Minoru Yoshida

发表

Phosphorylation of p27 Kip1 on Serine 10 Is Required for Its Binding to CRM1 and Nuclear Export*

K. Nakayama, K. Nakayama, T. Kamura, 2002, The Journal of Biological Chemistry.

The Cytoplasmic Shuttling and Subsequent Degradation of p27Kip1 Mediated by Jab1/CSN5 and the COP9 Signalosome Complex*

Minoru Yoshida, Maki Maeda, Toshiaki Tanaka, 2002, The Journal of Biological Chemistry.

Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.

R. Ueoka, K. Shin‐ya, M. Takagi, 2009, Toxicon : official journal of the International Society on Toxinology.

Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-1

N. Imamoto, Minoru Yoshida, Mami Yoshimura, 2018, Scientific Reports.

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

Minoru Yoshida, Iain W. Mattaj, Maarten Fornerod, 1997, Cell.

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

Minoru Yoshida, Makoto Fukuda, Mitsuhiro Yanagida, 1997, Nature.

Fluorescence detection of intron lariat RNA with reduction-triggered fluorescent probes.

S. Tsuneda, Yoshihiro Ito, Minoru Yoshida, 2011, Angewandte Chemie.

MALAT1 long non-coding RNA in cancer.

Minoru Yoshida, Shinichi Nakagawa, A. Mayeda, 2016, Biochimica et biophysica acta.

ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe

Y. Hiraoka, S. Horinouchi, Minoru Yoshida, 2006, Nature Biotechnology.

Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast

T. Toda, Minoru Yoshida, Masayuki Yamamoto, 2009, EMBO reports.

Real-time imaging of cotranscriptional splicing reveals a kinetic model that reduces noise: implications for alternative splicing regulation

D. Auboeuf, Minoru Yoshida, Ute Schmidt, 2011, The Journal of cell biology.

Changes in the Acetylome and Succinylome of Bacillus subtilis in Response to Carbon Source

M. Nishiyama, Minoru Yoshida, S. Kosono, 2015, PloS one.

Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.

Minoru Yoshida, A. Ito, M. Islam, 2014, Bioorganic & medicinal chemistry.

An efficient synthesis of SK-658 and its analogs as potent histone deacetylase inhibitors.

Minoru Yoshida, A. Ito, Tamaki Kato, 2015, Bioorganic chemistry.

Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.

Y. Hashimoto, Minoru Yoshida, Satoko Maeda, 2007, Bioorganic & medicinal chemistry letters.

Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.

Minoru Yoshida, Tamaki Kato, N. Nishino, 2004, Bioorganic & Medicinal Chemistry Letters.

Chlamydocin-hydroxamic acid analogues as histone deacetylase inhibitors.

Minoru Yoshida, Tamaki Kato, N. Nishino, 2004, Bioorganic & medicinal chemistry.

Design and synthesis of phthalimide-type histone deacetylase inhibitors.

Y. Hashimoto, Minoru Yoshida, Satoko Maeda, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors.

Minoru Yoshida, T. Yamori, A. Ito, 2016, European journal of medicinal chemistry.

Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy–Refractory Cancer Growth

K. Takayama, S. Inoue, Yutaka Suzuki, 2021, Cancer Research.

Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1

M. Furuno, Minoru Yoshida, S. Nakagawa, 2011, Genes to cells : devoted to molecular & cellular mechanisms.

The copper transport-associated protein Ctr4 can form prion-like epigenetic determinants in Schizosaccharomyces pombe

M. Tuite, J. Bähler, María Rodríguez-López, 2017, Microbial cell.

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

D. Botstein, G. Giaever, B. Andrews, 2009, Nature Biotechnology.

Stat5B Shuttles Between Cytoplasm and Nucleus in a Cytokine-Dependent and -Independent Manner1

K. Arai, Sumiko Watanabe, Minoru Yoshida, 2002, The Journal of Immunology.

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.

Minoru Yoshida, June-Tai Wu, C. Nicchitta, 2005, Molecular cell.

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

Minoru Yoshida, Hidenori Nakajima, Akito Tanaka, 2002, Cancer research.

[Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A].

Minoru Yoshida, Minoru Yoshida, 1990, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human

Minoru Yoshida, Yu Xia, Frederick P. Roth, 2016, Cell.

A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes

Minoru Yoshida, N. Kudo, S. Miyamoto, 2000 .

Splicing in oncogenesis and tumor suppression

Minoru Yoshida, Tilman Schneider-Poetsch, Daisuke Kaida, 2012, Cancer science.

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

Minoru Yoshida, Masao Doi, Hideaki Kakeya, 2013, Cell.

Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis

Minoru Yoshida, H. Osada, Wensheng Pan, 2020, Aging.

Functional Annotation of Chemical Libraries across Diverse Biological Processes

Minoru Yoshida, Yoshikazu Ohya, Michael Costanzo, 2017, bioRxiv.

Toward an HDAC6 inhibitor: synthesis and conformational analysis of cyclic hexapeptide hydroxamic acid designed from alpha-tubulin sequence.

Minoru Yoshida, Tamaki Kato, N. Nishino, 2004, Bioorganic & medicinal chemistry.

Cyclic tetrapeptides bearing a sulfhydryl group potently inhibit histone deacetylases.

Minoru Yoshida, Tamaki Kato, N. Nishino, 2003, Organic letters.

Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast

Minoru Yoshida, Akihisa Matsuyama, T. Kato, 2020, The Journal of Antibiotics.

Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer

S. Schreiber, N. Funata, S. Horiguchi, 2005, Oncogene.

Integrating yeast chemical genomics and mammalian cell pathway analysis

Sheena C. Li, Scott W. Simpkins, C. Myers, 2019, Acta Pharmacologica Sinica.

Nuclear export signal in CDC25B.

H. Nakagama, K. Yamashita, M. Shimura, 2004, Biochemical and biophysical research communications.

Identification of a trichothecene production inhibitor by chemical array and library screening using trichodiene synthase as a target protein.

M. Kimura, Tetsuo Kobayashi, Minoru Yoshida, 2017, Pesticide biochemistry and physiology.

New SIRT2 inhibitors: Histidine-based bleomycin spin-off.

Minoru Yoshida, T. Honma, A. Ito, 2019, Bioorganic & medicinal chemistry.

Along the Central Dogma-Controlling Gene Expression with Small Molecules.

Minoru Yoshida, Tilman Schneider-Poetsch, Tilman Schneider‐Poetsch, 2018, Annual review of biochemistry.

Evaluation of functional groups on amino acids in cyclic tetrapeptides in histone deacetylase inhibition

Minoru Yoshida, A. Ito, M. Islam, 2012, Amino Acids.

Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.

Minoru Yoshida, A. Ito, Tamaki Kato, 2010, Bioorganic & medicinal chemistry letters.

Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.

Minoru Yoshida, Satoko Maeda, Mohammed P. I. Bhuiyan, 2008, Bioorganic & medicinal chemistry.

Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.

S. Amagai, Minoru Yoshida, Satoko Maeda, 2007, Bioorganic & medicinal chemistry.

Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases.

Minoru Yoshida, Satoko Maeda, Mohammed P. I. Bhuiyan, 2006, Bioorganic & medicinal chemistry.

The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Alleviates Salinity Stress in Cassava

M. Seki, H. Sakakibara, Minoru Yoshida, 2017, Front. Plant Sci..

Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity.

Minoru Yoshida, T. Yamori, H. Abe, 2009, Chemistry.

Live imaging of H 3 K 9 acetylation in plant cells

M. Seki, Minoru Yoshida, A. Ito, 2017 .

Live imaging of H3K9 acetylation in plant cells

H. Kimura, M. Seki, Minoru Yoshida, 2017, Scientific Reports.

Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors.

Kam Y. J. Zhang, Ashutosh Kumar, Minoru Yoshida, 2013, Bioorganic & medicinal chemistry letters.

Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Minoru Yoshida, C. Olsen, N. Kudo, 2021, RSC Chemical Biology.

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.

Minoru Yoshida, John M Denu, J. Denu, 2015, Biochemistry.

Yakushinamides, Polyoxygenated Fatty Acid Amides That Inhibit HDACs and SIRTs, from the Marine Sponge Theonella swinhoei.

Minoru Yoshida, S. Okada, A. Ito, 2016, Journal of natural products.

