K. Xie

X. Le, K. Xie, Q. Shi, 2001, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma.

X. Le, K. Xie, Q. Shi, 2001, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Experimental animal models of pancreatic carcinogenesis and metastasis

J. Abbruzzese, K. Xie, D. Wei, 2003, International journal of gastrointestinal cancer.

Mouse models of metastatic pancreatic adenocarcinoma

J. Abbruzzese, Bailiang Wang, X. Le, 2001, International journal of gastrointestinal cancer.

A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy

J. Abbruzzese, Bailiang Wang, X. Le, 2001, International journal of gastrointestinal cancer.

Krüppel-like Factor 4 Induces p 27 Kip 1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells

X. Le, K. Xie, D. Wei, 2008 .

Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells.

X. Le, K. Xie, D. Wei, 2008, Cancer research.

Gene‐expression profiling in Chinese patients with colon cancer by coupling experimental and bioinformatic genomewide gene‐expression analyses

Hua-mei Tang, Zhihai Peng, X. Le, 2008, Cancer.

FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway

Chen Huang, Suyun Huang, K. Xie, 2015, Oncotarget.

Models of liver metastasis

Jun Zhang, K. Xie, 2005 .

Regulation of interleukin-8 expression in human melanoma cells by the organ environment.

C. Bucana, I. Fidler, K. Xie, 1995, Cancer research.

Krüppel-like Factor 4 Induces p27 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells

X. Le, K. Xie, D. Wei, 2008 .

Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.

I. Fidler, J. Abbruzzese, Suyun Huang, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Effects of sex and racial/ethnic group on the pattern of gastric cancer localization

J. Ajani, A. Rashid, James C Yao, 2002, Gastric Cancer.

Vitamin D receptor signaling and pancreatic cancer cell EMT.

K. Xie, Junli Guo, Shaojiang Zheng, 2015, Current pharmaceutical design.

Characteristics of Epstein-Barr virus-associated gastric cancer: A study of 235 cases at a comprehensive cancer center in U.S.A

James C Yao, T. Khoury, S. Alrawi, 2009, Journal of experimental & clinical cancer research : CR.

KLF4-Mediated Negative Regulation of IFITM3 Expression Plays a Critical Role in Colon Cancer Pathogenesis

Qiang Li, Dawei Li, Xiangyu Kong, 2011, Clinical Cancer Research.

Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide.

I. Fidler, K. Xie, Z. Dong, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Perfusion Computed Tomography as Functional Biomarker in Randomized Run-In Study of Bevacizumab and Everolimus in Well-Differentiated Neuroendocrine Tumors

K. Hess, C. Ng, James C Yao, 2015, Pancreas.

Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells.

J. Abbruzzese, X. Le, K. Xie, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia.

K. Matsushima, J. Abbruzzese, X. Le, 1999, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Signaling of miRNAs-FOXM1 in cancer and potential targeted therapy.

K. Xie, M. Shi, Jiujie Cui, 2013, Current drug targets.

Tumors face NO problems?

K. Xie, J. R. Lancaster, 2006, Cancer research.

Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors.

Suyun Huang, X. Le, K. Xie, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Targeted Disruption of Orchestration between Stroma and Tumor Cells in Pancreatic Cancer: Molecular Basis and Therapeutic Implications

K. Xie, Zhaoshen Li, Xiangyu Kong, 2013 .

Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer

K. Xie, Jie He, Xiaojia Li, 2022, Cellular Oncology.

Clinical significance of pancreatic ductal metaplasia

K. Xie, Tingting Jiang, Fang Wei, 2022, The Journal of pathology.

Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics

Shuxing Zhang, K. Xie, D. Wei, 2020, Cancer Research.

Targeting miRNAs for pancreatic cancer therapy.

K. Xie, M. Shi, D. Xie, 2014, Current pharmaceutical design.

HIF-1α links β-adrenoceptor agonists and pancreatic cancer cells under normoxic condition

K. Xie, Liang Han, Q. Ma, 2010, Acta Pharmacologica Sinica.

Supplemental Information KLF 4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis

Suyun Huang, K. Xie, Z. Jia, 2016 .

Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression*

Wenliang Li, Suyun Huang, K. Xie, 2015, The Journal of Biological Chemistry.

Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362.

I. Fidler, Shile Huang, K. Xie, 1995, Cancer research.

Clinical and In vitro Studies of Imatinib in Advanced Carcinoid Tumors

L. Ellis, K. Hess, J. Ajani, 2007, Clinical Cancer Research.

Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma.

L. Mishra, Suyun Huang, X. Le, 2012, Gastroenterology.

Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

Han Liu, Z. Wang, K. Xie, 2014, Clinical Cancer Research.

RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma

K. Xie, Q. Ma, Kaijie Wu, 2022, International journal of biological sciences.

Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis

T. McDonnell, J. Reed, John Calvin Reed, 1996, Cancer Immunology, Immunotherapy.

Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase.

Suyun Huang, X. Le, K. Xie, 2003, Cancer research.

Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma.

J. Abbruzzese, X. Le, K. Xie, 2001, Cancer research.

Use of retroviral vectors encoding murine inducible nitric oxide synthase gene to suppress tumorigenicity and cancer metastasis of murine melanoma.

I. Fidler, K. Xie, J. Yoneda, 1997, Cancer biotherapy & radiopharmaceuticals.

Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages.

I. Fidler, K. Xie, X. Qi, 1993, Journal of immunology.

Suppression of tumorigenicity and metastasis in murine UV-2237 fibrosarcoma cells by infection with a retroviral vector harboring the interferon-beta gene

C. Bucana, I. Fidler, Rakesh Kumar, 1998, Cancer Immunology, Immunotherapy.

Gastric Cancer: Antitumor Activity of RUNX3

Zhihai Peng, K. Xie, 2008 .

Regulation of carcinoembryonic antigen expression in human colon carcinoma cells by the organ microenvironment.

C. Bucana, I. Fidler, R. Radinsky, 1996, The American journal of pathology.

Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene.

I. Fidler, K. Xie, Z. Dong, 1997, Journal of the National Cancer Institute.

A cysteine proteinase, which cleaves human C3, the third component of complement, is involved in tumorigenicity and metastasis of human melanoma.

R. Frade, M. Bar‐eli, K. Xie, 1996, Cancer research.

Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma.

J. Ajani, Tsung-Teh Wu, A. Rashid, 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

Expression of theJE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells

C. Bucana, I. Fidler, M. Bar‐eli, 1994, Cancer Immunology, Immunotherapy.

Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma.

J. Abbruzzese, Hua-mei Tang, Zhihai Peng, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: a key to the cell cycle and apoptosis.

Zhihai Peng, K. Xie, Dapeng Li, 2005, International journal of oncology.

Krüppel-like Factor 4 Induces p27 Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells

X. Le, K. Xie, D. Wei, 2008 .

Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression‐free survival among patients with low‐grade neuroendocrine tumors

Douglas B. Evans, J. Vauthey, A. Rashid, 2007, Cancer.

Association of VEGF expression with poor prognosis among patients with low-grade neuroendocrine carcinoma.

E. Abdalla, J. Abbruzzese, K. Xie, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Differential regulation of type IV collagenases and metalloelastase in murine macrophages by the synthetic bacterial lipopeptide JBT 3002.

R. Kumar, I. Fidler, K. Xie, 2000, International journal of immunopharmacology.

Activation of inducible nitric oxide synthase gene in murine macrophages requires protein phosphatases 1 and 2A activities

I. Fidler, K. Xie, Xiulan Yang, 1995, Journal of leukocyte biology.

10 Immunohistochemical detection of activated Stat3 protein in pancreatic cancer

Suyun Huang, K. Xie, W. Gong, 2005 .

Expression of the JE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells.

C. Bucana, I. Fidler, M. Bar‐eli, 1994, Cancer immunology, immunotherapy : CII.

Pancreatic cancer

R. Wolff, Donghui Li, J. Abbruzzese, 2004, The Lancet.

Procathepsin-L, a proteinase that cleaves human C3 (the third component of complement), confers high tumorigenic and metastatic properties to human melanoma cells.

