M. Sykes

发表

An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation.

R. Bronson, W. Asavaroengchai, Hui Wang, 2007, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Surgical research review

M. Sykes, T. Wekerle, 2004 .

Clinical experience with mixed chimerism to induce transplantation tolerance

T. Fehr, M. Sykes, 2008, Transplant international : official journal of the European Society for Organ Transplantation.

Generation and persistence of human tissue-resident memory T cells in lung transplantation

C. Marboe, P. Sims, M. Sykes, 2019, Science Immunology.

Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice.

M. Sykes, Yong-Guang Yang, R. Wilkinson, 2004, The Journal of clinical investigation.

Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance.

Megan Sykes, M. Sykes, M. Mapara, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Outcomes of Recipients of Both Bone Marrow and Solid Organ Transplants: A Review

M. Sykes, T. Spitzer, B. Dey, 1998, Medicine.

Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus

M. Sykes, M. Nakayama, B. Roep, 2020, Journal of translational autoimmunity.

Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

D. Sachs, M. Sykes, R. Hawley, 2005, Nature Medicine.

Immunobiology of transplantation 1

M. Sykes, 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells

M. Sykes, M. Levings, A. Griesemer, 2015, Transplantation direct.

B cell tolerance and xenotransplantation

H. Ohdan, M. Sykes, P. Bardwell, 2005 .

Graft-versus-Host Disease and Graft-versus-Leukemic Effect in Allogeneic Bone Marrow Transplantation Role of Interferon-γ

M. Sykes, Yong-Guang Yang, 2002 .

Interleukin-12 inhibits graft-versus-host disease through an Fas-mediated mechanism associated with alterations in donor T-cell activation and expansion.

G. Szot, M. Sykes, B. Dey, 1998, Blood.

Modeling Human Leukemia Immunotherapy in Humanized Mice

Wei Li, M. Sykes, Yong-Guang Yang, 2016, EBioMedicine.

Position paper of the Ethics Committee of the International Xenotransplantation Association.

M. Sykes, M. Sandrin, A. D'apice, 2004, Transplantation.

Commentary: World Health Assembly resolution 57.18 on xenotransplantation.

M. Sykes, 2005, Transplantation.

B‐Cell‐Dependent Memory T Cells Impede Nonmyeloablative Mixed Chimerism Induction in Presensitized Mice

B. Yeap, M. Sykes, G. Benichou, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene.

A. Nienhuis, D. Bodine, D. Sachs, 1993, Transplantation.

Tolerance, Mixed Chimerism, and Chronic Transplant Arteriopathy1 2

R. Colvin, M. Sykes, Hiroshi Ito, 2001, The Journal of Immunology.

Title Minimum Information about T Regulatory Cells : A Step toward Reproducibility and Standardization Permalink

D. Hafler, J. Bluestone, J. Isaacs, 2018 .

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

D. Hafler, J. Bluestone, J. Isaacs, 2018, Front. Immunol..

Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

M. Sykes, Yong-Guang Yang, B. Dey, 1998, The Journal of clinical investigation.

Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets.

R. Bronson, M. Sykes, M. Grusby, 2000, The Journal of clinical investigation.

Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR.

R. Bronson, M. Sykes, A. Lokshin, 2006, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages.

T. Asahara, H. Ohdan, Hui Wang, 2007, Proceedings of the National Academy of Sciences of the United States of America.

Understanding Typhoid : A Mouse Model of Salmonella typhi Infection

M. Sykes, 2012 .

Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model

M. Sykes, Yong-Guang Yang, H. Kalscheuer, 2011, The Journal of Immunology.

Alloreactive CD8 T Cell Tolerance Requires Recipient B Cells, Dendritic Cells, and MHC Class II1

T. Fehr, M. Sykes, F. Haspot, 2008, The Journal of Immunology.

Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen.

M. Sykes, Y. Tomita, A. Khan, 1994, Journal of immunology.

Role of intrathymic rat class II+ cells in maintaining deletional tolerance in xenogeneic rat-->mouse bone marrow chimeras.

M. Sykes, B. Nikolic, D. Pearson, 1998, Transplantation.

Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions.

M. Sykes, H. Eom, R. Chakraverty, 2006, Blood.

Mixed Allogeneic Chimerism And Renal Allograft Tolerance In Cynomolgus Monkeys

R. Colvin, D. Sachs, T. Kawai, 1995, Transplantation.

Depletion of CD8 Memory T Cells for Induction of Tolerance of a Previously Transplanted Kidney Allograft

R. Colvin, T. Strom, D. Sachs, 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Long-Term Follow-Up of Recipients of Combined Human Leukocyte Antigen-Matched Bone Marrow and Kidney Transplantation for Multiple Myeloma With End-Stage Renal Disease

F. Delmonico, S. Saidman, K. Ballen, 2011, Transplantation.

Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation.

S. Saidman, F. Preffer, D. Dombkowski, 2003, Experimental hematology.

Characterization, biology, and expansion of regulatory T cells in the Cynomolgus macaque for preclinical studies

M. Sykes, L. Bühler, A. Griesemer, 2019, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Central Tolerance to Myogenic Cell Transplants Does Not Include Muscle Neoantigens

J. Rousseau, J. Tremblay, M. Sykes, 2008, Transplantation.

Posttransplant Hemophagocytic Lymphohistiocytosis Driven by Myeloid Cytokines and Vicious Cycles of T-Cell and Macrophage Activation in Humanized Mice

M. Sykes, Yong-Guang Yang, N. Danzl, 2019, Front. Immunol..

Twenty Year Follow Up of Histocompatibility Leukocyte Antigen-Matched Kidney and Bone Marrow Co-Transplantation for Multiple Myeloma with End Stage Renal Disease: Lessons Learned.

F. Delmonico, D. Sachs, T. Kawai, 2019, Transplantation.

Long‐Term Results in Recipients of Combined HLA‐Mismatched Kidney and Bone Marrow Transplantation Without Maintenance Immunosuppression

R. Colvin, S. Saidman, F. Preffer, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Use of skin grafting to demonstrate tolerance before kidney transplantation without immunosuppression in the recipient of a previous bone marrow transplant.

T. Fehr, M. Sykes, P. Bardwell, 2005, Transplantation.

Megan Sykes, MD: Michael J. Friedlander Professor of Medicine and Professor of Microbiology & Immunology and Surgical Sciences (in Surgery) and Director of Columbia Center for Translational Immunology Columbia University, New York City, NY.

M. Sykes, 2017, Transplantation.

CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

Hui Wang, M. Sykes, Yong-Guang Yang, 2021, bioRxiv.

Transgenic expression of human CD47 reduces phagocytosis of porcine endothelial cells and podocytes by baboon and human macrophages

D. Sachs, M. Sykes, D. Ayares, 2019, Xenotransplantation.

GalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels

T. Nagayasu, D. Sachs, M. Sykes, 2018, Xenotransplantation.

Tolerance in xenotransplantation

D. Sachs, M. Sykes, Kazuhiko Yamada, 2007, Current opinion in organ transplantation.

Transplanting organs from pigs to humans

D. Sachs, M. Sykes, 2019, Science Immunology.

Clinical outcomes of late rather than early full-donor chimerism in patients with advanced lymphomas receiving nonmyeloablative allogeneic hematopoietic SCT

S. Saidman, D. Ting, A. Muzikansky, 2008, Bone Marrow Transplantation.

Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimen

S. Saidman, D. Ting, N. Tarbell, 2007, Bone Marrow Transplantation.

Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.

R. Bronson, W. Asavaroengchai, M. Sykes, 2003, The Journal of clinical investigation.

Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY 720

R. Bronson, W. Asavaroengchai, M. Sykes, 2003 .

Homeostatic Expansion and Phenotypic Conversion of Human T Cells Depend on Peripheral Interactions with APCs

M. Sykes, Yong-Guang Yang, H. Kalscheuer, 2010, The Journal of Immunology.

Peripheral Interactions with APCs Conversion of Human T Cells Depend on Homeostatic Expansion and Phenotypic

M. Sykes, Yong-Guang Yang, H. Kalscheuer, 2010 .

Manipulating the immune system for anti‐tumor responses and transplant tolerance via mixed hematopoietic chimerism

M. Sykes, C. Gibbons, 2008, Immunological reviews.

Donor Bone Marrow-Derived T Cells Inhibit GVHD Induced by Donor Lymphocyte Infusion in Established Mixed Allogeneic Hematopoietic Chimeras

B. Yeap, Hui Wang, Shumei Wang, 2012, PloS one.

Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement

M. Rickels, B. Kovatchev, B. Ludwig, 2016, Transplantation.

Chimerism and central tolerance.

M. Sykes, Megan Sykes, 1996, Current opinion in immunology.

A Model for Personalized in Vivo Analysis of Human Immune Responsiveness

M. Sykes, Yong-Guang Yang, T. Spitzer, 2012, Science Translational Medicine.

B‐Cell Immunity in the Context of T‐Cell Tolerance after Combined Kidney and Bone Marrow Transplantation in Humans

R. Colvin, S. Saidman, D. Sachs, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Global Unresponsiveness as a Mechanism of Natural Killer Cell Tolerance in Mixed Xenogeneic Chimeras

M. Sykes, J. Rodriguez-Barbosa, T. Kawahara, 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction.

M. Sykes, H. Eom, T. Means, 2005, Experimental hematology.

Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation

G. Szot, M. Sykes, W. Yokoyama, 1993, The Journal of experimental medicine.

2007 IXA Presidential Address. Progress toward an ideal source animal: opportunities and challenges in a changing world

M. Sykes, 2008, Xenotransplantation.

Tolerance induction in clinical transplantation.

