P. Maxwell

D. Tibboel, R. Rottier, M. Tran, 2008, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF 2

C. Bartram, D. Gale, P. Maxwell, 2008 .

Hypoxia‐inducible factor as a physiological regulator

P. Maxwell, 2005, Experimental physiology.

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

P. Ratcliffe, C. Pugh, P. Maxwell, 1993, Proceedings of the National Academy of Sciences of the United States of America.

HIF-1’s Relationship to Oxygen: Simple yet Sophisticated

P. Maxwell, 2004, Cell cycle.

Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis

P. Maxwell, S. Harten, D. Haskard, 2006, Arthritis research & therapy.

HIF-1in humans: potential for involvement of Desferrioxamine elevates pulmonary vascular

Thomas G. Smith, P. Robbins, L. Winchester, 2015 .

Variations within oxygen-regulated gene expression in humans

Thomas G. Smith, J. Ragoussis, P. Robbins, 2008, Journal of applied physiology.

Gene regulation by hypoxia

P. Ratcliffe, C. Pugh, P. Maxwell, 2000 .

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

P. Maxwell, M. N. Patterson, 2014, Journal of visualized experiments : JoVE.

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.

P. Carmeliet, D. Lambrechts, F. Luyten, 2016, Cell metabolism.

VHL inactivation induces HEF1 and Aurora kinase A.

P. Maxwell, S. Harten, D. Shukla, 2010, Journal of the American Society of Nephrology : JASN.

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

D. Gale, P. Maxwell, K. Murphy, 2010, Haematologica.

A new approach to treating renal anaemia

P. Maxwell, 2019, Nature Reviews Nephrology.

Familial C3 glomerulopathy associated with CFHR5 mutations: clinical characteristics of 91 patients in 16 pedigrees.

K. Kyriacou, A. Hadjisavvas, K. Voskarides, 2011, Clinical journal of the American Society of Nephrology : CJASN.

Organ-Specific Collagen Expression: Implications for Renal Disease

P. Maxwell, George Bou-Gharios, C. Alexakis, 2005, Nephron Experimental Nephrology.

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

Kenneth G. C. Smith, M. Clatworthy, R. Bashford-Rogers, 2020, Nature Immunology.

HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore.

M. Ashcroft, D. Yellon, P. Maxwell, 2014, Cardiovascular research.

The Molecular Genetics and Pathology of Renal Cell Carcinoma

M. Tran, P. Maxwell, T. O'brien, 2010 .

Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective

P. Maxwell, 2020, Mobile DNA.

Reactivation of Snail Genes in Renal Fibrosis and Carcinomas: A Process of Reversed Embryogenesis?

P. Maxwell, M. Nieto, M. Esteban, 2007, Cell cycle.

Retrotransposition is associated with genome instability during chronological aging

W. Burhans, P. Maxwell, M. Curcio, 2011, Proceedings of the National Academy of Sciences.

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension.

D. Gale, T. Connor, P. Maxwell, 2011, Blood.

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

K. Alitalo, P. Maxwell, M. Mazzone, 2011, Nature.

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.

P. Carmeliet, P. Ratcliffe, C. Taylor, 2011, The Journal of clinical investigation.

Cancer esearch cular and Cellular Pathobiology ression Profiling in Progressive Stages of Fumarate-ratase Deficiency : The Contribution of Metabolic R nges to Tumorigenesis

L. Aaltonen, E. Volpi, B. Spencer‐Dene, 2010 .

Epistatic Role of the MYH9/APOL1 Region on Familial Hematuria Genes

K. Voskarides, D. Gale, A. Pierides, 2013, PloS one.

C3 glomerulonephritis and CFHR5 nephropathy.

D. Gale, P. Maxwell, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin.

D. Shukla, P. Maxwell, S. Harten, 2008, Molecular biology of the cell.

Mannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD Inhibitors.

Vijesh J. Bhute, P. Maxwell, J. Houghton, 2020, Kidney360.

Phd 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

P. Carmeliet, P. Ratcliffe, C. Taylor, 2017 .

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

P. Carmeliet, P. Ratcliffe, C. Taylor, 2017, The Journal of clinical investigation.

A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib

M. Gore, P. Maxwell, T. Eisen, 2009, BMJ Case Reports.

Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.

