H. Ohigashi

发表

Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27kip1 translocation and retinoblastoma protein phosphorylation by 1′-acetoxychavicol acetate

I. Matsui‐yuasa, A. Kojima-Yuasa, D. Kennedy, 2007, Amino Acids.

Citrus auraptene targets translation of MMP‐7 (matrilysin) via ERK1/2‐dependent and mTOR‐independent mechanism

A. Murakami, H. Ohigashi, K. Kawabata, 2006, FEBS letters.

Photocytotoxicity of water-soluble fullerene derivatives.

H. Ohigashi, E. Nakamura, H. Tokuyama, 1996, Bioscience, biotechnology, and biochemistry.

Ebselen, a Glutathione Peroxidase Mimetic Seleno-organic Compound, as a Multifunctional Antioxidant

E. Niki, H. Ohigashi, Yoshimasa Nakamura, 2002, The Journal of Biological Chemistry.

Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.

H. Ohigashi, K. Irie, Y. Nakagawa, 2005, Chemical record.

Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry.

H. Ohigashi, K. Irie, M. Shindo, 2003, Bioorganic & medicinal chemistry.

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.

U. Kikkawa, H. Konishi, H. Ohigashi, 2002, Pharmacology & therapeutics.

Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s

H. Ohigashi, A. Masuda, K. Irie, 2002 .

The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.

H. Ohigashi, K. Irie, Y. Nakamura, 2001, Bioorganic & medicinal chemistry letters.

Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding.

U. Kikkawa, H. Konishi, H. Ohigashi, 2001, Bioorganic & medicinal chemistry.

The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding.

H. Ohigashi, K. Irie, Y. Nakamura, 2001, Bioorganic & medicinal chemistry letters.

Diacylglycerol Kinase γ Is One of the Specific Receptors of Tumor-Promoting Phorbol Esters

H. Ohigashi, N. Saito, K. Irie, 2001 .

Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V.

H. Ohigashi, H. Hayashi, K. Irie, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D.

U. Kikkawa, H. Konishi, H. Ohigashi, 1999, Bioorganic & medicinal chemistry letters.

Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma.

H. Ohigashi, K. Irie, P. Wender, 1999, Bioorganic & medicinal chemistry.

Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma

H. Ohigashi, K. Irie, P. Wender, 1998 .

Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C

H. Ohigashi, K. Irie, P. Wender, 1997 .

Synthesis and characterization of the second cysteine-rich region of mouse skin PKCGh

H. Ohigashi, B. Miller, K. Irie, 1996 .

Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2005, Journal of the American Chemical Society.

Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages.

Y. Ikeda, A. Murakami, H. Ohigashi, 2008, Life sciences.

Epstein-Barr virus activation by tung oil, extracts of Aleurites fordii and its diterpene ester 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate.

Y. Ito, H. Ohigashi, H. Tokuda, 1983, Cancer letters.

The toxic conformation of the 42-residue amyloid beta peptide and its relevance to oxidative stress in Alzheimer's disease.

M. Nagao, T. Shirasawa, H. Ohigashi, 2007, Mini reviews in medicinal chemistry.

Inhibitory effects of 4-hydroxyderricin and xanthoangelol on lipopolysaccharide-induced inflammatory responses in RAW264 macrophages.

M. Yasuda, H. Ashida, H. Ohigashi, 2014, Journal of agricultural and food chemistry.

Allelochemicals of the tropical weed Sphenoclea zeylanica.

H. Ohigashi, T. Inoue, J. Harada, 2000, Phytochemistry.

Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression.

Takuji Tanaka, A. Murakami, H. Ohigashi, 2005, Biochemical pharmacology.

Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives

T. Sugimura, H. Ohigashi, M. Hirota, 2004, Journal of Cancer Research and Clinical Oncology.

Tigliane Type Diterpene-esters with Epstein–Barr Virus-inducing Activity from Sapium sebiferum

H. Ohigashi, H. Tokuda, M. Hirota, 1983 .

Piscicidal Constituents and Related Diterpene Esters from Aleurites fordii

H. Ohigashi, M. Hirota, K. Koshimįzu, 1979 .

Prevention by 1'-acetoxychavicol acetate of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form-positive, focal lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet.

E. Okajima, A. Murakami, H. Ohigashi, 1998, Carcinogenesis.

Apoptosis induced by 1'-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation.

A. Kojima, I. Matsui‐yuasa, D. Kennedy, 2000, Carcinogenesis.

Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting.

H. Narita, S. Masuda, M. Nagao, 2015, The Biochemical journal.

Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats.

Takuji Tanaka, S. Miyamoto, A. Murakami, 2006, Oncology reports.

Food as Medicine: The New Concept of “Medical Rice”

K. Ohtsubo, H. Ohigashi, T. Tsuno, 2016 .

Lack of Enhancing Effect of Lauric Acid on the Development of Aberrant Crypt Foci in Male ICR Mice Treated with Azoxymethane and Dextran Sodium Sulfate

Takuji Tanaka, S. Miyamoto, A. Murakami, 2007 .

Identification of coumarins from lemon fruit (Citrus limon) as inhibitors of in vitro tumor promotion and superoxide and nitric oxide generation.

A. Murakami, H. Ohigashi, Y. Sugiyama, 1999, Journal of agricultural and food chemistry.

Triterpenoids Isolated from Ziziphus jujuba Enhance Glucose Uptake Activity in Skeletal Muscle Cells.

H. Ohigashi, K. Kawabata, Masakazu Takahashi, 2017, Journal of nutritional science and vitaminology.

Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells

Y. Hirose, N. Yoshimi, H. Mori, 2002, Journal of Cancer Research and Clinical Oncology.

Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis.

Takuji Tanaka, S. Miyamoto, A. Murakami, 2013, BioFactors.

Inhibitory effects of new types of biflavonoid-related polyphenols; lophirone A and lophiraic acid, on some tumor promoter-induced biological responses in vitro and in vivo.

A. Murakami, H. Ohigashi, M. Hirota, 1991, Cancer letters.

Abscisic acid-dependent algal morphogenesis in the unicellular green alga Haematococcus pluvialis

H. Ohigashi, Makio Kobayashi, Y. Tsuji, 1997, Plant Growth Regulation.

Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.

S. Masuda, Y. Kawamoto, A. Murakami, 2000, Cancer research.

Suppression of N‐Nitrosomethylbenzylamine‐induced Rat Esophageal Tumorigenesis by Dietary Feeding of 1′‐Acetoxychavicol Acetate

Takuji Tanaka, A. Hara, H. Mori, 2000, Japanese journal of cancer research : Gann.

Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats.

Takuji Tanaka, A. Hara, H. Mori, 1998, Carcinogenesis.