T. Fehr, M. Sykes, 2004, Transplant immunology.

Thymic Education of Human T Cells and Regulatory T Cell Development in Humanized Mice

M. Sykes, Yong-Guang Yang, H. Li, 2014 .

Long-Term Survival of Xenogeneic Heart Grafts Achieved by Costimulatory Blockade and Transient Mixed Chimerism

M. Sykes, Hiroshi Ito, K. Hamano, 2006, Transplantation.

Tolerance in mixed chimerism - a role for regulatory cells?

M. Sykes, T. Wekerle, J. Kurtz, 2004, Trends in immunology.

Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells.

M. Sykes, G. Benichou, N. Anosova, 2004, Blood.

Specific unresponsiveness to a retrovirally-transferred class I antigen is controlled through the helper pathway.

D. Sachs, C. Fraser, M. Sykes, 1995, Journal of immunology.

Fetal porcine thymus engraftment, survival and CD4 reconstitution in αGal‐KO mice is impaired in the presence of high levels of antibodies against αGal

M. Sykes, J. Rodriguez-Barbosa, S. Houser, 2003, Xenotransplantation.

Natural killer cells and their role in graft rejection.

M. Sykes, J. Manilay, Megan Sykes, 1998, Current opinion in immunology.

Type 1 diabetes induction in humanized mice

M. Sykes, Yong-Guang Yang, M. Nakayama, 2017, Proceedings of the National Academy of Sciences.

Mixed bone marrow chimerism as a treatment for autoimmune diabetes.

I. Leykin, M. Sykes, B. Nikolic, 2001, Transplantation proceedings.

Transient Mixed Chimerism With Nonmyeloablative Conditioning Does Not Induce Liver Allograft Tolerance in Nonhuman Primates.

M. Sykes, B. Karolewski, Mercedes Martinez, 2020, Transplantation.

Bone marrow chimerism and transplantation tolerance.

M. Sykes, B. Nikolic, 1997, Current opinion in immunology.

Hypercholesterolemia induces T cell expansion in humanized immune mice

V. D’Agati, Hui Wang, M. Sykes, 2018, The Journal of clinical investigation.

Early regulation of CD8 T cell alloreactivity by CD4+CD25– T cells in recipients of anti‐CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor‐reactive CD8+ T cells, precluding a role for sustained regulation

T. Fehr, M. Sykes, T. Wekerle, 2005, European journal of immunology.

The fate of donor T-cell receptor transgenic T cells with known host antigen specificity in a graft-versus-host disease model.

D. Dombkowski, M. Sykes, A. Shimizu, 1999, Transplantation.

Use of CD9 expression to enrich for porcine hematopoietic progenitors.

R. Mulligan, D. Sachs, M. Sykes, 2002, Experimental hematology.

Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice

M. Sykes, N. Danzl, R. Madley, 2019, European journal of immunology.

Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance

M. Sykes, M. Sayegh, A. Chandraker, 1998, The Journal of experimental medicine.

Mixed chimerism and tolerance without whole body irradiation in a large animal model.

R. Colvin, D. Sachs, D. Neville, 2000, The Journal of clinical investigation.

Mac-1-Negative B-1b Phenotype of Natural Antibody-Producing Cells, Including Those Responding to Galα1,3Gal Epitopes in α1,3-Galactosyltransferase-Deficient Mice1

H. Ohdan, M. Sykes, Yong-Guang Yang, 2000, The Journal of Immunology.

MHC Class I Expression by Donor Hematopoietic Stem Cells Is Required to Prevent NK Cell Attack in Allogeneic, but Not Syngeneic Recipient Mice

Y. Hirata, M. Sykes, Joji Fujisaki, 2015, PloS one.

NK cell recovery, chimerism, function, and recognition in recipients of haploidentical hematopoietic cell transplantation following nonmyeloablative conditioning using a humanized anti-CD2 mAb, Medi-507.

S. Saidman, F. Preffer, D. Dombkowski, 2003, Experimental hematology.

Altered expression of Ly-49 receptors on NK cells developing in mixed allogeneic bone marrow chimeras.

M. Sykes, G. Waneck, J. Manilay, 1998, International immunology.

Long-term Survival of Transplanted Allogeneic Cells Engineered to Express a T Cell Chemorepellent

J. Bagley, D. Sachs, Tao Chen, 2007, Transplantation.

Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen

T. Sundt, D. Sachs, M. Sykes, 1990, The Journal of experimental medicine.

Marrow: Role of Donor Class II MHC and B Tolerance Induced by Allogeneic Bone Rapid Deletional Peripheral CD8 T Cell

M. Sykes, J. Kurtz, F. Haspot, 2013 .

Rapid Deletional Peripheral CD8 T Cell Tolerance Induced by Allogeneic Bone Marrow: Role of Donor Class II MHC and B Cells1

T. Fehr, M. Sykes, T. Wekerle, 2008, The Journal of Immunology.

Strategies for the Induction of Allograft Tolerance

M. Sykes, T. Wekerle, J. Kurtz, 2001 .

Mixed hematopoietic chimerism and transplantation tolerance: insights from experimental models

M. Sykes, T. Wekerle, J. Kurtz, 1999 .

Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen.

M. Sykes, D. Pearson, J. J. Sergio, 1998, Transplantation.

Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine.

S. Saidman, K. Ballen, F. Preffer, 2007, Experimental hematology.

-Producing g Infusion-Derived IFN-T Cells and Recipient Leukocyte + CD4Conditioning: A Critical Role for Recipient Chimeras Prepared with Nonmyeloablative Recipient Leukocyte Infusions in Mixed Host-versus-Graft Reactions Induced by Mechanisms of the Antitumor Responses and

M. Sykes, M. Rubio, Toshiki I. Saito, 2005 .

Mechanisms of the Antitumor Responses and Host-versus-Graft Reactions Induced by Recipient Leukocyte Infusions in Mixed Chimeras Prepared with Nonmyeloablative Conditioning: A Critical Role for Recipient CD4+ T Cells and Recipient Leukocyte Infusion-Derived IFN-γ-Producing CD8+ T Cells1

M. Sykes, M. Rubio, Toshiki I. Saito, 2005, The Journal of Immunology.

Effect of Ex Vivo–Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques

S. Hammer, V. D’Agati, C. Wuu, 2017, Transplantation.

inhibition of epithelial tissue injury promotion of lymphohematopoietic graft-versus-host reactions and in graft-versus-host disease reflect γ Paradoxical effects of IFN

B. Yeap, W. Asavaroengchai, Hui Wang, 2009 .

Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury.

B. Yeap, W. Asavaroengchai, Hui Wang, 2009, Blood.

Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma.

M. Sykes, M. Mapara, M. Rubio, 2003, Blood.

Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen.

M. Sykes, Y. Yang, D. Pearson, 1999, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia.

M. Sykes, R. Chakraverty, 2007, Blood.

Interleukin 2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T cells.

D. Sachs, M. Sykes, M. L. Romick, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Protection from graft-versus-host disease in fully allogeneic chimeras by prior administration of T cell-depleted syngeneic bone marrow.

D. Sachs, M. Sykes, C. H. Chester, 1988, Transplantation.

Graft-versus-leukemia effect using mixed allogeneic bone marrow transplantation.

D. Sachs, M. Sykes, Z. Bukhari, 1989, Bone marrow transplantation.

Mixed lymphohaemopoietic chimerism and graft-ver suslymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation

S. Saidman, F. Preffer, D. Sachs, 1999, The Lancet.

IL-2 reduces graft-versus-host disease and preserves a graft-versus-leukemia effect by selectively inhibiting CD4+ T cell activity.

M. Sykes, D. Pearson, M. Harty, 1993, Journal of immunology.

MECHANISMS OF SUPPRESSION IN MIXED ALLOGENEIC CHIMERAS

D. Sachs, M. Sykes, 1988, Transplantation.

Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies.

S. Saidman, F. Preffer, D. Sachs, 2000, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD.

D. Sachs, M. Sykes, M. Sheard, 1988, Journal of immunology.

Genetic analysis of the anti-leukemic effect of mixed allogeneic bone marrow transplantation.

D. Sachs, M. Sykes, 1989, Transplantation proceedings.

Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells.

R. Bronson, D. Sachs, M. Sykes, 2002, Blood.

Graft-versus-host-related immunosuppression is induced in mixed chimeras by alloresponses against either host or donor lymphohematopoietic cells

D. Sachs, M. Sykes, M. Sheard, 1988, The Journal of experimental medicine.

In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment

D. Sachs, M. Sykes, M. L. Romick, 1990, The Journal of experimental medicine.

Mixed allogeneic chimerism as an approach to transplantation tolerance.

D. Sachs, M. Sykes, 1988, Immunology today.

cells transplantation: evidence for anergy and deletion but not regulatory anti-CD154 monoclonal antibody and allogeneic bone marrow Mechanisms of early peripheral CD4 T-cell tolerance induction by

M. Sykes, G. Benichou, N. Anosova, 2013 .

Distinct Requirements for Achievement of Allotolerance Versus Reversal of Autoimmunity via Nonmyeloablative Mixed Chimerism Induction in NOD Mice

I. Leykin, M. Sykes, R. N. Smith, 2010, Transplantation.

CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.

M. Sykes, J. Kurtz, J. Der, 2009, Blood.

Murine Mobilized Peripheral Blood Stem Cells Have a Lower Capacity than Bone Marrow to Induce Mixed Chimerism and Tolerance

M. Sykes, T. Wekerle, N. Pilat, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Treatment of severe autoimmune disease by stem-cell transplantation

M. Sykes, B. Nikolic, 2005, Nature.

Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity.

I. Leykin, M. Sykes, R. N. Smith, 2004, Diabetes.

Induction of tolerance.