P. Robbins, P. Ratcliffe, M. McMullin, 2008, Advances in experimental medicine and biology.

Low oxygen stimulates the intellect

C. Koumenis, P. Maxwell, 2006, EMBO reports.

A common pathway for genetic events leading to pheochromocytoma.

P. Maxwell, 2005, Cancer cell.

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.

P. Ratcliffe, C. Pugh, P. Maxwell, 1998, The Journal of biological chemistry.

The hypoxia response pathway and β‐cell function

S. Grey, D. Withers, P. Maxwell, 2010, Diabetes, obesity & metabolism.

The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress

Svetlana V. Harbaugh, P. Carmeliet, J. Meller, 2008, Molecular and Cellular Biology.

Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein.

M. Tran, P. Maxwell, S. Harten, 2006, Journal of the American Society of Nephrology : JASN.

Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms

R. Playford, P. Maxwell, S. Harten, 2011, Laboratory Investigation.

Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.

Robert A. Harris, P. Carmeliet, M. Mollenhauer, 2010, Gastroenterology.

oss or Silencing of the PHD 1 Prolyl Hydroxylase Protects Livers of Mice gainst Ischemia / Reperfusion Injury

Robert A. Harris, P. Carmeliet, J. Weitz, 2022 .

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

P. Carmeliet, B. Thienpont, G. Carmeliet, 2018, Nature Communications.

Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis.

M. Clatworthy, N. Morrell, E. Chilvers, 2006, Blood.

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

E. L. West, A. Georgiadis, R. Ali, 2012, Development.

Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression

K. Eckardt, P. Maxwell, M. Wiesener, 2009, Journal of Molecular Medicine.

Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20)

P. Szlosarek, R. B. Pedley, M. Ashcroft, 2016, Scientific Reports.

Hypoxia-inducible factor 2 inhibitors show promise in advanced kidney cancer

P. Maxwell, N. Burrows, 2021, Nature Reviews Urology.

Targeting tumors through the HIF system

P. Ratcliffe, C. Pugh, P. Maxwell, 2000, Nature Medicine.

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.

R. Altura, S. Pollefeyt, L. Moons, 2007, Blood.

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

A. Harris, C. Wykoff, P. Ratcliffe, 2000, Oncogene.

Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998)

P. Carmeliet, R. Jain, M. Neeman, 1998 .

Xenon Treatment Protects Against Cold Ischemia Associated Delayed Graft Function and Prolongs Graft Survival in Rats

Hailin Zhao, C. Tralau-Stewart, P. Maxwell, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Independence of HIF1a and androgen signaling pathways in prostate cancer

I. Mills, D. Neal, M. Osborne, 2019, bioRxiv.

Analysis of Cis‐acting Sequences Required for Operation of the Erythropoietin 3’Enhancer in Different Cell Lines a

B. Ebert, P. Ratcliffe, P. Maxwell, 1994, Annals of the New York Academy of Sciences.

Genome-Wide Analysis Identifies Strong Association Between HLA and IgA Nephropathy

S. Heath, M. Farrall, I. Gut, 2010 .

Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations

P. Maxwell, 2016, BMC Genetics.

Preferential retrotransposition in aging yeast mother cells is correlated with increased genome instability.

C. Royer, P. Maxwell, Savanna Dorsey, 2015, DNA repair.

Extension of Saccharomyces paradoxus Chronological Lifespan by Retrotransposons in Certain Media Conditions Is Associated with Changes in Reactive Oxygen Species

P. Maxwell, D. VanHoute, 2014, Genetics.

Genetic Contribution to IgA Nephropathy

P. Maxwell, Yiming Wang, 2009 .

Recurrence of Complement Factor H-Related Protein 5 Nephropathy in a Renal Transplant

D. Gale, A. Pierides, P. Maxwell, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Copy number profiling in von hippel‐lindau disease renal cell carcinoma

M. Yao, P. Maxwell, E. Meyer, 2011, Genes, chromosomes & cancer.

Hypoxia response elements.

P. Ratcliffe, I. Stratford, C. Pugh, 1997, Oncology research.

Microchimeric Fetal Cells Are Recruited to Maternal Kidney following Injury and Activate Collagen Type I Transcription

P. Maxwell, N. Fisk, George Bou-Gharios, 2010, Cells Tissues Organs.

Retrosequence formation restructures the yeast genome.

