Ghada S. Hassan

发表

Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells.

H. Rui, F. Sotgia, M. Lisanti, 2006, The American journal of pathology.

Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer.

C. Supuran, Ghada S. Hassan, H. Alkahtani, 2018, Bioorganic chemistry.

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.

C. Supuran, Ghada S. Hassan, H. Abdel‐Aziz, 2019, European journal of medicinal chemistry.

Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression

M. Loda, F. Sotgia, M. Lisanti, 2007, Cancer biology & therapy.

Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer

Massimo Loda, Michael P. Lisanti, M. Loda, 2005, Journal of Biological Chemistry.

Trypanosoma cruzi Infection Induces Proliferation of Vascular Smooth Muscle Cells

G. Christ, M. Lisanti, C. Albanese, 2006, Infection and Immunity.

CD 154 : An ImmunoinflammatoryMediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis

Ghada S. Hassan, N. Alaaeddine, Daniel Yacoub, 2014 .

CD154: An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis

Ghada S. Hassan, N. Alaaeddine, W. Mourad, 2011, Clinical & developmental immunology.

Implication of CD154/CD40 Interaction in Healthy and Autoimmune Responses

Ghada S. Hassan, M. Polyak, W. Mourad, 2009 .

Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation

Ghada S. Hassan, H. Alkahtani, Wagdy M. Eldehna, 2020, Marine drugs.

Nonclassical antifolates, part 4. 5-(2-aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: synthesis, biological evaluation and molecular modeling study.

K. Mohamed, Ghada S. Hassan, W. Fayad, 2013, European journal of medicinal chemistry.

Effect of human urotensin-II infusion on hemodynamics and cardiac function.

Z. Ao, S. Douglas, R. Willette, 2003, Canadian journal of physiology and pharmacology.

CD154: the atherosclerotic risk factor in rheumatoid arthritis?

Ghada S. Hassan, Y. Merhi, N. Alaaeddine, 2013, Arthritis Research & Therapy.

CD40 ligand: a neo-inflammatory molecule in vascular diseases.

Ghada S. Hassan, Y. Merhi, W. Mourad, 2012, Immunobiology.

Fingolimod (FTY720) As an Anti-Multiple Sclerosis Oral Ultimate Therapy

Ghada S. Hassan, F. Alqahtani, F. Aleanizy, 2015 .

The Interaction of CD154 with the α5β1 Integrin Inhibits Fas-Induced T Cell Death

F. Aoudjit, Ghada S. Hassan, N. Alaaeddine, 2016, PloS one.

New benzimidazothiazole derivatives as anti-inflammatory, antitumor active agents: Synthesis, in-vitro and in-vivo screening and molecular modeling studies.

Ghada S. Hassan, H. Abdel‐Aziz, Mariam A. Ghaly, 2019, Bioorganic chemistry.

CD154 from the Cell Surface Inhibits CD40-Dependent and -Independent Cleavage of Monoclonal Antibody Targeting the CD154 Cleavage Site

Ghada S. Hassan, W. Mourad, Y. Darif, 2021 .

Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis

Ghada S. Hassan, W. Mourad, S. Salti, 2022, Cells.

Cyclohepta[b]thiophenes as Potential Antiproliferative Agents: Design, Synthesis, In Vitro, and In Vivo Anticancer Evaluation.

S. Geary, Ghada S. Hassan, A. Salem, 2020, ACS pharmacology & translational science.

New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies.

Ghada S. Hassan, H. Abdel‐Aziz, Mariam A. Ghaly, 2022, Bioorganic chemistry.

Distinct spatial distribution and roles of Kupffer cells and monocyte-derived macrophages in mouse acute liver injury

Mohamed N Abdelnabi, A. Di Polo, Ghada S. Hassan, 2022, Frontiers in Immunology.

CD154 inhibits death of T cells via a Cis interaction with the α5β1 integrin

F. Aoudjit, Ghada S. Hassan, W. Mourad, 2020, PloS one.

Role of CD154 in cancer pathogenesis and immunotherapy.

Ghada S. Hassan, W. Mourad, J. Stagg, 2015, Cancer treatment reviews.

Requirement of Transmembrane Domain for CD154 Association to Lipid Rafts and Subsequent Biological Events

Ghada S. Hassan, W. Mourad, Daniel Yacoub, 2012, PloS one.

Involvement of the cytoplasmic cysteine-238 of CD40 in its up-regulation of CD23 expression and its enhancement of TLR4-triggered responses.

Ghada S. Hassan, W. Mourad, Daniel Yacoub, 2015, International immunology.

