H. Motoshima

发表

Activation of AMP-activated Protein Kinase Suppresses Oxidized Low-density Lipoprotein-induced Macrophage Proliferation*

T. Asano, E. Araki, Norio Ishii, 2009, The Journal of Biological Chemistry.

Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2) and glucokinase genes: Insulin secretion in response to physiological concentrations of glucose

H. Motoshima, M. Shichiri, E. Araki, 1998, Diabetologia.

Role of insulin-induced reactive oxygen species in the insulin signaling pathway.

Xiangdong Wu, H. Motoshima, B. Goldstein, 2005, Antioxidants & redox signaling.

Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells

H. Motoshima, B. Goldstein, Shi-qiong Xu, 2006, Diabetes.

Bradykinin enhances insulin receptor tyrosine kinase in 32D cells reconstituted with bradykinin and insulin signaling pathways.

H. Motoshima, M. Shichiri, E. Araki, 2000, Diabetes research and clinical practice.

Regulation of TNFα converting enzyme activity in visceral adipose tissue of obese mice.

T. Kondo, E. Araki, Norio Ishii, 2013, Biochemical and biophysical research communications.

Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice

T. Kondo, E. Araki, Norio Ishii, 2016, Journal of clinical biochemistry and nutrition.

The Role of Heat Shock Response in Insulin Resistance and Diabetes

H. Kai, T. Kondo, E. Araki, 2014, Diabetes & metabolism journal.

Efficacy and safety of sitagliptin as add-on therapy on glycemic control and blood glucose fluctuation in Japanese type 2 diabetes subjects ongoing with multiple daily insulin injections therapy.

T. Kondo, E. Araki, T. Matsumura, 2013, Endocrine journal.

Impact of mitochondrial ROS production in the pathogenesis of insulin resistance.

E. Araki, T. Matsumura, H. Motoshima, 2007, Diabetes research and clinical practice.

Impact of Mitochondrial Reactive Oxygen Species and Apoptosis Signal–Regulating Kinase 1 on Insulin Signaling

H. Ichijo, E. Araki, T. Matsumura, 2006, Diabetes.

Insulin down-regulates resistin mRNA through the synthesis of protein(s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes

H. Motoshima, E. Araki, K. Sakai, 2003, Diabetologia.

The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H₂0₂ and plays an integral role in insulin signal transduction

H. Motoshima, J. Lambeth, B. Goldstein, 2022 .

Fluctuations in free or substrate-complexed lysozyme and a mutant of it detected on x-ray crystallography and comparison with those detected on NMR.

T. Ueda, T. Imoto, H. Motoshima, 2002, Journal of biochemistry.

Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma

T. Kondo, E. Araki, H. Motoshima, 2016, Endocrinology, diabetes & metabolism case reports.

Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1

E. Araki, T. Matsumura, H. Motoshima, 2016, PloS one.

A case of hyperinsulinemia of undetermined origin, successfully treated with long-acting octreotide.

T. Kondo, E. Araki, H. Motoshima, 2005, Endocrine journal.

Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas.

J. Miyazaki, H. Motoshima, M. Shichiri, 1998, Diabetes.

Activation of heat shock response improves biomarkers of NAFLD in patients with metabolic diseases

M. Suico, H. Kai, E. Araki, 2021, Endocrine connections.

Impact of mitochondrial ROS production on diabetic vascular complications.

E. Araki, T. Matsumura, H. Motoshima, 2007, Diabetes research and clinical practice.

Cell-Specific Regulation of IRS-1 Gene Expression: Role of E Box and C/EBP Binding Site in HepG2 Cells and CHO Cells

E. Araki, H. Motoshima, M. Shichiri, 1997, Diabetes.

Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes

E. Araki, T. Matsumura, H. Motoshima, 2013, Cardiovascular Diabetology.

Effect of salt concentration on the pKa of acidic residues in lysozyme.

T. Ueda, Y. Hashimoto, T. Imoto, 1995, Journal of biochemistry.

Involvement of bradykinin in acute exercise-induced increase of glucose uptake and GLUT-4 translocation in skeletal muscle: studies in normal and diabetic humans and rats.