P. Maxwell, M. Curcio, 2007, Genes & development.

Towards a primate single-cell atlas

P. Maxwell, G. Volpe, M. Esteban, 2022, Zoological research.

A novel COL4A1 frameshift mutation in familial kidney disease: the importance of the C-terminal NC1 domain of type IV collagen

D. Gale, T. Connor, P. Maxwell, 2016, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies

D. Gale, T. Connor, A. Segal, 2015, BMC Genomics.

The ERA-EDTA Working Group on inherited kidney disorders.

G. Remuzzi, C. Antignac, R. Gansevoort, 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Response to ‘Hepcidin levels in patients with renal disease’

D. Gale, P. Maxwell, M. Busbridge, 2009 .

The von Hippel-Lindau protein: a key player in oxygen homeostasis and matrix assembly

S. Mandriota, P. Maxwell, M. Esteban, 2004 .

Nasty shock after an anti-emetic.

P. Maxwell, J. Gleadle, P. Mason, 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α)

P. Ratcliffe, C. Pugh, P. Maxwell, 1998, The Journal of Biological Chemistry.

correction: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

P. Carmeliet, R. Jain, M. Neeman, 1998, Nature.

Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis

Michael I. Wilson, P. Ratcliffe, K. Eckardt, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

Eleanor, Joy, Josh, 2022 .

Mutations in mitochondrial DNA causing tubulointerstitial kidney disease

P. Chinnery, C. Gustafsson, D. Gale, 2017, PLoS genetics.

Oxygen sensors and angiogenesis.

P. Ratcliffe, P. Maxwell, 2002, Seminars in cell & developmental biology.

Inadvertent postdialysis anticoagulation due to heparin line locks

D. Gale, P. Maxwell, M. Laffan, 2007, Hemodialysis international. International Symposium on Home Hemodialysis.

Dialysis Survivors: Clinical Status of Patients on Treatment for More than 10 Years

P. Maxwell, E. Brown, D. Ashby, 2008, Nephron Clinical Practice.

Incorporation of Y′-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants

P. Maxwell, M. Curcio, M. Joan Curcio, 2008, Genetics.

Erythropoietin‐producing Cells in Transgenic Mice Expressing SV40 Large T Antigen Directed by Erythropoietin Control Sequences

D. Ferguson, P. Ratcliffe, P. Maxwell, 1994, Annals of the New York Academy of Sciences.

Single-cell atlas of a non-human primate reveals new pathogenic

Huanming Yang, Shiping Liu, P. Maxwell, 2020 .

The HIF pathway: implications for patterns of gene expression in cancer.

A. Harris, C. Wykoff, P. Ratcliffe, 2001, Novartis Foundation symposium.

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

M. Giacca, J. Rakic, V. Lambert, 2010, Cell.

Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences.

P. Maxwell, P. Pollard, Patrick J. Pollard, 2013, Kidney international.

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.

Alison Martin, B. Spencer‐Dene, G. Stamp, 2007, Cancer cell.

Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection.

M. Ashcroft, P. Maxwell, S. Harten, 2010, Antioxidants & redox signaling.

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

P. Carmeliet, D. Eyre, G. Carmeliet, 2019, Nature.

Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells

M. Ashcroft, P. Maxwell, S. Harten, 2011, Molecular Cancer.

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

R. Raval, M. Tran, P. Maxwell, 2006, Cancer research.

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

Sarah A. Teichmann, Dyanne Rampling, Imran Mushtaq, 2018, Science.

Regulation of the erythropoietin gene.

B. Ebert, D. Ferguson, P. Ratcliffe, 1995, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

The role of HIF in immunity.

D. Gale, P. Maxwell, 2010, The international journal of biochemistry & cell biology.

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

Gonçalo Abecasis, Michael J E Sternberg, Yun Li, 2009, Nature Genetics.

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

P H Watson, A. Harris, P. Watson, 2000, Cancer research.

Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective

P. Maxwell, 2020, Mobile DNA.

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

G. Reifenberger, P. Carmeliet, T. Acker, 2014, Nature Communications.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Huanming Yang, Jian Wang, Y. Liu, 2021, Nature.

