David K. Williams

发表

Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases.

David K Williams, John S Tokarski, J. Tokarski, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.

J. Tokarski, B. Koplowitz, J. Hunt, 2005, Bioorganic & medicinal chemistry letters.

Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.

J. Fargnoli, J. Tokarski, G. Trainor, 2010, Bioorganic & medicinal chemistry letters.

Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.

David S. Nirschl, David S Nirschl, J. Fargnoli, 2008, Bioorganic & medicinal chemistry letters.

Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists.

David K. Williams, R. Steffan, E. Trybulski, 2006, Bioorganic & medicinal chemistry letters.

Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors.

J. Fargnoli, J. Tokarski, J. Hunt, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.

L. Mueller, S. Sheriff, David K. Williams, 2006, Bioorganic & medicinal chemistry letters.

Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists.

Shana L. Posy, R. Talbott, S. Emanuel, 2014, Bioorganic & medicinal chemistry letters.

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.

Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.

J. Fargnoli, J. Tokarski, D. Xie, 2008, Journal of medicinal chemistry.

One-pot two step synthesis of 5-cyano-dihydropyrimidinones using polyphosphate ester

David K. Williams, R. Schmidt, L. Lombardo, 2008 .

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.

David K Williams, Patricia C Weber, D. Chakrabarti, 2005, Journal of medicinal chemistry.

Alkaloids of the Papaveraceae. XVI. Total synthesis of the pavinane alkaloid platycerine

David K. Williams, F. Stermitz, 1973 .

One‐Pot Two Step Synthesis of 5‐Cyano‐dihydropyrimidinones Using Polyphosphate Ester.

David K. Williams, R. Schmidt, L. Lombardo, 2008 .

Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

D. Chakrabarti, M. Gelb, F. Buckner, 2007, Antimicrobial Agents and Chemotherapy.

Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.

D. Chakrabarti, M. Gelb, F. Buckner, 2007, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of Biaryl Alkyl Ethers as Inhibitors of IDO1.

Xin Li, J. Hunt, L. Jayaraman, 2023, Bioorganic & medicinal chemistry letters.

Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

J. Hunt, David K. Williams, Weifang Shan, 2018, Bioorganic & medicinal chemistry letters.

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.