D. Flynn

发表

G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.

Xianglin Shi, Zhuo Zhang, B. Jiang, 2004, American journal of physiology. Cell physiology.

Protein-Protein Interactions: Principles, Techniques, and their Potential Role in New Drug Development

Faizan Ahmad, Nihal Ahmad, F. Ahmad, 2011, Journal of biomolecular structure & dynamics.

Confirmation of Gene Expression–Based Prediction of Survival in Non–Small Cell Lung Cancer

Yong Qian, Vincent Castranova, David G. Beer, 2008, Clinical Cancer Research.

Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma.

Holger Christiansen, Manfred Schwab, M. Schwab, 2002, Cancer cell.

PI3K activation is required for PMA-directed activation of cSrc by AFAP-110.

S. Weed, B. Jiang, L. C. Kelley, 2007, American journal of physiology. Cell physiology.

The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity

D. Flynn, Y. Qian, J. Baisden, 2001, Oncogene.

Chimeric constructs containing the SH4/Unique domains of cYes can restrict the ability of Src(527F) to upregulate heme oxygenase-1 expression efficiently.

D. Flynn, J. Hoey, J. Summy, 2000, Cellular signalling.

Identification and characterization of novel substrates for protein tyrosine kinases.

J. Parsons, D. Flynn, M. Schaller, 1993, Progress in nucleic acid research and molecular biology.

AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts.

D. Flynn, G. Gallick, J. Bomser, 2007, The Journal of clinical investigation.

p38 Signaling-mediated Hypoxia-inducible Factor 1α and Vascular Endothelial Growth Factor Induction by Cr(VI) in DU145 Human Prostate Carcinoma Cells*

Bing-Hua Jiang, Jenny R. Roberts, Xianglin Shi, 2002, The Journal of Biological Chemistry.

Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110.

S. Weed, D. Flynn, Valerie G Walker, 2004, Molecular and cellular biology.

Protein Kinase Cα Activates c-Src and Induces Podosome Formation via AFAP-110

S. Weed, D. Flynn, Valerie G Walker, 2004, Molecular and Cellular Biology.

AFAP-120

D. Flynn, C. Humphries, T. C. Koay, 1995, The Journal of Biological Chemistry.

A novel role for 3, 4-dichloropropionanilide (DCPA) in the inhibition of prostate cancer cell migration, proliferation, and hypoxia-inducible factor 1alpha expression

B. Jiang, J. Barnett, D. Flynn, 2006, BMC Cancer.

C/EBPβ activity and HPV-16 E6/E7 mRNA expression are not altered by imiquimod (ALDARA™) in human cervical cancer cells in vitro

D. Flynn, Michael R. Miller, M. Belcastro, 2004 .

A Polymorphic Variant of AFAP-110 Enhances

Y. Cho, J. Cunnick, J. Yu, 2010 .

Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells.

D. Flynn, G. Gillespie, Wenquan Wang, 2005, Cancer research.

Individualized Survival and Treatment Response Predictions for Breast Cancers Using Phospho-EGFR, Phospho-ER, Phospho-HER2/neu, Phospho-IGF-IR/In, Phospho-MAPK, and Phospho-p70S6K Proteins

V. Castranova, D. Flynn, J. Abraham, 2007 .

Individualized survival and treatment response predictions for breast cancers using phospho-EGFR, phospho-ER, phospho-HER2/neu, phospho-IGF-IR/In, phospho-MAPK, and phospho-p70S6K proteins.

Xianglin Shi, V. Castranova, Lan Guo, 2007, The International journal of biological markers.

Podosomes and Invadopodia: Related structures with Common Protein Components that May Promote Breast Cancer Cellular Invasion

J. Cunnick, D. Flynn, Youngjin Cho, 2008, Breast cancer : basic and clinical research.

Monoclonal antibodies directed against AFAP-110 recognize species-specific and conserved epitopes.

