R. Lobell

发表

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage.

Weikang Tao, Vicki J South, Yun Zhang, 2005, Cancer cell.

Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.

A. D. Rodrigues, E S Walsh, J B Gibbs, 2001, Journal of medicinal chemistry.

Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors.

Michael Reilly, Laura Sepp-Lorenzino, Weikang Tao, 2006, Bioorganic & medicinal chemistry letters.

Pre-clinical development of farnesyltransferase inhibitors

N. Kohl, R. Lobell, 1998, Cancer and Metastasis Reviews.

by a Farnesyl : Protein Transferase Inhibitor Develop Mammary Carcinomas That Can Be Growth-inhibited B Transgenic Mice ras Mouse Mammary Tumor Virus-Ki-Updated

R. Diehl, A. Kral, J. Davide, 2000 .

Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth

A. Burkhardt, N. Kohl, R. Lobell, 1997, BioFactors.

Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.

Youwei Yan, P. Coleman, L. Kuo, 2007, Bioorganic & medicinal chemistry letters.

Increased growth promoting but not mast cell degranulation potential of a covalent dimer of c-Kit ligand.

J. Ko, R. Lobell, K. Nocka, 1997, Blood.

Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

J. Davide, R. Lobell, C. Buser, 2002, Bioorganic & medicinal chemistry letters.

2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.

N. Kohl, R. Lobell, C. Buser, 2001, Bioorganic & medicinal chemistry letters.

Intracellular degradation of Fc gamma RIII in mouse bone marrow culture-derived progenitor mast cells prevents its surface expression and associated function.

M. Raizman, K. Austen, R. Lobell, 1993, The Journal of biological chemistry.

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.

John D. Schreier, Youwei Yan, P. Coleman, 2007, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.

P. Coleman, Christopher D. Cox, Weikang Tao, 2007, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.

Youwei Yan, P. Coleman, Christopher D. Cox, 2006, Bioorganic & medicinal chemistry letters.

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.

R. Diehl, A. Kral, J. Davide, 2000, Cancer research.

A Cell-Based Radioligand Binding Assay for Farnesyl: Protein Transferase Inhibitors

H. Burns, J. Davide, N. Kohl, 2003, Journal of biomolecular screening.

Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

Preclinical Models Geranylgeranyl : Protein Transferase Inhibitor Combinations in Evaluation of Farnesyl : Protein Transferase and Updated

A. Kral, D. Heimbrook, J. Davide, 2001 .

Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.

A. W. Shaw, T. Ciccarone, L. Beese, 2003, Journal of medicinal chemistry.

Diaryl ether inhibitors of farnesyl-protein transferase.

A. W. Shaw, T. Ciccarone, J. Davide, 1997, Bioorganic & medicinal chemistry letters.

Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.

Laura Sepp-Lorenzino, Weikang Tao, Youwei Yan, 2009, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.

W. F. Hoffman, Youwei Yan, L. Kuo, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.

Youwei Yan, S. Stirdivant, L. Kuo, 2007, Bioorganic & medicinal chemistry letters.

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors.

Lawrence C Kuo, Laura Sepp-Lorenzino, Weikang Tao, 2007, Bioorganic & medicinal chemistry letters.

3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6.

Lawrence C Kuo, Laura Sepp-Lorenzino, Weikang Tao, 2006, Bioorganic & medicinal chemistry letters.

Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase.

N. Kohl, R. Lobell, J. Gibbs, 1999, Bioorganic & medicinal chemistry letters.

Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

AraC-DNA looping: orientation and distance-dependent loop breaking by the cyclic AMP receptor protein.

R. Lobell, R. Schleif, 1991, Journal of molecular biology.

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

A. Kral, D. Heimbrook, J. Davide, 2001, Cancer research.

Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists.

Yongxin Han, S. Kargman, R. Lobell, 2009, Bioorganic & medicinal chemistry letters.

Prenylation of Ras GTPase superfamily proteins and their function in immunobiology.

R. Lobell, Robert B. Lobell, 1998, Advances in immunology.

3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.

A. D. Rodrigues, J Christopher Culberson, Ronald Robinson, 2002, Journal of medicinal chemistry.

Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I.

C. Fuchs, P. Deutsch, Sunil Sharma, 2002, Molecular cancer therapeutics.

Determinants of heat shock-induced chromosome puffing

J. Lis, R. Glaser, J. Simon, 1985, Cell.

Anions Modulate the Potency of Geranylgeranyl-Protein Transferase I Inhibitors*

D. Heimbrook, R. Lobell, C. Buser, 2001, The Journal of Biological Chemistry.

N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.

J. Huff, J. Davide, N. Kohl, 1999, Journal of medicinal chemistry.

A phase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies.

S. Soignet, P. Deutsch, C. Britten, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

A soluble chimeric complement inhibitory protein that possesses both decay-accelerating and factor I cofactor activities.

P. Higgins, R. Lobell, J. Ko, 1997, Journal of immunology.

Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.

Laura Sepp-Lorenzino, S. Stirdivant, M. Ikuta, 2012, Bioorganic & medicinal chemistry letters.

Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity.

S. Stirdivant, Weikang Tao, L. Sepp-Lorenzino, 2012, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.

Youwei Yan, P. Coleman, Christopher D. Cox, 2008, Journal of medicinal chemistry.

An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis

R. Diehl, Weikang Tao, Vicki J South, 2006, Molecular and Cellular Biology.

The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.

J. Davide, R. Lobell, J. Gibbs, 2002, Bioorganic & medicinal chemistry letters.

Expression and function of Fc gamma R in mouse mast cells.

R. Lobell, H. Katz, 1995, International Archives of Allergy and Immunology.

Encephalomyelitis Experimental Autoimmune Suppressive Dna Vaccination in Cytokine Milieu Determine the Efficacy of Presence of Cpg Dna and the Local

T. Olsson, R. Lobell, H. Wigzell, 2022 .

Expression and Function of Fc?R in Mouse Mast Cells

R. Lobell, H. Katz, 1995 .

Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.

W. F. Hoffman, Youwei Yan, P. Coleman, 2006, Bioorganic & medicinal chemistry letters.