From discovery to the coming generation of histone deacetylase inhibitors.

Minoru Yoshida, Akihisa Matsuyama, N. Nishino, 2003, Current medicinal chemistry.

Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Charles Boone, Y. Arita, Minoru Yoshida, 2011, Molecular bioSystems.

Winners of the 2015 JA Medals for excellence

Minoru Yoshida, 2016, The Journal of Antibiotics.

U2 snRNP Is Required for Expression of the 3′ End of Genes

I. Takasaki, Minoru Yoshida, Yumi Kawamura, 2014, PloS one.

A genetic screen to discover SUMOylated proteins in living mammalian cells

Minoru Yoshida, A. Ito, H. Saitoh, 2017, Scientific Reports.

Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.

Kam Y. J. Zhang, Jay W. Shin, M. Shirouzu, 2020, International journal of biological macromolecules.

Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors.

Yukihiro Itoh, Takayoshi Suzuki, Minoru Yoshida, 2007, Journal of medicinal chemistry.

Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores.

N. Matsumori, Minoru Yoshida, S. Matsunaga, 2016, Biochimica et biophysica acta.

Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state (2)H nuclear magnetic resonance.

N. Matsumori, Minoru Yoshida, S. Matsunaga, 2013, Biochemistry.

Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.

Minoru Yoshida, Satoko Maeda, J. Yamashita, 2008, Bioorganic & medicinal chemistry letters.

Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

Takehiro Suzuki, N. Dohmae, Minoru Yoshida, 2020, bioRxiv.

Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation-Inhibitory Activity.

A. Matsuda, Daisuke Sekine, M. Sodeoka, 2019, Chemistry.

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.

K. Ogawa, T. Umehara, S. Yokoyama, 2016, Journal of medicinal chemistry.

Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product.

S. Horinouchi, T. Kunoh, Tetsuo Yoshida, 2011, ACS chemical biology.

Genome-wide survey of ribosome collision

Yuichiro Mishima, T. Inada, Minoru Yoshida, 2019, bioRxiv.

Receptor-Independent Ectopic Activity of Prolactin Predicts Aggressive Lung Tumors and Indicates HDACi-Based Therapeutic Strategies.

E. Brambilla, C. Brambilla, Minoru Yoshida, 2015, Antioxidants & redox signaling.

Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF

S. Kojima, Minoru Yoshida, K. Ishigami, 2010, Cancer science.

Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods

Kam Y. J. Zhang, Ashutosh Kumar, Minoru Yoshida, 2020, International journal of molecular sciences.

Discovery of small molecule inhibitors targeting the SUMO–SIM interaction using a protein interface consensus approach

Kam Y. J. Zhang, T. Kigawa, A. Voet, 2014 .

Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A

Y. Hayashizaki, Harukazu Suzuki, M. Furuno, 2017, RNA.

Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression

D. Hume, W. Aird, T. Kodama, 2006, Arteriosclerosis, thrombosis, and vascular biology.

HDAC6 a new cellular stress surveillance factor

Minoru Yoshida, P. Matthias, S. Khochbin, 2008, Cell cycle.

Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications

Y. Sakakibara, K. Shin‐ya, T. Doi, 2012, BMC chemical biology.

Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation

Sheena C. Li, Charles Boone, M. Del Poeta, 2022, Nature Communications.

Ky-2, a Histone Deacetylase Inhibitor, Enhances High-Salinity Stress Tolerance in Arabidopsis thaliana.

Kazuki Saito, T. Taji, M. Seki, 2016, Plant & cell physiology.

Nucleocytoplasmic transport of fluorescent mRNA in living mammalian cells: nuclear mRNA export is coupled to ongoing gene transcription

Y. Ohshima, Minoru Yoshida, T. Funatsu, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

Inhibition of histone deacetylase causes reduction of appressorium formation in the rice blast fungus Magnaporthe oryzae.

M. Kimura, Minoru Yoshida, T. Teraoka, 2009, The Journal of general and applied microbiology.

Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.

T. Umehara, M. Shirouzu, H. Seimiya, 2019, Journal of medicinal chemistry.

Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains.

T. Yao, Minoru Yoshida, A. Ito, 2013, Molecular cell.

Nucleocytoplasmic transport and nuclear envelope integrity in the fission yeast Schizosaccharomyces pombe.

Minoru Yoshida, S. Sazer, 2004, Methods.

β-Subunit of Nuclear Pore-targeting Complex (Importin-β) Can Be Exported from the Nucleus in a Ran-independent Manner*

N. Imamoto, Minoru Yoshida, S. Kose, 1999, The Journal of Biological Chemistry.

Identification of a Chemical Modulator of EZH2-mediated Silencing by Cell-based High-throughput Screening Assay.

N. Kagaya, K. Shin‐ya, H. Kimura, 2019, Journal of biochemistry.

13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit.

S. Yokoyama, H. Hirota, Minoru Yoshida, 2005, Bioorganic & medicinal chemistry.

Interaction of the Hepatitis B Virus X Protein with the Crm1-dependent Nuclear Export Pathway*

X. Wang, M. Forgues, A. Marrogi, 2001, The Journal of Biological Chemistry.

Accumulation of multiacetylated forms of histones by trichostatin A and its developmental consequences in early starfish embryos

Takahiko Shimizu, Minoru Yoshida, T. Beppu, 1993, Roux's archives of developmental biology.

-Globin by Histone Deacetylase Inhibitors g Induction of

M. Su, P. Mccaffrey, Minoru Yoshida, 1997 .

Induction of g-Globin by Histone Deacetylase Inhibitors

M. Su, P. Mccaffrey, Minoru Yoshida, 1997 .

The Insulin Receptor: A Potential Target of Amarogentin Isolated from Gentiana rigescens Franch That Induces Neurogenesis in PC12 Cells

Minoru Yoshida, H. Osada, Lan Xiang, 2021, Biomedicines.

Involvement of p44/p42 MAP kinase in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblast-like-MC3T3-E1 cells

S. Takai, A. Ishisaki, O. Kozawa, 2006, Molecular and Cellular Endocrinology.

Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin

M. Yanagida, K. Nagao, C. Obuse, 2008, Journal of Cell Science.

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.

C. Hui, Minoru Yoshida, Xiaoyun Zhang, 2005, Differentiation; research in biological diversity.

Visualization of Sterol-Rich Membrane Domains with Fluorescently-Labeled Theonellamides

Y. Arita, Minoru Yoshida, S. Matsunaga, 2013, PloS one.

Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling.

Y. Arita, Minoru Yoshida, S. Matsunaga, 2010, Nature chemical biology.

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B

B. Ponder, Yusuke Nakamura, Y. Maehara, 2012, Nature Communications.

Genetically encoded FRET indicators for live-cell imaging of histone acetylation.

Minoru Yoshida, K. Sasaki, 2014, Methods in molecular biology.

A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7.

Minoru Yoshida, Ayako Yoshitani, F. Ling, 2008, Biochemical and biophysical research communications.

Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast

J. Simard, R. Zhao, Minoru Yoshida, 2017, Proceedings of the National Academy of Sciences.

The exploitation of FRET probes to track bromodomain/histone interactions in cells for bromodomain inhibitors.

Minoru Yoshida, K. Sasaki, 2016, Drug discovery today. Technologies.

Design and synthesis of mono and bicyclic tetrapeptides thioester as potent inhibitor of histone deacetylases

Minoru Yoshida, A. Ito, M. Islam, 2014, Amino Acids.

Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.

Minoru Yoshida, N. Nishino, B. Jose, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.

Minoru Yoshida, N. Nishino, B. Jose, 2004, Bioorganic & medicinal chemistry letters.

A novel series of vectors for chromosomal integration in fission yeast.

Minoru Yoshida, Akihisa Matsuyama, A. Shirai, 2008, Biochemical and biophysical research communications.

Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors.

K. Nunomura, Minoru Yoshida, A. Ito, 2022, ACS Medicinal Chemistry Letters.

A Genetically Encoded FRET Probe to Detect Intranucleosomal Histone H3K9 or H3K14 Acetylation Using BRD4, a BET Family Member.

Minoru Yoshida, A. Ito, Y. Nakao, 2016, ACS chemical biology.

