A. Koff

J. Pollard, H. Kiyokawa, W. Tong, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma

Narasimhan P. Agaram, Narasimhan P Agaram, L. Qin, 2022, Nature Communications.

HerpesSimplex VirusOrigin-Binding Protein (UL9)Loopsand Distorts theViral Replication Origin

A. Koff, And Petertegtmeyer, 1991 .

p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice.

H. Eguchi, A. Koff, S. Moss, 2005, Gastroenterology.

Inhibin and p27 interact to regulate gonadal tumorigenesis.

K. Burns, M. Matzuk, A. Koff, 2001, Molecular endocrinology.

Prolonged Induction of p21CiplmAFI/CDK2/PCNA Complex by Epidermal Growth Factor Receptor Activation Mediates Ligand-induced A431 Cell Growth Inhibition

A. Deblasio, J. Mendelsohn, Z. Fan, 2002 .

Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells.

R. Matorras, A. Koff, J. Arluzea, 2013, Human reproduction.

Cooperation between p27 and p107 during Endochondral Ossification Suggests a Genetic Pathway Controlled by p27 and p130

G. Stein, J. Lian, T. Capellini, 2007, Molecular and Cellular Biology.

p27 Repression of ErbB2-Induced Mammary Tumor Growth in Transgenic Mice Involves Skp2 and Wnt/B-Catenin Signaling

M. Lisanti, G. Inghirami, Richard J Lee, 2006 .

Regulatory role of p27kip1 in the mouse and human testis.

T. Beumer, H. L. Roepers-Gajadien, I. S. Gademan, 1999, Endocrinology.

Roles of cyclin-dependent kinase inhibitors: lessons from knockout mice.

H. Kiyokawa, A. Koff, 1998, Current topics in microbiology and immunology.

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

D. Schatz, A. Hayday, M. Owen, 1996, Genes & development.

Interweaving the Cell Cycle Machinery with Cell Differentiation

A. Koff, A. Vidal, Jeffrey P. Miller, 2007, Cell cycle.

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

James M. Roberts, Michel Philippe, F. Cross, 1991, Cell.

Transformation Oncogenic Signaling during Cell Protein Levels Reflect a Nexus ofkip 1 p 27 Molecular Bases of Disease

C. Hofstetter, A. Koff, A. Goldstein, 2012 .

Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis.

Stephen N. Jones, I. Leav, A. Koff, 2006, Cancer research.

Cdk pathway: Cyclin-dependent kinases and cyclin-dependent kinase inhibitors

A. Koff, D. Gitig, Diana M. Gitig, 2001, Methods in molecular biology.

Rho Activity Can Alter the Translation of p27 mRNA and Is Important for RasV12-induced Transformation in a Manner Dependent on p27 Status*

A. Koff, A. Vidal, Jeffrey P. Miller, 2002, The Journal of Biological Chemistry.

The REC1 gene of Ustilago maydis, which encodes a 3'-->5' exonuclease, couples DNA repair and completion of DNA synthesis to a mitotic checkpoint.

K. Onel, A. Koff, W. Holloman, 1996, Genetics.

The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.

A. Koff, A. Rosen, D. Shaffer, 2002, The Biochemical journal.

p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal

M. Chao, A. Koff, S. Dowdy, 2001, EMBO reports.

Cdk pathway: cyclin-dependent kinases and cyclin-dependent kinase inhibitors.

A. Koff, D. Gitig, 2001, Molecular biotechnology.

Rapamycin resistance tied to defective regulation of p27Kip1

J. Massagué, S. Marx, A. Marks, 1996, Molecular and cellular biology.

Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors.

W. Tap, A. Koff, Marta Kovatcheva, 2017, Molecular & cellular oncology.

Cell-cycle inhibitors: three families united by a common cause.

A. Koff, A. Vidal, 2000, Gene.

p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells

A. Koff, C. Weiss, M. Göttlicher, 1999 .

p53 regulates hematopoietic stem cell quiescence.