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

Kenneth G. C. Smith, M. Clatworthy, B. Huntly, 2020, Nature Immunology.

Molecular and Cellular Pathobiology Expression Profiling in Progressive Stages of Fumarate- Hydratase Deficiency: the Contribution of Metabolic Changes to Tumorigenesis

Ian Tomlinson, Yuen-Li Chung, L. Aaltonen, 2022 .

A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population

F. Kronenberg, B. Paulweber, T. Benzing, 2017, PloS one.

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Frederik De Smet, Elisabetta Dejana, Sonja Loges, 2009, Cell.

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

P. Carmeliet, G. Stamp, H. Lockstone, 2011, Cancer cell.

Consequences of ongoing retrotransposition in mammalian genomes

P. Maxwell, 2014 .

Identification of multiple transcription initiation, polyadenylation, and splice sites in the Drosophila melanogaster TART family of telomeric retrotransposons

R. Levis, J. Belote, P. Maxwell, 2006, Nucleic acids research.

Preferential Ty1 retromobility in mother cells and nonquiescent stationary phase cells is associated with increased concentrations of total Gag or processed Gag and is inhibited by exposure to a high concentration of calcium

P. Maxwell, Andrew C. Peifer, 2018, Aging.

Ty1 Mobilizes Subtelomeric Y′ Elements in Telomerase-Negative Saccharomyces cerevisiae Survivors

J. Boeke, P. Maxwell, M. Curcio, 2004, Molecular and Cellular Biology.

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

David Mole, Kiichi Hirota, Enli Liu, 2002, Nature Genetics.

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Robert A. Harris, P. Carmeliet, J. Nuyts, 2008, Nature Genetics.

Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor*

P. Ratcliffe, C. Pugh, P. Maxwell, 2001, The Journal of Biological Chemistry.

Activation of the HIF pathway in cancer.

P. Ratcliffe, C. Pugh, P. Maxwell, 2001, Current opinion in genetics & development.

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.

A. Harris, P. Ratcliffe, K. Gatter, 1998, Blood.

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

Xun Xu, Liqin Xu, Yong Hou, 2020, bioRxiv.

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.

P. Carmeliet, M. Mollenhauer, F. Lasitschka, 2010, Gastroenterology.

The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages

A. Harris, P. Ratcliffe, K. Gatter, 2000 .

Developmental and tissue-specific accumulation pattern for the Drosophila melanogaster TART ORF1 protein.

R. Levis, J. Belote, P. Maxwell, 2008, Gene.

Integrative Physiology Methods and Results: Studies of Cultured Ecs Demonstrated That Hypoxia (1% Oxygen) Induced Cezanne via Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting Traf6 for Deubiquitination

P. Evans, M. Ashcroft, J. Dean, 2022 .

Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1

T. Siu, S. Tam, H. Tse, 2017, The Journal of Biological Chemistry.

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

P. Ratcliffe, P. Maxwell, C. Pugh, 2001, Advances in experimental medicine and biology.

Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.

P. Ratcliffe, C. Pugh, P. Maxwell, 1998, The Journal of experimental biology.

Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-Inducible Factors

A. Bosserhoff, G. Schley, D. Gale, 2009, PloS one.

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia.

Patrick Aebischer, Nicole Déglon, P. Ratcliffe, 2002, Kidney international.

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.

M. McMullin, C. Harrison, P. Maxwell, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

Christopher J. Schofield, David I. Stuart, Timothy D. W. Claridge, 2002, Nature.

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

P. Ratcliffe, P. Maxwell, S. Clifford, 2001, Human molecular genetics.

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys.

Kai-Uwe Eckardt, Sebastian Bachmann, Ulrich Frei, 2002, Journal of the American Society of Nephrology : JASN.

Role of Gas6 in erythropoiesis and anemia in mice.

Diether Lambrechts, Greg Lemke, Marc Chanson, 2008, The Journal of clinical investigation.

Hypoxia and oxidative stress in breast cancer: Hypoxia signalling pathways

C. Pugh, P. Maxwell, J. Gleadle, 2001, Breast Cancer Research.

Oxygen regulated gene expression: erythropoietin as a model system.