Novel Pyruvate Kinase (PK) Inhibitors: New Target to Overcome Bacterial Resistance

Ghada S. Hassan, R. Khattab, Mardia T. El Sayed, 2020 .

Enhancement of Rituximab-induced cell death by the physical association of CD20 with CD40 molecules on the cell surface.

Ghada S. Hassan, H. El-Gabalawy, W. Mourad, 2014, International immunology.

Synthesis and antitumor testing of certain new fused triazolopyrimidine and triazoloquinazoline derivatives

Ghada S. Hassan, F. Badria, S. M. Bayomi, 2017 .

Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice.

M. Loda, M. Lisanti, D. Di Vizio, 2005, The Journal of biological chemistry.

Design, synthesis, anti-inflammatory activity and molecular docking of potential novel antipyrine and pyrazolone analogs as cyclooxygenase enzyme (COX) inhibitors.

Ghada S. Hassan, E. Zarie, N. Morsy, 2018, Bioorganic & medicinal chemistry letters.

Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC

Ghada S. Hassan, H. Abdel‐Aziz, Azza H. Rageh, 2019, BMC Chemistry.

New Imidazole-4-one and Imidazolidine-2,4-dione Analogues: Design, Synthesis, Antitumor activity and Molecular Modeling Study

Ghada S. Hassan, H. El-Subbagh, S. M. El-Sayed, 2018 .

CD154 Is Released from T-cells by a Disintegrin and Metalloproteinase Domain-containing Protein 10 (ADAM10) and ADAM17 in a CD40 Protein-dependent Manner*

Ghada S. Hassan, W. Mourad, Daniel Yacoub, 2013, The Journal of Biological Chemistry.

Coexpression of TLR2 or TLR4 with HLA-DR Potentiates the Superantigenic Activities of Mycoplasma arthritidis–Derived Mitogen

Ghada S. Hassan, W. Mourad, Y. El Fakhry, 2014, The Journal of Immunology.

Mycoplasma arthritidis Activities of HLA-DR Potentiates the Superantigenic Coexpression of TLR2 or TLR4 with

Ghada S. Hassan, W. Mourad, M. Shio, 2014 .

CD40-mediated cell death requires TRAF6 recruitment.

Ghada S. Hassan, W. Mourad, A. Nadiri, 2012, Immunobiology.

Novel 4(3H)-quinazolinone analogs: synthesis and anticonvulsant activity

Ghada S. Hassan, M. Sayed-Ahmed, O. Al‐Shabanah, 2013, Medicinal Chemistry Research.

New Thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, Molecular modeling and ADMET study.

Ghada S. Hassan, Sara T. A. Al-Rashood, Moataz A. Shaldam, 2020, Bioorganic & medicinal chemistry letters.

Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues.

Ghada S. Hassan, A. El-Emam, L. Gad, 2010, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

DNA binding studies of novel diazatruxenones analogs as potential anticancer agents: Synthesis, antitumor investigation, DNA binding, SAR and molecular modeling calculation.

Ghada S. Hassan, Mardia T. El Sayed, S. M. El-Sayed, 2020, Bioorganic chemistry.

Towards breast cancer targeting: Synthesis of tetrahydroindolocarbazoles, antibreast cancer evaluation, uPA inhibition, molecular genetic and molecular modelling studies.

Ghada S. Hassan, Mohamed El-Naggar, Mamdouh M. Ali, 2019, Bioorganic chemistry.

Synthesis, antimicrobial, anti-biofilm evaluation, and molecular modelling study of new chalcone linked amines derivatives

Ghada S. Hassan, Sara T. A. Al-Rashood, E. E. Habib, 2018, Journal of enzyme inhibition and medicinal chemistry.

Substituted thiazoles V. synthesis and antitumor activity of novel thiazolo[2,3-b]quinazoline and pyrido[4,3-d]thiazolo[3,2-a]pyrimidine analogues.

Ghada S. Hassan, Fatmah A. M. Al-Omary, H. El-Subbagh, 2012, European journal of medicinal chemistry.

Synthesis and anticancer activity of new thiazolo[3,2-a]pyrimidines: DNA binding and molecular modeling study.

Ghada S. Hassan, Ahmadi Abbas, Shahenda M. El-Messery, 2017, Bioorganic chemistry.

Design, synthesis, anti-inflammatory antitumor activities, molecular modeling and molecular dynamics simulations of potential naprosyn® analogs as COX-1 and/or COX-2 inhibitors.

Ghada S. Hassan, E. Zarie, H. Abdel‐Aziz, 2018, Bioorganic chemistry.