H. Motoshima, M. Shichiri, E. Araki, 2000, Metabolism: clinical and experimental.

AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells.

E. Araki, H. Motoshima, Kazuya Matsumoto, 2005, Biochemical and biophysical research communications.

Telmisartan Exerts Antiatherosclerotic Effects by Activating Peroxisome Proliferator-Activated Receptor-&ggr; in Macrophages

E. Araki, Norio Ishii, T. Matsumura, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation: impact of the suppression of nuclear translocation of ERK1/2.

E. Araki, Norio Ishii, T. Matsumura, 2007, Atherosclerosis.

Mineralocorticoid Receptor May Regulate Glucose Homeostasis through the Induction of Interleukin-6 and Glucagon-Like peptide-1 in Pancreatic Islets

E. Araki, T. Matsumura, H. Motoshima, 2019, Journal of clinical medicine.

Integration of multiple downstream signals determines the net effect of insulin on MAP kinase vs. PI 3'-kinase activation: potential role of insulin-stimulated H(2)O(2).

H. Motoshima, B. Goldstein, K. Mahadev, 2004, Cellular signalling.

Identification of a cis-acting element and a novel trans-acting factor of the human insulin receptor gene in HepG2 and rat liver cells.

Y. Ebina, H. Motoshima, M. Shichiri, 2001, Biochemical and biophysical research communications.

Nifedipine Induces Peroxisome Proliferator-Activated Receptor-&ggr; Activation in Macrophages and Suppresses the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice

E. Araki, Norio Ishii, T. Matsumura, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Impact of tissue macrophage proliferation on peripheral and systemic insulin resistance in obese mice with diabetes

K. Yamagata, E. Araki, Norio Ishii, 2020, BMJ open diabetes research & care.

Crystallization and preliminary X-ray crystallographic studies of a psychrophilic subtilisin-like protease Apa1 from Antarctic Pseudoalteromonas sp. strain AS-11.

H. Motoshima, Keiichi Watanabe, D. Dong, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects.

H. Kai, E. Araki, H. Motoshima, 2010, Obesity research & clinical practice.

Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions.

E. Araki, Norio Ishii, T. Matsumura, 2020, Biochemical and biophysical research communications.

Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation.

E. Araki, Norio Ishii, T. Matsumura, 2015, Biochemical and biophysical research communications.

Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials

M. Suico, H. Kai, E. Araki, 2014, EBioMedicine.

Impact of hepatic HSP72 on insulin signaling.

H. Kai, E. Araki, T. Matsumura, 2019, American journal of physiology. Endocrinology and metabolism.

Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis

M. Suico, H. Kai, E. Araki, 2012, Diabetes.

Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages.

E. Araki, Norio Ishii, T. Matsumura, 2013, Biochemical and biophysical research communications.

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.

S. Yamashita, T. Suda, M. Tabata, 2009, Biochemical and biophysical research communications.

Crystallization and preliminary X-ray crystallographic analysis of peptide deformylase from Thermus thermophilus HB8.

M. Tanokura, H. Motoshima, N. Kudo, 2004, Acta crystallographica. Section D, Biological crystallography.

Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice.

E. Araki, Norio Ishii, T. Matsumura, 2011, Biochemical and biophysical research communications.

Hyperglycemia potentiates H2O2 production in adipocytes and enhances insulin signal transduction: Potential role for oxidative inhibition of thiol-sensitive protein-tyrosine phosphatases

H. Motoshima, B. Goldstein, K. Mahadev, 2005 .

The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis

E. Araki, T. Matsumura, H. Motoshima, 2021, Internal medicine.

Genomic clones encoding two isoforms of pokeweed antiviral protein in seeds (PAP-S1 and S2) and the N-glycosidase activities of their recombinant proteins on ribosomes and DNA in comparison with other isoforms.

H. Motoshima, E. Honjo, Keiichi Watanabe, 2002, Journal of biochemistry.

Analysis of the stabilization of hen lysozyme by helix macrodipole and charged side chain interaction.

T. Ueda, Y. Hashimoto, T. Imoto, 1997, Journal of biochemistry.

Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial

M. Suico, H. Kai, E. Araki, 2016, Scientific Reports.

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction

H. Motoshima, J. Lambeth, B. Goldstein, 2004, Molecular and Cellular Biology.

Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone.