Modifying Effects of Dietary Factors on (−)-Epigallocatechin-3-gallate-induced Pro-matrix Metalloproteinase-7 Production in HT-29 Human Colorectal Cancer Cells

A. Murakami, H. Ohigashi, Mihye Kim, 2007, Bioscience, biotechnology, and biochemistry.

Metabolism and Absorption of Auraptene (7-Geranyloxylcoumarin) in Male SD Rats: Comparison With 7-Ethoxycoumarin

A. Murakami, H. Ohigashi, W. Kuki, 2008, Nutrition and cancer.

Zerumbone Suppresses Phorbol Ester-Induced Expression of Multiple Scavenger Receptor Genes in THP-1 Human Monocytic Cells

A. Murakami, H. Ohigashi, Ai Eguchi, 2007, Bioscience, biotechnology, and biochemistry.

Suppressive effects of demethylated metabolites of nobiletin on phorbol ester‐induced expression of scavenger receptor genes in THP‐1 human monocytic cells

Chi-Tang Ho, A. Murakami, H. Ohigashi, 2007, BioFactors.

Suppressive Effects of Natural and Synthetic Agents on Dextran Sulfate Sodium-induced Interleukin-1β Release from Murine Peritoneal Macrophages

A. Murakami, H. Ohigashi, K. Kwon, 2004, Bioscience, biotechnology, and biochemistry.

Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen‐induced arthritis in DBA/1J mice: Possible involvement of receptor activator of NF‐kappaB ligand (RANKL)‐induced osteoclastogenesis regulation

A. Murakami, H. Ohigashi, M. Uehara, 2007, BioFactors.

ReviewA Mainstay of Functional Food Science Present Status , and Future Outlook in Japan-History , JsgA

S. Arai, H. Ohigashi, T. Osawa, 2018 .

Flavonols enhanced production of anti-inflammatory substance(s) by Bifidobacterium adolescentis: prebiotic actions of galangin, quercetin, and fisetin.

H. Ohigashi, K. Kawabata, Y. Sugiyama, 2013, BioFactors.

Cellular response to the redox active lipid peroxidation products: induction of glutathione S-transferase P by 4-hydroxy-2-nonenal.

H. Ohigashi, T. Osawa, K. Uchida, 1997, Biochemical and biophysical research communications.

Arabidopsis CYP 707 A s Encode ( 1 )-Abscisic Acid 8 9-Hydroxylase , a Key Enzyme in the Oxidative Catabolism of Abscisic Acid 1

D. Ohta, H. Ohigashi, M. Mizutani, 2004 .

A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats.

A. Hara, H. Makita, H. Mori, 1997, Carcinogenesis.

Superoxide Scavenging Activity of Rosmarinic Acid from Perilla frutescens Britton Var. acuta f. viridis

H. Ohigashi, Yoshimasa Nakamura, Y. Ohto, 1998 .

Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes.

Takuji Tanaka, A. Hara, A. Murakami, 1998, Cancer research.

Citrus auraptene inhibits chemically induced colonic aberrant crypt foci in male F344 rats.

A. Hara, H. Makita, H. Mori, 1997, Carcinogenesis.

Chemoprevention of Azoxymethane‐induced Rat Colon Carcinogenesis by a Xanthine Oxidase Inhibitor, 1′‐Acetoxychavicol Acetate

Takuji Tanaka, H. Makita, Akira Kara, 1997, Japanese journal of cancer research : Gann.

Inhibition by (-)-Persenone A-related Compounds of Nitric Oxide and Superoxide Generation from Inflammatory Leukocytes

Ha Won Kim, A. Murakami, H. Ohigashi, 2000, Bioscience, biotechnology, and biochemistry.

Suppressive properties of extracts from Japanese edible plants regarding nitric oxide generation.

A. Murakami, H. Ohigashi, Shaw Watanabe, 2009, Asian Pacific journal of cancer prevention : APJCP.

Suppressive Effects of Selected Antioxidants on the Activated Leukocytes-induced Mutagenesis in the Co-culture Assay Systems

Ha Won Kim, A. Murakami, H. Ohigashi, 2004, Bioscience, biotechnology, and biochemistry.

Mutagenicity of reactive oxygen and nitrogen species as detected by co-culture of activated inflammatory leukocytes and AS52 cells.

Ha Won Kim, A. Murakami, H. Ohigashi, 2003, Carcinogenesis.

Screening of edible Japanese plants for suppressive effects on phorbol ester-induced superoxide generation in differentiated HL-60 cells and AS52 cells.

Ha Won Kim, A. Murakami, H. Ohigashi, 2002, Cancer letters.

An Avocado Constituent, Persenone A, Suppresses Expression of Inducible Forms of Nitric Oxide Synthase and Cyclooxygenase in Macrophages, and Hydrogen Peroxide Generation in Mouse Skin

Ha Won Kim, A. Murakami, H. Ohigashi, 2000, Bioscience, biotechnology, and biochemistry.

Screening of edible Japanese plants for nitric oxide generation inhibitory activities in RAW 264.7 cells.

A. Murakami, H. Ohigashi, Y. Nakamura, 1998, Cancer letters.

Advances in Brief Redox Regulation of Glutathione S-Transferase Induction by Benzyl Isothiocyanate : Correlation of Enzyme Induction with the Formation of Reactive Oxygen Intermediates 1

S. Masuda, Y. Kawamoto, A. Murakami, 2000 .

Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis

H. Ohigashi, M. Natsume, K. Kawabata, 2018, Bioscience, biotechnology, and biochemistry.

AFRICAN BURKITT'S LYMPHOMA AND AN EPSTEIN-BARR VIRUS-ENHANCING PLANT EUPHORBIA TRIUCALLI

Y. Ito, H. Ohigashi, T. Osato, 1987, The Lancet.

Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages.

Ha Won Kim, A. Murakami, H. Ohigashi, 2005, Antioxidants & redox signaling.

A phase II detoxification enzyme inducer from lemongrass: identification of citral and involvement of electrophilic reaction in the enzyme induction.

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 2003, Biochemical and biophysical research communications.

Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.

Ha Won Kim, T. Kinoshita, A. Murakami, 2002, Carcinogenesis.

A catechol antioxidant protocatechuic acid potentiates inflammatory leukocyte-derived oxidative stress in mouse skin via a tyrosinase bioactivation pathway.

H. Ohigashi, Y. Nakamura, K. Torikai, 2001, Free radical biology & medicine.

A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.

A. Murakami, H. Ohigashi, T. Osawa, 2000, Cancer letters.

Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate.

Takuji Tanaka, A. Murakami, H. Ohigashi, 1998, Cancer research.

