M. Sayegh

发表

Human HTm4 is a hematopoietic cell cycle regulator.

J. Kutok, D. Beach, D. Scadden, 2002, The Journal of clinical investigation.

Immunomodulation by Mesenchymal Stem Cells

Mohamed H. Sayegh, Mark Atkinson, Reza Abdi, 2008, Diabetes.

Immunomodulation by Mesenchymal Stem Cells

Mohamed H. Sayegh, Mark Atkinson, Reza Abdi, 2008, Diabetes.

The roles of the new negative T cell costimulatory pathways in regulating autoimmunity.

S. Khoury, M. Sayegh, 2004, Immunity.

Analysis of the Role of Negative T Cell Costimulatory Pathways in CD4 and CD8 T Cell-Mediated Alloimmune Responses In Vivo1

A. Sharpe, H. Auchincloss, M. Jurewicz, 2005, The Journal of Immunology.

Targeting the CXCR4–CXCL12 Axis Mobilizes Autologous Hematopoietic Stem Cells and Prolongs Islet Allograft Survival via Programmed Death Ligand 1

S. Rodig, R. Abdi, M. Jurewicz, 2011, The Journal of Immunology.

T-cell co-stimulatory blockade in kidney transplantation: back to the bench

M. Sayegh, L. Riella, 2011, Kidney international supplements.

Essential Role of PDL1 Expression on Nonhematopoietic Donor Cells in Acquired Tolerance to Vascularized Cardiac Allografts

A. Sharpe, J. Azzi, M. Sayegh, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Critical Role of Donor Tissue Expression of Programmed Death Ligand-1 in Regulating Cardiac Allograft Rejection and Vasculopathy

M. Sayegh, M. Azuma, H. Yagita, 2008, Circulation.

Harnessing negative T‐cell costimulatory pathways to promote engraftment

M. Sayegh, J. Popoola, 2007, Transplant international : official journal of the European Society for Organ Transplantation.

PDL1 Is Required for Peripheral Transplantation Tolerance and Protection from Chronic Allograft Rejection1

M. Grimm, M. Sayegh, A. Habicht, 2007, The Journal of Immunology.

Blockade In Vivo Regulatory T Cell Induced by ICOS-B 7 h + PD 1 + A Novel Alloantigen-Specific CD 8 Sayegh and

G. Freeman, R. Abdi, M. Jurewicz, 2007 .

T cell costimulatory pathways in allograft rejection and tolerance: what's new?

M. Sayegh, A. Habicht, 2007, Current opinion in organ transplantation.

A Novel Alloantigen-Specific CD8+PD1+ Regulatory T Cell Induced by ICOS-B7h Blockade In Vivo1

G. Freeman, R. Abdi, M. Jurewicz, 2007, The Journal of Immunology.

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2

P. Linsley, L. Turka, M. Sayegh, 1995, The Journal of experimental medicine.

CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses.

P. Linsley, R. Peach, J. Kupiec-Weglinski, 1997, Journal of immunology.

Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients.

L. Turka, M. Sayegh, W. Hancock, 1997, Transplantation.

Chronic blockade of CD28-B7-mediated T-cell costimulation by CTLA4Ig reduces intimal thickening in MHC class I and II incompatible mouse heart allografts.

M. Sayegh, M. Russell, T. Glysing-Jensen, 1997, Transplantation.

CD28-independent Costimulation of T Cells in Alloimmune Responses1

A. Sharpe, H. Auchincloss, L. Turka, 2001, The Journal of Immunology.

Physiologic regulation of alloimmune responses in vivo: the role of CTLA4 and TH1/TH2 cytokines.

M. Sayegh, A. Salama, M. Sho, 2001, Transplantation proceedings.

Rejection of Mouse Cardiac Allografts by Costimulation in trans1

A. Sharpe, H. Auchincloss, M. Sayegh, 2001, The Journal of Immunology.

Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models1

C. Ariyan, X. Zheng, M. Sayegh, 2001, The Journal of Immunology.

Physiological Mechanisms of Regulating Alloimmunity: Cytokines, CTLA-4, CD25+ Cells, and the Alloreactive T Cell Clone Size1

T. Strom, X. Zheng, M. Sayegh, 2002, The Journal of Immunology.

The CD154-CD40 T Cell Costimulation Pathway Is Required for Host Sensitization of CD8+ T Cells by Skin Grafts Via Direct Antigen Presentation1

F. Gao, Xiu‐da Shen, Y. Zhai, 2002, The Journal of Immunology.

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

S. Khoury, T. Chitnis, H. Auchincloss, 2003, The Journal of experimental medicine.

The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.