D. Flynn, Y. Qian, M. Hill, 1999, Hybridoma.

Immunohistochemical analysis of aldehyde dehydrogenase isoforms and their association with estrogen-receptor status and disease progression in breast cancer

R. Pohlig, D. Flynn, J. Sims-Mourtada, 2014, Breast cancer.

Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland

Y. Cho, J. Cunnick, D. Flynn, 2014, Oncogene.

Protein expression levels of the Src activating protein AFAP are developmentally regulated in brain.

D. Flynn, A. Berrebi, Roger L. Clem, 2003, Journal of neurobiology.

Specificity in signaling by c-Yes.

M. Sudol, M. Eck, D. Flynn, 2003, Frontiers in bioscience : a journal and virtual library.

c-Yes response to growth factor activation

M. Sudol, D. Flynn, David A. Clump, 2005, Growth factors.

ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling

Xianglin Shi, S. Dedhar, B. Jiang, 2005, Oncogene.

Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions.

K. Vuori, D. Wallach, D. Flynn, 2006, Cancer research.

Wound Healing and Cancer Stem Cells: Inflammation as a Driver of Treatment Resistance in Breast Cancer

D. Flynn, J. Sims-Mourtada, Lynn M. Opdenaker, 2015, Cancer growth and metastasis.

Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells

S. Weed, Y. Cho, J. Cunnick, 2008, Journal of Cell Science.

The effects of phosphorylation on adaptor protein function.

D. Flynn, L. Cherezova, A. Gatesman, 2002, Frontiers in bioscience : a journal and virtual library.

Cellular Pyrin Domain-Only Protein 2 Is a Candidate Regulator of Inflammasome Activation

Y. Rojanasakul, John Calvin Reed, Xianglin Shi, 2006, Infection and Immunity.

The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases

B. Jiang, D. Flynn, L. Cherezova, 2001, Oncogene.

Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity

D. Flynn, E. Westin, Y. Qian, 1998, Oncogene.

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate

J. Parsons, D. Flynn, A. Reynolds, 1993, Molecular and cellular biology.

Antitumor effect of β-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death

J. Zhao, Q. Li, Gangduo Wang, 2005, Cellular and Molecular Life Sciences CMLS.

Research Article Antitumor effect of b-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death

Jinshun Zhao, Gangduo Wang, Furong Huang, 2005 .

The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src

Xianglin Shi, B. Jiang, D. Flynn, 2003, Journal of Cell Science.

PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration.

J. Blenis, Xianglin Shi, B. Jiang, 2004, American journal of physiology. Cell physiology.

Identification andSequence Analysis ofcDNAsEncoding a 110-Kilodalton ActinFilament-Associated pp6`rc Substrate

D. Flynn, A. Reynolds, 1993 .

Mitogenic signal transduction in human breast cancer cells.

W. Wonderlin, D. Flynn, J. Strobl, 1995, General pharmacology.

A conformational change in Sindbis virus glycoproteins E1 and E2 is detected at the plasma membrane as a consequence of early virus-cell interaction

R. Johnston, D. Flynn, J. Mackenzie, 1990, Journal of virology.

Antibody-mediated activation of Sindbis virus.

R. Johnston, D. Flynn, J. Mackenzie, 1988, Virology.

AFAP‐110 is required for actin stress fiber formation and cell adhesion in MDA‐MB‐231 breast cancer cells

C. Stehlik, D. Flynn, G. Gallick, 2007, Journal of cellular physiology.

Analysis of the role of the leucine zipper motif in regulating the ability of AFAP‐110 to alter actin filament integrity

D. Flynn, N. Mazloum, Marietta Y. W. T. Lee, 2004, Journal of cellular biochemistry.

PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments.

Xianglin Shi, D. Flynn, N. Mazloum, 2002, Molecular biology of the cell.

Antiproliferative effect of β-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase

J. Zhao, Q. Li, Gangduo Wang, 2005, Cellular and Molecular Life Sciences CMLS.

Taxane‐induced hedgehog signaling is linked to expansion of breast cancer stem‐like populations after chemotherapy

D. Flynn, J. Sims-Mourtada, Lynn M. Opdenaker, 2015, Molecular carcinogenesis.

AFAP120 regulates actin organization during neuronal differentiation.