R. Frade, M. Bar‐eli, K. Xie, 1998, Cancer research.

Advances in Brief Direct Demonstration of Negative Regulation of Tumor Growth and Metastasis by Host-inducible Nitric Oxide Synthase 1

Suyun Huang, X. Le, K. Xie, 2003 .

Genetic disruption of host interferon-γ drastically enhances the metastasis of pancreatic adenocarcinoma through impaired expression of inducible nitric oxide synthase

Bailiang Wang, X. Le, K. Xie, 2001, Oncogene.

Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells.

I. Fidler, K. Xie, X. Qi, 1994, Cancer research.

Cytokine-induced apoptosis in transformed murine fibroblasts involves synthesis of endogenous nitric-oxide.

I. Fidler, K. Xie, Z. Dong, 1993, International journal of oncology.

Therapeutic resistance of pancreatic cancer: Roadmap to its reversal.

K. Xie, Chunyu Zhang, Sen Yu, 2020, Biochimica et biophysica acta. Reviews on cancer.

Interleukin-8 and human cancer biology.

K. Xie, K Xie, 2001, Cytokine & growth factor reviews.

Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency.

Suyun Huang, K. Xie, 2003, Free radical biology & medicine.

Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2

I. Fidler, D. McConkey, Suyun Huang, 1997, Oncogene.

Modeling liver metastasis using a tumor cell line derived from an enhanced green fluorescent protein transgenic mouse

Suyun Huang, X. Le, Qiang Li, 2009, Clinical & Experimental Metastasis.

Leukocyte-induced angiogenesis and subcutaneous growth of B16 melanoma.

C. Bucana, I. Fidler, K. Xie, 1994, Cancer biotherapy.

Celecoxib Inhibits Vascular Endothelial Growth Factor Expression in and Reduces Angiogenesis and Metastasis of Human Pancreatic Cancer via Suppression of Sp1 Transcription Factor Activity

J. Abbruzzese, K. Xie, D. Wei, 2004, Cancer Research.

A highly sensitive dual-channel chemical sensor for selective identification of B4O72−

K. Xie, Yu‐Jie Ding, Ji-Fa Wang, 2021 .

NF‐κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells

E. Lin, J. Abbruzzese, K. Xie, 2004 .

Interaction of the Sympathetic Nerve with Pancreatic Cancer Cells Promotes Perineural Invasion through the Activation of STAT3 Signaling

K. Xie, Q. Ma, Junhui Li, 2013, Molecular Cancer Therapeutics.

Chemical Therapeutics Interaction of the Sympathetic Nerve with Pancreatic Cancer Cells Promotes Perineural Invasion through the Activation of STAT 3 Signaling

Z. Wang, K. Xie, Q. Ma, 2013 .

Activation of Vitamin D Receptor Signaling Downregulates the Expression of Nuclear FOXM1 Protein and Suppresses Pancreatic Cancer Cell Stemness

L. Mishra, Suyun Huang, K. Xie, 2014, Clinical Cancer Research.

miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis.

Jianfei Xue, Suyun Huang, Kangyu Lin, 2016, Cancer research.

Molecular basis of gastric cancer development and progression

J. Ajani, K. Xie, Liwei Wang, 2004, Gastric Cancer.

m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.

Chuan He, Suyun Huang, Erik P. Sulman, 2017, Cancer cell.

Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer

S. Fang, Jun Zhang, Qiang Li, 2007, Clinical & Experimental Metastasis.

A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis.

Chen Huang, Suyun Huang, Zhihai Peng, 2012, Cancer research.

FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis.

W. Yung, R. Medema, H. Colman, 2011, Cancer cell.

FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis.

K. Xie, Chen Huang, Jiawei Du, 2014, Biochimica et biophysica acta.

The roles of FOXM1 in pancreatic stem cells and carcinogenesis

K. Xie, Jiujie Cui, Yong Gao, 2013, Molecular Cancer.

Epigenetic reprogramming in pancreatic premalignancy and clinical implications

K. Xie, Wei Zhang, Tingting Jiang, 2023, Frontiers in Oncology.

Regulation of EMT by KLF4 in gastrointestinal cancer.