Radicicol, a Protein Tyrosine Kinase Inhibitor, Suppresses the Expression of Mitogen-inducible Cyclooxygenase in Macrophages Stimulated with Lipopolysaccharide and in Experimental Glomerulonephritis (*)

H. Kwon, B. Jang, Minoru Yoshida, 1995, The Journal of Biological Chemistry.

Leptomycin B, an Inhibitor of the Nuclear Export Receptor CRM1, Inhibits COX-2 Expression*

K. Claffey, T. Hla, J. Paik, 2003, The Journal of Biological Chemistry.

Combined Effects of p53 Gene Therapy and Leptomycin B in Human Esophageal Squamous Cell Carcinoma

H. Matsubara, K. Matsushita, Minoru Yoshida, 2008, Oncology.

Splicing inhibition induces gene expression through canonical NF‐κB pathway and extracellular signal‐related kinase activation

N. Mukaida, Minoru Yoshida, A. Ito, 2014, FEBS letters.

Identification of a novel component C2ORF3 in the lariat–intron complex: lack of C2ORF3 interferes with pre‐mRNA splicing via intron turnover pathway

N. Kataoka, Minoru Yoshida, M. Ohno, 2014, Genes to cells : devoted to molecular & cellular mechanisms.

Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts.

A. Ishisaki, O. Kozawa, Minoru Yoshida, 2004, Prostaglandins, leukotrienes, and essential fatty acids.

Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium

R. Ueoka, E. Carreira, A. Oxenius, 2022, Nature Chemistry.

Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†

Minoru Yoshida, A. Ito, E. Mizutani, 2021, Biology of Reproduction.

Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily.

S. Takai, O. Kozawa, Minoru Yoshida, 2006, Prostaglandins, leukotrienes, and essential fatty acids.

Drug discovery from chemical genetics on histone deacetylase

Minoru Yoshida, 2006 .

FK 228 ( Depsipeptide ) as a Natural Prodrug That Inhibits Class I Histone Deacetylases 1

M. Nishiyama, S. Horinouchi, Minoru Yoshida, 2002 .

Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity

Minoru Yoshida, T. Yamori, A. Ito, 2016 .

Winners of the 2019 JA Ōmura Awards for excellence.

Minoru Yoshida, Richard E. Lee, 2020, The Journal of antibiotics.

IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line

M. Komada, T. Asano, N. Kataoka, 2018, Oncotarget.

Effect of Porphyromonas gingivalis outer membrane vesicles on gingipain-mediated detachment of cultured oral epithelial cells and immune responses.

Haruo Watanabe, M. Ohnishi, Minoru Yoshida, 2014, Microbes and infection.

Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2.

Kam Y. J. Zhang, K. Shin‐ya, Ashutosh Kumar, 2013, ACS chemical biology.

Spectomycin B 1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E 2

Kam Y. J. Zhang, K. Shin‐ya, Ashutosh Kumar, 2013 .

Live‐Cell Studies of p300/CBP Histone Acetyltransferase Activity and Inhibition

J. Boeke, L. Mahadevan, P. Cole, 2012, Chembiochem : a European journal of chemical biology.

Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo.

Minoru Yoshida, M. Muroi, Lan Xiang, 2022, Food & function.

Interactions between SAP155 and FUSE-Binding Protein-Interacting Repressor Bridges c-Myc and P27Kip1 Expression

D. Levens, T. Tomonaga, H. Matsubara, 2013, Molecular Cancer Research.

Cell Cycle and Senescence Interactions between SAP 155 and FUSE-Binding Protein-Interacting Repressor Bridges c-Myc and P 27 Kip 1 Expression

D. Levens, T. Tomonaga, H. Matsubara, 2013 .

Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast

M. Sodeoka, H. Hirota, Minoru Yoshida, 2016, Scientific Reports.

Protein acetylation involved in streptomycin biosynthesis in Streptomyces griseus.

S. Horinouchi, Minoru Yoshida, S. Kosono, 2017, Journal of proteomics.

The Yeast Checkpoint Kinase Dun1 Downregulates DIN7 in the Absence of DNA Damage

Minoru Yoshida, Ayako Yoshitani, F. Ling, 2008, Bioscience, biotechnology, and biochemistry.

Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.

Minoru Yoshida, A. Ito, A. Shah, 2016, Biological & pharmaceutical bulletin.

Mhr 1 expression levels regulate double-strand-break – induced replication and recombination of mtDNA at ori 5 in yeast

Akiko Hori, T. Shibata, Minoru Yoshida, 2013 .

Ferrichrome, a fungal-type siderophore, confers high ammonium tolerance to fission yeast

Minoru Yoshida, Akihisa Matsuyama, Yoko Yashiroda, 2022, Scientific Reports.

Promoter CIP1/WAF1 p21Deacetylase 6 and Represses the Runx2 (Cbfa1, AML-3) Interacts with

S. K. Zaidi, G. Stein, J. Lian, 2014 .

Steric structure-activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9.

Minoru Yoshida, H. Kagechika, A. Ito, 2016, Bioorganic & medicinal chemistry.

Biocompatibility and therapeutic potential of glycosylated albumin artificial metalloenzymes

Katsunori Tanaka, Minoru Yoshida, N. Kudo, 2019, Nature Catalysis.

Leptomycin B, a metabolite of Streptomyces, inhibits the expression of inducible nitric oxide synthase in BV2 microglial cells.

B. Jang, Jong-Wook Park, Minoru Yoshida, 2006, International journal of oncology.

Protein deacetylases: enzymes with functional diversity as novel therapeutic targets.

Minoru Yoshida, Akihisa Matsuyama, T. Shimazu, 2003, Progress in cell cycle research.

HDAC6 is a microtubule-associated deacetylase

Xiao-Fan Wang, T. Yao, R. Shao, 2002, Nature.

Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6

Minoru Yoshida, A. Ito, Satoko Maeda, 2012, FEBS letters.

Multiple Histone Deacetylases and the CREB-binding Protein Regulate Pre-mRNA 3′-End Processing*

S. Horinouchi, Minoru Yoshida, T. Shimazu, 2007, Journal of Biological Chemistry.

EFFECT OF HISTONE DEACETYLASE INHIBITORS ON TUBULIN ACETYLATION AND DEVELOPMENT IN VOLVOX CARTERI (VOLVOCALES) 1

J. Wong, Minoru Yoshida, Stephen M. Miller, 2006 .

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1

T. Tsunoda, Takafumi Suzuki, Masayuki Yamamoto, 2015, Science Signaling.

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap 1

T. Tsunoda, Takafumi Suzuki, Masayuki Yamamoto, 2015 .

Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells.

H. Aburatani, K. Shin‐ya, T. Umehara, 2022, Cell chemical biology.

GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression.

S. Horinouchi, S. Akinaga, Tetsuo Yoshida, 2002, The Journal of antibiotics.

Regulation of E2A Activities by Histone Acetyltransferases in B Lymphocyte Development*

T. Yao, Y. Zhuang, Minoru Yoshida, 2003, The Journal of Biological Chemistry.

Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.

Minoru Yoshida, A. Ito, Y. Nagaoka, 2018, ACS medicinal chemistry letters.

Identification and Characterization of an Inhibitor of Trichothecene 3-O-Acetyltransferase, TRI101, by the Chemical Array Approach

M. Kimura, Tetsuo Kobayashi, Minoru Yoshida, 2013, Bioscience, biotechnology, and biochemistry.

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

K. Nakayama, K. Nakayama, T. Kamura, 2004, Nature Cell Biology.

Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors.

Y. Hashimoto, Minoru Yoshida, Satoko Maeda, 2006, Bioorganic & medicinal chemistry.

Transcriptomic analysis of Arabidopsis thaliana plants treated with the Ky-9 and Ky-72 histone deacetylase inhibitors

M. Seki, Minoru Yoshida, A. Ito, 2018, Plant signaling & behavior.

Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.

S. Horinouchi, T. Yao, Minoru Yoshida, 2008, Biochemical and biophysical research communications.

SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1Tpp1 to modulate shelterin–Stn1 interaction in fission yeast

Minoru Yoshida, Venny Santosa, Katsunori Tanaka, 2014, Proceedings of the National Academy of Sciences.

Mating of the fission yeast occurs independently of pmd1+ gene product, a structural homologue of budding yeast STE6 and mammalian P-glycoproteins

S. Horinouchi, Minoru Yoshida, T. Beppu, 2004, Archives of Microbiology.

Heterologous gene expression by chromosomal integration in fission yeast.