H. Motoshima, B. Goldstein, M. Sinha, 2002, The Journal of clinical endocrinology and metabolism.

Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL.

H. Motoshima, B. Goldstein, K. Mahadev, 2004, Biochemical and biophysical research communications.

Spectroscopic Analyses of Manganese Ions Effects on the Conformational Changes of Inorganic Pyrophosphatase from Psychrophilic Shewanella sp. AS-11

H. Motoshima, Keiichi Watanabe, E. L. Ginting, 2014, The Protein Journal.

Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.

E. Araki, T. Matsumura, H. Motoshima, 2006, Diabetes.

Impact of Natural IRS-1 Mutations on Insulin Signals: Mutations of IRS-1 in the PTB Domain and Near SH2 Protein Binding Sites Result in Impaired Function at Different Steps of IRS-1 Signaling

E. Araki, H. Motoshima, M. Shichiri, 1997, Diabetes.

IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.

C. Kahn, E. Araki, H. Motoshima, 2007, Biochemical and biophysical research communications.

Insulin inhibits glucagon secretion by the activation of PI3-kinase in In-R1-G9 cells.

H. Motoshima, M. Shichiri, E. Araki, 1999, Diabetes research and clinical practice.

Oxidized Low Density Lipoprotein Activates Peroxisome Proliferator-activated Receptor-α (PPARα) and PPARγ through MAPK-dependent COX-2 Expression in Macrophages*

E. Araki, Norio Ishii, T. Matsumura, 2008, Journal of Biological Chemistry.

Identification of microRNA that represses IRS-1 expression in liver

E. Araki, H. Motoshima, Takafumi Senokuchi, 2018, PloS one.

Hypoglycemia induces mitochondrial reactive oxygen species production through increased fatty acid oxidation and promotes retinal vascular permeability in diabetic mice.

E. Araki, T. Matsumura, H. Motoshima, 2020, Antioxidants & redox signaling.

Low glucose induces mitochondrial reactive oxygen species via fatty acid oxidation in bovine aortic endothelial cells

E. Araki, T. Matsumura, H. Motoshima, 2017, Journal of diabetes investigation.

Cold Adaptation: Structural and Functional Characterizations of Psychrophilic and Mesophilic Acetate Kinase

H. Motoshima, Keiichi Watanabe, Md Abul Kashem Tang, 2014, The Protein Journal.

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes.

H. Motoshima, B. Goldstein, K. Mahadev, 2003, Diabetes.

AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer

E. Araki, H. Motoshima, B. Goldstein, 2006, The Journal of physiology.

Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome.

E. Araki, H. Motoshima, K. Nishida, 2007, Diabetes research and clinical practice.

Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice.

E. Araki, T. Matsumura, H. Motoshima, 2008, Biochemical and biophysical research communications.

Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes

T. Katoh, E. Araki, Norio Ishii, 2013, Cardiovascular Diabetology.

Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.

K. Inukai, E. Araki, T. Matsumura, 2008, Biochemical and biophysical research communications.

Relationship between local structure and stability in hen egg white lysozyme mutant with alanine substituted for glycine.

T. Ueda, T. Imoto, H. Motoshima, 2000, Protein engineering.

A 1‐year, prospective, observational study of Japanese outpatients with type 1 and type 2 diabetes switching from insulin glargine or detemir to insulin degludec in basal–bolus insulin therapy (Kumamoto Insulin Degludec Observational study)

E. Araki, Norio Ishii, T. Matsumura, 2016, Journal of diabetes investigation.

Insulin requirement profiles in Japanese hospitalized subjects with type 2 diabetes treated with basal-bolus insulin therapy.

E. Araki, Norio Ishii, T. Matsumura, 2015, Endocrine journal.

Comparison of the efficacy of sitagliptin and glimepiride dose‐up in Japanese patients with type 2 diabetes poorly controlled by sitagliptin and glimepiride in combination

E. Araki, T. Matsumura, H. Motoshima, 2013, Journal of diabetes investigation.

Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase–Dependent Cyclooxygenase-2 Expression in Macrophages

Takeshi Matsumura, Michael Brownlee, Eiichi Araki, 2007, Circulation research.

Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) an

H. Motoshima, M. Shichiri, E. Araki, 1999, Endocrine journal.

A mutation study of catalytic residue Asp 52 in hen egg lysozyme.

T. Ueda, Y. Hashimoto, T. Miki, 1996, Journal of biochemistry.

New perspectives on insulin therapy

E. Araki, H. Motoshima, Takafumi Senokuchi, 2020, Journal of diabetes investigation.

TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis.

E. Araki, T. Matsumura, H. Motoshima, 2009, Biochemical and biophysical research communications.

Adenosine Monophosphate-Activated Protein Kinase Suppresses Vascular Smooth Muscle Cell Proliferation Through the Inhibition of Cell Cycle Progression

T. Asano, E. Araki, T. Matsumura, 2005, Circulation research.

An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice.

H. Kai, E. Araki, H. Motoshima, 2010, American journal of physiology. Endocrinology and metabolism.

Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ.

E. Araki, Norio Ishii, T. Matsumura, 2019, Atherosclerosis.

Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis

Tomoaki Koga, K. Yamagata, E. Araki, 2018, Arteriosclerosis, thrombosis, and vascular biology.

A case of ectopic adrenocorticotropic hormone-producing pancreatic neuroendocrine tumor with multiple liver metastases.

E. Araki, H. Motoshima, K. Iyama, 2010, Endocrine journal.

Fluorescence Studies on the Stability, Flexibility and Substrate-Induced Conformational Changes of Acetate Kinases from Psychrophilic and Mesophilic Bacteria

H. Motoshima, Keiichi Watanabe, Md Abul Kashem Tang, 2012, The Protein Journal.

[Insulin receptor substrate-1 (IRS-1) gene].

H. Motoshima, M. Shichiri, E. Araki, 1997, Nihon rinsho. Japanese journal of clinical medicine.

Rapid and dramatic glucose‐lowering effect of bromocriptine in an inadequately controlled type 2 diabetes patient with prolactinoma

E. Araki, Norio Ishii, H. Motoshima, 2020, Journal of diabetes investigation.

A Case of Autoimmune Polyglandular Syndrome Type 3 Complicated with IgG4-related Disease.

E. Araki, H. Motoshima, H. Kishikawa, 2023, Internal medicine.

The effect of group‐based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome: the Tabaruzaka Study 1

E. Araki, T. Matsumura, H. Motoshima, 2010, Diabetes, obesity & metabolism.

Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor

K. Palczewski, B. A. Fox, T. Hori, 2002, Chembiochem : a European journal of chemical biology.

Crystal structure of rhodopsin: A G protein-coupled receptor.

K. Palczewski, B. A. Fox, T. Hori, 2000, Science.

Crystal structure of rhodopsin: a G protein-coupled receptor. Palczewski K,*(1) kumasaka T, hori T, behnke CA, motoshima H, fox BA, trong IL, teller DC, okada T, stenkamp RE, yamamoto M, miyano M. Science 2000;289:739-745

K. Palczewski, B. A. Fox, T. Hori, 2000, American journal of ophthalmology.

Protein-Coupled Receptor Crystal Structure of Rhodopsin : A G

K. Palczewski, B. A. Fox, T. Hori, 2008 .

Gly or Ala substitutions for Pro(210)Thr(211)Asn(212) at the β8-β9 turn of subtilisin Carlsberg increase the catalytic rate and decrease thermostability.

H. Motoshima, J. Ikuta, M. Miura, 2012, Biochimica et biophysica acta.

O R I G I N a L I N V E S T I G a T I O N Open Access Association between Circulating Leukocyte Subtype Counts and Carotid Intima-media Thickness in Japanese Subjects with Type 2 Diabetes

T. Katoh, E. Araki, Norio Ishii, 2022 .

An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice.

H. Kai, E. Araki, H. Motoshima, 2010, American journal of physiology. Endocrinology and metabolism.

Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.

K. Inukai, E. Araki, T. Matsumura, 2008, Biochemical and biophysical research communications.