Phenethyl isothiocyanate suppresses receptor activator of NF‐kappaB ligand (RANKL)‐induced osteoclastogenesis by blocking activation of ERK1/2 and p38 MAPK in RAW264.7 macrophages

A. Murakami, H. Ohigashi, Meiyu Song, 2007, BioFactors.

Citrus nobiletin inhibits azoxymethane‐induced large bowel carcinogenesis in rats

Takuji Tanaka, A. Murakami, H. Ohigashi, 2004, BioFactors.

Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice

Ha Won Kim, Takuji Tanaka, Y. Surh, 2004, International journal of cancer.

Chemopreventive Effect of a Xanthine Oxidase Inhibitor, 1′‐Acetoxychavicol Acetate, on Rat Oral Carcinogenesis

Takuji Tanaka, A. Hara, H. Makita, 1996, Japanese journal of cancer research : Gann.

Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis.

Y. Ikeda, A. Murakami, H. Ohigashi, 2005, Asian Pacific journal of cancer prevention : APJCP.

Synthesis of feruloyl-myo-insitol derivatives and their inhibitory effects on phorbol ester-induced superoxide generation and Esptein-Barr virus activation.

A. Murakami, H. Ohigashi, E. Nomura, 2002, Bioorganic & medicinal chemistry.

Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats.

A. Murakami, H. Ohigashi, T. Tanaka, 2001, Life sciences.

1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo.

Keisuke Ito, M. Kizaki, T. Nakazato, 2005, Cancer research.

A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress.

A. Murakami, H. Ohigashi, Y. Nakamura, 1999, Cancer letters.

FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid.

Ha Won Kim, A. Murakami, H. Ohigashi, 2002, Cancer letters.

Inhibition by 1'-acetoxychavicol acetate of lipopolysaccharide- and interferon-gamma-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW264 cells.

T. Sugimura, K. Wakabayashi, A. Murakami, 1998, Carcinogenesis.

Auraptene, a Citrus Coumarin, Inhibits 12‐0‐Tetradecanoylphorbol‐13‐acetate‐induced Tumor Promotion in ICR Mouse Skin, Possibly through Suppression of Superoxide Generation in Leukocytes

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 1997, Japanese journal of cancer research : Gann.

Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas‐ and mitochondria‐mediated pathway

Keisuke Ito, M. Kizaki, T. Nakazato, 2007, Cancer science.

Induction of Apoptosis in Human Myeloid Leukemic Cells by 1′-Acetoxychavicol Acetate through a Mitochondrial- and Fas-Mediated Dual Mechanism

Keisuke Ito, M. Kizaki, T. Nakazato, 2004, Clinical Cancer Research.

Molecular Basis for Protein Kinase C Isozyme-Selective Binding: The Synthesis, Folding, and Phorbol Ester Binding of the Cysteine-Rich Domains of All Protein Kinase C Isozymes

U. Kikkawa, H. Konishi, H. Ohigashi, 1998 .

A Piscicidal Constituent of Excoecaria agallocha

H. Ohigashi, K. Kawazu, K. Koshimįzu, 1974 .

Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis.

A. Murakami, H. Ohigashi, K. Kwon, 2005, Biochemical and biophysical research communications.

Analysis of Isomerization Process of 8′-Hydroxyabscisic Acid and its 3′-Fluorinated Analog in Aqueous Solutions

H. Ohigashi, N. Hirai, Y. Todoroki, 2000 .

Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (−)-indolactam-V

H. Ohigashi, K. Irie, Y. Nakagawa, 2004 .

Kurosu, a Traditional Vinegar Produced from Unpolished Rice, Suppresses Lipid Peroxidation in Vitro and in Mouse Skin

H. Ohigashi, Yoshimasa Nakamura, K. Torikai, 2000, Bioscience, biotechnology, and biochemistry.

Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice.

A. Nishikawa, A. Murakami, H. Ohigashi, 1999, Carcinogenesis.

Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.

H. Ohigashi, K. Irie, Y. Nakagawa, 2003, Bioorganic & medicinal chemistry letters.

Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum.

H. Ohigashi, H. Hayashi, K. Irie, 1999, Bioscience, biotechnology, and biochemistry.

Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V.

H. Ohigashi, H. Hayashi, K. Irie, 1998, Bioscience, biotechnology, and biochemistry.

Synthesis of 6-substituted indolactams by microbial conversion

H. Ohigashi, H. Nishino, H. Hayashi, 1995 .

Synthesis and biological activities of new conformationally fixed analogues of (−)-indolactam-V, the core structure of tumor-promoting teleocidins

H. Ohigashi, Yoshimasa Nakamura, K. Irie, 1995 .

Suppression by citrus auraptene of phorbol ester-and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation.

Takuji Tanaka, A. Murakami, H. Ohigashi, 2000, Carcinogenesis.

Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate

Y. Ikawa, H. Ohigashi, K. Irie, 2000, Bioscience, biotechnology, and biochemistry.

Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells.

A. Murakami, H. Ohigashi, M. Omura, 1999, Journal of agricultural and food chemistry.

Plant‐derived diterpene esters enhance HTLV‐I‐induced colony formation of lymphocytes in co‐culture

Y. Ito, H. Ohigashi, Yōhei Itō, 1986, International journal of cancer.

Modifying effects of carotenoids on superoxide and nitric oxide generation from stimulated leukocytes.

T. Maoka, A. Murakami, H. Ohigashi, 2000, Cancer letters.

Electrolytic reduction of abscisic acid methyl ester and its free acid.

H. Ohigashi, K. Kano, N. Hirai, 2012, Phytochemistry.

1,1-Dimethylallylcoumarins potently suppress both lipopolysaccharide- and interferon-gamma-induced nitric oxide generation in mouse macrophage RAW 264.7 cells.

A. Murakami, H. Ohigashi, M. Omura, 2000, Bioorganic & medicinal chemistry letters.

Occurrence of the insecticidal 16,17-didehydro-16(E)-stemofoline in Stemona collinsae.

H. Ohigashi, V. Santisopasri, K. Koshimįzu, 2001, Phytochemistry.

Xanthoxin, abscisic acid and its metabolite levels associated with apple fruit development

H. Ohigashi, S. Kondo, S. Setha, 2004 .

Deuterium-labeled Phaseic Acid and Dihydrophaseic Acids for Internal Standards

H. Ohigashi, S. Kondo, N. Hirai, 2003, Bioscience, biotechnology, and biochemistry.

Chemoprevention with Food Phytochemicals: Screening, Rodent Studies, and Action Mechanisms

A. Murakami, H. Ohigashi, K. Koshimįzu, 1998 .

1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin.

A. Murakami, H. Ohigashi, Y. Nakamura, 1996, Oncology.

Growth inhibitory activities of crude extracts obtained from herbal plants in the Ryukyu Islands on several human colon carcinoma cell lines.

M. Suzui, A. Murakami, H. Ohigashi, 2005, Asian Pacific journal of cancer prevention : APJCP.

Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice.

