O. Lozach

发表

Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes.

L. Meijer, F. Totzke, B. Voigt, 2005, Bioorganic & medicinal chemistry letters.

Evaluation of the transfection efficacies of quaternary ammonium salts prepared from sophorolipids.

O. Lozach, C. Stevens, K. V. Van Geem, 2016, Organic & biomolecular chemistry.

Synthetic phospholipids and phospho-bola-amphiphiles for nucleic acid delivery

O. Lozach, P. Midoux, T. Montier, 2016 .

Lipophosphoramidate-based bipolar amphiphiles: their syntheses and transfection properties.

O. Lozach, T. Montier, T. Le Gall, 2016, Organic & biomolecular chemistry.

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors.

Olivier Lozach, Laurent Meijer, Thierry Besson, 2006, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of Bolaamphiphilic Sophorolipids

T. Coenye, W. Soetaert, O. Lozach, 2018 .

Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities.

L. Meijer, O. Lozach, Ashok Kumar, 2005, Bioorganic & medicinal chemistry.

The Paullones: A Family of Pharmacological Inhibitors of Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3

L. Meijer, M. Leost, C. Kunick, 2005 .

Indirubins deplete striatal monoamines in the Intact and MPTP-treated mouse brain and block kainate-induced striatal astrogliosis.

L. Meijer, J. O'Callaghan, A. Skaltsounis, 2010, Neurotoxicology and teratology.

Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.

C. Johnson, L. Meijer, A. Skaltsounis, 2008, Journal of medicinal chemistry.

Biosynthesis of New Indigoid Inhibitors of Protein Kinases Using Recombinant Cytochrome P450 2A6

L. Meijer, F. Guengerich, O. Lozach, 2005, Chemistry & biodiversity.

Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A

L. Meijer, M. Leost, O. Lozach, 2004, Natural product research.

Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff's bases.

L. Meijer, O. Lozach, Ashok Kumar, 2006, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors.

L. Meijer, O. Lozach, G. Fournet, 2014, European journal of medicinal chemistry.

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance

L. Meijer, L. Alexopoulos, V. Gorgoulis, 2017, International journal of molecular sciences.

Synthesis and evaluation of new potent inhibitors of CK1 and CDK5, two kinases involved in Alzheimer’s disease

L. Meijer, O. Lozach, H. Galons, 2013, Medicinal Chemistry Research.

Synthesis and kinase inhibitory activity of novel substituted indigoids.

L. Meijer, C. Guguen-Guillouzo, O. Lozach, 2009, Bioorganic & medicinal chemistry.

Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors

L. Meijer, O. Lozach, Mélina Blairvacq, 2005, Journal of enzyme inhibition and medicinal chemistry.

An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives

L. Meijer, O. Lozach, M. Rahmouni, 2011 .

Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors.

L. Meijer, O. Lozach, S. Renault, 2010, European journal of medicinal chemistry.

Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.

L. Meijer, O. Lozach, N. Loaëc, 2013, Journal of medicinal chemistry.

Novel CDK Inhibition Profiles of Structurally Varied 1-Aza-9-oxafluorenes.

L. Meijer, F. Totzke, B. Voigt, 2005 .

Several Human Cyclin-Dependent Kinase Inhibitors, Structurally Related to Roscovitine, As New Anti-Malarial Agents

L. Meijer, J. Le bras, O. Lozach, 2014, Molecules.

Phenanthrene derivatives from Appendicula reflexa as new CDK1/cyclin B inhibitors

L. Meijer, O. Lozach, M. Litaudon, 2012 .

Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-β-carbolines

L. Meijer, C. Bailly, P. Renard, 2005 .

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

L. Meijer, O. Lozach, J. Bazureau, 2011, Molecules.

Antiinflammatory, analgesic and kinase inhibition activities of some acridine derivatives

L. Meijer, O. Lozach, S. Sondhi, 2004 .

Synthesis of 6-Pyridylaminopurines

L. Meijer, O. Lozach, S. Bouaziz, 2008 .

Synthesis of 6‐Pyridylaminopurines.

