. Tate, 1999, The Biochemical journal.

The role of G-proteins in myocardial preconditioning

N. Pyne, L. Piacentini, 1996 .

Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.

S. Pyne, N. Pyne, 2000, Pharmacology & therapeutics.

Sphingosine 1-phosphate and cancer.

S. Pyne, N. Pyne, D. Adams, 2017, Advances in biological regulation.

The sphingosine kinase inhibitor 2‐(p‐hyroxyanilino)‐4‐(p‐chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress‐dependent mechanism

S. Pyne, N. Pyne, R. Bittman, 2013, British journal of pharmacology.

Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors.

S. Pyne, N. Pyne, D. Adams, 2017, Trends in pharmacological sciences.

Cellular signal pathways in tracheal smooth muscle.

S. Pyne, N. Pyne, 1993, Cellular signalling.

Identification and characterization of both the cytosolic and particulate forms of cyclic GMP-stimulated cyclic AMP phosphodiesterase from rat liver.

M. Houslay, M. Cooper, N. Pyne, 1986, The Biochemical journal.

Differential effects of B2 receptor antagonists upon bradykinin‐stimulated phospholipase C and D in guinea‐pig cultured tracheal smooth muscle

S. Pyne, N. Pyne, 1993, British journal of pharmacology.

Regulation of Lysophosphatidic Acid-induced Epidermal Growth Factor Receptor Transactivation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells by Protein Kinase Cδ, Lyn Kinase, and Matrix Metalloproteinases*

Yutong Zhao, V. Natarajan, N. Pyne, 2006, Journal of Biological Chemistry.

The insulin- and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity.

M. Houslay, M. Cooper, N. Pyne, 1987, The Biochemical journal.

G-Proteins in Airways Smooth Muscle

S. Pyne, N. Pyne, 1994 .

Muscarinic blockade of β‐adrenoceptor‐stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine‐nucleotide binding regulatory proteins (Gs and Gi)

I. Rodger, S. Pyne, N. Pyne, 1992, British journal of pharmacology.

Translational aspects of sphingosine 1-phosphate biology.

S. Pyne, N. Pyne, 2011, Trends in molecular medicine.

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1).

P. Vandenabeele, M. Houslay, N. Pyne, 2003, European journal of biochemistry.

Guanine-nucleotide binding regulatory proteins as targets for novel drugs

N. Pyne, 1992 .

The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3.

P. Vandenabeele, N. Pyne, K. Wan, 2001, Cellular signalling.

The Regulation of the cGMP-binding cGMP Phosphodiesterase by Proteins That Are Immunologically Related to γ Subunit of the Photoreceptor cGMP Phosphodiesterase*

V. Arshavsky, N. Pyne, A. Lochhead, 1997, The Journal of Biological Chemistry.

PKC-dependent activation of the type II adenylate cyclase in airway smooth muscle limits the bradykinin-stimulated ERK-2 pathway.

S. Pyne, N. Pyne, N. Moughal, 1995, Biochemical Society transactions.

Insulin affects the ability of Gi to be ADP-ribosylated but does not elicit its phosphorylation in intact hepatocytes.

M. Houslay, N. Pyne, C. Heyworth, 1989, Biochemical and biophysical research communications.

Guanine nucleotide regulatory proteins in insulin's action and in diabetes.

K. Siddle, T. Palmer, R. O’Brien, 1989, Biochemical Society transactions.

Protein Kinase C-ϵ Regulates Sphingosine 1-Phosphate-mediated Migration of Human Lung Endothelial Cells through Activation of Phospholipase D2, Protein Kinase C-ζ, and Rac1*

J. Garcia, Yutong Zhao, V. Natarajan, 2008, Journal of Biological Chemistry.

Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors.

S. Pyne, N. Pyne, 2002, Biochimica et biophysica acta.

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

M. Ballantyne, S. Pyne, N. Pyne, 2019, European journal of pharmacology.

The functional PDGFβ receptor–S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor

V. Natarajan, S. Pyne, N. Pyne, 2006 .

The role of the cyclic GMP-inhibited cyclic AMP-specific phosphodiesterase (PDE3) in regulating clonal BRIN-BD11 insulin secreting cell survival.

B. Furman, N. Pyne, P. Flatt, 2000, Cellular signalling.

Receptor tyrosine kinase-GPCR signal complexes.

S. Pyne, N. Pyne, C. Waters, 2003, Biochemical Society transactions.

Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.

S. Pyne, N. Pyne, D. Tolan, 1997, The Biochemical journal.

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells.