M. Sykes, T. Wekerle, 2004, Surgery.

Lack of Role for CsA‐Sensitive or Fas Pathways in the Tolerization of CD4 T Cells Via BMT and Anti‐CD40L

L. Turka, M. Sykes, G. Benichou, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade.

H. Bergmeister, M. Sykes, F. Wrba, 2003, Blood.

Mixed chimerism and transplantation tolerance.

M. Sykes, T. Wekerle, Megan Sykes, 2001, Annual review of medicine.

Separate regulation of peripheral hematopoietic and thymic engraftment.

G. Szot, M. Sykes, T. Wekerle, 1998, Experimental hematology.

Mixed hematopoietic chimerism and transplantation tolerance

M. Sykes, B. Nikolic, 1997, Immunologic research.

Mechanisms of tolerance induced via mixed chimerism.

M. Sykes, 2007, Frontiers in bioscience : a journal and virtual library.

Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome

Yufeng Shen, G. Bhagat, M. Sykes, 2016, Science Immunology.

Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction.

D. Sachs, M. Sykes, C. Leguern, 1996, Transplant immunology.

Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement.

M. Rickels, B. Ludwig, G. Weir, 2016, Transplantation.

Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning

G. Szot, M. Sykes, D. Pearson, 1997, Nature Medicine.

Hematopoietic cell transplantation for the induction of allo- and xenotolerance.

M. Sykes, 1996, Clinical transplantation.

Xenograft Tolerance

Lorri A. Lee, D. Sachs, M. Sykes, 1994, Immunological reviews.

Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers.

D. Sachs, M. Sykes, Y. Zhou, 2000, Transplantation.

Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Gal alpha 1,3Gal-mediated graft rejection.

H. Ohdan, M. Sykes, A. Shimizu, 1999, The Journal of clinical investigation.

Host marrow has a competitive advantage that limits donor hematopoietic repopulation in mixed xenogeneic chimeras

H. Gritsch, M. Sykes, 1996 .

Evidence for nonimmune mechanisms in the loss of hematopoietic chimerism in rat→mouse mixed xenogeneic chimeras

M. Sykes, J. J. Sergio, L. A. Lee, 1995 .

Engraftment of rat bone marrow and its role in negative selection of murine T cells in mice conditioned with a modified nonmyeloablative regimen

M. Sykes, Y. Tomita, L. A. Lee, 1994 .

Mechanism of tolerance in mixed xenogeneic chimeras prepared with a nonmyeloablative conditioning regimen.

D. Sachs, M. Sykes, J. J. Sergio, 1994, Transplantation Proceedings.

HUMORAL TOLERANCE IN XENOGENEIC BMT RECIPIENTS CONDITIONED BY A NONMYELOABLATIVE REGIMEN

D. Sachs, M. Sykes, I. Aksentijevich, 1992, Transplantation.

Natural antibodies can inhibit bone marrow engraftment in the rat----mouse species combination.

D. Sachs, M. Sykes, I. Aksentijevich, 1991, Journal of immunology.

Natural antibodies against bone marrow cells of a concordant xenogeneic species.

D. Sachs, M. Sykes, I. Aksentijevich, 1991, Journal of immunology.

Rapid Functional Decline of Activated and Memory Graft-versus-Host–Reactive T Cells Encountering Host Antigens in the Absence of Inflammation

Charles P. Lin, M. Sykes, Alicia L. Carlson, 2015, The Journal of Immunology.

Chapter 1: Key ethical requirements and progress toward the definition of an international regulatory framework

M. Sykes, M. Tallacchini, R. Pierson III, 2009, Xenotransplantation.

Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor.

R. Colvin, H. Auchincloss, D. Sachs, 2001, Transplantation.

Xenotransplantation: immunological hurdles and progress toward tolerance

M. Sykes, A. Griesemer, Kazuhiko Yamada, 2014, Immunological reviews.

Induction of Human T‐Cell Tolerance to Pig Xenoantigens via Thymus Transplantation in Mice with an Established Human Immune System

M. Sykes, Yong-Guang Yang, K. Habiro, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy.

D. Sachs, M. Sykes, Kazuhiko Yamada, 2009, Transplant immunology.

Specific tolerance across a discordant xenogeneic transplantation barrier.

T. Sablinski, H. Gritsch, D. Sachs, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Xenogeneic thymus transplantation in a pig-to-baboon model1

R. Colvin, J. Wain, D. Sachs, 2003, Transplantation.

Tolerance induction using autologous bone marrow modified with an allogeneic class I MHC gene.

A. Nienhuis, D. Bodine, D. Sachs, 1993, Transplantation proceedings.

Graft-versus-Host Disease and Graft-versus-Leukemic Effect in Allogeneic Bone Marrow Transplantation: Role of Interferon-{gamma}

M. Sykes, Yong-Guang Yang, 2002 .

Recipient Dendritic Cells, But Not B Cells, Are Required Antigen‐Presenting Cells for Peripheral Alloreactive CD8+ T‐Cell Tolerance

M. Sykes, J. Kurtz, F. Haspot, 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

CD154 Blockade for Induction of Mixed Chimerism and Prolonged Renal Allograft Survival in Nonhuman Primates

R. Colvin, D. Sachs, T. Kawai, 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Earlier Low‐Dose TBI or DST Overcomes CD8+ T‐Cell‐Mediated Alloresistance to Allogeneic Marrow in Recipients of Anti‐CD40L

M. Sykes, Hiroshi Ito, T. Wekerle, 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

CD4 T Cell-Mediated Alloresistance to Fully MHC-Mismatched Allogeneic Bone Marrow Engraftment Is Dependent on CD40-CD40 Ligand Interactions, and Lasting T Cell Tolerance Is Induced by Bone Marrow Transplantation with Initial Blockade of this Pathway1

M. Sykes, Hiroshi Ito, J. Kurtz, 2001, The Journal of Immunology.

Tolerance Is Induced by Bone Marrow Ligand Interactions , and Lasting T Cell Engraftment Is Dependent on CD 40-CD 40 MHC-Mismatched Allogeneic Bone Marrow CD 4 T Cell-Mediated Alloresistance to Fully

M. Sykes, Hiroshi Ito, J. Kurtz, 2001 .

Mixed chimerism as an approach for the induction of transplantation tolerance.

M. Sykes, T. Wekerle, 1999, Transplantation.

Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death1

L. Turka, A. Wells, M. Sykes, 2001, The Journal of Immunology.

Cell Death Activation-Induced Cell Death and Passive Blockade Has Features of Both Transplantation with Costimulatory Peripheral Deletion After Bone Marrow

L. Turka, A. Wells, M. Sykes, 2001 .

Human Stem Cell-Derived Thymic Epithelial Cells Enhance Human T Cell Development in a Xenogeneic Thymus.

M. Sykes, N. Danzl, D. Chatterjee, 2021, The Journal of allergy and clinical immunology.

Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.

R. Winchester, A. Iuga, M. Sykes, 2021, Journal of autoimmunity.

Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts

M. Sykes, H. Kalscheuer, Kazuhiko Yamada, 2014, The Journal of Immunology.

Comparison of Human T Cell Repertoire Generated in Xenogeneic Porcine and Human Thymus Grafts

M. Sykes, Yong-Guang Yang, A. Shimizu, 2008, Transplantation.

Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism.

R. Bronson, D. Sachs, Lan Wang, 2004, Blood.

Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC.

D. Scadden, D. Sachs, M. Sykes, 1999, Journal of immunology.

Anti-CD40L Monoclonal Antibodies Can Replace Anti-CD4 Monoclonal Antibodies for the Nonmyeloablative Induction of Mixed Xenogeneic Chimerism

M. Sykes, Hiroshi Ito, Y. Takeuchi, 2006, Transplantation.

Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism1

M. Sykes, M. Mapara, Yong-Mi Kim, 2003, Transplantation.

Maturation of human monocyte-derived dendritic cells (MoDCs) in the presence of prostaglandin E2 optimizes CD4 and CD8 T cell-mediated responses to protein antigens: role of PGE2 in chemokine and cytokine expression by MoDCs.

M. Sykes, T. Means, A. Luster, 2005, International immunology.

Induction of tolerance through mixed chimerism.

D. Sachs, T. Kawai, M. Sykes, 2014, Cold Spring Harbor perspectives in medicine.

Thymic transplantation across an MHC class I barrier in swine.

R. Colvin, D. Sachs, M. Sykes, 1999, Journal of immunology.

Xenogeneic Tolerance Through Hematopoietic Cell and Thymic Transplantation

D. Sachs, M. Sykes, 1997 .

Donor‐specific growth factors promote swine hematopoiesis in severe combined immune deficient mice

M. Sykes, Yong-Guang Yang, R. Monroy, 1996 .

Natural killer cells weakly resist engraftment of allogeneic, long-term, multilineage-repopulating hematopoietic stem cells.

M. Sykes, J. J. Sergio, L. A. Lee, 1996, Transplantation.

Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro.

H. Snoeck, M. Sykes, Erin Bush, 2019, Cell stem cell.

prepared with nonmyeloablative conditioning chimeras T-cell-mediated rejection of the donor marrow in mixed allogeneic Graft-versus-host (GVH)-reactive donor CD4 cells can induce

M. Sykes, G. Benichou, Yong-Mi Kim, 2013 .

Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning.

M. Sykes, G. Benichou, M. Mapara, 2004, Blood.

β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells

D. Egli, M. Sykes, Yong Wang, 2017, Diabetes.

Natural suppressor cells in spleens of irradiated, bone marrow-reconstituted mice and normal bone marrow: lack of Sca-1 expression and enrichment by depletion of Mac1-positive cells.