G. Freeman, A. Sharpe, M. Sayegh, 2003, The Journal of clinical investigation.

T‐cell costimulatory pathways in allograft rejection and tolerance

M. Sayegh, D. Rothstein, 2003, Immunological reviews.

Regulatory functions of CD8+CD28- T cells in an autoimmune disease model.

S. Khoury, T. Chitnis, M. Sayegh, 2003, Journal of Clinical Investigation.

New TCR Transgenic Model for Tracking Allospecific CD4 T‐Cell Activation and Tolerance in Vivo

E. Palmer, L. Turka, M. Sayegh, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

CD70 Signaling Is Critical for CD28-Independent CD8+ T Cell-Mediated Alloimmune Responses In Vivo1

A. Sharpe, H. Auchincloss, M. Sayegh, 2005, The Journal of Immunology.

Role of the Programmed Death-1 Pathway in Regulation of Alloimmune Responses In Vivo1

L. Turka, M. Sayegh, A. Habicht, 2005, The Journal of Immunology.

ANALYSIS OF THE ROLE OF NEGATIVE T CELL COSTIMULATORY PATHWAYS IN CD4 AND CD8 MEDIATED ALLOIMMUNE RESPONSES IN VIVO

H. Auchincloss, M. Sayegh, T. Ueno, 2004 .

Clinical transplantation tolerance: a myth no more, but...

J. Azzi, M. Sayegh, 2009, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Global vaccination strategy to eradicate COVID-19: Beyond science

M. Sayegh, Hady Naal, Alaa Merhi, 2021, Journal of global health.

Interaction Between ICOS‐B7RP1 and B7‐CD28 Costimulatory Pathways in Alloimmune Responses In Vivo

M. Sayegh, A. Salama, M. Inobe, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Downregulation of intragraft IFN-gamma expression correlates with increased IgG1 alloantibody response following intrathymic immunomodulation of sensitized rat recipients.

H. Volk, J. Kupiec-Weglinski, M. Sayegh, 1995, Transplantation.

Indirect Recognition of MHC Class I Allopeptides Accelerates Lung Allograft Rejection in Miniature Swine

J. Wain, D. Sachs, J. Madsen, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells.

M. Sayegh, M. Clarkson, N. Najafian, 2006, Journal of the American Society of Nephrology : JASN.

Accelerated Memory Cell Homeostasis during T Cell Depletion and Approaches to Overcome It

J. Markmann, H. Waldmann, L. Turka, 2006, The Journal of Immunology.

Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens.

H. Weiner, D. Hafler, S. Khoury, 1994, Annual review of immunology.

Transplantation 50 years later--progress, challenges, and promises.

M. Sayegh, C. Carpenter, 2004, The New England journal of medicine.

Targeting CD28 to prevent transplant rejection

M. Sayegh, N. Najafian, M. Yeung, 2014, Expert opinion on therapeutic targets.

Heart Allografts Are under Strict Regulation Rejection of Single Class II MHC-Disparate Alloreactive T Cell Responses and Acute and

S. Schenk, K. Fukamachi, L. Turka, 2005 .

Alloreactive T Cell Responses and Acute Rejection of Single Class II MHC-Disparate Heart Allografts Are under Strict Regulation by CD4+CD25+ T Cells1

S. Schenk, K. Fukamachi, L. Turka, 2005, The Journal of Immunology.

Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance.

T. Strom, X. Zheng, M. Sayegh, 2003, Immunity.

Immunomodulatory Function of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Type 1 Diabetes1

M. Selig, M. Atkinson, S. Rodig, 2009, The Journal of Immunology.

Effects of explosive brain death on cytokine activation of peripheral organs in the rat.

K. Nadeau, G. Shaw, M. Sayegh, 1998, Transplantation.

Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses.

S. Grey, M. Sayegh, W. Hancock, 1995, Transplantation.

Costimulatory pathways in transplantation

M. Sayegh, T. Wekerle, N. Pilat, 2011, Seminars in immunology.

The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival.