Y. Liu, B. Reva, A. Deblasio, 2009, Cell stem cell.

Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin

P. Tegtmeyer, J. Schwedes, A. Koff, 1991, Journal of virology.

Tyrosine Phosphorylation of the p21 Cyclin-dependent Kinase Inhibitor Facilitates the Development of Proneural Glioma*

A. Koff, S. Blain, D. Ciznadija, 2012, The Journal of Biological Chemistry.

Application of molecular biology to individualize therapy for patients with liposarcoma.

S. Singer, G. Schwartz, A. Koff, 2015, American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting.

p 27 Kip 1 , a cyclin-Cdk inhibitor , links transforming growth factor-13 and contact inhibition to cell cycle arrest

James M. Roberts, J. Massagué, K. Polyak, 2007 .

Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27Kip1 Activity

P. Pandolfi, H. Kiyokawa, A. Koff, 1999, Molecular and Cellular Biology.

ZIC1 overexpression is oncogenic in liposarcoma.

C. Sander, N. Socci, B. Taylor, 2010, Cancer research.

CAN-10-0745 Cancer esearch apeutics , Targets , and Chemical Biology R 1 Overexpression Is Oncogenic in Liposarcoma

N. Socci, B. Taylor, C. Antonescu, 2010 .

CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought.

W. Tap, A. Koff, L. Davis, 2018, Cancer cell.

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

J. Chodera, S. Chandarlapaty, J. Reis-Filho, 2021, Cancer discovery.

Progression-Free Survival Among Patients With Well-Differentiated or Dedifferentiated Liposarcoma Treated With CDK4 Inhibitor Palbociclib: A Phase 2 Clinical Trial.

L. Qin, C. Antonescu, S. Singer, 2016, JAMA oncology.

Constitutive overexpression of cyclin D1 in human breast epithelial cells does not prevent G1 arrest induced by deprivation of epidermal growth factor

J. Chou, N. Rosen, J. Mendelsohn, 1999, Breast Cancer Research and Treatment.

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition

N. Socci, S. Singer, G. Schwartz, 2015, Oncotarget.

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

P. Pandolfi, C. Cordon-Cardo, A. Koff, 2001, Nature Genetics.

TRIM3, a tumor suppressor linked to regulation of p21Waf1/Cip1

C. Brennan, E. Holland, H. Erdjument-Bromage, 2013, Oncogene.

Formation of p27-CDK complexes during the human mitotic cell cycle.

A. Deblasio, A. Giordano, J. Mendelsohn, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.

C. Croce, N. Chiorazzi, F. Bullrich, 1995, Cancer research.

Strongly with the Clinical Course of Epithelial Ovarian Cancer Has Features of an Oncogene and Its Overexpression Correlates

G. Pavesi, D. Katsaros, R. Barakat, 2015 .

A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma

C. Baumgartner, A. Koff, B. Pelzmann, 2021, PLoS computational biology.

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

F. Di Cunto, C. Missero, G. Dotto, 1996, Genes & development.

ATRX is a regulator of therapy induced senescence in human cells

Heather Geiger, N. Robine, S. Singer, 2017, Nature Communications.

oligodendrocytes independently of cell cycle withdrawal

M. Chao, A. Koff, J. Zezula, 2001 .

Regulation of the cell cycle by CDK inhibitors.

H. Kiyokawa, A. Koff, M. Park, 1998, Results and problems in cell differentiation.

Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma.

C. Cordon-Cardo, J. Massagué, H. Scher, 1999, Journal of the National Cancer Institute.

Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27 deficient mice with growth-factor induced oligodendrogliomas

M. Resh, E. Holland, M. Squatrito, 2009, Oncogene.

Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

James M. Roberts, J. Massagué, K. Polyak, 1993, Science.

Cell-Free Degradation of p27kip1, a G1 Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome

A. Koff, Hoang Nguyen, D. Gitig, 1999, Molecular and Cellular Biology.

Enhanced Ribosomal Association of p27Kip1 mRNA Is a Mechanism Contributing to Accumulation during Growth Arrest*

M. Pagano, H. Kiyokawa, Jie Yan, 1997, The Journal of Biological Chemistry.

Bcl-2 Retards Cell Cycle Entry through p27Kip1, pRB Relative p130, and Altered E2F Regulation

M. Ewen, J. Decaprio, Jerry M. Adams, 2000, Molecular and Cellular Biology.

p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.