D. Sachs, M. Sykes, Y. Sharabi, 1990, Cellular immunology.

Mechanisms Involved in the Establishment of Tolerance Through Costimulatory Blockade and BMT: Lack of Requirement for CD40L‐Mediated Signaling for Tolerance or Deletion of Donor‐reactive CD4+ Cells

M. Sykes, Hiroshi Ito, T. Wekerle, 2001, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance.

M. Sykes, M. Sayegh, A. Chandraker, 1999, Transplantation.

Myeloma Responses and Tolerance Following Combined Kidney and Nonmyeloablative Marrow Transplantation: In Vivo and In Vitro Analyses

R. Colvin, T. Fehr, F. Delmonico, 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Induction Of Kidney Allograft Tolerance After Transient Lymphohematopoietic Chimerism In Patients With Multiple Myeloma And End-Stage Renal Disease1

F. Delmonico, S. Saidman, D. Sachs, 2002, Transplantation.

Role of VLA-4 and VLA-5 in ex vivo maintenance of human and pig hematopoiesis in human stroma-supported long-term cultures.

Hui Wang, M. Sykes, Yong-Guang Yang, 2005, Experimental hematology.

Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons

D. Sachs, M. Sykes, D. Ayares, 2020, Xenotransplantation.

Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice.

D. Sachs, M. Sykes, J. Rodriguez-Barbosa, 2005, Transplant immunology.

Murine CD4 T Cells Selected in a Highly Disparate Xenogeneic Porcine Thymus Graft Do Not Show Rapid Decay in the Absence of Selecting MHC in the Periphery1

M. Sykes, J. Rodriguez-Barbosa, A. Ezquerra, 2002, The Journal of Immunology.

Class I Barrier in Swine Thymic Transplantation Across an MHC

R. Colvin, D. Sachs, M. Sykes, 1999 .

Pig MHC mediates positive selection of mouse CD4+ T cells with a mouse MHC-restricted TCR in pig thymus grafts.

M. Sykes, J. J. Sergio, Y. Zhao, 1998, Journal of immunology.

Functionally and phenotypically mature mouse CD8+ T cells develop in porcine thymus grafts in mice

M. Sykes, R. Barth, D. Pearson, 1998, Xenotransplantation.

Pig MHC Mediates Positive Selection of Mouse

M. Sykes, Yong Zhao, J. J. Sergio, 1998 .

TCR in Pig Thymus Grafts T Cells with a Mouse MHC-Restricted + CD 4 Pig MHC Mediates Positive Selection of Mouse

M. Sykes, Yong Zhao, J. J. Sergio, 1998 .

Bone marrow transplantation as a means of inducing tolerance.

D. Sachs, M. Sykes, 1990, Seminars in immunology.

Immuno-intervention for the induction of transplantation tolerance through mixed chimerism.

D. Sachs, T. Kawai, A. Cosimi, 2011, Seminars in immunology.

Mixed chimerism for the induction of tolerance: potential applicability in clinical composite tissue grafting.

D. Sachs, M. Sykes, T. Wekerle, 1998, Transplantation proceedings.

JAKing up immunosuppression

M. Sykes, 2003, Nature Medicine.

Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

M. Sykes, M. Sayegh, Hiroshi Ito, 2000, Nature Medicine.

Faculty Opinions recommendation of Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen.

M. Sykes, 2002 .

Progress in xenotransplantation: overcoming immune barriers

D. Sachs, M. Sykes, 2022, Nature Reviews Nephrology.

The role of interleukin-12 in preserving the graft-versus-leukemia effect of allogeneic CD8 T cells independently of GVHD.

M. Sykes, Y. Yang, Megan Sykes, 1999, Leukemia & lymphoma.

Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus-host disease in mice.

G. Szot, M. Sykes, A. Shimizu, 1997, Blood.

Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts

A. Iafrate, R. Colvin, S. Saidman, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Graft-versus-host alloresponses to treat nonlymphohematopoietic tumors: is there a solid approach?

M. Sykes, 2001, Journal of immunotherapy.

Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4-CD8- and alpha beta TCR+NK1.1+ cells.

M. Sykes, 1990, Journal of immunology.

In vitro and in vivo analysis of bone marrow-derived CD3+, CD4-, CD8-, NK1.1+ cell lines.

D. Sachs, M. Sykes, M. L. Romick, 1990, Cellular immunology.

Achieving alloengraftment without graft-versus-host disease: approaches using mixed allogeneic bone marrow transplantation.

D. Sachs, M. Sykes, Y. Sharabi, 1988, Bone marrow transplantation.

Expression and purification of soluble murine CD40L monomers and polymers in yeast Pichia pastoris.

M. Sykes, C. Hermanrud, Christene A. Huang, 2011, Protein expression and purification.

Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney–Bone Marrow Transplantation to Induce Transplantation Tolerance

R. Colvin, F. Preffer, D. Dombkowski, 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

NK Cell Tolerance in Mixed Allogeneic Chimeras1

H. Ohdan, M. Sykes, Yong Zhao, 2003, The Journal of Immunology.

Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance.

M. Sykes, Y. Tomita, A. Khan, 1996, Transplantation.

Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity1

D. Sachs, M. Sykes, J. Rodriguez-Barbosa, 2003, Transplantation.

Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice.

G. Szot, D. Sachs, M. Sykes, 1997, Journal of immunology.

B cell tolerance to xenoantigens

H. Ohdan, M. Sykes, 2003, Xenotransplantation.

Tolerization of Galα1,3Gal‐reactive B cells in pre‐sensitized α1,3‐galactosyltransferase‐deficient mice by nonmyeloablative induction of mixed chimerism

H. Ohdan, M. Sykes, Yong-Guang Yang, 2001 .

mixed hematopoietic chimerism Induction of human T-cell tolerance to porcine xenoantigens through

R. Bronson, D. Sachs, Lan Wang, 2013 .

Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high‐dose bone marrow transplantation for the induction of mixed chimerism and tolerance

M. Sykes, T. Wekerle, B. Nikolic, 2002 .

Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance

M. Sykes, T. Wekerle, B. Nikolic, 2002, Transplant international : official journal of the European Society for Organ Transplantation.

T Cell And B Cell Tolerance To Galα1,3gal-expressing Heart Xenografts Is Achieved In α1,3-galactosyltransferase-deficient Mice By Nonmyeloablative Induction Of Mixed Chimerism1

H. Ohdan, M. Sykes, Yong-Guang Yang, 2001 .

Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance.

M. Sykes, B. Nikolic, A. Khan, 2001, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT.

M. Sykes, B. Nikolic, K. Swenson, 2000, Blood.

Interleukin-l 2 Inhibits Murine Graft-Versus-Host Disease

Denise, M. Sykes, Nguyễn, 2000 .

Engraftment of discordant xenogeneic swine bone marrow cells in immunodeficient mice

M. Sykes, Yong-Guang Yang, J. J. Sergio, 1997 .

Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation.

M. Sykes, Y. Tomita, A. Khan, 1996, Transplantation.

Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation.

D. Sachs, M. Sykes, Y. Tomita, 1996, Transplantation.

Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects.

G. Szot, M. Sykes, D. Pearson, 1994, Blood.

T Cell Subsets Resisting Induction of Mixed Chimerism Across Various Histocompatibility Barriers

D. Sachs, M. Sykes, Y. Sharabi, 1993 .

Multiple mixed chimeras: reconstitution of lethally irradiated mice with syngeneic plus allogeneic bone marrow from multiple strains.

D. Sachs, M. Sykes, C. H. Chester, 1989, Research in immunology.

Effects of T cell depletion in radiation bone marrow chimeras. II. Requirement for allogeneic T cells in the reconstituting bone marrow inoculum for subsequent resistance to breaking of tolerance

D. Sachs, M. Sykes, M. Sheard, 1988, The Journal of experimental medicine.

Enhanced CD4 reconstitution by grafting neonatal porcine tissue in alternative locations is associated with donor-specific tolerance and suppression of preexisting xenoreactive T cells.

D. Sachs, M. Sykes, J. Rodriguez-Barbosa, 2001, Transplantation.

Immune monitoring of transplant patients in transient mixed chimerism tolerance trials.

M. Sykes, 2017, Human immunology.

Preparation of hybrid porcine thymus containing non‐human primate thymic epithelial cells in miniature swine

M. Sykes, Y. Ariyoshi, A. Shimizu, 2019, Xenotransplantation.

Occurrence of specific humoral non‐responsiveness to swine antigens following administration of GalT‐KO bone marrow to baboons

D. Sachs, M. Sykes, A. Griesemer, 2010, Xenotransplantation.

Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade.

D. Sachs, M. Sykes, L. Bühler, 2002, Transplantation.

THE IMPORTANCE OF NONIMMUNE FACTORS IN RECONSTITUTION BY DISCORDANT XENOGENEIC HEMATOPOIETIC CELLS1,2

Lorri A. Lee, T. Sablinski, H. Gritsch, 1994, Transplantation.

Differing Mechanisms of Early and Late B Cell Hyporesponsiveness Induced by Mixed Chimerism

H. Ohdan, M. Sykes, T. Kawahara, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

This information is current as Macrophages in Mice Elimination of Porcine Hemopoietic Cells

M. Sykes, Yong-Guang Yang, A. Thall, 2001 .

Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives

M. Sykes, M. A. Podestà, 2022, Frontiers in Immunology.

Transplantation tolerance in nonhuman primates and humans

M. Sykes, A. Griesemer, 2019, Bone Marrow Transplantation.

Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival

D. Sachs, M. Sykes, D. Ayares, 2019, Xenotransplantation.

Title: Tracking donor-reactive T cells: evidence for clonal deletion in tolerant kidney transplant patients

Yufeng Shen, H. Robins, T. Kawai, 2016 .