A. Merrill, S. Pyne, N. Pyne, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Does the Sphingosine 1-Phosphate Receptor-1 Provide a Better or Worse Prognostic Outcome for Breast Cancer Patients?

S. Pyne, N. Pyne, 2018, Front. Oncol..

Sphingosine Kinases as Druggable Targets.

S. Pyne, N. Pyne, D. Adams, 2018, Handbook of experimental pharmacology.

1 ROLE OF SPHINGOSINE 1-PHOSPHATE RECEPTORS , SPHINGOSINE KINASES AND SPHINGOSINE IN CANCER AND INFLAMMATION

A. Martelli, S. Pyne, N. Pyne, 2017 .

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells

S. Pyne, N. Pyne, S. Pitson, 2016, Oncotarget.

Selectivity and Specificity of Sphingosine 1-Phosphate Receptor Ligands: “Off-Targets” or Complex Pharmacology?

S. Pyne, N. Pyne, 2011, Front. Pharmacol..

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells*

Y. Fujiwara, J. Edwards, S. Pyne, 2010, The Journal of Biological Chemistry.

De novo synthesis of ceramide involves a pathway in which serine and palmitoyl CoA undergo

A. Merrill, S. Pyne, N. Pyne, 2018 .

Pertussis toxin sensitive endothelin-1 coupling to inositol phosphate formation via a GTP-binding protein: comparison in SHR and WKY cultured aortic smooth muscle cells.

J. Reid, C. Hamilton, G. Nixon, 1995, Clinical and experimental hypertension.

Lipid phosphate phosphatases and lipid phosphate signalling.

S. Pyne, N. Pyne, N. Ktistakis, 2005, Biochemical Society transactions.

Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools.

S. Pyne, N. Pyne, N. Ktistakis, 2005, The Biochemical journal.

Ectopic Expression of Bovine Type 5 Phosphodiesterase Confers a Renal Phenotype in Drosophila*

N. Pyne, S. Davies, J. Dow, 2004, Journal of Biological Chemistry.

Recent advances in the role of sphingosine 1‐phosphate in cancer

S. Pyne, N. Pyne, 2020, FEBS letters.

Sphingosine Kinases: Emerging Structure-Function Insights.

S. Pyne, N. Pyne, D. Adams, 2016, Trends in biochemical sciences.

Supplemental Information Sphingosine kinases : emerging structure-function insights

S. Pyne, N. Pyne, D. Adams, 2016 .

Structure–Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors

S. Pyne, N. Pyne, R. Bittman, 2013, Journal of medicinal chemistry.

The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells

V. Natarajan, S. Pyne, N. Pyne, 2013, Biomolecules.

Synthesis of selective inhibitors of sphingosine kinase 1.

S. Pyne, N. Pyne, R. Bittman, 2013, Chemical communications.

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.

S. Pyne, N. Pyne, R. Bittman, 2012, The international journal of biochemistry & cell biology.

Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.

S. Pyne, N. Pyne, R. Bittman, 2011, Cancer research.

FTY720 Analogues as Sphingosine Kinase 1 Inhibitors

S. Pyne, N. Pyne, R. Bittman, 2011, The Journal of Biological Chemistry.

Effect of type‐selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN‐BD11

B. Furman, N. Pyne, P. Flatt, 2000, British journal of pharmacology.

Effects of type‐selective phosphodiesterase inhibitors on glucose‐induced insulin secretion and islet phosphodiesterase activity

B. Furman, N. Pyne, R. Shafiee‐Nick, 1995, British journal of pharmacology.

Glucagon desensitisation of adenylate cyclase in hepatocytes: an action mediated by a distinct population of glucagon receptors coupled to inositol phospholipid metabolism

M. Houslay, N. Pyne, M. Wakelam, 1987 .

Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi

G. Milligan, M. Houslay, N. Pyne, 1989, FEBS letters.

Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells.

S. Pyne, N. Pyne, A. Conway, 2000, Cellular signalling.

Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes.

M. Houslay, N. Pyne, H. G. Nimmo, 1989, The Biochemical journal.

(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.

M. Gotoh, T. Pham, D. Baker, 2010, Cellular signalling.

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells

S. Pyne, N. Pyne, 2017, Molecules.

Extracellular actions of sphingosine I-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis.

S. Pyne, N. Pyne, R. Tate, 1999, Biochemical Society transactions.

Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model.

S. Pyne, N. Pyne, A. Conway, 1999, Cellular signalling.

Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.

S. Pyne, N. Pyne, J. Long, 2008, The Biochemical journal.

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration.