A. Sharpe, M. Sayegh, T. Judge, 1999, Journal of immunology.

Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide

H. Weiner, S. Khoury, M. Sayegh, 1993, The Journal of experimental medicine.

Critical, but Conditional, Role of OX40 in Memory T Cell-Mediated Rejection1

L. Turka, X. Li, M. Sayegh, 2006, The Journal of Immunology.

This information is current as Memory T Cell-Mediated Rejection Critical , but Conditional , Role of OX 40 in LiLaurence

L. Turka, X. Li, M. Sayegh, 2006 .

Homeostatic proliferation is a barrier to transplantation tolerance

J. Markmann, L. Turka, M. Sayegh, 2004, Nature Medicine.

The thymic way to transplantation tolerance.

N. Perico, G. Remuzzi, M. Sayegh, 1995, Journal of the American Society of Nephrology : JASN.

The role of B/T costimulatory signals in the immunopotentiating activity of neisserial porin.

M. Sayegh, A. Chandraker, F. Michon, 1999, The Journal of infectious diseases.

Why do we reject a graft? Role of indirect allorecognition in graft rejection.

M. Sayegh, 1999, Kidney international.

Indirect allorecognition of donor class I and II major histocompatibility complex peptides promotes the development of transplant vasculopathy.

M. Sayegh, J. Stone, A. Chandraker, 2001, Journal of the American Society of Nephrology : JASN.

Major histocompatibility complex–derived peptides as novel forms of immunosuppression

M. Sayegh, A. Waaga, B. Murphy, 1999 .

Immune parameters affecting adenoviral vector gene therapy in the brain.

P. Wen, H. Fine, S. Khoury, 1998, Journal of neurovirology.

Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.

D. Kasper, A. Sharpe, M. Sayegh, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Interactions between cyclosporine and newer antidepressant medications.

M. Sayegh, J. Vella, 1998, American journal of kidney diseases : the official journal of the National Kidney Foundation.

The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology.

G. Danovitch, T. Strom, A. Krensky, 1999, Journal of the American Society of Nephrology : JASN.

Intact parathyroid hormone levels in renal insufficiency

P. Aliabadi, M. Sayegh, J. Lazarus, 1995, Calcified Tissue International.

Imaging cell biology in transplantation

Pilhan Kim, S. Yun, M. Sayegh, 2016, Transplant international : official journal of the European Society for Organ Transplantation.

Live Images of Donor Dendritic Cells Trafficking via CX3CR1 Pathway

Pilhan Kim, S. Yun, R. Abdi, 2016, Front. Immunol..

Sijilli: a mobile electronic health records system for refugees in low-resource settings.

M. Sayegh, Nour El Arnaout, S. Saleh, 2019, The Lancet. Global health.

Allograft rejection mediated by memory T cells is resistant to regulation

L. Turka, M. Sayegh, K. Wood, 2007, Proceedings of the National Academy of Sciences.

Acquired systemic tolerance to rat cardiac allografts induced by intrathymic inoculation of synthetic polymorphic MHC class I allopeptides.

M. Sayegh, B. Murphy, M. Hardy, 1996, Transplantation.

The role of novel T cell costimulatory pathways in autoimmunity and transplantation.

M. Sayegh, A. Salama, A. Yamada, 2002, Journal of the American Society of Nephrology : JASN.

Immunobiology of Allograft Destruction

M. Sayegh, D. Salomon, 1996 .

Kaposi's sarcoma after renal transplantation.

M. Sayegh, J. Vella, R. Mosher, 1997, The New England journal of medicine.

CTLA4-Ig: a novel immunosuppressive agent

M. Sayegh, N. Najafian, 2000, Expert opinion on investigational drugs.

Finally, CTLA4Ig graduates to the clinic.

M. Sayegh, 1999, The Journal of clinical investigation.

Costimulation Blockade in Transplantation.

M. Sayegh, T. Grimmig, M. Yeung, 2019, Advances in experimental medicine and biology.

A novel mechanism for the immunomodulatory functions of class II MHC-derived peptides.

T. Chitnis, M. Sayegh, M. Lin, 2003, Journal of the American Society of Nephrology : JASN.

Involvement of the direct and indirect pathways of allorecognition in tolerance induction.

H. Auchincloss, M. Sayegh, K. Womer, 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

CTLA 4 Ig-Induced Linked Regulation of Allogeneic T Cell Responses 1

D. Sachs, J. Madsen, M. Sayegh, 2001 .

CTLA4Ig-Induced Linked Regulation of Allogeneic T Cell Responses1

D. Sachs, J. Madsen, M. Sayegh, 2001, The Journal of Immunology.

Role of indirect allorecognition in allograft rejection.