Immune tolerance in recipients of combined haploidentical bone marrow and kidney transplantation

M. Sykes, Megan Sykes, 2015, Bone Marrow Transplantation.

Translational studies in hematopoietic cell transplantation: treatment of hematologic malignancies as a stepping stone to tolerance induction.

M. Sykes, T. Spitzer, S. Strober, 2011, Seminars in immunology.

Mechanisms of Transplantation Tolerance in Animals and Humans

M. Sykes, 2009, Transplantation.

Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials.

M. Sykes, 2009, Transplantation.

High antigen levels do not preclude B‐cell tolerance induction to α1,3‐Gal via mixed chimerism

M. Sykes, F. Haspot, P. Bardwell, 2008, Xenotransplantation.

B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells.

M. Sykes, M. Carroll, F. Haspot, 2007, Blood.

Monitoring Antidonor Alloantibodies as a Predictive Assay for Renal Allograft Tolerance/Long-term Observations in Nonhuman Primates

R. Colvin, S. Saidman, T. Strom, 2006, Transplantation.

Roles of Deletion and Regulation in Creating Mixed Chimerism and Allograft Tolerance Using a Nonlymphoablative Irradiation-Free Protocol

T. Strom, S. Alexopoulos, X. Zheng, 2005, The Journal of Immunology.

Using a Nonlymphoablative Irradiation-Free Mixed Chimerism and Allograft Tolerance Roles of Deletion and Regulation in Creating

T. Strom, S. Alexopoulos, X. Zheng, 2005 .

Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites.

M. Sykes, Hiroshi Ito, Y. Takeuchi, 2004, Blood.

Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation.

S. Saidman, N. Tarbell, D. Sachs, 2003, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Porcine mononuclear cells adhere to human fibronectin independently of very late antigen‐5: implications for donor‐specific tolerance induction in xenotransplantation

M. Sykes, A. Simon, A. Warrens, 2002, Xenotransplantation.

Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-&agr; and tumor growth factor-&bgr; antibodies

J. Jackson, M. Sykes, J. Down, 2002, Transplantation.

Non-myeloblative induction of mixed hematopoietic chimerism: application to transplantation tolerance and hematologic malignancies in experimental and clinical studies.

M. Sykes, T. Spitzer, 2002, Cancer treatment and research.

Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance.

M. Sykes, M. Mapara, D. Pearson, 2001, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

HIGHLY DISPARATE XENOGENEIC SKIN GRAFT TOLERANCE INDUCTION BY FETAL PIG THYMUS IN THYMECTOMIZED MICE: Conditioning Requirements and the Role of Coimplantation of Fetal Pig Liver1

M. Sykes, J. Rodriguez-Barbosa, Yong Zhao, 2001, Transplantation.

Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation.

S. Saidman, D. Sachs, M. Sykes, 2001, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Both γδ T Cells and NK Cells Inhibit the Engraftment of Xenogeneic Rat Bone Marrow Cells and the Induction of Xenograft Tolerance in Mice1

M. Sykes, B. Nikolic, D. T. Cooke, 2001, The Journal of Immunology.

High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response.

D. Sachs, M. Sykes, L. Bühler, 2000, Transplantation.

Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier

D. Bodine, D. Sachs, M. Sykes, 2000, Xenotransplantation.

Role of antibody-independent complement activation in rejection of porcine bone marrow cells in mice.

M. Sykes, Y. Zhou, Y. Yang, 2000, Transplantation.

Levels of Ly-49 receptor expression are determined by the frequency of interactions with MHC ligands: evidence against receptor calibration to a "useful" level.

M. Sykes, G. Waneck, J. Manilay, 1999, Journal of immunology.

The role of atypical T cells and NK cells in inhibiting primary engraftment of xenogeneic donor rat bone marrow cells.

M. Sykes, B. Nikolic, D. T. Cooke, 1999, Transplantation proceedings.

Receptor Calibration to a ''Useful'' Level with MHC Ligands: Evidence Against Determined by the Frequency of Interactions Levels of Ly-49 Receptor Expression Are

M. Sykes, G. Waneck, J. Manilay, 1999 .

Hematopoietic chimerism and tolerance of T cells, B cells, and NK cells.

H. Ohdan, M. Sykes, T. Wekerle, 1998, Transplantation proceedings.

Function of porcine adhesion molecules in a human marrow microenvironment.

D. Sachs, M. Sykes, A. Simon, 1998, Transplantation.

Resistance to monoclonal antibody-induced CD8+ T-cell depletion in thymectomized MHC class II-deficient mice.

M. Sykes, Y. Zhao, 1997, Transplantation.

The mechanism of specific prolongation of class I‐mismatched skin grafts induced by retroviral gene therapy

D. Sachs, M. Sykes, J. Iacomini, 1997, European journal of immunology.

Tolerance and xenograft survival

D. Sachs, A. Cosimi, M. Sykes, 1995, Nature Medicine.

Xenochimerism and tolerance

M. Sykes, 1995 .

Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow.

D. Sachs, M. Sykes, Y. Tomita, 1994, Blood.

Xenotolerance Through Bone Marrow Transplantation

D. Sachs, M. Sykes, Y. Sharabi, 1991 .

Mixed Hematopoietic Chimerism for the Simultaneous Induction of T and B Cell Tolerance

M. Sykes, T. Kawahara, I. Shimizu, 2005, Transplantation.

Skin graft tolerance across a discordant xenogeneic barrier

D. Sachs, M. Sykes, Yong Zhao, 1996, Nature Medicine.

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.

G. Freeman, T. Honjo, T. Fehr, 2008, Blood.

Tolerization of Anti–Galα1-3Gal Natural Antibody–forming B Cells by Induction of Mixed Chimerism

H. Ohdan, M. Sykes, Yong-Guang Yang, 1998, The Journal of experimental medicine.

Mixed xenogeneic porcine chimerism tolerizes human anti‐pig natural antibody‐producing cells in a humanized mouse model

A. Vecchione, M. Sykes, M. Hölzl, 2021, Xenotransplantation.

Impact of Mixed Xenogeneic Porcine Hematopoietic Chimerism on Human NK Cell Recognition in a Humanized Mouse Model

M. Sykes, S. Chen, M. Hölzl, 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Hematopoietic Cell Transplantation for Induction of Transplantation Tolerance: From Animal Models to Clinical Trials

M. Sykes, 2010 .

Decay-Accelerating Factor Prevents Acute Humoral Rejection Induced by Low Levels of Anti-αGal Natural Antibodies

M. Sykes, I. Shimizu, Guiling Zhao, 2006, Transplantation.

T Cells from Presensitized Donors Fail to Cause Graft-versus-Host Disease in a Pig-to-Mouse Xenotransplantation Model

D. Sachs, Lan Wang, M. Sykes, 2004, Transplantation.

Stem cell activity of porcine c-kit+ hematopoietic cells.

D. Sachs, M. Sykes, Yong-Guang Yang, 2003, Experimental hematology.

Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier.

M. Sykes, Yong-Guang Yang, M. Abe, 2002, Blood.

Mixed Chimerism Review and Transplant Tolerance

M. Sykes, Transplantation Section, 2001 .

In vivo T-cell depletion enhances production of anti-GALalpha1,3GAL natural antibodies in alpha1,3-galactosyltransferase-deficient mice.

H. Ohdan, M. Sykes, A. Thall, 2000, Transplantation.

Reduction of anti-Galα1–3Gal natural antibodies in sera of α1,3-galactosyltransferase-deficient mice receiving gal-positive bone marrow transplantation

H. Ohdan, M. Sykes, Yong-Guang Yang, 1999 .

Interleukin-12 prevents severe acute graft-versus-host disease (GVHD) and GVHD-associated immune dysfunction in a fully major histocompatibility complex haplotype-mismatched murine bone marrow transplantation model.

M. Sykes, B. Dey, Y. Yang, 1997, Transplantation.

CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors.

V. Boussiotis, M. Sykes, Julia A. Brown, 2008, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Characterization of Anti-Gal Antibody-Producing Cells of Baboons and Humans

H. Ohdan, M. Sykes, Yong-Guang Yang, 2006, Transplantation.

Pharmacokinetic and pharmacodynamic study of a clinically effective anti‐CD2 monoclonal antibody

J. Hope, D. Sachs, M. Sykes, 2019, Scandinavian journal of immunology.

CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase.

D. Fuchs, M. Sykes, G. Brandacher, 2007, Transplantation.

Clinical relevance of recipient leukocyte infusion as antitumor therapy following nonmyeloablative allogeneic hematopoietic cell transplantation.

M. Sykes, M. Rubio, Toshiki I. Saito, 2006, Experimental hematology.

Role of indirect allo- and autoreactivity in anti-tumor responses induced by recipient leukocyte infusions (RLI) in mixed chimeras prepared with nonmyeloablative conditioning.

M. Sykes, M. Rubio, Guiling Zhao, 2006, Clinical immunology.

Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism.

F. Delmonico, S. Saidman, D. Sachs, 1999, Transplantation.

Transplantation: moving to the next level

M. Sykes, 2014, Immunological reviews.

Mixed Chimerism, Lymphocyte Recovery, and Evidence for Early Donor-Specific Unresponsiveness in Patients Receiving Combined Kidney and Bone Marrow Transplantation to Induce Tolerance

S. Saidman, F. Preffer, D. Dombkowski, 2010, Transplantation.

Anti‐tumour response despite loss of donor chimaerism in patients treated with non‐myeloablative conditioning and allogeneic stem cell transplantation

S. Saidman, N. Tarbell, F. Preffer, 2005, British journal of haematology.

Layers of regulation in induction of mixed chimerism by anti-CD40L

M. Sykes, C. Lucas, 2011, Chimerism.

A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo.