S. Pyne, N. Pyne, G. Tigyi, 2006, The Biochemical journal.

Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gs alpha) by protein kinase C.

N. Pyne, M. Freissmuth, S. Palmer, 1992, The Biochemical journal.

The role of sphingosine 1-phosphate in inflammation and cancer.

S. Pyne, N. Pyne, R. Bittman, 2014, Advances in biological regulation.

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer

E. Mallon, J. Edwards, S. Pyne, 2012, British Journal of Cancer.

Adenylyl cyclase in lung from hypersensitive guinea pig displays increased responsiveness to guanine nucleotides and isoprenaline: the role of the G proteins Gs and Gi.

S. Pyne, N. Pyne, P. Stevens, 1993, Biochimica et biophysica acta.

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes.

G. Milligan, M. Houslay, P. Parker, 1990, The Biochemical journal.

Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon.

G. Milligan, M. Houslay, N. Pyne, 1989, The Biochemical journal.

Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat.

G. Milligan, M. Houslay, N. Anderson, 1987, The Biochemical journal.

The phorbol ester TPA inhibits cyclic AMP phosphodiesterase activity in intact hepatocytes

M. Houslay, N. Pyne, F. Irvine, 1986, FEBS letters.

Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis.

J. Pfeilschifter, S. Schwalm, A. Huwiler, 2020, Cellular signalling.

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells*

V. Natarajan, S. Pyne, N. Pyne, 2010, The Journal of Biological Chemistry.

Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis.

S. Pyne, N. Pyne, Hui-Rong Jiang, 2016, Chemistry and physics of lipids.

The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor.

V. Natarajan, S. Pyne, N. Pyne, 2006, Prostaglandins & other lipid mediators.

The γ-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung

V. Arshavsky, N. Pyne, H. Brzeski, 2007, Cell Biochemistry and Biophysics.

Lung phosphodiesterase isoenzymes.

N. Pyne, F. Burns, N. J. Pyne, 1993, Agents and actions. Supplements.

Interaction of the catalytic subunit of protein kinase A with the lung type V cyclic GMP phosphodiesterase: modulation of non-catalytic binding sites.

N. Pyne, F. Burns, 1992, Biochemical and biophysical research communications.

Glucagon activates two distinct signal transduction systems in hepatocytes, which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase

M. Houslay, N. Pyne, E. Kilgour, 1990 .

An insulin mediator preparation serves to stimulate the cyclic GMP activated cyclic AMP phosphodiesterase rather than other purified insulin-activated cyclic AMP phosphodiesterases.

M. Houslay, N. Pyne, 1988, Biochemical and biophysical research communications.

Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue.

M. Houslay, N. Pyne, B. Price, 1987, Biochemical pharmacology.

The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat.

B. Furman, N. Pyne, R. Shafiee‐Nick, 1997, European journal of pharmacology.

Isolation and characterization of insulin-stimulated, high-affinity cAMP phosphodiesterases from rat liver.

M. Houslay, M. Cooper, N. Pyne, 1988, Methods in enzymology.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

Stephen P. H. Alexander, C. Southan, D. Fabbro, 2021, British journal of pharmacology.

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.

S. Pyne, N. Pyne, R. Bittman, 2013, Bioorganic & medicinal chemistry.

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases

G. Baillie, M. Houslay, A. Ong, 2019, Proceedings of the National Academy of Sciences.

Characterization of an extract from the leaves of Cissampelos sympodialis Eichl. on the spontaneous tone of isolated trachea

S. Pyne, N. Pyne, G. Thomas, 1997 .

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

S. Pyne, N. Pyne, S. Mackay, 2014, Archives of Toxicology.

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

S. Pyne, N. Pyne, A. I. Gray, 2012, British journal of pharmacology.

Sphingosine 1-phosphate signalling in mammalian cells

S. Pyne, N. Pyne, 2000 .

Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.

S. Pyne, N. Pyne, D. Adams, 2019, Journal of medicinal chemistry.

Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells.

S. Pyne, N. Pyne, J. Long, 2009, Stem cells and development.

Sphingosine 1-phosphate and cancer

S. Pyne, N. Pyne, 2010, Nature Reviews Cancer.

Crystal Structure of Sphingosine Kinase 1 with PF-543.

S. Knapp, J. Elkins, S. Pyne, 2014, ACS medicinal chemistry letters.

Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances.

S. Pyne, N. Pyne, D. Adams, 2016, Progress in lipid research.

The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism.

Carolyn A. Converse, N. Pyne, J. Tettey, 2013, Gene.

Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells.

Yutong Zhao, V. Natarajan, S. Pyne, 2006, The Biochemical journal.

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers

J. Edwards, S. Pyne, N. Pyne, 2012, Front. Oncol..

Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells.

S. Pyne, N. Pyne, C. Waters, 2004, Cellular signalling.

Experimental systems for studying the role of G-protein-coupled receptors in receptor tyrosine kinase signal transduction.

S. Pyne, N. Pyne, C. Waters, 2004, Methods in enzymology.

The platelet-derived growth factor receptor stimulation of p42/p44 mitogen-activated protein kinase in airway smooth muscle involves a G-protein-mediated tyrosine phosphorylation of Gab1.

S. Pyne, N. Pyne, S. Rakhit, 2000, Molecular pharmacology.

Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells.

S. Pyne, N. Pyne, G. Tigyi, 2007, Advances in enzyme regulation.

Gabor Tigyi, Y. Fujiwara, V. Natarajan, 2022 .

c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells.

S. Pyne, N. Pyne, C. Waters, 2005, Cellular signalling.

The Inhibitory γ Subunit of the Type 6 Retinal cGMP Phosphodiesterase Functions to Link c-Src and G-protein-coupled Receptor Kinase 2 in a Signaling Unit That Regulates p42/p44 Mitogen-activated Protein Kinase by Epidermal Growth Factor*

N. Pyne, K. Wan, C. Waters, 2003, The Journal of Biological Chemistry.

Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.

T. Palmer, S. Pyne, N. Pyne, 2001, The Journal of biological chemistry.

Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of G(i/o), G protein-coupled receptor kinase 2, beta-arrestin I, and endocytic processing.

S. Pyne, N. Pyne, S. Rakhit, 2001, Molecular pharmacology.

G-protein-coupled Receptor Stimulation of the p42/p44 Mitogen-activated Protein Kinase Pathway Is Attenuated by Lipid Phosphate Phosphatases 1, 1a, and 2 in Human Embryonic Kidney 293 Cells*

S. Pyne, N. Pyne, B. Sambi, 2001, The Journal of Biological Chemistry.

PDGF-stimulated cyclic AMP formation in airway smooth muscle: assessment of the roles of MAP kinase, cytosolic phospholipase A2, and arachidonate metabolites.

S. Pyne, N. Pyne, 1998, Cellular signalling.

The Platelet-Derived Growth Factor Receptor Stimulation of p 42 / p 44 Mitogen-Activated Protein Kinase in Airway Smooth Muscle Involves a G-Protein-Mediated Tyrosine Phosphorylation of Gab 1

S. Pyne, N. Pyne, S. Rakhit, 2000 .

Sphingosine 1-phosphate signalling in mammalian cells.

S. Pyne, N. Pyne, 2000, The Biochemical journal.

Phosphorylation of the recombinant spliced variants of the alpha-sub-unit of the stimulatory guanine-nucleotide binding regulatory protein (Gs) by the catalytic sub-unit of protein kinase A.

S. Pyne, N. Pyne, M. Freissmuth, 1992, Biochemical and biophysical research communications.

Cyclic nucleotide phosphodiesterases in pancreatic islets

B. Furman, N. Pyne, 2003, Diabetologia.

High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.

E. Mallon, J. Edwards, L. Mcglynn, 2010, The American journal of pathology.

The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells.

D. Siderovski, S. Pyne, N. Pyne, 2006, Cellular signalling.

Ceramide and sphingosine 1-phosphate in adipose dysfunction.

S. Pyne, N. Pyne, Zijian Fang, 2019, Progress in lipid research.

Ceramide and sphingosine 1-phosphate in adipose dysfunction.

S. Pyne, N. Pyne, Zijian Fang, 2019, Progress in lipid research.

Sphingosine 1-phosphate signalling in cancer.

J. Edwards, S. Pyne, N. Pyne, 2012, Biochemical Society transactions.

A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells

S. Pyne, N. Pyne, F. Torta, 2021, The Journal of biological chemistry.

Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle.

S. Pyne, N. Pyne, A. Conway, 1997, The American journal of physiology.

Bradykinin-stimulated phosphatidate and 1,2-diacylglycerol accumulation in guinea-pig airway smooth muscle: evidence for regulation 'down-stream' of phospholipases.

S. Pyne, N. Pyne, 1994, Cellular signalling.

Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle.