Minoru Yoshida, Akihisa Matsuyama, 2012, Methods in molecular biology.

Dynamics and regulation of lysine-acetylation during one-cell stage mouse embryos.

Minoru Yoshida, S. Kishigami, A. Ito, 2013, Biochemical and biophysical research communications.

Bacillus subtilis strains used in this study.

M. Nishiyama, Minoru Yoshida, S. Kosono, 2015 .

Curacin E from the Brittle Star Ophiocoma scolopendrina.

R. Ueoka, Minoru Yoshida, S. Okada, 2016, Journal of natural products.

A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

T. Umehara, M. Shirouzu, Y. Shinkai, 2023, Nature Communications.

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

S. Horinouchi, Minoru Yoshida, Kun-Hyung Lee, 1999, Oncogene.

Genome-wide screening of genes associated with momilactone B sensitivity in the fission yeast Schizosaccharomyces pombe

Sheena C. Li, Charles Boone, J. Piotrowski, 2021, G3.

Discovery of Fungal Denitrification Inhibitors by Targeting Copper Nitrite Reductase from Fusarium oxysporum

Minoru Yoshida, Ashutosh Kumar, Kam Y. J. Zhang, 2017, J. Chem. Inf. Model..

Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity.

M. Sodeoka, Minoru Yoshida, A. Ito, 2010, Journal of the American Chemical Society.

Garbled messages and corrupted translations.

Minoru Yoshida, Tilman Schneider-Poetsch, Takeo Usui, 2010, Nature chemical biology.

Inhibition of protein synthesis and activation of stress‐activated protein kinases by onnamide A and theopederin B, antitumor marine natural products

S. Horinouchi, Minoru Yoshida, S. Matsunaga, 2005, Cancer science.

Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment.

C. Myers, Charles Boone, R. Deshpande, 2011, Organic letters.

Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.

Minoru Yoshida, A. Ito, M. Islam, 2014, Bioorganic & medicinal chemistry.

A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B

Minoru Yoshida, Ken Matsumoto, R. Kurokawa, 2017, Scientific Reports.

Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.

K. Shin‐ya, A. Ganesan, P. Townsend, 2008, Biochemical pharmacology.

A screening system for inhibitors of trichothecene biosynthesis: hydroxylation of trichodiene as a target

M. Kimura, Minoru Yoshida, T. Nishiuchi, 2008, Biotechnology Letters.

Production of 3-acetylnivalenol by transgenic Fusarium graminearum expressing Tri13 of type A trichothecene-producer: participation of the encoded cytochrome P450 monooxygenase in type B trichothecene biosynthesis

M. Kimura, Minoru Yoshida, T. Tokai, 2012 .

Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3′ end of human genes

M. Carmo-Fonseca, Minoru Yoshida, J. Rino, 2011, Nature Structural &Molecular Biology.

Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite

Xiao-Fan Wang, T. Yao, R. Shao, 2002 .

4-O-Acetylation and 3-O-Acetylation of Trichothecenes by Trichothecene 15-O-Acetyltransferase Encoded by Fusarium Tri3

M. Kimura, Minoru Yoshida, T. Kamakura, 2008, Bioscience, biotechnology, and biochemistry.

Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation*

Minoru Yoshida, Eun-Joo Jeon, Norikazu Nishino, 2006, Journal of Biological Chemistry.

Global Analysis of Gel Mobility of Proteins and Its Use in Target Identification*

S. Horinouchi, Minoru Yoshida, R. Arai, 2008, Journal of Biological Chemistry.

PP1 control of M phase entry exerted through 14‐3‐3‐regulated Cdc25 dephosphorylation

S. Shenolikar, S. Kornbluth, Minoru Yoshida, 2003, The EMBO journal.

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

S. Horinouchi, Minoru Yoshida, T. Beppu, 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

Structure-activity Relationship for FR901464: A Versatile Method for the Conversion and Preparation of Biologically Active Biotinylated Probes

S. Horinouchi, Minoru Yoshida, K. Ishigami, 2004, Bioscience, biotechnology, and biochemistry.

Synthesis, structure determination, and biological evaluation of destruxin E.

K. Shin‐ya, T. Doi, Masahito Yoshida, 2010, Organic letters.

Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure.

H. Ikeda, K. Shin‐ya, Teppei Kawahara, 2019, ACS chemical biology.

Induction of γ-Globin by Histone Deacetylase Inhibitors

M. Su, P. Mccaffrey, Minoru Yoshida, 1997 .

Short-step Syntheses of All Stereoisomers of Preussin and Their Bioactivities

S. Horinouchi, Minoru Yoshida, K. Kasahara, 2002, Bioscience, biotechnology, and biochemistry.

Splicing modulators: on the way from nature to clinic

Minoru Yoshida, Tilman Schneider-Poetsch, Tilman Schneider‐Poetsch, 2021, The Journal of Antibiotics.

Splicing Inhibitors: From Small Molecule to RNA Metabolism

Minoru Yoshida, Tilman Schneider‐Poetsch, 2014 .

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

M. Hagiwara, S. Horinouchi, Minoru Yoshida, 2007, Nature Chemical Biology.

Spliceostatin A interaction with SF3B limits U1 snRNP availability and causes premature cleavage and polyadenylation.

Y. Hayashizaki, Harukazu Suzuki, M. Furuno, 2021, Cell chemical biology.

A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P‐glycoproteins

M. Nishiyama, S. Horinouchi, Minoru Yoshida, 1992, Molecular microbiology.

A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.

T. Haystead, S. Kornbluth, Minoru Yoshida, 2006, Molecular Biology of the Cell.

LUBAC accelerates B-cell lymphomagenesis by conferring B cells resistance to genotoxic stress.

H. Kiyonari, N. Kagaya, K. Shin‐ya, 2020, Blood.

Improving Measures of Chemical Structural Similarity Using Machine Learning on Chemical–Genetic Interactions

Sheena C. Li, Scott W. Simpkins, C. Myers, 2021, J. Chem. Inf. Model..

Runx2 (Cbfa1, AML-3) Interacts with Histone Deacetylase 6 and Represses the p21CIP1/WAF1 Promoter

S. K. Zaidi, G. Stein, J. Lian, 2002, Molecular and Cellular Biology.

Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns.

Takehiro Suzuki, N. Dohmae, Minoru Yoshida, 2021, Cell chemical biology.

Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast.

H. Taoka, S. Horinouchi, Minoru Yoshida, 2007, Biochemical and biophysical research communications.

Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm

Minoru Yoshida, A. Verdel, S. Khochbin, 2000, Current Biology.

Screening and identification of a non-peptide antagonist for the peptide hormone receptor in Arabidopsis

Y. Matsubayashi, Minoru Yoshida, Hidefumi Shinohara, 2019, Communications Biology.

Erasers of histone acetylation: the histone deacetylase enzymes.

E. Seto, Minoru Yoshida, 2014, Cold Spring Harbor perspectives in biology.

ErasersofHistoneAcetylation:TheHistone Deacetylase Enzymes

E. Seto, Minoru Yoshida, 2014 .

Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A)

Minoru Yoshida, A. Ito, Satoko Maeda, 2012, FEBS letters.

Molecular Cloning and Cell Cycle-dependent Expression of Mammalian CRM1, a Protein Involved in Nuclear Export of Proteins*

M. Yanagida, N. Kudo, S. Horinouchi, 1997, The Journal of Biological Chemistry.

Radicicol Binds and Inhibits Mammalian ATP Citrate Lyase*

S. Horinouchi, Minoru Yoshida, K. Kasahara, 2000, The Journal of Biological Chemistry.

Rolling Circle Translation of Circular RNA in Living Human Cells

Minoru Yoshida, Aya Shibata, Yoshihiro Ito, 2015, Scientific Reports.

Apoptotic Regulation by the Crk Adapter Protein Mediated by Interactions with Wee1 and Crm1/Exportin

R. Hollingsworth, S. Kornbluth, Minoru Yoshida, 2002, Molecular and Cellular Biology.

MDMX elevation by a novel Mdmx–p53 interaction inhibitor mitigates neuronal damage after ischemic stroke

Tsutomu Sasaki, Minoru Yoshida, S. Matsumura, 2022, Scientific Reports.

