C. Heinen

发表

The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway.

Joanna Groden, Christopher D. Heinen, G. Babcock, 2002, Gastroenterology.

Milestones of Lynch syndrome: 1895–2015

Christopher D. Heinen, H. Lynch, C. Heinen, 2015, Nature Reviews Cancer.

HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions.

Richard Fishel, Christopher D. Heinen, M. Berardini, 2002, Cancer cell.

The predicted truncation from a cancer‐associated variant of the MSH2 initiation codon alters activity of the MSH2‐MSH6 mismatch repair complex

Christopher D. Heinen, C. Heinen, J. Cyr, 2012, Molecular carcinogenesis.

Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future

Christopher D. Heinen, N. de Wind, L. Rasmussen, 2012, Human mutation.

Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.

Adam S. Mastrocola, C. Heinen, 2010, DNA repair.

Lynch Syndrome-associated Mutations in MSH2 Alter DNA Repair and Checkpoint Response Functions In Vivo

Adam S. Mastrocola, C. Heinen, 2010, Human mutation.

Application of a five-tiered scheme for standardized classification of 2 , 360 unique mismatch repair gene variants lodged on the InSiGHT locus-specific database

P. Møller, L. Rasmussen, A. Spurdle, 2013 .

ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage

C. Heinen, D. Gupta, A. Cowan, 2018, Proceedings of the National Academy of Sciences.

Response DamageNovel Mismatch Repair-dependent Human Pluripotent Stem Cells Have a DNA and Chromosomes :

Christopher D. Heinen, C. Heinen, D. Gupta, 2014 .

Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation

C. Fenoglio-Preiser, A. Noffsinger, C. Heinen, 1997, Genes, chromosomes & cancer.

Loss of mismatch repair promotes a direct selective advantage in human stem cells

Christopher D. Heinen, C. Heinen, Caroline J Guild, 2022, Stem cell reports.

DNA Mismatch Repair Proteins Are Required for Efﬁcient Herpes Simplex Virus 1 Replication (cid:1)

Christopher D. Heinen, Adam S. Mastrocola, S. Weller, 2011 .

Magnesium influences the discrimination and release of ADP by human RAD51.

R. Fishel, C. Heinen, K. Shim, 2006, DNA repair.

DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication

Christopher D. Heinen, Adam S. Mastrocola, S. Weller, 2011, Journal of Virology.

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.

M. Andersen, R. Clewell, B. Engelward, 2016, Mutation research. Reviews in mutation research.

The mismatch repair-dependent DNA damage response: Mechanisms and implications.

Christopher D. Heinen, C. Heinen, D. Gupta, 2019, DNA repair.

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

Rodney J Scott, John-Paul Plazzer, Finlay Macrae, 2013, Nature Genetics.

hXRCC2 Enhances ADP/ATP Processing and Strand Exchange by hRAD51*

Richard Fishel, Christopher D. Heinen, R. Fishel, 2004, Journal of Biological Chemistry.

Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways

Christopher D. Heinen, A. Cheng, C. Heinen, 2019, Nature Communications.

Casilio-ME: Enhanced CRISPR-based DNA demethylation by RNA-guided coupling methylcytosine oxidation and DNA repair pathways

A. Cheng, C. Heinen, Sheng Li, 2019 .

Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.

Christopher D. Heinen, C. Heinen, 2010, Mutation research.

Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer.

Emily J. Greenspan, Christopher D. Heinen, C. Heinen, 2006, Carcinogenesis.

Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework

Lea M. Starita, Fergus J. Couch, Jonathan S. Berg, 2019, Genome Medicine.

Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome

L. Rasmussen, C. Heinen, 2014 .

Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays

Christopher D. Heinen, C. Heinen, Lene Juel Rasmussen, 2012, Hereditary Cancer in Clinical Practice.

Signaling mismatch repair: the mechanics of an adenosine-nucleotide molecular switch.

M. Berardini, R. Fishel, C. Heinen, 2000, Cold Spring Harbor symposia on quantitative biology.

Cancer Cell Properties

Christopher D. Heinen, C. Heinen, K. Goss, 2001 .

DNA Repair and Tumorigenesis: Lessons from Hereditary Cancer Syndromes

Christopher D. Heinen, R. Fishel, C. Heinen, 2002, Cancer biology & therapy.

Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer.

R. Stevens, C. Giardina, H. Swede, 2007, Cancer letters.

Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.

Emily J. Greenspan, Christopher D. Heinen, M. O'brien, 2007, Cancer Research.

A calibrated cell-based functional assay to aide classification of MLH1 DNA mismatch repair gene variants

Christopher D. Heinen, S. Tavtigian, C. Heinen, 2021, bioRxiv.

Functional interrogation of Lynch syndrome‐associated MSH2 missense variants via CRISPR‐Cas9 gene editing in human embryonic stem cells

Christopher D. Heinen, H. Reddi, C. Heinen, 2019, Human mutation.

Functional Interrogation of Lynch Syndrome Associated MSH2 Missense Variants Using CRISPR-Cas9 Gene Editing in Human Embryonic Stem Cells

Christopher D. Heinen, C. Heinen, Abhijit Rath, 2018, bioRxiv.

Human Pluripotent Stem Cells Have a Novel Mismatch Repair-dependent Damage Response*

Christopher D. Heinen, C. Heinen, D. Gupta, 2014, The Journal of Biological Chemistry.

Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer.

Christopher D. Heinen, C. Heinen, 2016, DNA repair.

Microsatellite instability in aberrant crypt foci from human colons.

N. Shivapurkar, C. Heinen, J. Groden, 1996, Cancer research.

Hereditary Cancer-associated Missense Mutations in hMSH6 Uncouple ATP Hydrolysis from DNA Mismatch Binding*

Christopher D. Heinen, C. Heinen, Jennifer L. Cyr, 2008, Journal of Biological Chemistry.

Response to: Design of a Core Classification Process for DNA Mismatch Repair Variations of A Priori Unknown Functional Significance

L. Rasmussen, S. Tavtigian, R. Hofstra, 2013, Human mutation.

Increased Frequency of Serrated Aberrant Crypt Foci Among Smokers

Christopher D. Heinen, H. Swede, C. Heinen, 2010, The American Journal of Gastroenterology.

Biochemical Characterization of the Human RAD51 Protein

Richard Fishel, R. Fishel, C. Heinen, 2002, The Journal of Biological Chemistry.

Microsatellite instability in colorectal adenocarcinoma cell lines that have full-length adenomatous polyposis coli protein.

R. White, C. Heinen, J. Groden, 1995, Cancer research.

Enhanced gene targeting to evaluate Lynch syndrome alterations

R. Fishel, C. Heinen, 2016, Proceedings of the National Academy of Sciences.

Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy

Christopher D. Heinen, H. Swede, C. Heinen, 2012, Cancer Causes & Control.

Human MSH2 (hMSH2) Protein Controls ATP Processing by hMSH2-hMSH6*

Robert A. Forties, Christopher D. Heinen, M. Hingorani, 2011, The Journal of Biological Chemistry.

Loss of DNA Mismatch Repair Imparts a Selective Advantage in Planarian Adult Stem Cells

Christopher D. Heinen, Alissa M. Resch, B. Graveley, 2011, PloS one.