M. Sayegh, C. Carpenter, 1996, International reviews of immunology.

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.

S. Khoury, T. Chitnis, M. Sayegh, 2001, The Journal of clinical investigation.

Transplant nephrectomy improves survival following a failed renal allograft.

A. Go, M. Sayegh, Shuko Lee, 2010, Journal of the American Society of Nephrology.

Allograft Acceptance by TLR Ligands Mechanisms Underlying Blockade of

Wenda Gao, T. Strom, L. Turka, 2008 .

Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance

Ajay K. Singh, D. Mount, M. Sayegh, 2013 .

Membranous Lupus Nephritis in a Renal Allograft: Response to Mycophenolate Mofetil Therapy

M. Sayegh, M. Denton, E. Galvanek, 2001, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

RENAL TRANSPLANTATION

M. Sayegh, C. Carpenter, 1996, Radiologic Clinics of North America.

Calcineurin Inhibitors: 40 Years Later, Can’t Live Without …

J. Azzi, M. Sayegh, S. Mallat, 2013, The Journal of Immunology.

Distinct tolerance pathways in sensitized allograft recipients after selective blockade of activation signal 1 or signal 2.

H. Volk, J. Kupiec-Weglinski, M. Sayegh, 1999, Transplantation.

Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection

C. Ricordi, A. Secchi, P. Fiorina, 2013, Diabetes.

Tolerance and chronic rejection.

M. Sayegh, C. Carpenter, 1997, Kidney international. Supplement.

B cell-targeted therapies in autoimmunity: rationale and progress

P. Fiorina, M. Sayegh, 2009, F1000 biology reports.

Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes

J. Bluestone, S. Rodig, R. Abdi, 2008, Diabetes.

Hepatocyte growth factor prevents the development of chronic allograft nephropathy in rats.

K. Matsumoto, J. Wang, M. Sayegh, 2001, Journal of the American Society of Nephrology : JASN.

Mechanisms of allo-recognition. Recognition by in vivo-primed T cells of specific major histocompatibility complex polymorphisms presented as peptides by responder antigen-presenting cells.

M. Sayegh, C. Carpenter, L. Gallon, 1994, Transplantation.

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

T. Strom, L. Turka, X. Li, 1999, Nature Medicine.

Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody.

P. Linsley, T. Starzl, J. Fung, 1997, Transplantation.

Role of CXC chemokine receptor 3 pathway in renal ischemic injury.

H. Auchincloss, R. Abdi, M. Jurewicz, 2006, Journal of the American Society of Nephrology : JASN.

The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection.

H. Auchincloss, R. Abdi, M. Sayegh, 2002, Diabetes.

CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis.

R. Peach, M. Sayegh, C. Pusey, 2000, The Journal of clinical investigation.

The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury.

K. Nadeau, M. Sayegh, A. Chandraker, 1997, The Journal of clinical investigation.

CD28-b7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury.

K. Nadeau, R. Peach, M. Sayegh, 1997, Kidney international.

HLA class II-restricted binding of muramyl peptides to B lymphocytes of normal and narcoleptic subjects.

D. Silverman, C. E. Alvarez, M. Sayegh, 1990, Human immunology.

A rendezvous before rejection: Where do T cells meet transplant antigens?

D. Briscoe, M. Sayegh, 2002, Nature Medicine.

Accelerated Allograft Vasculopathy With Rituximab After Cardiac Transplantation.

A. Kfoury, R. Starling, M. Sayegh, 2019, Journal of the American College of Cardiology.

In vitro and in vivo immunomodulatory effects of RDP1258, a novel synthetic peptide.

M. Sayegh, M. Denton, A. Chandraker, 1999, Journal of the American Society of Nephrology : JASN.

CD4+ mononuclear cells induce cytokine expression, vascular smooth muscle cell proliferation, and arterial occlusion after endothelial injury.

D. Adams, M. Karnovsky, M. Sayegh, 1994, The American journal of pathology.

TIM4 Regulates the Anti-Islet Th2 Alloimmune Response

J. Markmann, A. Secchi, L. Turka, 2015, Cell transplantation.

Regulatory CD 25 T Cells in Human Kidney Transplant Recipients

M. Sayegh, A. Salama, M. Clarkson, 2003 .

Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance

M. Sykes, M. Sayegh, A. Chandraker, 1998, The Journal of experimental medicine.

The role of donor and recipient B7-1 (CD80) in allograft rejection.