Recent advances in target identification of bioactive natural products

Minoru Yoshida, 2019, Bioscience, biotechnology, and biochemistry.

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.

A. Ganesan, G. Packham, Minoru Yoshida, 2007, Journal of medicinal chemistry.

Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.

H. Seno, Takeshi Kimura, T. Chiba, 2018, JCI insight.

Repression of PML Nuclear Body-Associated Transcription by Oxidative Stress-Activated Bach2

Hiroshi Suzuki, K. Tanimoto, Minoru Yoshida, 2004, Molecular and Cellular Biology.

14-3-3 regulates the nuclear import of class IIa histone deacetylases.

Minoru Yoshida, Yoshihiro Miwa, S. Horinouchi, 2008, Biochemical and biophysical research communications.

Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells.

J. Paik, T. Kwon, B. Jang, 2004, Biochemical pharmacology.

Epigenetics: Bioprobes that Target Epigenetic Modifications

Minoru Yoshida, A. Ito, 2017 .

Design and synthesis of peptide-MCA substrates for a novel assay of histone methyltransferases and their inhibitors.

Minoru Yoshida, A. Ito, N. Nishino, 2014, Bioorganic & medicinal chemistry.

Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification.

M. Sodeoka, Minoru Yoshida, A. Ito, 2013, Bioorganic & medicinal chemistry letters.

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

K. Shin‐ya, Y. Shinkai, M. Takagi, 2012, The Journal of Antibiotics.

Trichostatin A, a Histone Deacetylase Inhibitor, Suppresses Collagen Synthesis and Prevents TGF-β1-Induced Fibrogenesis in Skin Fibroblasts

D. Schuppan, T. Niki, P. de Bleser, 2002 .

Bach1 inhibits oxidative stress–induced cellular senescence by impeding p53 function on chromatin

T. Noda, Y. Katoh, Minoru Yoshida, 2008, Nature Structural &Molecular Biology.

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14‐3‐3‐mediated inhibition of Cdc25 nuclear import

S. Kornbluth, Minoru Yoshida, Jing Yang, 1999, The EMBO journal.

New insights into chemical biology from ORFeome libraries.

Minoru Yoshida, Yoko Yashiroda, Akihisa Matsuyama, 2008, Current opinion in chemical biology.

MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action

Minoru Yoshida, Chad L. Myers, Hamid Safizadeh, 2017, bioRxiv.

Caenorhabditis elegans CED-9 protein isabifunctional cell-death inhibitor

E. Nishida, M. Yanagida, M. Fukuda, 1997 .

Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts.

T. Shibata, O. Kozawa, Minoru Yoshida, 2003, Archives of biochemistry and biophysics.

Self-activation of Serine/Threonine Kinase AfsK on Autophosphorylation at Threonine-168

S. Horinouchi, H. Nagasawa, Minoru Yoshida, 2006, The Journal of Antibiotics.

Nuclear Export of Human β-Catenin Can Occur Independent of CRM1 and the Adenomatous Polyposis Coli Tumor Suppressor*

Minoru Yoshida, B. Henderson, Alexandra Eleftheriou, 2001, The Journal of Biological Chemistry.

Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance

Ryo Maeda, Minoru Yoshida, Naoki Okashita, 2017, PLoS genetics.

Subtype selective substrates for histone deacetylases.

F. Dequiedt, E. Verdin, Minoru Yoshida, 2004, Journal of medicinal chemistry.

Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity.

Minoru Yoshida, T. Yamori, A. Ito, 2014, European journal of medicinal chemistry.

Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.

Minoru Yoshida, T. Yamori, A. Ito, 2013, European journal of medicinal chemistry.

The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response1[OPEN]

M. Seki, Minoru Yoshida, A. Ito, 2017, Plant Physiology.

Histone deacetylase as a new target for cancer chemotherapy

M. Nishiyama, S. Horinouchi, Minoru Yoshida, 2001, Cancer Chemotherapy and Pharmacology.

Histone deacetylase inhibitors block nuclear factor‐κB‐dependent transcription by interfering with RNA polymerase II recruitment

K. Ogawa, S. Horinouchi, Minoru Yoshida, 2011, Cancer science.

E3 ubiquitin ligase that recognizes sugar chains

H. Kawasaki, Keiji Tanaka, T. Chiba, 2002, Nature.

A unique kinesin‐like protein, Klp8, is involved in mitosis and cell morphology through microtubule stabilization

Minoru Yoshida, I. Mabuchi, R. Arai, 2019, Cytoskeleton.

Identification of zinc finger transcription factor EGR2 as a novel acetylated protein.

Minoru Yoshida, A. Ito, Y. Nakao, 2017, Biochemical and biophysical research communications.

Direct Demonstration of Rapid Degradation of Nuclear Sterol Regulatory Element-binding Proteins by the Ubiquitin-Proteasome Pathway*

Minoru Yoshida, R. Sato, M. Shimizu, 2001, The Journal of Biological Chemistry.

Rolling-Circle Replication in Mitochondrial DNA Inheritance: Scientific Evidence and Significance from Yeast to Human Cells

Minoru Yoshida, F. Ling, 2020, Genes.

Heme regulates gene expression by triggering Crm1‐dependent nuclear export of Bach1

Hiroshi Suzuki, M. Ikeda-Saito, Minoru Yoshida, 2004, The EMBO journal.

Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by 1H NMR.

N. Matsumori, S. Hanashima, Minoru Yoshida, 2016, Bioorganic & medicinal chemistry.

Identification of ryuvidine as a KDM5A inhibitor

T. Mizukami, S. Wada, M. Hasegawa, 2019, Scientific Reports.

Detection of pre-mRNA splicing in vitro by an RNA-templated fluorogenic reaction.

S. Tsuneda, Yoshihiro Ito, Minoru Yoshida, 2012, Bioorganic & medicinal chemistry letters.

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions

Minoru Yoshida, Yoshikazu Ohya, Michael Costanzo, 2018, PLoS Comput. Biol..

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interaction networks

Minoru Yoshida, Yoshikazu Ohya, Michael Costanzo, 2018 .

Large-scale interpretation of chemical-genetic interaction profiles using a genetic interaction network

Minoru Yoshida, Justin Nelson, Yoshikazu Ohya, 2017, bioRxiv.

Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments

Minoru Yoshida, Henry N. Ward, Raamesh Deshpande, 2019, Nature Protocols.

CHAP31 Induces Apoptosis Only via the Intrinsic Pathway in Human Esophageal Cancer Cells

H. Matsubara, K. Matsushita, Minoru Yoshida, 2010, Oncology.

A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor.

H. Seimiya, Y. Sugimoto, Minoru Yoshida, 2010, Biochemical and biophysical research communications.

Induction of a Ribotoxic Stress Response That Stimulates Stress-Activated Protein Kinases by 13-Deoxytedanolide, an Antitumor Marine Macrolide

S. Horinouchi, H. Ichijo, Minoru Yoshida, 2006, Bioscience, biotechnology, and biochemistry.

Brain-specific Expression of N-Acetylglucosaminyltransferase IX (GnT-IX) Is Regulated by Epigenetic Histone Modifications*

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2011, The Journal of Biological Chemistry.

A series of promoters for constitutive expression of heterologous genes in fission yeast

Minoru Yoshida, Akihisa Matsuyama, A. Shirai, 2008, Yeast.

Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways

Minoru Yoshida, Frederick P Roth, Xiaomu Wei, 2013, Science Signaling.

RK‐287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model

H. Seimiya, Minoru Yoshida, Yoko Yashiroda, 2018, Cancer science.

pDUAL, a multipurpose, multicopy vector capable of chromosomal integration in fission yeast

S. Horinouchi, Minoru Yoshida, Akihisa Matsuyama, 2004, Yeast.

Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract

Minoru Yoshida, Lan Xiang, Qiaobei Wu, 2019, Oxidative medicine and cellular longevity.

Design and Discovery of an Orally Efficacious Spiroindolinone-based Tankyrase Inhibitor for the Treatment of Colon Cancer.