Synthesis and Biological Evaluation of Some Polymethoxylated Fused Pyridine Ring Systems as Antitumor Agents

Ghada S. Hassan, H. El-Subbagh, Sherif A F Rostom, 2009, Archiv der Pharmazie.

Tyrosine kinase inhibition effects of novel Pyrazolo[1,5-a]pyrimidines and Pyrido[2,3-d]pyrimidines ligand: Synthesis, biological screening and molecular modeling studies.

Ghada S. Hassan, H. Abdel‐Aziz, M. Nayel, 2018, Bioorganic chemistry.

Nonclassical antifolates, part 5. Benzodiazepine analogs as a new class of DHFR inhibitors: synthesis, antitumor testing and molecular modeling study.

Ghada S. Hassan, Sara T. A. Al-Rashood, Fatmah A. M. Al-Omary, 2014, European journal of medicinal chemistry.

Synthesis and antitumor activity of certain new thiazolo[2,3-b]quinazoline and thiazolo[3,2-a]pyrimidine analogs

Ghada S. Hassan, 2013, Medicinal Chemistry Research.

Substituted thiazoles VII. Synthesis and antitumor activity of certain 2-(substituted amino)-4-phenyl-1,3-thiazole analogs.

Ghada S. Hassan, Fatmah A. M. Al-Omary, H. El-Subbagh, 2012, Bioorganic & medicinal chemistry letters.

Substituted thiazoles VI. Synthesis and antitumor activity of new 2-acetamido- and 2 or 3-propanamido-thiazole analogs.

Ghada S. Hassan, Fatmah A. M. Al-Omary, H. El-Subbagh, 2012, European journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modeling study of 2-(1,3,4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors.

Ghada S. Hassan, Sara T. A. Al-Rashood, M. Nagi, 2014, Bioorganic & medicinal chemistry letters.

Nonclassical antifolates, part 3: synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones.

Ghada S. Hassan, M. Nagi, Fatmah A. M. Al-Omary, 2013, European journal of medicinal chemistry.

Synthesis, antitumor testing and molecular modeling study of some new 6-substituted amido, azo or thioureido-quinazolin-4(3H)-ones.

Ghada S. Hassan, Mariam A. Ghaly, H. El-Subbagh, 2019, Bioorganic chemistry.

Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.

Ghada S. Hassan, Sara T. A. Al-Rashood, M. Nagi, 2016, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation and molecular modeling study of thiadiazolo[3,2-a][1,3]diazepine analogues of HIE-124 as a new class of short acting hypnotics.

Ghada S. Hassan, H. El-Subbagh, Shahenda M. El-Messery, 2016, European journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modeling study of some new thiazolodiazepine analogs as CNS active agents.

Ghada S. Hassan, Sara T. A. Al-Rashood, H. El-Subbagh, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of Thiazole-Based Derivatives as Potential Acetylcholinesterase Inhibitors

Ghada S. Hassan, J. Joubert, A. El-Emam, 2021, ACS omega.

New ultra-short acting hypnotic: synthesis, biological evaluation, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124).

J. Lehmann, A. Kadi, Ghada S. Hassan, 2008, Bioorganic & medicinal chemistry letters.

Novel 4(3H)-quinazolinone analogs: synthesis and anticonvulsant activity

Ghada S. Hassan, M. Sayed-Ahmed, O. Al‐Shabanah, 2013, Medicinal Chemistry Research.

Menadione.

Ghada S. Hassan, 2020, Profiles of drug substances, excipients, and related methodology.

Chapter Six - Menadione

Ghada S. Hassan, 2013 .

Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3H)-one as DHFR inhibitors.

Ghada S. Hassan, Hanan H. Georgey, M. Raafat, 2017, Bioorganic chemistry.

Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3]diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12,6]diazepine analogues.

A. Kadi, Ghada S. Hassan, M. Sayed-Ahmed, 2011, European journal of medicinal chemistry.

SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.

C. Supuran, D. Vullo, Ghada S. Hassan, 2019, Bioorganic chemistry.

Loss of Caveolin-1 Causes the Hyper-Proliferation of Intestinal Crypt Stem Cells, with Increased Sensitivity to Whole Body ?-Radiation

F. Sotgia, M. Lisanti, C. Minetti, 2005, Cell cycle.

Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity.

Mohamed A. Abdelrahman, C. Supuran, Ghada S. Hassan, 2019, Bioorganic chemistry.

Novel Diamide-Based Benzenesulfonamides as Selective Carbonic Anhydrase IX Inhibitors Endowed with Antitumor Activity: Synthesis, Biological Evaluation and In Silico Insights

Mohamed A. Abdelrahman, C. Supuran, Ghada S. Hassan, 2019, International journal of molecular sciences.

Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity

A. Hamed, Ghada S. Hassan, M. M. Al-Sanea, 2020, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents

Ghada S. Hassan, H. Alkahtani, H. Abdel‐Aziz, 2019, Journal of enzyme inhibition and medicinal chemistry.

CD154 Resistant to Cleavage from Intracellular Milieu and Cell Surface Induces More Potent CD40-Mediated Responses

Ghada S. Hassan, W. Mourad, Y. Darif, 2021, The Journal of Immunology.

Thiadiazolodiazepine analogues as a new class of neuromuscular blocking agents: Synthesis, biological evaluation and molecular modeling study.

Ghada S. Hassan, A. Abdel-Aziz, A. El-Azab, 2017, European journal of medicinal chemistry.

Synthesis, Ultra‐Short Acting Hypnotic Activity, and Metabolic Profile of Ethyl 8‐Oxo‐5,6,7,8‐tetrahydro‐thiazolo[3,2‐a] [1,3]diazepin‐3‐carboxylate (HIE‐124)

J. Lehmann, A. Kadi, Ghada S. Hassan, 2008, Archiv der Pharmazie.

Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction.

M. Lisanti, T. Williams, Ghada S. Hassan, 2006, American journal of physiology. Heart and circulatory physiology.

Expression of urotensin-II in human coronary atherosclerosis

S. Douglas, E. Ohlstein, Ghada S. Hassan, 2005, Peptides.

A role for urotensin II in restenosis following balloon angioplasty: use of a selective UT receptor blocker.

S. Douglas, E. Ohlstein, Ghada S. Hassan, 2005, Journal of molecular and cellular cardiology.

CD40 Ligand and Its Receptors in Atherothrombosis

Ghada S. Hassan, Y. Merhi, W. Mourad, 2012 .

CD154 and its receptors in inflammatory vascular pathologies.

Ghada S. Hassan, Y. Merhi, W. Mourad, 2009, Trends in immunology.

Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis

Ghada S. Hassan, N. Alaaeddine, G. Hilal, 2019, World journal of gastroenterology.

Urogenital alterations in aged male caveolin-1 knockout mice.

G. Christ, S. Woodman, M. Lisanti, 2004, The Journal of urology.

Targeting microbial resistance: Synthesis, antibacterial evaluation, DNA binding and modeling study of new chalcone-based dithiocarbamate derivatives.

Ghada S. Hassan, H. Alkahtani, Sara T. A. Al-Rashood, 2019, Bioorganic chemistry.

BASNEF Model: it’s Effect on Blood Glucose Level among Children with Diabetes Mellitus

Ghada S. Hassan, H. Sayed, H. N. El-aasar, 2020 .

An unexpected role for MHC class II

Ghada S. Hassan, W. Mourad, 2011, Nature Immunology.

Design, synthesis, and antitumor activity of PLGA nanoparticles incorporating a discovered benzimidazole derivative as EZH2 inhibitor.

Ghada S. Hassan, Sara T. A. Al-Rashood, N. Saleh, 2021, Chemico-biological interactions.

Synthesis and antitumor activity of certain new thiazolo[2,3-b]quinazoline and thiazolo[3,2-a]pyrimidine analogs

Ghada S. Hassan, 2013, Medicinal Chemistry Research.

Caveolae and caveolin-1: novel potential targets for the treatment of cardiovascular disease.

M. Lisanti, Ghada S. Hassan, P. G. Frank, 2007, Current pharmaceutical design.

Chapter 10 Caveolae and Caveolins in the Vascular System: Functional Roles in Endothelia, Macrophages, and Smooth Muscle Cells

M. Lisanti, Ghada S. Hassan, P. G. Frank, 2005 .

Caveolin-1 deficiency stimulates neointima formation during vascular injury.

M. Lisanti, Ghada S. Hassan, P. G. Frank, 2004, Biochemistry.

Targeting EGFR tyrosine kinase: Synthesis, in vitro antitumor evaluation, and molecular modeling studies of benzothiazole-based derivatives.

Ghada S. Hassan, Mariam A. Ghaly, Shahenda M. El-Messery, 2020, Bioorganic chemistry.

Fingolimod (FTY720) as an Anti-Multiple Sclerosis Oral Ultimate Therapy

Ghada S. Hassan, F. Alqahtani, F. Aleanizy, 2015 .

CD40 translocation to lipid rafts: Signaling requirements and downstream biological events

Ghada S. Hassan, M. Polyak, Maria J Polyak, 2011, European journal of immunology.