A. Murakami, H. Ohigashi, T. Tanaka, 2000, Cancer research.

Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

Y. Ito, H. Ohigashi, H. Tokuda, 1986, Cancer letters.

Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors.

A. Murakami, H. Ohigashi, K. Koshimįzu, 2003, Mutation research.

Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse.

A. Murakami, H. Ohigashi, Y. Nakamura, 1996, Cancer letters.

Identification of pheophorbide a and its related compounds as possible anti-tumor promoters in the leaves of Neptunia oleracea.

A. Murakami, H. Ohigashi, Y. Nakamura, 1996, Bioscience, biotechnology, and biochemistry.

Ursolic acid: an anti- and pro-inflammatory triterpenoid.

Y. Ikeda, A. Murakami, H. Ohigashi, 2008, Molecular nutrition & food research.

Toward the chemical ecology of medicinal plant use in chimpanzees: The case ofVernonia amygdalina, a plant used by wild chimpanzees possibly for parasite-related diseases

H. Ohigashi, D. Warhurst, D. Allen, 1994, Journal of Chemical Ecology.

Chemical Ecology of the Medicinal Use of Vernonia amygdalina by Chimpanzees

H. Ohigashi, M. Huffman, K. Koshimįzu, 1996 .

Chemoprevention: Insights into biological mechanisms and promising food factors

A. Murakami, H. Ohigashi, K. Koshimįzu, 1999 .

Dextran sulfate sodium enhances interleukin-1 beta release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages.

A. Murakami, H. Ohigashi, K. Kwon, 2007, Life sciences.

Modifying Effects of 1'-Acetoxychavicol Acetate (ACA) and the Novel Synthetic Retinoids Re-80, Am-580 and Am-55P in a Two-Stage Carcinogenesis Model in Female Rats

K. Imaida, M. Hirose, Satoru Takahashi, 2004, Toxicologic pathology.

Screening for in vitro anti-tumor promoting activities of edible plants from Thailand.

A. Murakami, H. Ohigashi, K. Koshimįzu, 1995, Cancer letters.

Piscicidal Constituents of Calophyllum Inophyllum

H. Ohigashi, K. Kawazu, N. Takahashi, 2017 .

Ring conformational requirement for biological activity of abscisic acid probed by the cyclopropane analogues

H. Ohigashi, N. Hirai, Y. Todoroki, 1996 .

Anti-tumor promotion with food phytochemicals: a strategy for cancer chemoprevention.

A. Murakami, H. Ohigashi, A Murakami, 1996, Bioscience, biotechnology, and biochemistry.

Screening of tissue cultures and thalli of lichens and some of their active constituents for inhibition of tumor promoter-induced Epstein-Barr virus activation.

A. Murakami, H. Ohigashi, Y. Yamamoto, 1995, Chemical & pharmaceutical bulletin.

Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes.

H. Ohigashi, K. Irie, P. Wender, 1999, Bioorganic & medicinal chemistry letters.

Biosynthesis of Abscisic Acid by the Non-mevalonate Pathway in Plants, and by the Mevalonate Pathway in Fungi

H. Ohigashi, R. Yoshida, N. Hirai, 2000, Bioscience, biotechnology, and biochemistry.

Isolation and identification of DPPH radical scavenging compounds in Kurosu (Japanese unpolished rice vinegar).

H. Ohigashi, Yoshimasa Nakamura, K. Uenakai, 2002, Journal of agricultural and food chemistry.

Tastes of Chimpanzee Plant Foods1

T. Nishida, H. Ohigashi, K. Koshimįzu, 2000, Current Anthropology.

Anti-tumor Promoting Activity of Bufadienolides from Kalanchoe pinnata and K. daigremontiana × butiflora

K. Akiyama, A. Murakami, H. Ohigashi, 2001, Bioscience, biotechnology, and biochemistry.

Bitter Steroid Glucosides, Vernoniosides A1, A2, and A3, and Related B1 from a Possible Medicinal Plant, Vernonia amygdalina, Used by Wild Chimpanzees.

T. Nishida, H. Ohigashi, M. Hirota, 1992 .

Bitter principle and a related steroid glucoside from Vernonia amygdalina, a possible medicinal plant for wild chimpanzees

H. Nozaki, T. Nishida, H. Ohigashi, 1991 .

Antioxidant compounds from the leaves of Peucedanum japonicum thunb.

H. Ohigashi, H. Kikuzaki, N. Nakatani, 2003, Journal of agricultural and food chemistry.

Screening for the In Vitro Anti-tumor-promoting Activities of Edible Plants from Malaysia

A. Ali, A. Murakami, H. Ohigashi, 2000, Bioscience, biotechnology, and biochemistry.

Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation.

A. Murakami, H. Ohigashi, K. Koshimįzu, 1998, Planta medica.

Actinidic Acid, a New Triterpene Phytoalexin from Unripe Kiwi Fruit

H. Ohigashi, M. Tsuda, N. Hirai, 2001, Bioscience, biotechnology, and biochemistry.

TRITERPENE PHYTOALEXINS FROM NECTARINE FRUITS

H. Ohigashi, M. Tsuda, N. Hirai, 1999 .

Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L.

Y. Ito, H. Ohigashi, H. Tokuda, 1986, Cancer letters.

Quantification of ABA and its metabolites in sweet cherries usingdeuterium-labeled internal standards

H. Ohigashi, S. Kondo, S. Setha, 2005, Plant Growth Regulation.

Revised chirality of the acyl group of 8'-O-(3-hydroxy-3-methylglutaryl)-8'-hydroxyabscisic acid.

H. Ohigashi, M. Hirota, N. Hirai, 2004, Phytochemistry.

Arabidopsis CYP707As Encode (+)-Abscisic Acid 8′-Hydroxylase, a Key Enzyme in the Oxidative Catabolism of Abscisic Acid1

D. Ohta, H. Ohigashi, M. Mizutani, 2004, Plant Physiology.

Synthesis, biological activity and metabolism of (S)-(+)-3′-Fluoroabscisic acid

H. Ohigashi, N. Hirai, Y. Todoroki, 1995 .

New phenylphenalenones from banana fruit

H. Ohigashi, N. Hirai, T. Kamo, 2001 .

Steroid glucosides from vernonia amygdalina, a possible chimpanzee medicinal plant

H. Ohigashi, M. Hirota, M. Huffman, 1993 .

In Vitro Absorption and Metabolism of Nobiletin, a Chemopreventive Polymethoxyflavonoid in Citrus Fruits

A. Murakami, H. Ohigashi, C. Ito, 2001, Bioscience, biotechnology, and biochemistry.

Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 2004, FEBS letters.

Possible inhibitor of tumor promotion and related polyphenol from Lophira alata, a medicinal plant in tropical west Africa.