K. Xie, M. Shi, Jiujie Cui, 2013, Current cancer drug targets.

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

P. Wei, Suyun Huang, K. Xie, 2018, Nature Communications.

A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer

J. Ajani, J. Abbruzzese, Suyun Huang, 2005, Clinical & Experimental Metastasis.

ZFPM2-AS1, a Novel lncRNA, Attenuates the p53 Pathway and Promotes Gastric Carcinogenesis by Stabilizing MIF

M. Guan, Zhaoshen Li, K. Xie, 2018, Oncogene.

Molecular Basis for Vascular Endothelial Growth Factor Expression in Tumor

K. Xie, James C. Yao, J. Yao, 2008 .

Constitutive and inducible expression and regulation of vascular endothelial growth factor.

Suyun Huang, K. Xie, D. Wei, 2004, Cytokine & growth factor reviews.

KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis.

Suyun Huang, K. Xie, D. Wei, 2016, Cancer cell.

Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression.

D. Tan, Suyun Huang, B. Dai, 2009, Cancer research.

PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

K. Xie, Ying Chen, Guanzhen Yu, 2015, Molecular Cancer.

PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

K. Xie, Ying Chen, Guanzhen Yu, 2015, Molecular Cancer.

The Role of CD44 and Cancer Stem Cells.

K. Xie, D. Wei, X. Zuo, 2018, Methods in molecular biology.

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.

K. Aldape, M. Cobb, Xiao Zhen Zhou, 2009, Molecular cell.

Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer.

J. Ajani, Tsung-Teh Wu, Suyun Huang, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitination by USP22

K. Aldape, J. Woodgett, Suyun Huang, 2016, Nature Cell Biology.

Inhibition of the growth and metastasis of human colon cancer by restoration of RUNX3 expression in cancer cells.

Hua-mei Tang, Zhihai Peng, X. Le, 2008, International Journal of Oncology.

Genome-Wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer

Zhihai Peng, K. Xie, D. Wei, 2003, International journal of gastrointestinal cancer.

KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis.

Suyun Huang, K. Xie, D. Wei, 2016, Cancer research.

Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial–Mesenchymal Transition

K. Xie, Zhaoshen Li, Fanyang Kong, 2018, Clinical Cancer Research.

Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression.

Tsung-Teh Wu, Suyun Huang, Tsung-Teh Wu, 2005, Cancer research.

Association between Expression of Transcription Factor Sp1 and Increased Vascular Endothelial Growth Factor Expression, Advanced Stage, and Poor Survival in Patients with Resected Gastric Cancer

Tsung-Teh Wu, Manal M. Hassan, J. Ajani, 2004, Clinical Cancer Research.

Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity.

Suyun Huang, Jun Zhang, X. Le, 2010, Cancer research.

Overexpression of Phosphorylated Mammalian Target of Rapamycin Predicts Lymph Node Metastasis and Prognosis of Chinese Patients with Gastric Cancer

Qiang Li, K. Xie, Z. Jia, 2009, Clinical Cancer Research.

Tissue microarray analysis reveals strong clinical evidence for a close association between loss of annexin A1 expression and nodal metastasis in gastric cancer

Qiang Li, K. Xie, Ying Chen, 2008, Clinical & Experimental Metastasis.

FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes.

K. Aldape, P. Wei, Dawei Li, 2010, Cancer research.

Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.

I. Fidler, K. Matsushima, N. Mukaida, 1999, Cancer research.

Human Ovarian Carcinoma Cells Hypoxia-induced Elevation in Interleukin-8 Expression by Updated Version

I. Fidler, K. Matsushima, N. Mukaida, 1999 .

Regulation of vascular endothelial growth factor expression in human colon cancer by interleukin-1β

L. Ellis, Y. Akagi, K. Xie, 1999, British Journal of Cancer.

Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis.

C. Bucana, M. Bar‐eli, Suyun Huang, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Ductal metaplasia in pancreas.

K. Xie, Shu Li, 2022, Biochimica et biophysica acta. Reviews on cancer.

Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis.

K. Xie, Chen Huang, 2012, Cytokine & growth factor reviews.

Regulation of cancer metastasis by stress pathways

Suyun Huang, K. Xie, 2004, Clinical & Experimental Metastasis.

Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells.

