Y. Yamashita

发表

A new structural class of proteasome inhibitors identified by microbial screening using yeast-based assay.

Sreenath V. Sharma, S. Akinaga, T. Mizukami, 2004, Biochemical pharmacology.

Belactosin A, a novel antitumor antibiotic acting on cyclin/CDK mediated cell cycle regulation, produced by Streptomyces sp.

K. Ochiai, T. Mizukami, A. Asai, 2000, The Journal of antibiotics.

Telomerase inhibitors identified by a forward chemical genetics approach using a yeast strain with shortened telomere length.

S. Akinaga, T. Mizukami, A. Asai, 2006, Chemistry & biology.

K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.

H. Saya, S. Akinaga, Takeshi Takahashi, 2009, Cancer research.

Belactosin A, a Novel Antitumor Antibiotic Acting on Cyclin/CDK Mediated Cell Cycle Regulation, Produced by Streptomyces sp.

K. Ochiai, T. Mizukami, A. Asai, 2000 .

Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity.

T. Nakashima, S. Soga, Y. Yamashita, 2008, Bioorganic & medicinal chemistry letters.

UCS15A, a non-kinase inhibitor of Src signal transduction

Sreenath V. Sharma, T. Tamaoki, H. Nakano, 2001, Oncogene.

Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.

S. Akinaga, T. Tsujita, Y. Yamashita, 2014, Bioorganic & medicinal chemistry letters.

Reconstitution of telomerase activity utilizing human catalytic subunit expressed in insect cells.

T. Mizukami, A. Asai, Y. Yamashita, 2002, Biochemical and biophysical research communications.

Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol.

H. Nakano, Y. Yamashita, S. Kawada, 1990, Biochemical pharmacology.

A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models

S. Akinaga, Y. Yamashita, C. Murakata, 2015, Molecular Cancer Therapeutics.

Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors.

T. Naoe, S. Akinaga, Y. Shiotsu, 2008, Bioorganic & medicinal chemistry letters.

Telomerase inhibitors--oligonucleotide phosphoramidates as potential therapeutic agents.

C. Harley, J. Shay, A. Asai, 2001, Nucleosides, nucleotides & nucleic acids.

A novel telomerase template antagonist (GRN163) as a potential anticancer agent.

C. Harley, S. Akinaga, A. Asai, 2003, Cancer research.

UCE6, a new antitumor antibiotic with topoisomerase I-mediated DNA cleavage activity produced by actinomycetes: producing organism, fermentation, isolation and biological activity.

T. Ashizawa, H. Nakano, Y. Yamashita, 1997, The Journal of antibiotics.

Induction of topoisomerase II-mediated DNA cleavage by the plant naphthoquinones plumbagin and shikonin

H. Nakano, Y. Yamashita, M. Nagashima, 1992, Antimicrobial Agents and Chemotherapy.

UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity, from Streptomyces sp.

H. Nakano, K. Gomi, Y. Yamashita, 1992, The Journal of antibiotics.

Antitumor quinolones with mammalian topoisomerase II mediated DNA cleavage activity.

T. Ashizawa, H. Nakano, M. Morimoto, 1992, Cancer research.

Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus.

H. Nakano, Y. Yamashita, S. Kawada, 1991, Biochemistry.

Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidin.

H. Nakano, Y. Yamashita, S. Kawada, 1991, Cancer research.

Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces.

H. Nakano, Y. Yamashita, K. Takahashi, 1990, The Journal of antibiotics.

Aranorosin and a novel derivative inhibit the anti-apoptotic functions regulated by Bcl-2.

T. Nakashima, Y. Yamashita, Y. Kanda, 2008, Biochemical and biophysical research communications.

UCS1025A, a novel antibiotic produced by Acremonium sp.

S. Akinaga, T. Mizukami, A. Asai, 2000, The Journal of antibiotics.

Chrolactomycin, a novel antitumor antibiotic produced by Streptomyces sp.

S. Akinaga, T. Mizukami, A. Asai, 2001, The Journal of antibiotics.

UCH9, a new antitumor antibiotic produced by Streptomyces. II. Structure elucidation of UCH9 by mass and NMR spectroscopy.

H. Nakano, Y. Yamashita, H. Ogawa, 1998, The Journal of antibiotics.

UCH9, a new antitumor antibiotic produced by Streptomyces: I. Producing organism, fermentation, isolation and biological activities.

T. Ashizawa, H. Nakano, Y. Yamashita, 1998, The Journal of antibiotics.

Pyrronamycin A and B, novel antitumor antibiotics containing pyrrole-amide repeating unit, produced by Streptomyces sp.

K. Ochiai, T. Ashizawa, T. Mizukami, 2000, The Journal of antibiotics.

Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes.

T. Mizukami, H. Nakano, Y. Yamashita, 1995, Planta medica.

UCE1022, a new antitumor antibiotic with topoisomerase I mediated DNA cleavage activity, from Paecilomyces.

H. Nakano, K. Gomi, Y. Yamashita, 1993, The Journal of antibiotics.

Solution structure of the novel antitumor drug UCH9 complexed with d(TTGGCCAA)2 as determined by NMR.

Y. Kyōgoku, Y. Yamashita, M. Katahira, 1998, Nucleic acids research.

MPC1001, a new antitumor antibiotic produced by Cladorrhinum sp.

Y. Yamashita, A. Hasegawa, R. Nakai, 2004, The Journal of antibiotics.

Induction of mammalian DNA topoisomerase I-mediated DNA cleavage and DNA winding by bulgarein.

H. Nakano, Y. Yamashita, Y. Saitoh, 1993, The Journal of biological chemistry.

Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives.

T. Ashizawa, H. Nakano, M. Okabe, 1992, Biochemistry.

Halohydrin and oxime derivatives of radicicol: synthesis and antitumor activities.

S. Akinaga, T. Mizukami, A. Asai, 2002, Bioorganic & medicinal chemistry.

Oligonucleotide N3′ → P5′ Thio-phosphoramidate Telomerase Template Antagonists as Potential Anticancer Agents

C. Harley, S. Akinaga, A. Asai, 2003, Nucleosides, nucleotides & nucleic acids.

Correlation between the formation of cleavable complex with topoisomerase I and growth-inhibitory activity for saintopin-type antibiotics.

T. Mizukami, H. Nakano, Y. Yamashita, 1997, Molecular pharmacology.

UCE6, a new antitumor antibiotic with topoisomerase I mediated DNA cleavage activity, from actinomycetes.

H. Nakano, Y. Yamashita, Y. Saitoh, 1993, Journal of antibiotics (Tokyo. 1968).

Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin.

H. Nakano, Y. Yamashita, S. Kawada, 1990, Cancer research.

Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purification.

K. Ochiai, H. Nakano, Y. Yamashita, 1995, The Journal of antibiotics.

UCH 9 , a New Antitumor Antibiotic Produced by Streptomyces : I . Producing Organism , Fermentation , Isolation and Biological Activities

Y. Yamashita, H. Ogawa, S. Chiba, 2008 .

UCT1072s, new antitumor antibiotics with topoisomerase II mediated DNA cleavage activity, from Aspergillus sp.

T. Ashizawa, T. Mizukami, A. Asai, 1999, The Journal of antibiotics.

Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors.

T. Naoe, S. Akinaga, Y. Shiotsu, 2008, Bioorganic & medicinal chemistry letters.

K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.

H. Saya, S. Akinaga, Takeshi Takahashi, 2009, Cancer research.