A. Rao, T. Fehr, M. Sykes, 2010, Blood.

Position Paper of the Ethics Committee of the International Xenotransplantation Association

M. Sykes, M. Sandrin, A. D'apice, 2003, Xenotransplantation.

Invariant NKT Cells Are Required for Antitumor Responses Induced by Host-Versus-Graft Responses

M. Sykes, Toshiki I. Saito, H. Li, 2010, The Journal of Immunology.

Host-Versus-Graft Responses Antitumor Responses Induced by Invariant NKT Cells Are Required for

M. Sykes, Toshiki I. Saito, H. Li, 2010 .

Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation

D. Sachs, M. Sykes, D. Amarnath, 2021, Xenotransplantation.

Interleukin-12 inhibits murine graft-versus-host disease.

G. Szot, M. Sykes, P. Nguyen, 1995, Blood.

Selective inhibition of CD4 graft-versus-host activity in IL-2-treated mice.

M. Sykes, D. Pearson, M. Harty, 1993, Transplantation proceedings.

THE MECHANISM OF IL‐2-MEDIATED PROTECTION AGAINST GVHD IN MICE: II. Protection Occurs Independently of NK/LAK Cells1

M. Sykes, V. S. Abraham, 1992, Transplantation.

Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. evidence for pig-specific T-cell unresponsiveness1

R. Colvin, D. Sachs, M. Sykes, 2003, Transplantation.

Mechanism of tolerance following class II gene transduction of autologous swine bone marrow.

T. Sablinski, D. Sachs, M. Sykes, 1997, Transplantation proceedings.

The critical role of mouse CD4+ cells in the rejection of highly disparate xenogeneic pig thymus grafts

M. Sykes, J. Rodriguez-Barbosa, T. Wekerle, 2000, Xenotransplantation.

International Human Xenotransplantation Inventory

P. Morel, M. Sykes, L. Bühler, 2010, Transplantation.

Efficacy of adhesive interactions in pig-to-human xenotransplantation.

M. Sykes, A. Simon, A. Warrens, 1999, Immunology today.

Positive and negative selection of functional mouse CD4 cells by porcine MHC in pig thymus grafts.

D. Sachs, M. Sykes, J. J. Sergio, 1997, Journal of immunology.

Discordant xenogeneic neonatal thymic transplantation can induce donor-specific tolerance.

D. Sachs, M. Sykes, D. Pearson, 1997, Transplantation.

Advances in xenotransplantation: is the Gal knockout pig essential to clinical success?

M. Sykes, Kazuhiko Yamada, 2007 .

The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice.

D. Sachs, M. Sykes, J. Rodriguez-Barbosa, 2000, Transplantation.

Cross-species interaction of porcine and human integrins with their respective ligands: implications for xenogeneic tolerance induction.

D. Sachs, M. Sykes, A. Simon, 1998, Transplantation.

Effects of T cell depletion in radiation bone marrow chimeras. III. Characterization of allogeneic bone marrow cell populations that increase allogeneic chimerism independently of graft-vs-host disease in mixed marrow recipients.

T. Sundt, D. Sachs, M. Sykes, 1989, Journal of immunology.

Results of Gal‐Knockout Porcine Thymokidney Xenografts

D. Sachs, M. Sykes, S. Robson, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction.

D. Kraft, S. Damrauer, D. Sachs, 2007, The Journal of infectious diseases.

XENOGENEIC THYMUS TRANSPLANTATION IN A PIG-TO-

R. Colvin, J. Wain, D. Sachs, 2003 .

Xenogeneic thymic replacement to achieve immune restoration in HIV infection

R. Johnson, D. Sachs, M. Sykes, 2003 .

Cells to Porcine Donor MHC Grafts and Specific Tolerance of Human T Normal Development in Porcine Thymus

D. Scadden, D. Sachs, M. Sykes, 1999 .

Persistence of donor-derived protein in host myeloid cells after induced rejection of engrafted allogeneic bone marrow cells.

Charles P. Lin, M. Sykes, Joji Fujisaki, 2009, Experimental hematology.

Allospecific Rejection of MHC Class I‐Deficient Bone Marrow by CD8 T Cells

T. Fehr, S. Beyaz, M. Sykes, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

GalT-KO pigs: is the cup half empty or half full?

R. Colvin, D. Sachs, M. Sykes, 2007, Transplantation.

Vascularized Thymic Lobe Transplantation in a Pig-to-Baboon Model: A Novel Strategy for Xenogeneic Tolerance Induction and T-cell Reconstitution

D. Sachs, D. Neville, M. Sykes, 2005, Transplantation.

Decreased graft-versus-host disease after haplotype mismatched bone marrow allografts in miniature swine following interleukin-2 treatment

T. Sablinski, M. Sykes, H. Kitamura, 2000, Bone Marrow Transplantation.

Novel approaches to the control of graft versus host disease.

M. Sykes, 1993, Current opinion in immunology.

OriginalClinicalScienceçGeneral Long-term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation

M. Sykes, D. Farber, Mercedes Martinez, 2017 .

Human–porcine receptor–ligand compatibility within the immune system: relevance for xenotransplantation

M. Sykes, A. Warrens, P. Theodore, 1999, Xenotransplantation.

Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model.

M. Sykes, Yong-Guang Yang, K. Habiro, 2008, Blood.

48 – Transplantation Immunology

M. Sykes, 2012 .

Dynamics of B Cell Recovery In Kidney/Bone Marrow Transplant Recipients

S. Saidman, F. Preffer, D. Sachs, 2017, Transplantation.

Mechanism of protection from graft-versus-host disease mortality by IL-2. III. Early reductions in donor T cell subsets and expansion of a CD3+CD4-CD8- cell population.

D. Sachs, M. Sykes, V. S. Abraham, 1992, Journal of immunology.

Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants.

B. Yeap, N. Tarbell, D. Sachs, 2003, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12–14, 2018

E. Wolf, R. Pierson, M. Luo, 2019, Xenotransplantation.

Xenotransplantation: current status and a perspective on the future

Megan Sykes, M. Sykes, Yong-Guang Yang, 2007, Nature Reviews Immunology.

Mechanisms of transplant tolerance induction using costimulatory blockade.

M. Sykes, T. Wekerle, J. Kurtz, 2002, Current opinion in immunology.

Nonalloreactive T Cells Prevent Donor Lymphocyte Infusion–Induced Graft-versus-Host Disease by Controlling Microbial Stimuli

R. Bronson, M. Sykes, H. Li, 2012, The Journal of Immunology.

An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues

Charles P. Lin, Charles Lin, Ronjon Chakraverty, 2006, The Journal of experimental medicine.

Organ transplantation—how much of the promise has been realized?

Megan Sykes, R. Lechler, L. Turka, 2005, Nature Medicine.

HLA-mismatched renal transplantation without maintenance immunosuppression.

V. Sharma, M. Suthanthiran, R. Colvin, 2008, The New England journal of medicine.

Hematopoietic stem cell quiescence maintained by p21cip1/waf1.

D. Scadden, D. Dombkowski, T. Cheng, 2000, Science.

Hematopoietic Stem Cell Quiescence Maintained by p 21 cip 1 / waf 1

D. Scadden, D. Dombkowski, T. Cheng, 2022 .

IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host-disease.

G. Szot, M. Sykes, J. Szebeni, 1994, Transplantation.

Role for CD47-SIRPα signaling in xenograft rejection by macrophages

Hideki Ohdan, Megan Sykes, Hiroyuki Tahara, 2007, Proceedings of the National Academy of Sciences.

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

Charles P. Lin, D. Côté, Lev Silberstein, 2011, Nature.

Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.

Clare L. Bennett, G. Freeman, S. Henderson, 2010, The Journal of clinical investigation.

Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets.

M. Sykes, D. Turner, D. Farber, 2013, Immunity.

High Throughput Human T Cell Receptor Sequencing: A New Window Into Repertoire Establishment and Alloreactivity

M. Sykes, Jianing Fu, M. Khosravi-Maharlooei, 2021, Frontiers in Immunology.

Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation.

Aaron M. Rosenfeld, Yufeng Shen, A. Iuga, 2021, The Journal of clinical investigation.

Alloimmune T cells in transplantation

M. Sykes, S. DeWolf, Susan Dewolf, 2017, The Journal of clinical investigation.

Mixed chimerism and transplant tolerance.

M. Sykes, Megan Sykes, 2001, Immunity.

IL-2-induced GVHD protection is not inhibited by cyclosporine and is maximal when IL-2 is given over a 25 h period beginning on the day following bone marrow transplantation.

G. Szot, M. Sykes, D. Pearson, 1995, Bone marrow transplantation.

Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells.

M. Sykes, Yong-Guang Yang, Min-Guang Wang, 2002, Blood.

Dose and timing of interleukin (IL)-12 and timing and type of total-body irradiation: effects on graft-vs.-host disease inhibition and toxicity of exogenous IL-12 in murine bone marrow transplant recipients.

G. Szot, M. Sykes, B. Blazar, 1999, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Emerging concepts in haematopoietic cell transplantation

M. Sykes, H. Li, 2012, Nature Reviews Immunology.

High-Yield Monocyte, Macrophage, and Dendritic Cell Differentiation from Induced Pluripotent Stem Cells

M. Wallet, C. Mathews, D. Egli, 2021, bioRxiv.

Lineage‐Negative Side‐Population (SP) Cells with Restricted Hematopoietic Capacity Circulate in Normal Human Adult Blood: Immunophenotypic and Functional Characterization

D. Scadden, F. Preffer, D. Dombkowski, 2002, Stem cells.

How Safe Are Universal Pluripotent Stem Cells?