C. Bucana, Q. Wei, K. Xie, 1997, The Journal of investigative dermatology.

A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism

M. Fallon, S. Guha, K. Xie, 2019, Oncogene.

Pancreatic cancer stromal biology and therapy

K. Xie, Keping Xie, Dacheng Xie, 2015, Genes & diseases.

Targeted destruction of the orchestration of the pancreatic stroma and tumor cells in pancreatic cancer cases: molecular basis for therapeutic implications.

K. Xie, Zhaoshen Li, Xiangyu Kong, 2012, Cytokine & growth factor reviews.

Protein arginine methylation promotes therapeutic resistance in human pancreatic cancer.

K. Xie, Jie He, Victoria K. Xie, 2020, Cytokine & growth factor reviews.

p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models.

M. Hung, Y. Zou, B. Spohn, 2001, Cancer Research.

Activation of stat3 in human melanoma promotes brain metastasis.

K. Aldape, J. Gershenwald, R. Sawaya, 2006, Cancer research.

Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and β-catenin signaling in pancreatic ductal adenocarcinoma cells.

Suyun Huang, K. Xie, D. Wei, 2014, Gastroenterology.

Alpha-methylacyl-CoA racemase expression is upregulated in gastric adenocarcinoma: a study of 249 cases.

P. Cagle, T. Khoury, S. Alrawi, 2008, International journal of clinical and experimental pathology.

A Novel KLF4/LDHA Signaling Pathway Regulates Aerobic Glycolysis in and Progression of Pancreatic Cancer

Jun Zhang, K. Xie, D. Wei, 2014, Clinical Cancer Research.

FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression

Suyun Huang, K. Xie, D. Wei, 2014, Clinical Cancer Research.

Expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Expression of Vascular Endothelial Growth Factor in and Angiogenic Phenotype of Human Gastric Cancer

K. Aldape, J. Ajani, R. Sawaya, 2005, Clinical Cancer Research.

Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models.

Jun Zhang, Qiang Li, K. Xie, 2008, International journal of oncology.

Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer

Huamin Wang, Jun Zhang, X. Le, 2007, Cancer.

Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A.

Jun Zhang, X. Le, Qiang Li, 2007, Cancer research.

Pancreatic Adenocarcinoma-mediated Suppression of Growth and Metastasis of β Gene Is Required for Interferon-Nitric Oxide Synthase II Intact Updated Version

J. Abbruzzese, X. Le, K. Xie, 2000 .

Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition.

K. Aldape, Jun Yao, P. Steeg, 2011, Cancer research.

Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

J. Abbruzzese, Suyun Huang, Zhihai Peng, 2003, Oncogene.

DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-Like Factor 4 Expression

Jing Wang, Z. Ju, K. Xie, 2017, Clinical Cancer Research.

Hyperglycemia as a mechanism of pancreatic cancer metastasis.

Han Liu, K. Xie, Liang Han, 2012, Frontiers in bioscience.

Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling.

Suyun Huang, K. Xie, D. Wei, 2015, Cancer research.

The Critical Role of Dysregulated FOXM1–PLAUR Signaling in Human Colon Cancer Progression and Metastasis

P. Wei, Dawei Li, Chen Huang, 2012, Clinical Cancer Research.

Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma.

J. Abbruzzese, Zhihai Peng, X. Le, 2001, Cancer research.

Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells

K. Xie, Yan Lu, Xu Dong, 2015, Oncotarget.

Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer

K. Xie, Junli Guo, Shaojiang Zheng, 2016, International journal of biological sciences.

FOXM1c Promotes Pancreatic Cancer Epithelial-to-Mesenchymal Transition and Metastasis via Upregulation of Expression of the Urokinase Plasminogen Activator System

K. Xie, Chen Huang, Qi Li, 2014, Clinical Cancer Research.

Human Cancer Biology TheCritical Role ofDysregulatedFOXM 1 – PLAURSignaling in Human Colon Cancer Progression and Metastasis

P. Wei, Dawei Li, Chen Huang, 2012 .

Suppression of tumor growth and metastasis of murine renal adenocarcinoma by syngeneic fibroblasts genetically engineered to secrete the JE/MCP-1 cytokine.