T. Umehara, M. Shirouzu, H. Seimiya, 2020, Journal of medicinal chemistry.

Reactive oxygen species stimulate mitochondrial allele segregation toward homoplasmy in human cells

T. Shibata, Minoru Yoshida, R. Niu, 2016, Molecular biology of the cell.

Selective Induction of Cyclin‐Dependent Kinase Inhibitors and Their Roles in Cell Cycle Arrest Caused by Trichostatin A, an Inhibitor of Histone Deacetylase

M. Yoshida, S. Horinouchi, Minoru Yoshida, 1999, Annals of the New York Academy of Sciences.

Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation*

H. Ryoo, Je-Yong Choi, S. Bae, 2006, Journal of Biological Chemistry.

Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation

T. Mak, H. Nishina, A. Suzuki, 2021, Cancer science.

Identification of the determinants of 2-deoxyglucose sensitivity in cancer cells by shRNA library screening.

Minoru Yoshida, Ken Matsumoto, Hiroki Kobayashi, 2015, Biochemical and biophysical research communications.

Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress

Y. Ohya, A. Matsuura, Minoru Yoshida, 2019, Oxidative medicine and cellular longevity.

Altered acetylation and succinylation profiles in Corynebacterium glutamicum in response to conditions inducing glutamate overproduction

Minoru Yoshida, Yumi Kawamura, Hisashi Kawasaki, 2015, MicrobiologyOpen.

Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.

T. Umehara, M. Shirouzu, Minoru Yoshida, 2023, Journal of medicinal chemistry.

HIV‐1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses

D. Trouche, G. Legube, Minoru Yoshida, 2005, The EMBO journal.

The Role of Acetylation in the Subcellular Localization of an Oncogenic Isoform of Translation Factor eIF5A

Minoru Yoshida, A. Ito, Satoko Maeda, 2012, Bioscience, biotechnology, and biochemistry.

Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.

Minoru Yoshida, Shinichi Nishimura, Hisashi Kawasaki, 2009, Chemistry & biology.

Identification of 1, 2, 5-Oxadiazoles as a New Class of SENP2 Inhibitors Using Structure Based Virtual Screening

Minoru Yoshida, Ashutosh Kumar, Kam Y. J. Zhang, 2014, J. Chem. Inf. Model..

Regulation of Small Mitochondrial DNA Replicative Advantage by Ribonucleotide Reductase in Saccharomyces cerevisiae

Minoru Yoshida, F. Ling, Elliot Bradshaw, 2017, G3: Genes, Genomes, Genetics.

Din7 and Mhr1 expression levels regulate double-strand-break–induced replication and recombination of mtDNA at ori5 in yeast

Akiko Hori, T. Shibata, Minoru Yoshida, 2013, Nucleic acids research.

Oxidative Stress Abolishes Leptomycin B-sensitive Nuclear Export of Transcription Repressor Bach2 That Counteracts Activation of Maf Recognition Element*

N. Kudo, Minoru Yoshida, K. Igarashi, 2000, The Journal of Biological Chemistry.

Establishment of a high-throughput detection system for DNA demethylating agents

T. Ushijima, N. Hattori, Minoru Yoshida, 2018, Epigenetics.

Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma.

N. Seki, H. Matsubara, Minoru Yoshida, 2012, International journal of oncology.

Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine

T. Umehara, Minoru Yoshida, H. Kagechika, 2018, ChemMedChem.

Protein Acetylation and the Physiological Role of HDACs

Minoru Yoshida, P. Matthias, C. Seiser, 2011, Journal of biomedicine & biotechnology.

phd1 +, a histone deacetylase gene of Schizosaccharomyces pombe, is required for the meiotic cell cycle and resistance to trichostatin A 1

M. Yoshida, S. Horinouchi, Minoru Yoshida, 1998, FEBS letters.

Proteomic analysis of organ‐specific post‐translational lysine‐acetylation and ‐methylation in mice by use of anti‐acetyllysine and ‐methyllysine mouse monoclonal antibodies

Minoru Yoshida, Y. Komatsu, Hisako Iwabata, 2005, Proteomics.

Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.

S. Horinouchi, Minoru Yoshida, K. Igarashi, 2007, Journal of biochemistry.

Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Minoru Yoshida, C. Olsen, N. Kudo, 2021, RSC chemical biology.

Selective inhibitors of SIRT2 regulate perinuclear α-tubulin acetylation, migration, and invasion of breast cancer cells

Minoru Yoshida, C. Olsen, N. Kudo, 2020, bioRxiv.

Cell Proliferation: From Signal Transduction to Cell Cycle

Minoru Yoshida, 2000 .

Trichostatin and Leptomycin: Inhibition of Histone Deacetylation and Signal‐Dependent Nuclear Export

M. Yoshida, S. Horinouchi, Minoru Yoshida, 1999, Annals of the New York Academy of Sciences.

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

Y. Saeki, Keiji Tanaka, T. Asano, 2012, Biochemical and biophysical research communications.

Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast

E. Nishida, M. Yanagida, M. Fukuda, 1999, Genes to cells : devoted to molecular & cellular mechanisms.

Translational control of cell division by Elongator.

Damien Hermand, Minoru Yoshida, Marc Dieu, 2012, Cell reports.

A Novel Nuclear Export Signal Sensitive to Oxidative Stress in the Fission Yeast Transcription Factor Pap1*

T. Toda, N. Kudo, H. Taoka, 1999, The Journal of Biological Chemistry.

Chromosomal Region Maintenance 1 (CRM1)-dependent Nuclear Export of Smad Ubiquitin Regulatory Factor 1 (Smurf1) Is Essential for Negative Regulation of Transforming Growth Factor-β Signaling by Smad7*

K. Miyazono, T. Imamura, Minoru Yoshida, 2003, The Journal of Biological Chemistry.

In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation

S. Horinouchi, Minoru Yoshida, Akihisa Matsuyama, 2002, The EMBO journal.

Novel Specific Inhibitors for Analysis of Eukaryotic Cell Cycle Control

Minoru Yoshida, T. Beppu, 1991 .

FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast

Minoru Yoshida, Akihisa Matsuyama, Yoko Yashiroda, 2022, iScience.

Balance between exocytosis and endocytosis determines the efficacy of sterol-targeting antibiotics.

Minoru Yoshida, H. Kakeya, S. Nishimura, 2014, Chemistry & biology.

Chemical and structural biology of protein lysine deacetylases

Minoru Yoshida, A. Ito, S. Kosono, 2017, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Cessation of Cytokinesis in Schizosaccharomyces pombe during Growth after Release from High Hydrostatic Pressure Treatment

S. Furukawa, T. Kawarai, H. Ogihara, 2008, Bioscience, biotechnology, and biochemistry.

SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression

D. Levens, T. Tomonaga, H. Matsubara, 2012, Molecular Cancer Research.

Heteroduplex Joint Formation Free of Net Topological Change by Mhr1, a Mitochondrial Recombinase*

T. Shibata, Minoru Yoshida, F. Ling, 2009, Journal of Biological Chemistry.

JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634

K. Shin‐ya, M. Takagi, Minoru Yoshida, 2009, The Journal of Antibiotics.

Nucleus in a Cytokine-Dependent and Stat 5 B Shuttles Between Cytoplasm and and Sumiko

K. Arai, Sumiko Watanabe, Minoru Yoshida, 2002 .

Cascade Reaction in Human Live Tissue Allows Clinically Applicable Diagnosis of Breast Cancer Morphology

Katsunori Tanaka, S. Noguchi, E. Morii, 2018, Advanced science.

Mitochondrial fission proteins Fis1 and Mdv1, but not Dnm1, play a role in maintenance of heteroplasmy in budding yeast

Minoru Yoshida, F. Ling, Elliot Bradshaw, 2012, FEBS letters.

Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement

Minoru Yoshida, A. Ito, M. Otsuka, 2019, Molecules.

The role of class I histone deacetylase (HDAC) on gluconeogenesis in liver.

E. Araki, Minoru Yoshida, A. Ito, 2011, Biochemical and biophysical research communications.

Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations

Y. Goto, M. Shirouzu, Minoru Yoshida, 2020, Nature Chemical Biology.

Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1

Minoru Yoshida, F. Ling, Elliot Bradshaw, 2019, Scientific Reports.

Effect of lysine succinylation on the regulation of 2-oxoglutarate dehydrogenase inhibitor, OdhI, involved in glutamate production in Corynebacterium glutamicum

Minoru Yoshida, Hisashi Kawasaki, Makoto Nishiyama, 2017, Bioscience, biotechnology, and biochemistry.

Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol.

N. Matsumori, S. Hanashima, Minoru Yoshida, 2019, Biochimica et Biophysica Acta - Biomembranes.

Hot springs and cool natural products.

H. Kwon, Minoru Yoshida, M. Imoto, 2008, Nature chemical biology.

Gliotoxin analogues from a marine-derived fungus, Penicillium sp., and their cytotoxic and histone methyltransferase inhibitory activities.

Minoru Yoshida, S. Okada, S. Matsunaga, 2012, Journal of natural products.

Methotrexate suppresses inflammatory agonist induced interleukin 6 synthesis in osteoblasts.

A. Ishisaki, O. Kozawa, Minoru Yoshida, 2005, The Journal of rheumatology.

Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors.

T. Umehara, S. Yokoyama, T. Terada, 2011, Chemistry & biology.

Real-time imaging of histone H4 hyperacetylation in living cells

Minoru Yoshida, S. Khochbin, N. Nishino, 2009, Proceedings of the National Academy of Sciences.

Intra-species cell-cell communication in yeast.

Minoru Yoshida, Yoko Yashiroda, 2019, FEMS yeast research.

Winners of the 2017 JA Ōmura Awards for excellence

Minoru Yoshida, 2018, Journal of antibiotics (Tokyo. 1968).

The SAGA Histone Acetyltransferase Complex Regulates Leucine Uptake through the Agp3 Permease in Fission Yeast*

Minoru Yoshida, Yoko Yashiroda, M. Hamamoto, 2012, The Journal of Biological Chemistry.

RNAi screening reveals a synthetic chemical–genetic interaction between ATP synthase and PFK1 in cancer cells

Minoru Yoshida, H. Harada, Hiroki Kobayashi, 2023, Cancer science.

Mitochondrial fusion increases the mitochondrial DNA copy number in budding yeast

Akiko Hori, Minoru Yoshida, F. Ling, 2011, Genes to cells : devoted to molecular & cellular mechanisms.

Basidifferquinone, a New Inducer for Fruiting-body Formation of a Basidiomycetes Favolus arcularius from a Streptomyces Strain I. Screening and Isolation

S. Horinouchi, Minoru Yoshida, T. Beppu, 1990 .

Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum

M. Nishiyama, T. Umehara, M. Shirouzu, 2017, Molecular microbiology.

Maintenance of G 2 arrest in the Xenopus oocyte : a role for 14-3-3-mediated inhibition of Cdc 25 nuclear import

S. Kornbluth, Minoru Yoshida, Jing Yang, 2013 .

Mammalian Chemical Genomics towards Identifying Targets and Elucidating Modes‐of‐Action of Bioactive Compounds

Minoru Yoshida, Ken Matsumoto, 2021, Chembiochem : a European journal of chemical biology.

Basidifferquinone, a New Inducer for Fruiting-body Formation of a Basidiomycetes Favolus arcularius from a Streptomyces Strain II. Structure of Basidifferquinone

S. Horinouchi, Minoru Yoshida, T. Beppu, 1990 .

Mobilitome: A dataset describing gel mobility of a proteome

Minoru Yoshida, Akihisa Matsuyama, A. Shirai, 2014 .

Mitochondrial localization of fission yeast manganese superoxide dismutase is required for its lysine acetylation and for cellular stress resistance and respiratory growth.

Takehiro Suzuki, N. Dohmae, Minoru Yoshida, 2011, Biochemical and biophysical research communications.

Cyclic tetrapeptides with –SS– bridging between amino acid side chains for potent histone deacetylases’ inhibition

Minoru Yoshida, A. Ito, N. Nishino, 2013, Amino Acids.

Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.

Minoru Yoshida, A. Ito, M. Hoque, 2012, Bioorganic & medicinal chemistry letters.

Cytoplasmic localization and nucleo-cytoplasmic shuttling of BAF53, a component of chromatin-modifying complexes.

Minoru Yoshida, Hyockman Kwon, Ji Yeon Lee, 2003, Molecules and cells.

Design and synthesis of mono and bicyclic tetrapeptides thioester as potent inhibitor of histone deacetylases

Minoru Yoshida, A. Ito, M. Islam, 2014, Amino Acids.

Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs.

Minoru Yoshida, Yoko Yashiroda, 2003, Current medicinal chemistry.

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

K. Shin‐ya, Y. Shinkai, M. Takagi, 2014, The Journal of Antibiotics.

Development of live-cell imaging probes for monitoring histone modifications.

Minoru Yoshida, A. Ito, K. Sasaki, 2012, Bioorganic & medicinal chemistry.

Expression Gene c-myc Repressor Serves as a Molecular Switch for SAP 155-Mediated Splicing of FUSE-Binding Protein-Interacting

D. Levens, T. Tomonaga, H. Matsubara, 2012 .

Signaling and Regulation SAP 155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression

D. Levens, T. Tomonaga, H. Matsubara, 2012 .

Preparation of Cell Lysates of Fission Yeast for Immunoprecipitation.

Minoru Yoshida, Akihisa Matsuyama, A. Shirai, 2018, Methods in molecular biology.

Protein acetylation on 2-isopropylmalate synthase from Thermus thermophilus HB27

M. Nishiyama, Minoru Yoshida, S. Kosono, 2019, Extremophiles.

Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2

Minoru Yoshida, A. Ito, N. Kudo, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

Identification of Fungal and Bacterial Denitrification Inhibitors Targeting Copper Nitrite Reductase.

Kam Y. J. Zhang, Minoru Yoshida, Akihisa Matsuyama, 2023, Journal of agricultural and food chemistry.

Eukaryotic translation initiation factor 5A (eIF5A) is essential for HIF-1α activation in hypoxia.

Minoru Yoshida, A. Ito, M. Ishfaq, 2016, Biochemical and biophysical research communications.

Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Minoru Yoshida, A. Ito, N. Kudo, 2017, The Journal of Antibiotics.

New Rev-export inhibitor from Alpinia galanga and structure-activity relationship.

Y. Ye, Motomasa Kobayashi, Minoru Yoshida, 2009, Bioorganic & medicinal chemistry letters.

New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix.

N. Kudo, Y. Ye, S. Aoki, 2002, Bioorganic & medicinal chemistry letters.

Targeting cholesterol in a liquid-disordered environment by theonellamides modulates cell membrane order and cell shape.

Minoru Yoshida, Shinichi Nishimura, Shigeki Matsunaga, 2015, Chemistry & biology.

Antiviral and virucidal activities against herpes simplex viruses of umesu phenolics extracted from Japanese apricot

K. Ikeda, Minoru Yoshida, A. H. Koyama, 2019, Microbiology and immunology.

The Protein Farnesyltransferase Regulates HDAC6 Activity in a Microtubule-dependent Manner*

F. Khuri, F. Tamanoi, P. Giannakakou, 2009, Journal of Biological Chemistry.

Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1

Minoru Yoshida, F. Ling, Elliot Bradshaw, 2019, Scientific Reports.

Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-1

N. Imamoto, Minoru Yoshida, Mami Yoshimura, 2018, Scientific Reports.

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export.

K. Nakayama, K. Nakayama, T. Kamura, 2015, The Journal of Biological Chemistry.

Protein acetylation on 2-isopropylmalate synthase from Thermus thermophilus HB27

M. Nishiyama, Minoru Yoshida, S. Kosono, 2019, Extremophiles.

A Role for Hsc70 in Regulating Nucleocytoplasmic Transport of a Temperature-sensitive p53 (p53Val-135)*

S. Horinouchi, Minoru Yoshida, Y. Yoneda, 2001, Journal of Biological Chemistry.

2-Octyl-4H-1,3,2-benzodioxaphosphorin 2-oxide labelled with tritium in the octyl and aryl moieties

J. Casida, Minoru Yoshida, Shao-yong Wu, 1994 .

Identification of Sumoylation Inhibitors Targeting a Predicted Pocket in Ubc9

Minoru Yoshida, Ashutosh Kumar, Kam Y. J. Zhang, 2014, J. Chem. Inf. Model..

Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication

Akiko Hori, T. Shibata, Minoru Yoshida, 2008, Nucleic acids research.

Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.

Minoru Yoshida, A. Ito, M. Otsuka, 2020, Bioorganic & medicinal chemistry letters.