L. Meijer, O. Lozach, S. Bouaziz, 2008 .

Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors.

L. Meijer, O. Lozach, N. Loaëc, 2012, European journal of medicinal chemistry.

Rebeccamycin Derivatives as Dual DNA-Damaging Agents and Potent Checkpoint Kinase 1 Inhibitors

L. Meijer, P. Peixoto, B. Pfeiffer, 2008, Molecular Pharmacology.

Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors.

L. Meijer, O. Lozach, J. Robert, 2014, Bioorganic & medicinal chemistry letters.

Novel lipid-based quaternary ammonium sophorolipid amphiphiles with antimicrobial and transfection activities.

T. Coenye, W. Soetaert, O. Lozach, 2019, ChemSusChem.

Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.

L. Meijer, C. Bailly, O. Lozach, 2006, Journal of medicinal chemistry.

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents.

L. Meijer, P. Le Pape, O. Lozach, 2012, European journal of medicinal chemistry.

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.

L. Meijer, J. Endicott, O. Lozach, 2008, Journal of medicinal chemistry.

Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd(0) catalysed reductive N-heteroannulation.

L. Meijer, J. Nuzillard, O. Lozach, 2010, Organic & biomolecular chemistry.

9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication.

L. Meijer, C. Kunick, O. Lozach, 2008, Journal of medicinal chemistry.

Palladium-Catalyzed Synthesis of Substituted Pyrido[2,3-d]pyridazines at Positions 5 and 8

L. Meijer, F. Bihel, J. Bourguignon, 2012 .

Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones.

L. Meijer, O. Lozach, S. Connon, 2010, Bioorganic & medicinal chemistry letters.

Anticancer Alkaloid Lamellarins Inhibit Protein Kinases

Poonsakdi Ploypradith, Olivier Lozach, Laurent Meijer, 2008, Marine drugs.

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors.

L. Meijer, O. Lozach, Abdelouahid Samadi, 2009, Bioorganic & medicinal chemistry letters.

Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases.

Olivier Lozach, Laurent Meijer, L. Meijer, 2005, Journal of medicinal chemistry.

Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.

L. Meijer, O. Lozach, C. Guillouzo, 2011, European journal of medicinal chemistry.

10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A

L. Meijer, S. Knapp, K. Baumann, 2015, Journal of medicinal chemistry.

Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents.

L. Meijer, A. Abadi, O. Lozach, 2006, European journal of medicinal chemistry.

A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors.

L. Meijer, O. Lozach, D. Grierson, 2007, Bioorganic & medicinal chemistry.

Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.

L. Meijer, C. Bailly, O. Lozach, 2008, Bioorganic & medicinal chemistry.

Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases.

L. Meijer, O. Lozach, P. Retailleau, 2012, Journal of medicinal chemistry.

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.

L. Meijer, O. Lozach, J. Robert, 2008, European journal of medicinal chemistry.

Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors.

L. Meijer, O. Lozach, D. Grierson, 2006, Bioorganic & medicinal chemistry letters.

Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.

L. Meijer, J. Endicott, M. Kubbutat, 2007, Cancer research.

Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3.

L. Meijer, O. Lozach, J. Robert, 2006, Bioorganic & medicinal chemistry letters.

Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties.

L. Meijer, B. Voigt, O. Lozach, 2003, Journal of medicinal chemistry.

Synthesis and target identification of hymenialdisine analogs.

L. Meijer, D. Fabbro, N. Gray, 2004, Chemistry & biology.

Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.

L. Meijer, C. Guguen-Guillouzo, O. Lozach, 2012, Journal of medicinal chemistry.

Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.

L. Meijer, O. Lozach, S. Routier, 2012, European journal of medicinal chemistry.

An efficient method for the preparation of new analogs of leucettamine B under solvent-free microwave irradiation

L. Meijer, O. Lozach, S. Renault, 2009 .

Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors.

