F. Roletto

发表

Structure-based drug design to the discovery of new 2-aminothiazole CDK2 inhibitors.

Anna Vulpetti, E. Casale, A. Vulpetti, 2006, Journal of molecular graphics & modelling.

3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding.

Anna Vulpetti, Antonella Isacchi, Enrico Pesenti, 2004, Journal of medicinal chemistry.

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).

S. Pang, G. Trainor, M. Poss, 2009, Bioorganic & medicinal chemistry letters.

4,5-Dihydro-1H-pyrazolo[4,3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors.

F. Fiorentini, M. Brasca, F. Roletto, 2010, Bioorganic & medicinal chemistry letters.

Dual Targeting of CDK and Tropomyosin Receptor Kinase Families by the Oral Inhibitor PHA-848125, an Agent with Broad-Spectrum Antitumor Efficacy

A. Isacchi, C. Mercurio, F. Colotta, 2010, Molecular Cancer Therapeutics.

Basic fibroblast growth factor stimulates hepatocyte growth factor/scatter factor secretion by human mesenchymal cells

A. Galvani, F. Roletto, C. Cristiani, 1996, Journal of cellular physiology.

Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.

R. Bosotti, A. Isacchi, A. Montagnoli, 2008, Journal of medicinal chemistry.

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.

J. Bischoff, C. Mercurio, A. Vulpetti, 2006, Bioorganic & medicinal chemistry letters.

First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.

A. Isacchi, A. Montagnoli, J. Berthelsen, 2009, Journal of medicinal chemistry.

Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

A. Isacchi, A. Montagnoli, R. D'Alessio, 2010, Journal of medicinal chemistry.

Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor.

A. Isacchi, E. Casale, C. Mercurio, 2009, Journal of medicinal chemistry.

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

Paola Storici, Maurizio Rocchetti, Enrico Pesenti, 2006, Journal of medicinal chemistry.

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.

A. Vulpetti, F. Roletto, P. Cappella, 2005, Journal of medicinal chemistry.

Benzodipyrazoles: a new class of potent CDK2 inhibitors.

Anna Vulpetti, Alexander Cameron, Roberto D'Alessio, 2005, Bioorganic & medicinal chemistry letters.

Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.

V. Croci, D. Volpi, F. Roletto, 2010, Bioorganic & medicinal chemistry.

3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization.

Anna Vulpetti, Enrico Pesenti, Ciro Mercurio, 2005, Journal of medicinal chemistry.

6‐Substituted Pyrrolo[3,4‐c]pyrazoles: An Improved Class of CDK2 Inhibitors

C. Mercurio, A. Vulpetti, D. Ballinari, 2007, ChemMedChem.

Stabilization of recombinant human basic fibroblast growth factor by chemical modifications of cysteine residues.

F Bertolero, G. Cauet, F. Roletto, 1992, European journal of biochemistry.

STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529

J. Bischoff, C. Mercurio, A. Vulpetti, 2005 .