H. Nozaki, A. Murakami, H. Ohigashi, 1991 .

Use of Vernonia amygdalina by wild chimpanzee: Possible roles of its bitter and related constituents

H. Ohigashi, M. Huffman, K. Koshimįzu, 1994, Physiology & Behavior.

In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia.

A. Murakami, H. Ohigashi, V. Santisopasri, 2002, Journal of ethnopharmacology.

Quassinoids from Eurycoma longifolia as plant growth inhibitors.

A. Murakami, H. Ohigashi, V. Santisopasri, 2001, Phytochemistry.

Structure of β-amyloid fibrils and its relevance to their neurotoxicity: Implications for the pathogenesis of Alzheimer’s disease

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2005 .

Arachidonic acid cascade inhibitors modulate phorbol ester-induced oxidative stress in female ICR mouse skin: differential roles of 5-lipoxygenase and cyclooxygenase-2 in leukocyte infiltration and activation.

H. Ohigashi, Yoshimasa Nakamura, T. Osawa, 2003, Free radical biology & medicine.

Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit.

A. Murakami, H. Ohigashi, Y. Nakamura, 2000, Journal of agricultural and food chemistry.

Flavanols, as Plant Growth Inhibitors from Roots of Peach, Prunus persica Batsh. cv. ‘Hakuto ’

H. Ohigashi, A. Sugiura, H. Fukui, 1982 .

A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase.

Takuji Tanaka, A. Murakami, H. Ohigashi, 2000, Carcinogenesis.

Food Factors for Cancer Prevention

H. Ohigashi, T. Osawa, J. Terao, 1997, Springer Japan.

Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats.

A. Murakami, H. Ohigashi, T. Tanaka, 2000, Carcinogenesis.

Resiniferonol-related Diterpene Esters from Daphne odora Thunb. and their Ornithine Decarboxylase-inducing Activity in Mouse Skin

T. Sugimura, H. Ohigashi, M. Hirota, 1982 .

Zerumbone Induces Heme Oxygenase-1 Expression in Mouse Skin and Cultured Murine Epidermal Cells through Activation of Nrf2

J. K. Kundu, Y. Surh, H. Na, 2011, Cancer Prevention Research.

Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters.

A. Murakami, H. Ohigashi, M. Hirota, 1992, Bioscience, biotechnology, and biochemistry.

Isolation and Identification of Acetylenic Spiroketal Enol Ethers from Artemisia lactiflora as Inhibitors of Superoxide Generation Induced by a Tumor Promoter in Differentiated HL-60 Cells

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 1998 .

Inhibitory Effects of Curcumin and Tetrahydrocurcuminoids on the Tumor Promoter‐induced Reactive Oxygen Species Generation in Leukocytes in vitro and in vivo

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 1998, Japanese journal of cancer research : Gann.

Glyceroglycolipids from Citrus hystrix, a Traditional Herb in Thailand, Potently Inhibit the Tumor-Promoting Activity of 12-O-Tetradecanoylphorbol 13-Acetate in Mouse Skin

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 1995 .

In Vitro Absorption and Metabolism of a Citrus Chemopreventive Agent, Auraptene, and Its Modifying Effects on Xenobiotic Enzyme Activities in Mouse Livers

K. Sasaki, A. Murakami, H. Ohigashi, 2000, Nutrition and cancer.

Targeting NOX, INOS and COX‐2 in inflammatory cells: Chemoprevention using food phytochemicals

A. Murakami, H. Ohigashi, 2007, International journal of cancer.

Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells

A. Murakami, H. Ohigashi, 2006, Biological chemistry.

Molecular targets for antiinflammation and dietary component-drug synergy.

A. Murakami, H. Ohigashi, L. Thompson, 2006 .

Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid.

A. Murakami, H. Ohigashi, H. Nishino, 2000, BioFactors.

Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin

A. Murakami, H. Ohigashi, K. Koshimįzu, 2002, BioFactors.

Triterpene Phytoalexins from Strawberry Fruit

H. Ohigashi, R. Yoshida, M. Tsuda, 2000, Bioscience, biotechnology, and biochemistry.

Aggregated Ursolic Acid, a Natural Triterpenoid, Induces IL-1β Release from Murine Peritoneal Macrophages: Role of CD361

S. Yamashita, Y. Ikeda, A. Murakami, 2007, The Journal of Immunology.

African Burkitt's lymphoma: a plant, Euphorbia tirucalli, reduces Epstein-Barr virus-specific cellular immunity.

H. Ohigashi, T. Osato, S. Imai, 1994, Anticancer research.

Chromosome translocation and c-MY Cactivation by Epstein-Barr virus and Euphorbia tirucalli in B lymphocytes

H. Ohigashi, T. Osato, S. Imai, 1991, The Lancet.

Changes in the Content and Biosynthesis of Phytoalexins in Banana Fruit

H. Ohigashi, M. Tsuda, N. Hirai, 2000, Bioscience, biotechnology, and biochemistry.

Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis

H. Ohigashi, M. Natsume, K. Kawabata, 2015, Bioscience, biotechnology, and biochemistry.

Cyclopentenone Prostaglandins as Potential Inducers of Phase II Detoxification Enzymes

Y. Kawamoto, H. Ohigashi, Yoshimasa Nakamura, 2000, The Journal of Biological Chemistry.

A Mainstay of Functional Food Science in Japan—History, Present Status, and Future Outlook

S. Arai, H. Ohigashi, T. Osawa, 2001, Bioscience, biotechnology, and biochemistry.

Possible anti-tumour promoting properties of traditional Thai food items and some of their active constituents.

A. Murakami, H. Ohigashi, K. Koshimįzu, 1994, Asia Pacific journal of clinical nutrition.

Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols.

H. Ohigashi, E. Takahashi, M. Kobayashi, 1991, FEMS microbiology letters.

Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, of Boesenbergia pandurata

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 1993 .

1'-Acetoxychavicol Acetate as a Potent Inhibitor of Tumor Promoter-induced Epstein-Barr Virus Activation from Languas galanga, a Traditional Thai Condiment

A. Murakami, H. Ohigashi, K. Koshimįzu, 1993 .

Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines.

A. Murakami, H. Ohigashi, M. Miyamoto, 2004, BioFactors.

Differentiation of 4α- and 4β-phorbol diesters by fast atom bombardment mass spectrometry

H. Ohigashi, Makoto Suzuki, K. Koshimįzu, 1993 .

Possible anti-tumour promoters: bi- and tetraflavonoids from Lophira alata

A. Murakami, H. Ohigashi, M. Hirota, 1992 .

The modifying effects of green tea polyphenols on acute colitis and inflammation‐associated colon carcinogenesis in male ICR mice

Takuji Tanaka, S. Miyamoto, A. Murakami, 2010, BioFactors.

Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.

Takuji Tanaka, S. Miyamoto, A. Murakami, 2008, Carcinogenesis.

Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation.

A. Murakami, H. Ohigashi, K. Koshimįzu, 1999, Bioscience, biotechnology, and biochemistry.

Combinatorial Effects of Nonsteroidal Anti-inflammatory Drugs and Food Constituents on Production of Prostaglandin E2 and Tumor Necrosis Factor-α in RAW264.7 Murine Macrophages

A. Murakami, H. Ohigashi, K. Koshimįzu, 2003, Bioscience, biotechnology, and biochemistry.

Screening of edible plants against possible anti-tumor promoting activity.

H. Ohigashi, H. Tokuda, A. Kondo, 1988, Cancer letters.

Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages.

Y. Ikeda, A. Murakami, H. Ohigashi, 2005, Biochemical pharmacology.

Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-γ-induced IκB degradation in RAW264.7 macrophages

A. Murakami, H. Ohigashi, Kazuhiko Matsumoto, 2003 .

Structure-activity relationships of (1'S)-1'-acetoxychavicol acetate, a major constituent of a southeast Asian condiment plant Languas galanga, on the inhibition of tumor-promoter-induced Epstein-Barr virus activation.

A. Murakami, H. Ohigashi, K. Koshimįzu, 2000, Journal of Agricultural and Food Chemistry.

(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.

A. Murakami, H. Ohigashi, K. Kawabata, 2005, Carcinogenesis.

1'-Acetoxychavicol acetate induces apoptosis of myeloma cells via induction of TRAIL.

Keisuke Ito, M. Kizaki, T. Nakazato, 2005, Biochemical and biophysical research communications.

Modulation of MAPK Pathways by Food Phytochemicals: Risks and Benefits

Y. Ikeda, A. Murakami, H. Ohigashi, 2008 .

Involvement of the Mitochondrial Death Pathway in Chemopreventive Benzyl Isothiocyanate-induced Apoptosis*

H. Ohigashi, Yoshimasa Nakamura, T. Osawa, 2002, The Journal of Biological Chemistry.

Effects of (+)-8′,8′,8′-trifluoroabscisic acid on a-amylase expression and sugar accumulation in rice cells

H. Ohigashi, M. Kashem, T. Mitsui, 1998, Planta.

Indolactam-V Is Involved in the CH/π Interaction with Pro-11 of the PKCδ C1B Domain: Application for the Structural Optimization of the PKCδ Ligand

H. Ohigashi, K. Irie, Y. Nakagawa, 2005 .

Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination.

Takuji Tanaka, A. Murakami, H. Ohigashi, 2003, Biochemical pharmacology.

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2003, The Journal of biological chemistry.

1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a Superoxide Generation Inhibitor from Perilla frutescens var. crispa

A. Murakami, H. Ohigashi, K. Kawabata, 2011, Bioscience, biotechnology, and biochemistry.

Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.

T. Shirasawa, Takahiko Shimizu, H. Ohigashi, 2005, Bioorganic & medicinal chemistry.

Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action.

A. Murakami, H. Ohigashi, Tomohiro Shigemori, 2005, The Journal of nutrition.

Nobiletin, a Citrus Flavonoid, Down-Regulates Matrix Metalloproteinase-7 (matrilysin) Expression in HT-29 Human Colorectal Cancer Cells

A. Murakami, H. Ohigashi, K. Kawabata, 2005, Bioscience, biotechnology, and biochemistry.

New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages.

A. Murakami, H. Ohigashi, T. Kawada, 2005, Biochemical pharmacology.

Epstein-Barr virus-enhancing plant promoters in east Africa.

H. Ohigashi, T. Osato, M. Hirota, 1986, AIDS research.

Epstein-Barr virus-inducing activity of Euphorbiaceae plants commonly grown in Cameroon.

Y. Ito, H. Ohigashi, H. Tokuda, 1985, Cancer letters.

Larva-Development Inhibitors of Black Pepper

H. Ohigashi, S. Nishimuro, 1983 .

Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction.

Takuji Tanaka, N. Colburn, M. Yasuda, 2009, Carcinogenesis.

Running title: Anti-tumor promoting effects of linoleic acid metabolite

Takuji Tanaka, M. Yasuda, D. Hou, 2009 .

Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages.

A. Murakami, H. Ohigashi, Kazuhiko Matsumoto, 2003, Cancer letters.

Extract of Kurosu, a Vinegar From Unpolished Rice, Inhibits Azoxymethane-Induced Colon Carcinogenesis in Male F344 Rats

Takuji Tanaka, H. Ohigashi, H. Kohno, 2004, Nutrition and cancer.

An Environmental Plant Factor Enhancing EBV-Specific Events in East Africa: Reduction of Killer T-Cell Function and Its Protection by Hot Spring Water

H. Ohigashi, T. Osato, S. Imai, 1989 .

Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ

U. Kikkawa, H. Ohigashi, K. Irie, 1997 .

Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p′-DDT in U937 macrophages

Dalei Wu, F. Matsumura, A. Murakami, 2010, Archives of Toxicology.

E V ects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p (cid:2) -DDT in U937 macrophages

Dalei Wu, F. Matsumura, A. Murakami, 2010 .

Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.

H. Ohigashi, K. Irie, Y. Nakagawa, 2004, Current pharmaceutical design.

Search for Naturally-occurring Antioxidative Chemopreventors on the Basis of the Involvement of Leukocyte-derived Reactive Oxygen Species in Carcinogenesis.

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 2000, Asian Pacific journal of cancer prevention : APJCP.

Antitumoral and antimicrobial activities of bitter sesquiterpene lactones of Vernonia amygdalina, a possible medicinal plant used by wild chimpanzees.

H. Ohigashi, M. Huffman, K. Koshimįzu, 1993, Bioscience, biotechnology, and biochemistry.

Antischistosomal activities of sesquiterpene lactones and steroid glucosides from Vernonia amygdalina, possibly used by wild chimpanzees against parasite-related diseases.

H. Ohigashi, M. Huffman, H. Sugiyama, 1992, Bioscience, biotechnology, and biochemistry.

Physiological activities and the active constituents of potentially medicinal plants used by wild chimpanzees of the Mahale mountains, Tanzania

T. Nishida, H. Ohigashi, M. Huffman, 1993, International Journal of Primatology.

Possible Medicinal Plants Used by Wild Chimpanzees, and Their Physiologically Active Compounds

T. Nishida, H. Ohigashi, M. Huffman, 1991 .

Dietary Supplementation of the Citrus Antioxidant Auraptene Inhibits N,N-Diethylnitrosamine-Induced Rat Hepatocarcinogenesis

Takuji Tanaka, A. Hara, Y. Hirose, 2004, Oncology.