D. Flynn, L. Lanier, Xiaohua Xu, 2009, Differentiation; research in biological diversity.

A Polymorphic Variant of AFAP-110 Enhances cSrc Activity.

Y. Cho, J. Cunnick, J. Yu, 2010, Translational oncology.

A Shope Fibroma virus PYRIN-only protein modulates the host immune response

Y. Rojanasakul, John Calvin Reed, Xianglin Shi, 2007, Virus Genes.

Population-Based Molecular Prognosis of Breast Cancer by Transcriptional Profiling

Xianglin Shi, E. Harner, Yan Ma, 2007, Clinical Cancer Research.

Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling

Vincent Castranova, Nancy Lan Guo, Val Vallyathan, 2009, Particle and Fibre Toxicology.

SRChing for the substrates of Src

S. Weed, J. Parsons, S. Kanner, 2014, Oncogene.

The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation.

D. Flynn, H. Zot, W. Van Winkle, 2000, Experimental cell research.

Characterization of an alternatively spliced AATYK mRNA: Expression pattern of AATYK in the brain and neuronal cells

E. Reddy, S. Baker, C. Reddy, 2001, Oncogene.

Effects of the protein tyrosine phosphatase CD45 on FcgammaRIIa signaling and neutrophil function.

D. Flynn, S. Ericson, H. Gao, 2000, Experimental hematology.

Individualized Survival and Treatment Response Predictions in Breast Cancer Patients: Involvements of Phospho-EGFR and Phospho-Her2/neu Proteins.

Xianglin Shi, V. Castranova, D. Flynn, 2008, The open clinical cancer journal.

The integrity of the SH3 binding motif of AFAP-110 is required to facilitate tyrosine phosphorylation by, and stable complex formation with, Src

D. Flynn, A. C. Guappone, 1997, Molecular and Cellular Biochemistry.

An in vivo system for analysis of stable complex formation between Src and AFAP-110

D. Flynn, Y. Qian, A. C. Guappone, 1996 .

Cdc42 Regulates Arsenic-induced NADPH Oxidase Activation and Cell Migration through Actin Filament Reorganization*

Xianglin Shi, V. Castranova, D. Flynn, 2005, Journal of Biological Chemistry.

Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation.

V. Castranova, X. Shi, S. Leonard, 1997, Annals of clinical and laboratory science.

Cr(VI) increases tyrosine phosphorylation through reactive oxygen species-mediated reactions

Liying Wang, B. Jiang, Xianglin Shi, 2001, Molecular and Cellular Biochemistry.

NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors

M. Ladanyi, A. Drilon, R. Somwar, 2020, Communications Biology.

Adaptor proteins

D. Flynn, Daniel C Flynn, 2001, Oncogene.

AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes.

Y. Cho, J. Cunnick, D. Flynn, 2011, European journal of cell biology.

Hydrogen Peroxide Formation and Actin Filament Reorganization by Cdc42 Are Essential for Ethanol-induced in Vitro Angiogenesis*

Xianglin Shi, S. Leonard, Jia Luo, 2003, The Journal of Biological Chemistry.

The SH3 and SH2 domains are capable of directing specificity in protein interactions between the non-receptor tyrosine kinases cSrc and cYes

M. Sudol, D. Flynn, J. Summy, 2000, Oncogene.

Vanadium (IV) formation in the reduction of vanadate by glutathione reductase/NADPH and the role of molecular oxygen.

X. Shi, N. Dalal, D. Flynn, 1997, Annals of clinical and laboratory science.

Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death.

J. Zhao, Q. Li, E. Reed, 2005, Cellular and molecular life sciences : CMLS.

Formation of a stable src–AFAP‐110 complex through either an amino‐terminal or a carboxy‐terminal SH2‐binding motif

D. Flynn, T. Weimer, Anne C. Guappone, 1998, Molecular carcinogenesis.

Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions.

K. Vuori, D. Wallach, D. Flynn, 2006, Cancer research.