M. Lisanti, G. Inghirami, D. Di Vizio, 2006, Cancer research.

p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.

C. Cordon-Cardo, J. Rosai, A. Koff, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Somatic cell type specific gene transfer reveals a tumor-promoting function for p21Waf1/Cip1

C. Cordon-Cardo, M. Leversha, E. Holland, 2007, The EMBO journal.

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior

S. Nimer, Yan Liu, A. Koff, 2009, Cell cycle.

Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody.

M. Rubin, J. Mendelsohn, Z. Fan, 1996, Oncogene.

Phase 2 study of the CDK4 inhibitor abemaciclib in dedifferentiated liposarcoma.

L. Qin, C. Antonescu, S. Singer, 2019, Journal of Clinical Oncology.

A U-Rich Element in the 5′ Untranslated Region Is Necessary for the Translation of p27 mRNA

A. Koff, A. Vidal, M. Markus, 2000, Molecular and Cellular Biology.

Functional analysis of pRb2/p130 interaction with cyclins.

A. Giordano, P. Claudio, C. Howard, 1996, Cancer research.

Misexpression of Cyclin B3 Leads to Aberrant Spermatogenesis

K. Manova, A. Koff, Jale Refik-Rogers, 2006, Cell cycle.

p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.

S. Rafii, S. Zacharoulis, Anna H. Bramley, 2005, Proceedings of the National Academy of Sciences of the United States of America.

receptor in developing thymus and hepatoma cells induction and inhibition of proliferation by the intracellularKip 1 p 27

A. Koff, C. Weiss, M. Göttlicher, 1999 .

of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells

A. Koff, C. Weiss, S. Kolluri, 1999 .

Cyclin-dependent kinase inhibitors in restriction point control, genomic stability, and tumorigenesis.

A. Koff, S S Millard, A Koff, 1998, Journal of cellular biochemistry. Supplement.

Cyclins, Cdks, and cyclin kinase inhibitors.

J. Massagué, K. Polyak, M. Ohtsubo, 1994, Cold Spring Harbor symposia on quantitative biology.

Functional Analysis of pRb 2 / pl 30 Interaction with Cyclins 1

A. Giordano, P. Claudio, C. Howard, 2006 .

Expression of cyclin D1, but not cyclins E and A, is related to progression in bilharzial bladder cancer.

C. Cordon-Cardo, H. Scher, Z. F. Zhang, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence

L. Qin, C. Antonescu, K. Manova, 2018, Oncogene.

Noncatalytic Requirement for Cyclin A-cdk2 in p27 Turnover

F. Traganos, A. Koff, Hoang Nguyen, 2004, Molecular and Cellular Biology.

The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity.

A. Koff, Yuhui Liu, N. Yeh, 2014, The Biochemical journal.

Cell Stem Cell p 53 Maintains HSC Quiescence

B. Reva, A. Deblasio, S. Menéndez, 2008 .

ATRX is a regulator of therapy induced senescence in human cells

Heather Geiger, N. Robine, S. Singer, 2017, Nature Communications.

PDGF-BB Regulates p27 Expression through ERK-dependent RNA Turn-over in Vascular Smooth Muscle Cells*

K. Kent, K. Kubota, A. Koff, 2005, Journal of Biological Chemistry.

The Zinc Finger Gene ZIC2 Has Features of an Oncogene and Its Overexpression Correlates Strongly with the Clinical Course of Epithelial Ovarian Cancer

D. Katsaros, R. Barakat, G. Cattoretti, 2012, Clinical Cancer Research.

Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion

S. Chandarlapaty, J. Reis-Filho, B. Weigelt, 2023, bioRxiv.

Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma.

E. Holland, A. Koff, D. Ciznadija, 2011, Cancer research.