D. Egli, M. Sykes, R. Creusot, 2020, Cell stem cell.

B-cell reconstitution and xenoreactive anti-pig natural antibody production in severe combined immunodeficient mice reconstituted with immunocompetent B cells from varying sources.

M. Sykes, R. Barth, E. Degoma, 1998, Transplantation.

Cross-species compatibility of intercellular adhesion molecule-1 (CD54) with its ligands.

D. Sachs, M. Sykes, A. Simon, 2000, Transplantation.

Induction of mixed chimerism through transplantation of CD45-congenic mobilized peripheral blood stem cells after nonmyeloablative irradiation.

M. Sykes, T. Wekerle, E. Selzer, 2006, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Short-Term Immunosuppression Facilitates Induction of Mixed Chimerism and Tolerance after Bone Marrow Transplantation without Cytoreductive Conditioning

M. Sykes, T. Wekerle, S. Bigenzahn, 2005, Transplantation.

Antiviral T cell competence and restriction specificity of mixed allogeneic (P1 + P2----P1) irradiation chimeras.

R. Zinkernagel, D. Sachs, M. Sykes, 1989, Cellular immunology.

The Fourth International Workshop on Clinical Transplant Tolerance

P. Nickerson, T. Kawai, J. Madsen, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Mechanism of protection from graft-vs-host disease in murine mixed allogeneic chimeras. I. Development of a null cell population suppressive of cell-mediated lympholysis responses and derived from the syngeneic bone marrow component.

D. Sachs, M. Sykes, A. Eisenthal, 1988, Journal of immunology.

Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant.

S. Saidman, F. Preffer, D. Dombkowski, 2002, Cytokines, cellular & molecular therapy.

Mixed chimerism.

D. Sachs, M. Sykes, 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Dissociating graft-vs-host disease from the graft-vs-leukemia effect of allogeneic T cells: the potential role of IL-2.

M. Sykes, 1992, Bone marrow transplantation.

Transplantation: Bone marrow and solid organ transplantation start to converge

M. Sykes, 1999 .

Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance.

D. Sachs, M. Sykes, Y. Sharabi, 1992, Bone marrow transplantation.

Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients

Yufeng Shen, Tatsuo Kawai, Megan Sykes, 2015, Science Translational Medicine.

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.

S. Beyaz, M. Sykes, D. Vignali, 2011, Blood.

Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool.

Michael T. Simpson, Xinzheng V. Guo, Yufeng Shen, 2019, Cell stem cell.

American Society of Transplantation Symposium on B Cells in Transplantation: Harnessing Humoral Immunity from Rodent Models to Clinical Practice

A. Kirk, W. Baldwin, M. Sykes, 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Longitudinal Studies of a B Cell–Derived Signature of Tolerance in Renal Transplant Recipients

A. Kirk, W. Marks, D. Sachs, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The Host Environment Regulates the Function of CD8+ Graft-versus-Host-Reactive Effector Cells1

F. Fallah-Arani, M. Sykes, H. Eom, 2008, The Journal of Immunology.

Induction of mixed vs full chimerism to potentiate GVL effects after bone-marrow transplantation.

M. Sykes, M. Mapara, 2005, Methods in molecular medicine.

Immune tolerance: mechanisms and application in clinical transplantation

M. Sykes, Megan Sykes, 2007, Journal of internal medicine.

Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies.

James Hope, Megan Sykes, F. Preffer, 2003, Transplantation.

Quantifying size and diversity of the human T cell alloresponse.

Yufeng Shen, M. Sykes, A. Obradović, 2018, JCI insight.

Human organ and tissue transplantation. Commentary

Abdallah S. Daar, Megan Sykes, Francis L. Delmonico, 2005 .

Achievement of sustained remissions despite loss of donor chimerism in patients with chemotherapy-refractory non-Hodgkins lymphoma treated with nonmyeloablative conditioning and allogeneic stem cell transplantation

S. Saidman, D. Sachs, M. Sykes, 2001 .

Immune evasion by chimeric trachea.

M. Sykes, 2010, The New England journal of medicine.

Macrochimerism in Intestinal Transplantation: Association With Lower Rejection Rates and Multivisceral Transplants, Without GVHD

J. Emond, M. Sykes, T. Kato, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Mechanisms of Mixed Chimerism-Based Transplant Tolerance.

M. Sykes, J. Zuber, 2017, Trends in immunology.

Response to ‘Tolerance Versus Immunosuppression: A Perspective’

T. Kawai, A. Cosimi, M. Sykes, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

Andrew D. Luster, Gordon J. Freeman, Christian Brander, 2009, Journal of Virology.

Interleukin-15 Receptor α Chain Knockout NOD-SCID mice have reduced numbers of NK cells, develop thymic lymphomas and fail to engraft human hematopoietic cells

A. Vecchione, M. Wiles, M. Sykes, 2021, bioRxiv.

HSC extrinsic sex-related and intrinsic autoimmune disease-related human B-cell variation is recapitulated in humanized mice.

E. Meffre, M. Sykes, R. Goland, 2017, Blood advances.

A New Window into the Human Alloresponse

Yufeng Shen, M. Sykes, S. DeWolf, 2016, Transplantation.

Attenuation of phagocytosis of xenogeneic cells by manipulating CD47.

Hui Wang, Shumei Wang, M. Sykes, 2007, Blood.

Early expansion of donor-specific Tregs in tolerant kidney transplant recipients.

Michael T. Simpson, Yufeng Shen, L. Turka, 2018, JCI insight.

T cell repertoire analysis suggests a prominent bystander response in human cardiac allograft vasculopathy

D. Mancini, C. Marboe, M. Sykes, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Elimination of Porcine Hemopoietic Cells by Macrophages in Mice1

M. Sykes, Yong-Guang Yang, A. Thall, 2002, The Journal of Immunology.

Prospective Tracking of Donor-Reactive T-Cell Clones in the Circulation and Rejecting Human Kidney Allografts

Stephan M. Winkler, A. Heinzel, M. Sykes, 2021, Frontiers in Immunology.

Cellular modulation of acute graft-vs.-host disease.

D. Sachs, M. Sykes, C. Colby, 1997, Biology of Blood and Marrow Transplantation.

Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors

M. Sykes, 2022 .

The prospect of universal coronavirus immunity: a characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses

P. Muranski, M. Sykes, R. Ciubotariu, 2023, bioRxiv.

Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro

M. Sykes, A. Obradović, D. Berglund, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Impact of CMV Reactivation, Treatment Approaches, and Immune Reconstitution in a Nonmyeloablative Tolerance Induction Protocol in Cynomolgus Macaques

A. Iuga, C. Wuu, M. Sykes, 2020, Transplantation.

OX40- and CD27-Mediated Costimulation Synergizes with Anti–PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence

Clare L. Bennett, G. Freeman, A. Rogel, 2015, The Journal of Immunology.

HLA-mismatched renal transplantation without maintenance immunosuppression.

V. Sharma, M. Suthanthiran, R. Colvin, 2008, The New England journal of medicine.

Peritoneal Cavity B Cells Are Precursors of Splenic IgM Natural Antibody-Producing Cells 1

H. Ohdan, M. Sykes, Yong-Guang Yang, 2003, The Journal of Immunology.

Mechanisms of Donor‐Specific Tolerance in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation

F. Preffer, D. Sachs, T. Kawai, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Mixed Bone Marrow Reconstitution Across MHC Barriers

D. Sachs, M. Sykes, C. H. Chester, 1991 .

Mixed Bone Marrow Chimeras as an Approach to Transplantation Tolerance

D. Sachs, M. Sykes, C. H. Chester, 1987 .

Tolerance Induction for Xenotransplantation

M. Sykes, Yong-Guang Yang, Yong Zhao, 1997, World Journal of Surgery.

Protecting the host naturally

M. Sykes, T. Spitzer, 2005, Nature Medicine.

IXA Honorary Member Lecture, 2017: The long and winding road to tolerance

M. Sykes, 2018, Xenotransplantation.

Deletion of donor‐reactive T cell clones after human liver transplant

Yufeng Shen, H. Robins, M. Sykes, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Safety and pharmacodynamics of anti‐CD2 monoclonal antibody treatment in cynomolgus macaques – an experimental study

K. Reimann, A. Iuga, D. Sachs, 2020, Transplant international : official journal of the European Society for Organ Transplantation.

Effects of xenogeneic thymic transplantation in baboons.

J. Wain, D. Sachs, D. Neville, 2001, Transplantation proceedings.

T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism.

H. Ohdan, M. Sykes, H. Kitamura, 2001, Transplantation.

(2) Cotransplantation of vascularized thymus and kidney from GalT‐KO pigs to baboons

D. Sachs, M. Sykes, A. Griesemer, 2007 .

Abnormal Regulatory and Effector T Cell Function Predispose to Autoimmunity following Xenogeneic Thymic Transplantation1

R. Bronson, M. Sykes, A. Shimizu, 2008, The Journal of Immunology.

Response to Valdes‐Gonzalez ‘‘Clinical trial of islet xenotransplantation in Mexico’’

M. Sykes, R. Pierson III, J. Soulillou, 2007, Xenotransplantation.

Reduced positive selection of a human TCR in a swine thymus using a humanized mouse model for xenotolerance induction

M. Sykes, N. Danzl, Grace Nauman, 2019, Xenotransplantation.

Tolerance to discordant xenografts. I. Sharing of human natural antibody determinants on miniature swine bone marrow cells and endothelial cells.

D. Sachs, M. Sykes, D. Vitiello, 1994, Transplantation.

Xenotransplantation of pig islets into Mexican children: were the fundamental ethical requirements to proceed with such a study really met?