O. Lozach, B. Baratte, S. Ruchaud, 2016, European journal of medicinal chemistry.

New derivatives of pyrrolo[3,4-d]pyridazinone and their anticancer effects.

O. Lozach, W. Malinka, A. Redzicka, 2004, Farmaco.

Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors.

L. Meijer, Vasanthanathan Poongavanam, J. Kongsted, 2014, Bioorganic & medicinal chemistry.

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.

L. Meijer, P. Bonnet, C. Guguen-Guillouzo, 2016, European journal of medicinal chemistry.

Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

L. Meijer, O. Lozach, M. Sauvain, 2006, Bioorganic & medicinal chemistry.

Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A

L. Meijer, O. Lozach, B. Bodo, 2013, Molecules.

Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety.

L. Meijer, K. Menzel, O. Lozach, 2008, Journal of natural products.

Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.

L. Meijer, P. Furet, B. Chaudhuri, 2002, Journal of medicinal chemistry.

Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors.

L. Meijer, P. Bonnet, C. Guguen-Guillouzo, 2015, European journal of medicinal chemistry.

Design and Microwave Synthesis of New (5Z) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-Amino-5-arylidene-1,3-thiazol-4(5H)-one as New Inhibitors of Protein Kinase DYRK1A

L. Meijer, O. Lozach, M. Rahmouni, 2021, Pharmaceuticals.

Identification of potential cellular targets of aloisine A by affinity chromatography.

L. Meijer, O. Lozach, J. Lemoine, 2009, Bioorganic & medicinal chemistry.

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[boxs]

Lin Tang, Hervé Galons, Olivier Lozach, 2005, Journal of Biological Chemistry.

Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors.

L. Meijer, P. Bonnet, O. Lozach, 2014, European journal of medicinal chemistry.

First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors.

V. Tan, P. Colas, O. Lozach, 2011, Biotechnology journal.

Leucettines, a family of pharmacological inhibitors of DYRKs & CLKs kinases derived from the marine sponge Leucettamine B

L. Meijer, S. Knapp, O. Fedorov, 2012 .

A facile consensus ranking approach enhances virtual screening robustness and identifies a cell-active DYRK1α inhibitor.

Vassilios Myrianthopoulos, Emmanuel Mikros, Sofia Vasilakaki, 2018, Future medicinal chemistry.

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases

Daniel Cappel, Vassilios Myrianthopoulos, Emmanuel Mikros, 2012, ACS medicinal chemistry letters.

Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.

L. Meijer, N. Gresh, O. Lozach, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors.

L. Meijer, O. Lozach, S. Ruchaud, 2012, European journal of medicinal chemistry.

Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors.

L. Meijer, O. Lozach, N. Loaëc, 2014, Journal of natural products.

Substitution of unsaturated lipid chains by thioether-containing lipid chains in cationic amphiphiles: physicochemical consequences and application for gene delivery.

V. Vié, O. Lozach, T. Montier, 2019, Organic and biomolecular chemistry.

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

L. Meijer, S. Knapp, O. Fedorov, 2011, Journal of medicinal chemistry.

Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors.

L. Meijer, O. Lozach, C. Guillou, 2016, European journal of medicinal chemistry.

Synthesis and evaluation of new potent inhibitors of CK1 and CDK5, two kinases involved in Alzheimer’s disease

L. Meijer, O. Lozach, H. Galons, 2013, Medicinal Chemistry Research.

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

L. Meijer, O. Lozach, E. Débiton, 2011, Journal of medicinal chemistry.

Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide.

L. Meijer, R. Kiss, B. Ducommun, 2012, European journal of medicinal chemistry.

Inhibitors of Protein Kinases and Protein Phosphates Contributors

L. Meijer, D. Fabbro, M. Yacoub, 2005 .

Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors.

L. Meijer, P. Bonnet, O. Lozach, 2014, European journal of medicinal chemistry.

First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors.

V. Tan, P. Colas, O. Lozach, 2011, Biotechnology Journal.