M. Bar‐eli, K. Xie, R. Singh, 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.

X. Le, Qiang Li, K. Xie, 2011, Cancer research.

Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells

J. Abbruzzese, Bailiang Wang, X. Le, 2001, Oncogene.

Genetic disruption of host nitric oxide synthase II gene impairs melanoma‐induced angiogenesis and suppresses pleural effusion

X. Le, K. Xie, Q. Shi, 2001, International journal of cancer.

in Human Colon Cancer by Insulin-like Growth Factor-I Regulation of Vascular Endothelial Growth Factor Expression

L. Ellis, Liu, K. Xie, 2006 .

Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer

J. Ajani, Tsung-Teh Wu, Suyun Huang, 2005, Gastric Cancer.

Methylation of RNA N6-methyladenosine in modulation of cytokine responses and tumorigenesis.

Li Ma, Suyun Huang, K. Xie, 2019, Cytokine.

HGF/Met and FOXM1 Form a Positive Feedback Loop and Render Pancreatic Cancer Cells Resistance to Met Inhibition and Aggressive Phenotypes

Suyun Huang, K. Xie, D. Wei, 2015, Oncogene.

Molecular and Cellular Pathobiology A Novel FoxM 1-Caveolin Signaling Pathway Promotes Pancreatic Cancer Invasion and Metastasis

Chen Huang, Suyun Huang, Zhihai Peng, 2012 .

The Regulation of Hypoxic Genes by Calcium Involves c-Jun/AP-1, Which Cooperates with Hypoxia-Inducible Factor 1 in Response to Hypoxia

M. Blagosklonny, K. Xie, K. Salnikow, 2002, Molecular and Cellular Biology.

Loss of KLF4 and Consequential Downregulation of Smad7 Exacerbate Oncogenic TGF-β Signaling in and Promote Progression of Hepatocellular Carcinoma

Senlin Zhao, Hua-mei Tang, Zhihai Peng, 2016, Oncogene.

Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence

Hua Zhao, Xifeng Wu, Manal M. Hassan, 2007, Cancer.

Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.

J. Abbruzzese, K. Xie, James L Abbruzzese, 2003, Cancer cell.

Loss of Krüppel-Like Factor 4 Expression Contributes to Sp1 Overexpression and Human Gastric Cancer Development and Progression

J. Ajani, X. Le, Qiang Li, 2006, Clinical Cancer Research.

Activation of nitric oxide synthase gene for inhibition of cancer metastasis

I. Fidler, K. Xie, Z. Dong, 1996, Journal of leukocyte biology.

PFTK1 Promotes Gastric Cancer Progression by Regulating Proliferation, Migration and Invasion

Jie Cao, Qiuhong Wang, Yingying Wang, 2015, PloS one.

Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.

L. Ellis, Y. Akagi, K. Xie, 1998, Cancer research.

Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis.

P. Steeg, R. Sawaya, Suyun Huang, 2008, Cancer research.

Altered Expression of Transcription Factor Sp1 Critically Impacts the Angiogenic Phenotype of Human Gastric Cancer

Tsung-Teh Wu, Suyun Huang, Zhihai Peng, 2005, Clinical & Experimental Metastasis.

Therapy of cancer metastasis by activation of the inducible nitric oxide synthase

I. Fidler, K. Xie, 1998, Cancer and Metastasis Reviews.

Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis.

X. Le, K. Xie, Q. Shi, 2000, Cancer research.

ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin.

K. Xie, Z. Jia, Hongwei Wang, 2017, Cancer research.

Altered Sphingolipid Metabolism in Patients with Metastatic Pancreatic Cancer

K. Xie, Z. Jia, T. Fox, 2013, Biomolecules.

Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer.

Chen Huang, Suyun Huang, X. Le, 2013, Cancer research.

Transcriptional anti-angiogenesis therapy of human pancreatic cancer.

K. Xie, D. Wei, Suyun Huang, 2006, Cytokine & growth factor reviews.

Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells

K. Aldape, C. Patterson, R. Sawaya, 2015, Oncotarget.

Advances in Brief Influence of Nitric Oxide Synthase II Gene Disruption on Tumor Growth and Metastasis 1

Bailiang Wang, X. Le, K. Xie, 2000 .