Chavicol, as a Larva-growth Inhibitor, from Viburnum japonicum Spreng

H. Ohigashi, K. Koshimįzu, 1976 .

Inhibitory Effects of 1′‐Acetoxychavicol Acetate on N‐Nitrosobis(2‐oxopropyl)‐amine‐induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters

H. Son, A. Nishikawa, F. Furukawa, 2000, Japanese journal of cancer research : Gann.

Synthesis and Phorbol Ester Binding of the Cysteine-rich Domains of Diacylglycerol Kinase (DGK) Isozymes

H. Ohigashi, Y. Shirai, N. Saito, 2003, The Journal of Biological Chemistry.

Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2002, Biochemical and biophysical research communications.

Suppressive Effects of Edible Thai Plants on Superoxide and Nitric Oxide Generation.

Ha Won Kim, A. Murakami, H. Ohigashi, 2002, Asian Pacific Journal of Cancer Prevention.

Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s.

H. Ohigashi, A. Masuda, K. Irie, 2004, Bioorganic & Medicinal Chemistry.

Extract of vinegar "Kurosu" from unpolished rice inhibits the development of colonic aberrant crypt foci induced by azoxymethane.

H. Ohigashi, H. Kohno, K. Uenakai, 2003, Journal of experimental & clinical cancer research : CR.

Title Soybean extracts increase cell surface ZIP 4 abundance and cellular zinc levels : A potential novel strategy to enhance zinc absorption by ZIP 4 targeting

H. Narita, S. Masuda, M. Nagao, 2019 .

An approach to functional food: cancer preventive potential of vegetables and fruits and their active constituents.

A. Murakami, H. Ohigashi, Akira Murakami, 2009, Nutrition reviews.

Phenylphenalenone-type Phytoalexins from Unripe Buñgulan Banana Fruit.

H. Ohigashi, M. Tsuda, N. Hirai, 1998, Bioscience, biotechnology, and biochemistry.

3-Hydroxyuridine, an allelopathic factor of an African tree, Baillonella toxisperma

H. Ohigashi, K. Koshimįzu, M. Kaji, 1989 .

Synthesis of novel polyphenols consisted of ferulic and gallic acids, and their inhibitory effects on phorbol ester-induced Epstein-Barr virus activation and superoxide generation.

A. Murakami, H. Ohigashi, E. Nomura, 2002, Bioorganic & medicinal chemistry.

Suppressive effects of novel ferulic acid derivatives on cellular responses induced by phorbol ester, and by combined lipopolysaccharide and interferon-gamma.

M. Kadota, A. Murakami, H. Ohigashi, 2000, Cancer letters.

Nobiletin, a citrus flavonoid, suppresses phorbol ester‐induced expression of multiple scavenger receptor genes in THP‐1 human monocytic cells

A. Murakami, H. Ohigashi, Ai Eguchi, 2006, FEBS letters.

Antitumor Promoters from Edible Plants

A. Murakami, H. Ohigashi, K. Koshimįzu, 1994 .

Screening for in vitro anti-tumor-promoting activities of edible plants from Indonesia.

A. Murakami, H. Ohigashi, H. Morita, 1998, Cancer Detection and Prevention.

Anti-tumor Promoters from Edible Thai Plants: Isolation, Cancer Preventive Potential, and Action Mechanisms

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 1997 .

Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces

H. Ohigashi, K. Irie, Y. Nakagawa, 1998 .

Screening for the of Edible Plantsin Vitro Anti-tumor-promoting from Malaysia Activities

A. Murakami, H. Ohigashi, K. Koshimįzu, 2017 .

Search for Chemopreventive Agents on the Basis of the Involvement of Oxidative Stress and Inflammation in Carcinogenesis

A. Murakami, H. Ohigashi, Yoshimasa Nakamura, 2002 .

Synthesis and biological activity of 7'-,8'−, and 9'-alkyl analogues of abscisic acid

H. Ohigashi, N. Hirai, Y. Todoroki, 1995 .

Chemoprevention of Oral and Colon Carcinogenesis by Natural Compounds Protocatechuic Acid, 1′-Acetoxychavicol Acetate, S-Methyl Methane Thiosulfonate, and Hesperidin from Vegetables and Fruits

Takuji Tanaka, H. Makita, H. Mori, 1997 .

Ursolic Acid Enhances Cyclooxygenases and Tumor Necrosis Factor-α Expression in Mouse Skin

Y. Ikeda, A. Murakami, H. Ohigashi, 2006 .

Biological activities of abscisic acid analogs in the morphological change of the green alga Haematococcus pluvialis

H. Ohigashi, Makio Kobayashi, Y. Tsuji, 1998 .

Toxic dose of a simple phenolic antioxidant, protocatechuic acid, attenuates the glutathione level in ICR mouse liver and kidney.

H. Ohigashi, Y. Nakamura, K. Torikai, 2001, Journal of agricultural and food chemistry.

Cancer prevention with food factors: alone and in combination.

A. Murakami, H. Ohigashi, 2004, BioFactors.

H. Ohigashi, V. Santisopasri, S. Jiwajinda, 2000, Bioscience, biotechnology, and biochemistry.

Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.

Takuji Tanaka, S. Miyamoto, A. Murakami, 2010, Chemico-biological interactions.

Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha.

A. Murakami, H. Ohigashi, K. Kawabata, 2000, Cancer research.

Role of Tumor Necrosis Factor-- stimulated RAW 264 . 7 Cells : The γ Cocultured with Interferon-but not Tumor Promoter-resistant , JB 6 Mouse Epidermal Cells Nitric Oxide Synthase Is Induced in Tumor Promoter-sensitive

H. Ohigashi, K. Kawabata, Yoshimasa Nakamura, 2000 .

Distance Measurement between Tyr10 and Met35 in Amyloid β by Site‐Directed Spin‐Labeling ESR Spectroscopy: Implications for the Stronger Neurotoxicity of Aβ42 than Aβ40

H. Ohigashi, K. Irie, H. Hara, 2007 .

Biosynthesis of Abscisic Acid by the Direct Pathway via Ionylideneethane in a Fungus, Cercospora cruenta

H. Ohigashi, R. Yoshida, N. Hirai, 2004, Bioscience, biotechnology, and biochemistry.

Protein kinase C regulatory domain surrogate peptides : Effects of metal ions on folding, phorbol ester-binding, and selectivity

H. Ohigashi, K. Irie, P. Wender, 1997 .

Chemoprevention with Dietary Plants: Promising Phytochemicals, Animal Model Studies and Possible Mechanisms of Action

H. Ohigashi, 2008 .

Mass spectrometric identification of a phorbol diester 12-O-hexadecanoylphorbol-13-acetate, an Epstein-Barr virus-activating substance, in the soil collected from under Sapium sebiferum.