B. Ebert, P. Ratcliffe, J. Firth, 1997, Kidney international.

Regulation of HIF-1 by oxygen: The role of prolyl hydroxylase and the VHL tumor suppressor

P. Ratcliffe, P. Maxwell, 2003 .

Low doses of DNA damaging agents extend Saccharomyces cerevisiae chronological lifespan by promoting entry into quiescence

P. Maxwell, Emily M. Ross, 2018, Experimental Gerontology.

The impact of hypoxia on B cells in COVID-19

Kenneth G. C. Smith, S. Richardson, B. Göttgens, 2021, eBioMedicine.

The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

P. Ratcliffe, P. Maxwell, D. Mole, 2021, Nature Genetics.

SET1B facilitates activation of the hypoxia response through site-specific histone methylation

P. Ratcliffe, P. Maxwell, D. Mole, 2020 .

Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element

P. Maxwell, W. Tian, D. Shukla, 2012, Oncogene.

Epigenetic regulation of HIF-1 alpha in renal cancer cells involves HIF-1 alpha/2 alpha binding to a reverse hypoxia-response element

P. Maxwell, W. Tian, D. Shukla, 2012 .

Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

A. Harris, P. Ratcliffe, C. Taylor, 2002, Cancer research.

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.

A. Harris, P. Ratcliffe, H. Turley, 2000, The American journal of pathology.

Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney

M. Nieto, P. Maxwell, A. Boutet, 2006, The EMBO journal.

Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans.

P. Robbins, P. Maxwell, K. Dorrington, 2000, Journal of applied physiology.

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

E. Laurenti, D. Adams, J. Fitzgibbon, 2017, Nature Cell Biology.

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

K. Eckardt, P. Maxwell, 2016, Nature Reviews Nephrology.

The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity*

G. Schley, P. Maxwell, W. Tian, 2013, The Journal of Biological Chemistry.

Developmentally arrested structures preceding cerebellar tumors in von Hippel–Lindau disease

A. Vortmeyer, E. Oldfield, R. Lonser, 2011, Modern Pathology.

Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease.

A. Vortmeyer, M. Raffeld, J. Li, 2008, Neoplasia.

Genetic insights into the hypoxia-inducible factor (HIF) pathway.

P. Maxwell, S. Kiriakidis, M. Esteban, 2007, Advances in enzyme regulation.

The HIF pathway in cancer.

P. Maxwell, 2005, Seminars in cell & developmental biology.

Renal Cell Carcinoma HIF-2 in von Hippel-Lindau-Associated Hypoxia-Inducible Factor 1 ( HIF-1 ) and Contrasting Properties of

Ratcliffe, A. Harris, R. Raval, 2005 .

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.

P. Ratcliffe, C. Pugh, P. Maxwell, 2004, Advances in enzyme regulation.

HIF-1: an oxygen response system with special relevance to the kidney.

P. Maxwell, 2003, Journal of the American Society of Nephrology : JASN.

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma

P. Vandenabeele, S. Vanharanta, J. Pober, 2016, Oncotarget.

Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia

H. Gröne, K. Eckardt, P. Maxwell, 2007, International journal of cancer.

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

Thomas G. Smith, F. Formenti, D. O'Connor, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Competing Interests: PHM, CWP,

Thomas G. Smith, P. Robbins, P. Ratcliffe, 2022 .

Insights into the Role of the von Hippel-Lindau Gene Product

P. Ratcliffe, P. Maxwell, C. Pugh, 2001, Nephron Experimental Nephrology.

Genetic evidence for a tumor suppressor role of HIF-2alpha.

P. Carmeliet, R. Jain, T. Acker, 2005, Cancer cell.

HIF-1, An Oxygen and Metal Responsive Transcription Factor

P. Maxwell, K. Salnikow, Patrick Maxwell, 2004, Cancer biology & therapy.

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

P. Carmeliet, D. Eyre, G. Carmeliet, 2019, Nature.

Rolling back human pluripotent stem cells to an eight-cell embryo-like stage

Junwen Wang, P. Maxwell, Longqi Liu, 2022, Nature.

End-stage renal failure associated with congenital deafness

D. Gale, P. Maxwell, H. Dorkins, 2008, NDT plus.

Host Factors That Control Long Terminal Repeat Retrotransposons in Saccharomyces cerevisiae: Implications for Regulation of Mammalian Retroviruses

P. Maxwell, M. Curcio, 2007, Eukaryotic Cell.

Dent Disease in Chinese Children and Findings from Heterozygous Mothers: Phenotypic Heterogeneity, Fetal Growth, and 10 Novel Mutations.