Dynamic changes in lysine acetylation and succinylation of the elongation factor Tu in Bacillus subtilis.

M. Nishiyama, Minoru Yoshida, S. Kosono, 2019, Microbiology.

Identification of new SUMO activating enzyme 1 inhibitors using virtual screening and scaffold hopping.

Minoru Yoshida, Kam Y. J. Zhang, Ashutosh Kumar, 2016, Bioorganic & medicinal chemistry letters.

Interaction between dexamethasone and butyrate in apoptosis induction: non-additive in thymocytes and synergistic in a T cell-derived leukemia cell line

D. Bernhard, R. Kofler, A. Csordás, 1999, Cell Death and Differentiation.

Increases in Mitochondrial DNA Content and 4977-bp Deletion upon ATM/Chk2 Checkpoint Activation in HeLa Cells

Minoru Yoshida, R. Niu, F. Ling, 2012, PloS one.

Radicicol Potentiates Neurotrophin‐Mediated Neurite Outgrowth and Survival of Cultured Sensory Neurons from Chick Embryo

M. Sano, Minoru Yoshida, S. Kitajima, 1999, Journal of neurochemistry.

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

H. Handa, Y. Yamaguchi, Minoru Yoshida, 2014, The Journal of Antibiotics.

Kerriamycin B inhibits protein SUMOylation

Minoru Yoshida, Hiroyuki Osada, Hisashi Kawasaki, 2009, The Journal of Antibiotics.

Corrigendum: ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe

Y. Hiraoka, S. Horinouchi, Minoru Yoshida, 2006, Nature Biotechnology.

Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression

H. Kwon, S. Horinouchi, T. Obinata, 1997, Oncogene.

Lysine long-chain fatty acylation regulates the TEAD transcription factor.

T. Umehara, M. Sodeoka, Takehiro Suzuki, 2023, Cell reports.

Tiludronate inhibits prostaglandin F2α-induced vascular endothelial growth factor synthesis in osteoblasts

A. Ishisaki, O. Kozawa, Minoru Yoshida, 2005, Molecular and Cellular Endocrinology.

Mechanism of CellCycle Arrest Caused byHistone Deacetylase Inhibitors in Human Carcinoma Cells

Minoru Yoshida, 2000 .

Bicyclic tetrapeptide histone deacetylase inhibitors with methoxymethyl ketone and boronic acid zinc-binding groups.

Minoru Yoshida, A. Ito, M. Islam, 2014, Bioorganic chemistry.

A genetic screen to discover SUMOylated proteins in living mammalian cells

Minoru Yoshida, A. Ito, H. Saitoh, 2017, Scientific Reports.

MCR-12-0673 R : FIR-SAP 155 interaction integrates c-Myc and p 27 Kip 1 expression

D. Levens, T. Tomonaga, H. Matsubara, 2013 .

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region.

N. Kudo, N. Matsumori, H. Taoka, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses.

Y. Shinkai, M. Sodeoka, Minoru Yoshida, 2018, Chemical communications.

Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.

Yukihiro Itoh, Takayoshi Suzuki, Minoru Yoshida, 2006, Journal of medicinal chemistry.

First JA Medal goes to a paper on decalpenic acid

Minoru Yoshida, Gerard D. Wright, 2012, Journal of antibiotics (Tokyo. 1968).

Functional expression of human P‐glycoprotein in Schizosaccharomyces pombe

K. Ueda, Minoru Yoshida, T. Beppu, 1993, FEBS letters.

RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

Minoru Yoshida, H. Kakeya, H. Osada, 2015, The Journal of Antibiotics.

A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells

Minoru Yoshida, N. Kudo, H. Osada, 2020, Bioscience, biotechnology, and biochemistry.

Adenylyl cyclase-cAMP system inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts

A. Ishisaki, O. Kozawa, Minoru Yoshida, 2005, Molecular and Cellular Endocrinology.

HTLV‐1 Tax protein interacts with cyclin‐dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

M. Yoshida, Toshiharu Suzuki, Minoru Yoshida, 1996, The EMBO journal.

Assay methods for small ubiquitin-like modifier (SUMO)-SUMO-interacting motif (SIM) interactions in vivo and in vitro using a split-luciferase complementation system.

Kam Y. J. Zhang, A. Voet, Minoru Yoshida, 2014, Analytical Biochemistry.

Assay methods for SUMO–SIM interactions in vivo and in vitro using a split-luciferase complementation system

Kam Y. J. Zhang, A. Voet, Minoru Yoshida, 2013 .

Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast

Minoru Yoshida, Akihisa Matsuyama, H. Kakeya, 2020, The Journal of Antibiotics.

Resource A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human Graphical

Haiyuan Yu, Yu Xia, Xiaomu Wei, 2022 .

Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments

Sheena C. Li, Scott W. Simpkins, C. Myers, 2019, Nature Protocols.

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1.

M. Yanagida, N. Kudo, E. Schreiner, 1998, Experimental cell research.

Hygromycin A and Methoxyhygromycin, Novel Inhibitors of K88 Antigen Synthesis of Enterotoxic Escherichia coli Strain

Minoru Yoshida, T. Uozumi, T. Beppu, 1986 .

Winners of the 2014 JA Medals for excellence

Minoru Yoshida, Gerard D. Wright, 2015, The Journal of Antibiotics.

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

D. Fujiwara, M. Yoshida, S. Horinouchi, 1994, The Journal of biological chemistry.

FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

M. Yoshida, S. Horinouchi, Minoru Yoshida, 1998, Experimental cell research.

Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions.

Tobias Rumpf, Minoru Yoshida, M. Jung, 2018, Chemical record.

Three leucine-rich sequences and the N-terminal region of double-stranded RNA-activated protein kinase (PKR) are responsible for its cytoplasmic localization.

Minoru Yoshida, K. Nakajima, T. Takizawa, 2000, Journal of biochemistry.

Identification of Sumoylation Activating Enzyme 1 Inhibitors by Structure-Based Virtual Screening

Minoru Yoshida, Ashutosh Kumar, Kam Y. J. Zhang, 2013, J. Chem. Inf. Model..

PostMod: sequence based prediction of kinase-specific phosphorylation sites with indirect relationship

Dongsup Kim, Minoru Yoshida, Inkyung Jung, 2010, BMC Bioinformatics.

Proteome and acylome analyses of the functional interaction network between the carbazole‐degradative plasmid pCAR1 and host Pseudomonas putida KT2440

Minoru Yoshida, S. Kosono, K. Okada, 2018, Environmental microbiology reports.

Amplification of recombinant adenoviral transgene products occurs by inhibition of histone deacetylase.

D. Tang, M. Yoshida, J. Engler, 1997, Virology.

SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1Tpp1 to modulate shelterin–Stn1 interaction in fission yeast

Minoru Yoshida, Venny Santosa, Katsunori Tanaka, 2014, Proceedings of the National Academy of Sciences.

UBL3 Interacts with Alpha-Synuclein in Cells and the Interaction Is Downregulated by the EGFR Pathway Inhibitor Osimertinib

M. Setou, Minoru Yoshida, T. Kahyo, 2023, bioRxiv.

A series of promoters for constitutive expression of heterologous genes in fission yeast

Minoru Yoshida, Akihisa Matsuyama, A. Shirai, 2008, Yeast.

Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.

Minoru Yoshida, A. Ito, M. Hoque, 2012, Bioorganic & Medicinal Chemistry Letters.

Expression of Differentiation-related Markers in Teratocarcinoma Cells via Histone Hyperacetylation by Trichostatin A

Minoru Yoshida, Y. Hoshikawa, T. Beppu, 1991 .

Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells.

M. Yoshida, K. Mori, Minoru Yoshida, 1990, The Journal of antibiotics.

Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.

S. Horinouchi, T. Yao, Minoru Yoshida, 2008, Biochemical and biophysical research communications.

ArticleHDAC 6 Regulates Hsp 90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

C. Nicchitta, Xuan Zhao, T. Yao, 2005 .

Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state (2)H nuclear magnetic resonance.

N. Matsumori, Minoru Yoshida, S. Matsunaga, 2013, Biochemistry.

Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors.

T. Umehara, S. Yokoyama, T. Terada, 2011, Chemistry & biology.

Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.

H. Seno, Takeshi Kimura, T. Chiba, 2018, JCI insight.