S. Pyne, N. Pyne, J. Chapman, 1996, European journal of biochemistry.

The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts

S. Pyne, N. Pyne, D. Adams, 2018, Oncotarget.

Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase Cɛ, but not p42/44MAPK

Wu Song, J. Parratt, N. Pyne, 1996, Molecular and Cellular Biochemistry.

Protein kinase C-dependent cyclic AMP formation in airway smooth muscle: the role of type II adenylate cyclase and the blockade of extracellular-signal-regulated kinase-2 (ERK-2) activation.

S. Pyne, N. Pyne, N. Moughal, 1994, The Biochemical journal.

Platelet-derived growth factor activates a mammalian Ste20 coupled mitogen-activated protein kinase in airway smooth muscle.

S. Pyne, N. Pyne, 1997, Cellular signalling.

Adenylate cyclase, cyclic AMP and extracellular-signal-regulated kinase-2 in airway smooth muscle: modulation by protein kinase C and growth serum.

S. Pyne, N. Pyne, N. Moughal, 1995, Biochemical Journal.

Bradykinin-dependent activation of adenylate cyclase activity and cyclic AMP accumulation in tracheal smooth muscle occurs via protein kinase C-dependent and -independent pathways.

S. Pyne, N. Pyne, P. Stevens, 1994, The Biochemical journal.

The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle.

S. Pyne, N. Pyne, 1996, The Biochemical journal.

Phosphodiesterase isozymes from the hearts of dogs subjected to cardiac pacing

J. Parratt, N. Pyne, C. Lugnier, 1997 .

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension

S. Pyne, N. Pyne, Giora Volpert, 2016, Cellular signalling.

Platelet-derived-growth-factor stimulation of the p 42 / p 44 mitogen-activated protein kinase pathway in airway smooth muscle : role of pertussis-toxin-sensitive G-proteins , cSrc tyrosine kinases and phosphoinositide 3-kinase

S. Pyne, N. Pyne, A. Conway, 1999 .

Protean agonism of the lysophosphatidic acid receptor‐1 with Ki16425 reduces nerve growth factor‐induced neurite outgrowth in pheochromocytoma 12 cells

S. Pyne, N. Pyne, G. Tigyi, 2006, Journal of neurochemistry.

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor negative breast cancer

E. Mallon, S. Pyne, N. Pyne, 2012, British Journal of Cancer.

The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung.

N. Pyne, I. Rodger, F. Burns, 1992, The Biochemical journal.

Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

Vasco M. Barreto, Chunxu Qu, C. Mullighan, 2021, Nature Communications.

Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?

S. Pyne, N. Pyne, 2017, Trends in molecular medicine.

cGMP signal termination.

V. Arshavsky, N. Pyne, A. Lochhead, 1996, Biochemical Society transactions.

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.

S. Pyne, N. Pyne, R. Bittman, 2013, Cellular signalling.

Prevention of Restenosis

S. Pyne, N. Pyne, C. Wainwright, 2001 .

Sphingosine 1-phosphate turnover in GtoPdb v.2023.1

S. Pyne, N. Pyne, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

Short Periods of Hypoxia Upregulate Sphingosine Kinase 1 and Increase Vasodilation of Arteries to Sphingosine 1-Phosphate (S1P) via S1P3

S. Pyne, N. Pyne, C. Daly, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Protein Kinase C- Regulates Sphingosine 1-Phosphate-mediated Migration of Human Lung Endothelial Cells through Activation of Phospholipase D2,

Yutong Zhao, V. Natarajan, N. Pyne, 2008 .

An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen‐activated protein kinase pathway in animal and cellular models of pulmonary hypertension

M. Maclean, N. Pyne, F. Murray, 2003, British journal of pharmacology.

The mediator is the message: is it part of the answer of insulin's action?

M. Houslay, N. Pyne, M. Wakelam, 1986 .

Characterization of an extract from the leaves of Cissampelos sympodialis Eichl. on the spontaneous tone of isolated trachea

S. Pyne, N. Pyne, G. Thomas, 1997 .

The identification of apparently novel cyclic AMP and cyclic GMP phosphodiesterase activities in guinea‐pig tracheal smooth muscle

N. Pyne, F. Burns, P. Stevens, 1994, British journal of pharmacology.

Assessment of agonism at G‐protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

S. Pyne, N. Pyne, R. Tate, 2001, British journal of pharmacology.

The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts.

V. Arshavsky, N. Pyne, R. Tate, 2002, Genomics.

The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells.

N. Pyne, K. Wan, R. Tate, 2001, The Journal of biological chemistry.

Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis

S. Pyne, N. Pyne, 2014, Oncogene.