P. Maxwell, Tingting Xu, K. Lai, 2016, The Journal of pediatrics.

Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis

Frcp, K. Kyriacou, A. Hadjisavvas, 2010, The Lancet.

Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils

C. Scheiermann, S. Nourshargh, M. Tran, 2006, The Journal of experimental medicine.

The pVHL-associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma

P. Ratcliffe, P. Maxwell, S. Clifford, 2001, Oncogene.

Rrm3 Protects the Saccharomyces cerevisiae Genome From Instability at Nascent Sites of Retrotransposition

P. Maxwell, R. Stamenova, M. Curcio, 2009, Genetics.

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice

P. Carmeliet, J. López-Barneo, K. Channon, 2008, Molecular and Cellular Biology.

Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

Andy Neely, J. G. Bartlett, Chris Abell, 2022, Scientific Reports.

HIF, a missing link between metabolism and cancer

Miguel A Esteban, P. Maxwell, M. Esteban, 2005, Nature Medicine.

VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function

S. Vanharanta, M. Ashcroft, P. Maxwell, 2018, Front. Oncol..

Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease.

D. Gale, P. Maxwell, K. Murphy, 2009, Kidney international.

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury.

Peter Hill, Peter Carmeliet, P. Carmeliet, 2008, Journal of the American Society of Nephrology : JASN.

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

C. Sotiriou, A. Harris, C. Wykoff, 2004, British Journal of Cancer.

Effects of VHL deficiency on endolymphatic duct and sac.

A. Vortmeyer, E. Oldfield, J. Butman, 2005, Cancer research.

Genetic loci influencing kidney function and chronic kidney disease

Mark N. Wass, Graham M Lord, P. Elliott, 2010, Nature Genetics.

HLA has strongest association with IgA nephropathy in genome-wide analysis.

S. Heath, M. Farrall, I. Gut, 2010, Journal of the American Society of Nephrology : JASN.

Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells.

P. Maxwell, S. Harten, M. Esteban, 2009, Advances in enzyme regulation.

Renal Carcinomas in Clear Cell α Overexpression of Hypoxia-inducible Factor-1 Constitutive Activation of Hypoxia-inducible Genes Related to Updated Version

H. Gröne, K. Eckardt, P. Maxwell, 2001 .

Recurrence of autonomous hyperparathyroidism in dialysis patients.

C. Winearls, P. Maxwell, 1997, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition

Roberto Mayor, Patrick H. Maxwell, Elias H. Barriga, 2013, The Journal of cell biology.

Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene.

Hui Guo, P. Maxwell, M. Lam, 2004, Journal of the American Society of Nephrology : JASN.

What might retrotransposons teach us about aging?

P. Maxwell, 2016, Current Genetics.

Incidence of End-Stage Renal Disease in the Turkish-Cypriot Population of Northern Cyprus: A Population Based Study

D. Gale, T. Connor, P. Maxwell, 2013, PloS one.

Critical Amplification by Gas6 of the Epo-Dependent Erythropoietic Response to Anemia: Novel Opportunities for Anemia Treatment.

P. Carmeliet, D. Collen, P. Maxwell, 2004 .

Vascular Biology , Atherosclerosis , and Endothelium Biology Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy

R. Ali, P. Maxwell, F. Mowat, 2012 .

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.

P. Carmeliet, D. Collen, P. Maxwell, 2003, The Journal of clinical investigation.

Oxygen homeostasis and cancer: insights from a rare disease.

P. Maxwell, 2002, Clinical medicine.

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.

P. Ratcliffe, C. Pugh, P. Maxwell, 2002, Advances in enzyme regulation.

Renal cyst formation in Fh 1-deficient mice is independent of the Hif / Phd pathway

P. Carmeliet, G. Stamp, H. Lockstone, 2011 .

Renal Carcinoma and von Hippel–Lindau Disease

T. Connor, P. Maxwell, 2010 .

Cardiopulmonary phenotype associated with human PHD2 mutation

Thomas G. Smith, P. Robbins, P. Maxwell, 2017, Physiological reports.