M. Sykes, E. Cozzi, 2006, European journal of endocrinology.

Letter to Authors

M. Sykes, D. Cooper, 2006 .

Clinical trial of islet xenotransplantation in Mexico

B. Hering, M. Sykes, P. O’Connell, 2006, Xenotransplantation.

Guidelines for xenotransplantation.

M. Sykes, M. Sandrin, A. D'apice, 2003, New England Journal of Medicine.

Novel H-shunt Venovenous Bypass for Liver Transplantation in Cynomolgus Macaques.

M. Sykes, A. Romanov, Mercedes Martinez, 2017, Comparative medicine.

World Health Organization resolution on xenotransplantation

M. Sykes, M. Sandrin, M. Rees, 2004, Xenotransplantation.

Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire.

Yufeng Shen, Megan Sykes, Keshav Motwani, 2019, The Journal of clinical investigation.

T1D patient-derived hematopoietic stem cells are programmed to generate Tph, Tfh, and autoimmunity-associated B cell subsets in human immune system mice.

M. Sykes, G. Fousteri, N. Danzl, 2022, Clinical immunology.

Transplant Arteriopathy Tolerance, Mixed Chimerism, and Chronic

R. Colvin, M. Sykes, P. Russell, 2001 .

Splenic IgM Natural Antibody-Producing Peritoneal Cavity B Cells Are Precursors of

H. Ohdan, M. Sykes, Yong-Guang Yang, 2003 .

CD40L‐stimulated B cells for ex‐vivo expansion of polyspecific non‐human primate regulatory T cells for translational studies

M. Sykes, A. Griesemer, S. Ho, 2020, Clinical and experimental immunology.

Extreme Oxygen Sensitivity of Electronic Properties of Carbon Nanotubes

Neil Rodrigues, Megan Sykes, D. Scadden, 2022 .

Clonal deletion as a mechanism of transplantation tolerance.

M. Sykes, B. Nikolic, 1996, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Deletion of donor-reactive T cell clones following human liver transplantation

Yufeng Shen, M. Sykes, A. Shaked, 2020 .

A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons.

D. Sachs, M. Sykes, L. Bühler, 2000, Transplantation proceedings.

Origin, phenotype and autoimmune potential of T cells in human immune system mice receiving neonatal human thymus tissue

Hui Wang, M. Sykes, Amber N. Wolabaugh, 2023, Frontiers in Immunology.

Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs

M. Sykes, N. Danzl, M. Hölzl, 2022, The Journal of Immunology.

The Women of FOCIS: Promoting Equality and Inclusiveness in a Professional Federation of Clinical Immunology Societies

E. Reed, M. Sykes, M. Roncarolo, 2022, Frontiers in Immunology.

Transient-mixed Chimerism With Nonmyeloablative Conditioning Does Not Induce Liver Allograft Tolerance in Nonhuman Primates.

M. Sykes, B. Karolewski, Mercedes Martinez, 2020, Transplantation.

Reply to 'Critics slam Russian trial to test pig pancreas for diabetes'

R. Pierson, B. Hering, M. Sykes, 2007, Nature Medicine.

Developing pig-to-human organ transplants

M. Sykes, 2022, Science.

Understanding the Role of the Immune System in Improving Tissue Regeneration

M. Sykes, M. Friedlander, 2022 .

T cell repertoire profiling in allografts and native tissues in recipients with COVID–19 after solid organ transplantation: Insight into T cell–mediated allograft protection from viral infection

M. Sykes, Jianing Fu, J. Weiner, 2022, Frontiers in Immunology.

Leveraging the lymphohematopoietic graft-versus-host reaction (LGVHR) to achieve allograft tolerance and restore self tolerance with minimal toxicity

M. Sykes, 2023, Immunotherapy advances.

Induction of specific tolerance to MHC-disparate allografts through genetic engineering.

A. Nienhuis, D. Bodine, D. Sachs, 1993, Experimental nephrology.

Xenotransplantation from pig to cynomolgus monkey: the potential for overcoming xenograft rejection through induction of chimerism.

T. Sablinski, R. Colvin, M. Sykes, 1994, Transplantation proceedings.

Xenotransplantation from pig to cynomolgus monkey: approach toward tolerance induction.

T. Kawai, H. Bazin, M. Sykes, 1993, Transplantation proceedings.

Effect of natural antibody on xenogeneic bone marrow engraftment.

D. Sachs, M. Sykes, I. Aksentijevich, 1992, Transplantation proceedings.

Enhanced porcine hematopoiesis in mice receiving donor-specific interleukin-3.

M. Sykes, R. Monroy, Y. Yang, 1996, Transplantation proceedings.

INHIBITION OF GRAFT‐VERSUS‐HOST DISEASE BY INTERLEUKIN‐2 TREATMENT IS ASSOCIATED WITH ALTERED CYTOKINE PRODUCTION BY EXPANDED GRAFT‐VERSUS‐HOST‐REACTIVE CD4+ HELPER CELLS

J Szebeni, G. Szot, M. Sykes, 1995, Transplantation.

The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity.

D. Schadendorf, P. Shah, J. Marine, 2023, Cancer cell.

Tribute to Eda T. Bloom, PhD

M. Sykes, J. Fishman, Carolyn Wilson, 2008 .

Cheng, T. et al. Hematopoietic stem cell quiescence maintained by 21cip1/waf1. Science 287, 1804-1808

D. Scadden, D. Dombkowski, T. Cheng, 2000 .

Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade.

M. Sykes, M. Sayegh, A. Chandraker, 1999, Transplantation proceedings.

Both gamma delta T cells and NK cells inhibit the engraftment of xenogeneic rat bone marrow cells and the induction of xenograft tolerance in mice.

M. Sykes, B. Nikolic, D. T. Cooke, 2001, Journal of immunology.

Induction of tolerance through mixed chimerism.

D. Sachs, T. Kawai, M. Sykes, 2014, Cold Spring Harbor perspectives in medicine.

HLA-mismatched renal transplantation without maintenance immunosuppression.

D. Sachs, T. Kawai, A. Cosimi, 2013, The New England journal of medicine.

β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells

D. Egli, M. Sykes, Yong Wang, 2017, Diabetes.

High antigen levels do not preclude B‐cell tolerance induction to α1,3‐Gal via mixed chimerism

M. Sykes, F. Haspot, P. Bardwell, 2008, Xenotransplantation.

Graft-versus-Host Disease and Graft-versus-Leukemic Effect in Allogeneic Bone Marrow Transplantation: Role of Interferon-{gamma}

M. Sykes, Yong-Guang Yang, 2002 .

Invariant NKT Cells Are Required for Antitumor Responses Induced by Host-Versus-Graft Responses

M. Sykes, Toshiki I. Saito, H. Li, 2010, The Journal of Immunology.

Occurrence of specific humoral non‐responsiveness to swine antigens following administration of GalT‐KO bone marrow to baboons

D. Sachs, M. Sykes, A. Griesemer, 2010, Xenotransplantation.

Experience with porcine thymic transplantation in baboons.

D. Sachs, D. Neville, M. Sykes, 2000, Transplantation Proceedings.

Xenogeneic thymic transplantation in a pig-to-nonhuman primate model.

J. Wain, D. Sachs, D. Neville, 1999, Transplantation Proceedings.

On cardiac xenotransplantation and the role of xenogeneic tolerance.

E. Bacha, M. Sykes, A. Goldstone, 2022, The Journal of thoracic and cardiovascular surgery.

LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L.

S. Beyaz, M. Sykes, D. Vignali, 2011, Blood.

Mixed swine/human long-term bone marrow cultures.

D. Sachs, M. Sykes, C. Leguern, 1994, Transplantation proceedings.

Humoral tolerance in mixed xenogeneic chimeras prepared by a nonmyeloablative conditioning regimen.

T. Sundt, D. Sachs, M. Sykes, 1991, Transplantation proceedings.

Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.

Clare L. Bennett, S. Henderson, F. Fallah-Arani, 2010, The Journal of clinical investigation.

T.32. Mechanisms of Donor-Specific Unresponsiveness Following Loss of Chimerism in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation

S. Saidman, F. Preffer, D. Sachs, 2009 .

Integrated analysis toolset for defining and tracking alloreactive T-cell clones after human solid organ and hematopoietic stem cell transplantation

Megan Sykes, Yufeng Shen, Jianing Fu, 2021, Softw. Impacts.

A step closer to effective transplant tolerance?

J. Bluestone, H. Waldmann, L. Turka, 2012, Nature Medicine.

The first Joint Conference of the Cell Transplant Society (CTS), International Pancreas and Islet Transplant Association (IPITA), and International Xenotransplantation Association (IXA), all sections of The Transplantation Society (TTS), took place in Minneapolis, Minn, USA, from September 15-20, 20

B. Hering, D. Sutherland, M. Sykes, 2008, Transplantation proceedings.

A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo.

A. Rao, T. Fehr, M. Sykes, 2010, Blood.

Pitfalls and Future Directions of Contemporary Pediatric Valve Surgery: the Case for Living Valve Substitutes

E. Bacha, M. Sykes, G. Ferrari, 2023, Current Pediatrics Reports.

Effect of natural killer cell depletion on long-term multilineage allogeneic bone marrow engraftment.

D. Sachs, M. Sykes, L. Lee, 1993, Transplantation proceedings.

Ethics Committee of the International Xenotransplantation Association. Guidelines for xenotransplantation

M. Sykes, 2003 .

Immune evasion by chimeric trachea.

M. Sykes, 2010, The New England journal of medicine.

Alloresistance to K locus class I-mismatched bone marrow engraftment is mediated entirely by CD4+ and CD8+ T cells.

D. Sachs, M. Sykes, C. Leguern, 1996, Bone marrow transplantation.

Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene.

D. Sachs, M. Sykes, J. Iacomini, 1997, Transplantation proceedings.