W. Windsor

发表

Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor

E. Lees, T. Fischmann, P. Kirschmeier, 2010, Molecular Cancer Therapeutics.

linical Development aciclib ( SCH 727965 ) , a Novel and Potent Ther lin-Dependent Kinase Inhibitor

Parry, E. Lees, P. Kirschmeier, 2010 .

A continuous spectrophotometric assay for the hepatitis C virus serine protease.

W. Windsor, B. Malcolm, B. Beyer, 1999, Analytical biochemistry.

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Shuxia Zhao, Leigh Zawel, Stephen Fawell, 2013, Cancer discovery.

Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase.

M. Snow, P. Weber, P. Kirschmeier, 2002, Journal of medicinal chemistry.

Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase.

J. English, P. Kirschmeier, W. Windsor, 2014, Journal of medicinal chemistry.

Structural and biological stability of the human interleukin 10 homodimer.

P. Mui, W. Windsor, N. Murgolo, 1998, Biochemistry.

Novel Tricyclic Inhibitors of Farnesyl Protein Transferase

W. R. Bishop, P. Kirschmeier, J. Schwartz, 1995, The Journal of Biological Chemistry.

In vitro kinetic profiling of hepatitis C virus NS3 protease inhibitors by progress curve analysis.

W. Windsor, Rumin Zhang, 2013, Methods in molecular biology.

Expression and purification of phosphorylated and non-phosphorylated human MEK1.

Catherine K. Smith, W. Windsor, T. Mayhood, 2007, Protein expression and purification.

Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

W. Windsor, S. Narula, C. Lunn, 1995, Nature.

3-Phosphoinositide–Dependent Protein Kinase-1 Regulates Proliferation and Survival of Cancer Cells with an Activated Mitogen-Activated Protein Kinase Pathway

Zhuomei Lu, W. Windsor, A. Boyapati, 2010, Molecular Cancer Research.

Discovery of hydroxyaniline amides as selective Extracellular Regulated Kinase (Erk) inhibitors.

W. Windsor, A. Samatar, D. Carr, 2015, Bioorganic & medicinal chemistry letters.

Crystallization and preliminary X‐ray investigation of recombinant human interleukin 10

W. Cook, W. Windsor, N. Murgolo, 1995, Proteins.

Farnesyl protein transferase: Identification of K164α and Y300β as catalytic residues by mutagenesis and kinetic studies

Zhengliang L. Wu, M. Demma, E. Radisky, 1999 .

A point mutation of human interferon γ abolishes receptor recognition

W. Windsor, S. Narula, N. Murgolo, 1992 .

Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2.

M. Snow, P. Weber, P. Mui, 1997, Biochemistry.

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.

David K Williams, Patricia C Weber, D. Chakrabarti, 2005, Journal of medicinal chemistry.

Fluorescence polarization assay and inhibitor design for MDM2/p53 interaction.

Yaolin Wang, J. Gesell, Yaolin Wang, 2004, Analytical biochemistry.

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.

Zhanghua Wu, P. Weber, L. Beese, 1998, Biochemistry.

Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships.

P. Weber, R. Doll, W. Windsor, 1999, Journal of medicinal chemistry.

High-level expression, purification, kinetic characterization and crystallization of protein farnesyltransferase beta-subunit C-terminal mutants.

M. Demma, P. C. Weber, W. Windsor, 1999, Protein engineering.

Improving tolerance of Candida antarctica lipase B towards irreversible thermal inactivation through directed evolution.

W. Windsor, W. Suen, V. Madison, 2003, Protein engineering.

Development of a Fluorescence Polarization Bead-Based Coupled Assay to Target Different Activity/Conformation States of a Protein Kinase

P. Kirschmeier, C. Kumar, S. Koseoglu, 2004, Journal of biomolecular screening.

Double‐stranded DNA‐induced localized unfolding of HCV NS3 helicase subdomain 2

D. Wyss, W. Windsor, Dingjiang Liu, 2003, Protein science : a publication of the Protein Society.

Purification of Xenopus transcription factor IIIA and 5 S RNA from 7 S ribonucleoprotein particle by ammonium sulfate precipitation.

C. Wu, W. Windsor, Y. Liao, 1988, Analytical biochemistry.

Method for quantitative protein-ligand affinity measurements in compound mixtures.

Patrick J. Curran, W. Windsor, D. A. Annis, 2007, Analytical chemistry.

Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I*

W. R. Bishop, P. Kirschmeier, W. Windsor, 1997, The Journal of Biological Chemistry.

Kinetics of oxygen binding and subunit assembly for the hemoglobin alpha subunit.

J. Philo, W. Windsor, M. Potschka, 1992, Biophysical chemistry.

MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.

K. Cox, P. Kirschmeier, R. Doll, 2018, ACS medicinal chemistry letters.

Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.

P. Kirschmeier, R. Doll, W. Windsor, 2018, Bioorganic & medicinal chemistry letters.

Probing the substrate specificity of hepatitis C virus NS3 serine protease by using synthetic peptides

W. Windsor, Rumin Zhang, J. Durkin, 1997, Journal of virology.

Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

W. Windsor, S. Narula, C. Lunn, 1995, Nature.

Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10.

P. Mui, W. Windsor, Rumin Zhang, 1993, Biochemistry.

Purification and crystallization of a complex between human interferon γ receptor (extracellular domain) and human interferon γ

W. Cook, W. Windsor, J. Fossetta, 1996 .

Selective proteolytic cleavage of recombinant human interleukin 4. Evidence for a critical role of the C-terminus.

W. Windsor, H. Le, P. Trotta, 1991, Biochemistry.

A homology model of human interferon α‐2

W. Windsor, S. Ealick, N. Murgolo, 1993 .

Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor.

Patrick J. Curran, E. Lees, T. Fischmann, 2013, Bioorganic & medicinal chemistry letters.

Ligand binding affinity determined by temperature-dependent circular dichroism: cyclin-dependent kinase 2 inhibitors.

W. Windsor, T. Mayhood, Todd W. Mayhood, 2005, Analytical biochemistry.

Structure-guided discovery of cyclin-dependent kinase inhibitors.

Emma Lees, David Parry, Kamil Paruch, 2008, Biopolymers.

Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease.

W. Windsor, Rumin Zhang, J. Durkin, 2002, Bioorganic & medicinal chemistry letters.

Purification and crystallization of a complex between human interferon gamma receptor (extracellular domain) and human interferon gamma.

W. Cook, W. Windsor, J. Fossetta, 1996, Proteins.

A point mutation of human interferon gamma abolishes receptor recognition.

W. Windsor, S. Narula, N. Murgolo, 1992, Protein Engineering.

Thermodynamics of nucleotide and non-ATP-competitive inhibitor binding to MEK1 by circular dichroism and isothermal titration calorimetry.

Catherine K. Smith, W. Windsor, William T Windsor, 2007, Biochemistry.

Analysis of the conformation and stability of Escherichia coli derived recombinant human interleukin 4 by circular dichroism.

W. Windsor, H. Le, P. Trotta, 1991, Biochemistry.

Novel Tricyclic Inhibitors of Farnesyl Protein Transferase BIOCHEMICAL CHARACTERIZATION AND INHIBITION OF Ras MODIFICATION IN TRANSFECTED Cos CELLS*

P. Kirschmeier, J. Catino, R. Doll, 1995 .