M. O’Brien

发表

Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.

Paul G Wyatt, Valerio Berdini, V. Berdini, 2008, Journal of medicinal chemistry.

Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.

Gianni Chessari, Brent Graham, Christopher W Murray, 2010, Journal of medicinal chemistry.

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.

Mladen Vinković, Paul G Wyatt, Jayne Curry, 2009, Journal of medicinal chemistry.

N-Sulfonyloxy-β-lactam Inhibitors for β-Lactamases

J. Samama, M. O’Brien, S. Mobashery, 2000 .

The Design and Synthesis of Potent Inhibitors of Hepatitis C Virus NS3–4A Proteinase

N. Jennings, F. Wilson, M. Carr, 1999, Antiviral chemistry & chemotherapy.

Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.

Gianni Chessari, Brent Graham, Jose Cosme, 2010, Journal of medicinal chemistry.

Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918

Alicia P. Higueruelo, Flavia Autore, M. O’Brien, 2021, Heliyon.

Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): a Calcitonin Gene-Related Pepti

M. Congreve, J. Mason, F. Deflorian, 2020, Journal of medicinal chemistry.

Potent mechanism-based inhibition of the TEM-1 .beta.-lactamase by novel N-sulfonyloxy .beta.-lactams

I. Massova, M. O’Brien, S. Mobashery, 1995 .

The identification of α-ketoamides as potent inhibitors of hepatitis c virus nS3-4a proteinase

N. Jennings, F. Wilson, P. Jones, 2001 .

An investigation into coking on catalyst support materials & supported metal catalysts

M. O’Brien, 1997 .

Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket

M. Congreve, C. Murray, V. Berdini, 2014, ChemMedChem.

Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.

M. Congreve, C. Murray, G. Chessari, 2010, Journal of medicinal chemistry.

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.

V. Berdini, P. Wyatt, L. Fazal, 2009, Journal of medicinal chemistry.

The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders.

Alicia P. Higueruelo, M. O’Brien, S. Watson, 2023, ACS medicinal chemistry letters.