H. Ohigashi, T. Osato, K. Koshimįzu, 1991, Cancer letters.

1′-Acetoxychavicol acetate-induced cytotoxicity is accompanied by a rapid and drastic modulation of glutathione metabolism

I. Matsui‐yuasa, S. Xu, A. Kojima-Yuasa, 2008, Amino Acids.

Reply to letter to the editor Comment on: Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/Ksj-db/db mice

Takuji Tanaka, S. Miyamoto, A. Murakami, 2010 .

Auraptene Decreases the Activity of Matrix Metalloproteinases in Dextran Sulfate Sodium-Induced Ulcerative Colitis in ICR Mice

A. Murakami, H. Ohigashi, K. Kawabata, 2006, Bioscience, biotechnology, and biochemistry.

The biosynthetic pathway to abscisic acid via ionylideneethane in the fungus Botrytis cinerea.

H. Ohigashi, R. Yoshida, N. Hirai, 2004, Phytochemistry.

Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet.

K. Yamamoto, H. Mori, M. Shimizu, 2001, Life sciences.

Desorption chemical ionization mass spectrometry of phorbol esters

H. Ohigashi, Makoto Suzuki, K. Koshimįzu, 1991 .

New Ingenol-Esters as Piscicidal Constituents of Euphorbia cotinifolia L.

H. Ohigashi, M. Hirota, K. Koshimįzu, 1980 .

Polymethylated Flavonoids: Cancer Preventive and Therapeutic Potentials Derived from Anti-inflammatory and Drug Metabollsm-Modifying Properties

A. Murakami, H. Ohigashi, 2004 .

Synthesis and biological activity of 3′-chloro, -bromo, and -iodoabscisic acids, and biological activity of 3′-fluoro-8′-hydroxyabscisic acid

H. Ohigashi, N. Hirai, Y. Todoroki, 1999 .

Synthesis and Biological Activities of 8'-Methylene- and 8'-Methylidyneabscisic Acids.

H. Ohigashi, N. Hirai, Y. Todoroki, 1997, Bioscience, biotechnology, and biochemistry.

Synthesis, Biological Activity, and Metabolism of 8',8',8'-Trideuteroabscisic Acid.

H. Ohigashi, N. Hirai, Y. Todoroki, 1997, Bioscience, biotechnology, and biochemistry.

Synthesis and Biological Activity of 3′-Chloro, -Bromo, and -Iodoabscisic Acids, and Biological Activity of 3′-Fluoro-8′-hydroxyabscisic Acid.

H. Ohigashi, N. Hirai, Y. Todoroki, 2000 .

( )-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK 1 / 2 pathway in HT-29 human colorectal cancer cells

A. Murakami, H. Ohigashi, K. Kawabata, 2005 .

Bitter cyanoglucosides from Lophira alata

A. Murakami, H. Ohigashi, M. Hirota, 1993 .

Neurotoxicity and Physicochemical Properties of Aβ Mutant Peptides from Cerebral Amyloid Angiopathy

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2003, Journal of Biological Chemistry.

Aggregation and neurotoxicity of mutant amyloid β (Aβ) peptides with proline replacement: importance of turn formation at positions 22 and 23

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2002 .

Pivotal role of electrophilicity in glutathione S-transferase induction by tert-butylhydroquinone.

H. Ohigashi, Yoshimasa Nakamura, T. Osawa, 2003, Biochemistry.

Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2005, Journal of bioscience and bioengineering.

Suppressive activity of a fermented grain food product on dextran sulfate sodium‐induced experimental colitis in mice

Takuji Tanaka, A. Murakami, H. Ohigashi, 2004, BioFactors.

Growth inhibition of colon cancer cells by auraptene is not correlated with the modulation of beta-catenin-TCF signaling

Takuji Tanaka, Y. Hirose, H. Mori, 2004 .

Analysis of the Secondary Structure of β-Amyloid (Aβ42) Fibrils by Systematic Proline Replacement*

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2004, Journal of Biological Chemistry.

Involvement of protein tyrosine phosphorylation and reduction of cellular sulfhydryl groups in cell death induced by 1' -acetoxychavicol acetate in Ehrlich ascites tumor cells.

A. Kojima, T. Hasuma, Y. Yano, 2002, Chemico-biological interactions.

Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells.

Ha Won Kim, A. Murakami, H. Ohigashi, 2008, Cancer letters.

Enzymes Peroxidation and with Induction of Phase II Drug-metabolizing Correlates with Suppression of Cell Proliferation and Lipid Activity in Rat Large Bowel Tumorigenesis : The Inhibition Auraptene Exerts Dose-dependent Chemopreventive Citrus Updated

Wataru, Hajime, Ota, 2006 .

Possible anti-tumor promoting properties of marine algae and in vivo activity of Wakame seaweed extract.

H. Ohigashi, Y. Sakai, K. Koshimįzu, 1992, Bioscience, biotechnology, and biochemistry.

Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.

M. Nagao, T. Shirasawa, Takahiko Shimizu, 2004, The Journal of biological chemistry.

Novel bioassay system for evaluating anti-oxidative activities of food items: Use of basolateral media from differentiated Caco-2 cells

A. Murakami, H. Ohigashi, Ai Eguchi, 2005, Free radical research.

Allelochemicals of gooseweed, sphenoclea zeylanica

H. Ohigashi, J. Harada, S. Sakashita, 1997 .

Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.

Takuji Tanaka, S. Miyamoto, A. Murakami, 2010, Chemico-biological interactions.

Mechanism of the formation of a dehydrated ion by an unusual loss of oxygen at the 4'-carbonyl group of abscisic acid methyl ester in electron ionization mass spectrometry.

H. Ohigashi, N. Hirai, N. Takeda, 2005, Journal of mass spectrometry : JMS.

Synthesis and Biological Activities of New Conformationally Restricted Analogues of (−)-Indolactam-V: Elucidation of the Biologically Active Conformation of the Tumor-Promoting Teleocidins

H. Ohigashi, Yoshimasa Nakamura, H. Nishino, 1996 .

Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters.

H. Ohigashi, N. Saito, K. Irie, 2001, Biochemical and biophysical research communications.

Binding Selectivity of Conformationally Restricted Analogues of (−)-Indolactam-V to the C1 Domains of Protein Kinase C Isozymes

H. Ohigashi, A. Masuda, K. Irie, 2002, Bioscience, biotechnology, and biochemistry.

Suppression of Free Radical-Induced Mutation of Animal Cell Genes by Food Factors

Ha Won Kim, A. Murakami, H. Ohigashi, 2003 .

Metabolism and Absorption of Auraptene (7-Geranyloxylcoumarin) in Male SD Rats: Comparison With 7-Ethoxycoumarin

A. Murakami, H. Ohigashi, W. Kuki, 2008, Nutrition and cancer.