Immune Sculpting of Norepinephrine on MHC-I, B7-1, IDO and B7-H1 Expression and Regulation of Proliferation and Invasion in Pancreatic Carcinoma Cells

Han Liu, Min Zhang, K. Xie, 2012, PloS one.

Overexpression of PhosphorylatedMammalianTarget of Rapamycin Predicts Lymph NodeMetastasis and Prognosis of Chinese Patients with Gastric Cancer

Ying Chen, ZhiliangJia, Qiang Li, 2009 .

The Novel KLF4/MSI2 Signaling Pathway Regulates Growth and Metastasis of Pancreatic Cancer

K. Xie, D. Wei, Z. Jia, 2016, Clinical Cancer Research.

KLF4α up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer.

Huamin Wang, X. Le, Qiang Li, 2010, Gastroenterology.

Metastasis of Human Melanoma Component of Complement , Is Involved in Tumorigenicity and A Cysteine Proteinase , Which Cleaves Human C 3 , the Third Updated

M. Bar‐eli, Suyun Huang, K. Xie, 2006 .

STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1α.

K. Xie, Z. Jia, Zhaoshen Li, 2017, Cancer research.

Metformin potentiates rapamycin and cisplatin in gastric cancer in mice

Suyun Huang, K. Xie, Ying Chen, 2015, Oncotarget.

Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.

L. Mishra, D. Tan, Suyun Huang, 2012, Gastroenterology.

Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: analysis of a single institution's experience over 15 years.

K. Hess, J. Ajani, Tsung-Teh Wu, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

BASIC—LIVER, PANCREAS, AND BILIARY TRACT KLF4 Up-regulation Promotes Cell Cycle Progression and Reduces Survival Time of Patients With Pancreatic Cancer

Huamin Wang, X. Le, Qiang Li, 2010 .

KLF4 transcription factor in tumorigenesis

K. Xie, Zhihong He, Jie He, 2023, Cell Death Discovery.

LIMS1 Promotes Pancreatic Cancer Cell Survival under Oxygen–Glucose Deprivation Conditions by Enhancing HIF1A Protein Translation

Na Li, He Ren, Jihui Hao, 2019, Clinical Cancer Research.

The FOXC1/FBP1 signaling axis promotes colorectal cancer proliferation by enhancing the Warburg effect

Xinxiang Li, P. Wei, Ye Xu, 2018, Oncogene.

A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis

J. Abbruzzese, Bailiang Wang, Suyun Huang, 2003, Oncogene.

Correction: ZFPM2-AS1, a novel lncRNA, attenuates the p53 pathway and promotes gastric carcinogenesis by stabilizing MIF

M. Guan, K. Xie, Zhaoshen Li, 2018, Oncogene.

Loss of Kru « ppel-Like Factor 4 Expression Contributes to Sp 1 Overexpression and Human Gastric Cancer Development and Progression

DaoyanWei, X. Le, ZhiliangJia, 2006 .

Krüppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6

L. Mishra, Hua-mei Tang, Zhihai Peng, 2015, Clinical Cancer Research.

Acinar cells and the development of pancreatic fibrosis.

K. Xie, Jianhong An, Tingting Jiang, 2023, Cytokine & growth factor reviews.

Lamin B1 Is a Novel Therapeutic Target of Betulinic Acid in Pancreatic Cancer

K. Xie, Z. Jia, Zhaoshen Li, 2013, Clinical Cancer Research.

Molecular and Cellular Pathobiology Dysregulated Expression of FOXM 1 Isoforms Drives Progression of Pancreatic Cancer

Chen Huang, Suyun Huang, X. Le, 2013 .

Pancreatic Cancer Dysregulated Expression of FOXM 1 Isoforms Drives Progression of Updated

Chen Huang, Suyun Huang, X. Le, 2013 .

Nitric oxide and pancreatic cancer pathogenesis, prevention, and treatment.

K. Xie, Liwei Wang, 2010, Current pharmaceutical design.

NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells.