Inherited Renal Tumour Syndromes

T. Connor, P. Maxwell, 2014 .

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.

James B. Mitchell, A. Harris, G. Semenza, 2004, Cancer research.

A novel COL4A1 frameshift mutation in familial kidney disease: the importance of the C-terminal NC1 domain of type IV collagen

D. Gale, T. Connor, P. Maxwell, 2016, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

P. Carmeliet, B. Thienpont, G. Carmeliet, 2018, Nature Communications.

Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy.

P. Maxwell, M. Lam, K. Lai, 2006, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor

P. Maxwell, S. Kiriakidis, C. Schofield, 2017, Kidney international.

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor

P. Maxwell, S. Kiriakidis, C. Schofield, 2017, Kidney international.

Distinct novel mutations affecting the same base in the NIPA1 gene cause autosomal dominant hereditary spastic paraplegia in two Chinese families

Jiandong Sun, P. Maxwell, D. Geng, 2005, Human mutation.

Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation.

M. Maze, Hailin Zhao, D. Ma, 2009, Journal of the American Society of Nephrology : JASN.

Seeing the smoking gun: a sensitive and specific method to visualize loss of the tumour suppressor, fumarate hydratase, in human tissues

P. Maxwell, 2011, The Journal of pathology.

Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.

G. Schley, K. Eckardt, B. Klanke, 2011, Journal of the American Society of Nephrology : JASN.

Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer.

Madeleine Moussa, Hideki Sakai, Joseph L Chin, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine

P. Sham, Shuhua Xu, Yingnan Cao, 2017, Scientific Reports.

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

David I Stuart, Christopher J Schofield, Michael I. Wilson, 2002, Nature.

MACROPHAGE SKEWING BY PHD 2 HAPLODEFICIENCY PREVENTS ISCHEMIA BY INDUCING ARTERIOGENESIS

K. Alitalo, P. Maxwell, M. Mazzone, 2012 .

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.

A. Harris, M. Ashcroft, P. Maxwell, 2012, The Journal of clinical investigation.

Loss of prolyl hydroxylase-1 protects in colitis through reduced epithelial cell apoptosis and enhanced barrier function Short Title: PHD1 loss is protective in colitis

P. Carmeliet, F. Lasitschka, E. Cummins, 2022 .

Genetic Studies of IgA Nephropathy

P. Maxwell, Yiming Wang, 2005, Nephron Experimental Nephrology.

Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19

Nicola K. Wilson, Kenneth G. C. Smith, K. Stirrups, 2022, iScience.

Single-cell atlas of a non-human primate reveals new pathogenic 1 mechanisms of COVID-19 2

Huanming Yang, Shiping Liu, P. Maxwell, 2020 .

Corrigendum: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

J. Saez-Rodriguez, B. Huntly, K. Franze, 2016, Nature.

Human CHCHD 4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

A. Harris, M. Ashcroft, P. Maxwell, 2018 .

Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations

P. Maxwell, 2016, BMC Genetics.

Expression of Hypoxia-inducible Factors in Human Renal Cancer : Relationship to Angiogenesis and to the von Hippel-Lindau Gene Mutation 1

A. Harris, P. Ratcliffe, C. Taylor, 2002 .

Characterization and localization of expression of an erythropoietin‐induced gene, ERIC‐1/TACC3, identified in erythroid precursor cells

P. Maxwell, P. Maxwell, A. Maxwell, 2001, British journal of haematology.

The macrophage – a novel system to deliver gene therapy to pathological hypoxia

A. Harris, P. Ratcliffe, C. Lewis, 2000, Gene Therapy.

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.

Thomas G. Smith, P. Robbins, P. Ratcliffe, 2006 .

Increasing evidence that genetic variation in Complement factor H related 5 (CFHR5) causes disease: A commentary on ‘Atypical haemolytic uremic syndrome and genetic aberrations in the complement factor-H-related 5 gene’

P. Maxwell, 2012, Journal of Human Genetics.

Regulation of HIF by the von Hippel‐Lindau Tumour Suppressor: Implications for Cellular Oxygen Sensing

P. Ratcliffe, C. Pugh, P. Maxwell, 2001, IUBMB life.

Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients.

D. Gale, J. Feehally, P. Maxwell, 2010, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.