E. Lin, J. Abbruzzese, K. Xie, 2004, International journal of cancer.

Expression of Autocrine Motility Factor Correlates with the Angiogenic Phenotype of and Poor Prognosis for Human Gastric Cancer

S. Fang, Suyun Huang, K. Xie, 2005, Clinical Cancer Research.

Expression of AutocrineMotility Factor Correlateswith theAngiogenic Phenotype of and Poor Prognosis for Human Gastric Cancer

S. Fang, Suyun Huang, K. Xie, 2005 .

Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53.

H. Ananthaswamy, K. Xie, W. Jiang, 1999, Cancer research.

Nucleolar protein treacle ribosome biogenesis factor 1 maintains gastric cancer cell proliferation by regulating R‐loop associated DNA replication stress

Yuan Zhang, Y. Nie, Haiying Liu, 2023, Journal of gastroenterology and hepatology.

Hippo transducer TAZ promotes epithelial mesenchymal transition and supports pancreatic cancer progression

K. Xie, Z. Jia, Jiujie Cui, 2015, Oncotarget.

Advances in Brief Direct Correlation between Nitric Oxide Synthase II Inducibility and Metastatic Ability of UV-2237 Murine Fibrosarcoma Cells Carrying Mutant p 53 1

H. Ananthaswamy, Suyun Huang, K. Xie, 2000 .

Senescence program and its reprogramming in pancreatic premalignancy

K. Xie, Xiaojia Li, Kailing Yang, 2023, Cell death & disease.

Authentication of experimental materials: A remedy for the reproducibility crisis?

Fei Li, Jim Hu, Tong-Chuan He, 2015, Genes & diseases.

Zonula Occludens Proteins Signaling in Inflammation and Tumorigenesis

K. Xie, Jie He, Sen Yu, 2023, International journal of biological sciences.

Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer

K. Xie, Jie He, Hongli Huang, 2023, Journal for ImmunoTherapy of Cancer.

Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

K. Xie, Fanyang Kong, Junli Guo, 2023, Genes & diseases.

Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

Han Liu, Z. Wang, K. Xie, 2014, Clinical Cancer Research.

FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression

Suyun Huang, K. Xie, D. Wei, 2014, Clinical Cancer Research.

Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling.

Suyun Huang, K. Xie, D. Wei, 2015, Cancer research.

Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer.

Chen Huang, Suyun Huang, X. Le, 2013, Cancer research.

Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and β-catenin signaling in pancreatic ductal adenocarcinoma cells.

Suyun Huang, K. Xie, D. Wei, 2014, Gastroenterology.

The Critical Role of Dysregulated FOXM1–PLAUR Signaling in Human Colon Cancer Progression and Metastasis

P. Wei, Dawei Li, Chen Huang, 2012, Clinical Cancer Research.

m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.

Zhike Lu, Chuan He, E. Sulman, 2017, Cancer cell.

Deep learning-based gastric cancer diagnosis and clinical management

K. Xie, Jidong Peng, 2023, Journal of Radiation Research and Applied Sciences.

Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.

L. Mishra, D. Tan, Suyun Huang, 2012, Gastroenterology.

Lamin B1 Is a Novel Therapeutic Target of Betulinic Acid in Pancreatic Cancer

K. Xie, Z. Jia, Zhaoshen Li, 2013, Clinical Cancer Research.

Treatment with bevacizumab (BEV) upregulates expression of the transcription factor Sp1 and its downstream target genes in human carcinoid cells: Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A (MIT)

K. Xie, Liwei Wang, Z. Jia, 2007 .

FOXM1c Promotes Pancreatic Cancer Epithelial-to-Mesenchymal Transition and Metastasis via Upregulation of Expression of the Urokinase Plasminogen Activator System

K. Xie, Chen Huang, Qi Li, 2014, Clinical Cancer Research.

Expression of Autocrine Motility Factor Correlates with the Angiogenic Phenotype of and Poor Prognosis for Human Gastric Cancer

Suyun Huang, K. Xie, D. Wei, 2005, Clinical Cancer Research.

Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor Infiltrates.

K. Xie, Jie He, Q. Zou, 2023, Clinical cancer research : an official journal of the American Association for Cancer Research.

Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.

X. Le, Qiang Li, K. Xie, 2011, Cancer research.

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.

K. Aldape, M. Cobb, M. Tremblay, 2009, Molecular cell.