P. Linsley, A. Sharpe, T. Strom, 1997, Journal of immunology.

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.

P. Linsley, R. Peach, M. Sayegh, 1996, Proceedings of the National Academy of Sciences of the United States of America.

IL-17-Dependent Mechanism Intra-abdominal Sepsis by an T Cells Mediate Abscess Formation in + CD 4

D. Kasper, M. Sayegh, A. Tzianabos, 2003 .

CD4+ T Cells Mediate Abscess Formation in Intra-abdominal Sepsis by an IL-17-Dependent Mechanism 1

D. Kasper, M. Sayegh, A. Tzianabos, 2003, The Journal of Immunology.

Bacterial Pathogens Induce Abscess Formation by CD4+ T-Cell Activation via the CD28–B7-2 Costimulatory Pathway

R. Peach, M. Sayegh, A. Tzianabos, 2000, Infection and Immunity.

Mechanisms of Tolerance Induced by Donor‐Specific Transfusion and ICOS‐B7h Blockade in a Model of CD4+ T‐Cell‐Mediated Allograft Rejection

L. Turka, M. Sayegh, A. Salama, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Alloreactive T Cell Clone Size + Alloimmunity : Cytokines , CTLA-4 , CD 25 Physiological Mechanisms of Regulating

T. Strom, X. Zheng, M. Sayegh, 2002 .

A novel in vivo regulatory role of P-glycoprotein in alloimmunity.

M. Grimm, M. Sayegh, T. Ueno, 2010, Biochemical and biophysical research communications.

Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease.

R. Lechler, R. Kalluri, M. Sayegh, 2003, Kidney international.

Tolerance is the achievable ‘Holy Grail’ in transplantation

M. Sayegh, Xueli Yuan, M. Ansari, 2006 .

Human Tolerance Maternal Acceptance of the Fetus: True

M. Sayegh, I. Guleria, 2013 .

Maternal Acceptance of the Fetus: True Human Tolerance

M. Sayegh, I. Guleria, 2007, The Journal of Immunology.

Requirements for induction and maintenance of peripheral tolerance in stringent allograft models.

T. Strom, X. Zheng, M. Sayegh, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.

M. Sayegh, D. Rothstein, H. Yagita, 2011, The Journal of clinical investigation.

Live Without Calcineurin Inhibitors : 40 Years Later , Can ' t

J. Azzi, M. Sayegh, S. Mallat, 2013 .

Induction of transplantation tolerance to fully mismatched cardiac allografts by T cell mediated delivery of alloantigen.

J. Bagley, M. Sayegh, P. Jindra, 2010, Clinical immunology.

TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy.

D. Briscoe, M. Sayegh, M. Melter, 2004, Transplantation.

Following Islet Transplantation by Gene Prevention of Recurrent Type 1 Diabetes Induction of Robust Diabetes Resistance and Donnarumma

J. Bagley, M. Sayegh, J. Iacomini, 2007 .

Induction of Robust Diabetes Resistance and Prevention of Recurrent Type 1 Diabetes Following Islet Transplantation by Gene Therapy1

J. Bagley, M. Sayegh, J. Iacomini, 2007, The Journal of Immunology.

THE CD154-CD40 COSTIMULATORY PATHWAY IN TRANSPLANTATION

M. Sayegh, A. Yamada, 2002, Transplantation.

CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment.

T. Strom, M. Sayegh, X. Zheng, 1999, Journal of immunology.

New reagents on the horizon for immune tolerance.

J. Bluestone, A. Saxon, J. Matthews, 2007, Annual review of medicine.

Mechanisms of PDL1-mediated regulation of autoimmune diabetes.

J. Bluestone, M. Atkinson, P. Fiorina, 2007, Clinical immunology.

DEPLETING ANTI-CD4 MONOCLONAL ANTIBODY CURES NEW-ONSET DIABETES, PREVENTS RECURRENT AUTOIMMUNE DIABETES, AND DELAYS ALLOGRAFT REJECTION IN NONOBESE DIABETIC MICE1

C. Ferran, S. Grey, H. Auchincloss, 2004, Transplantation.

CD8+ T Cells by Skin Grafts Via Direct of Pathway Is Required for Host Sensitization The CD154-CD40 T Cell Costimulation

F. Gao, Xiu‐da Shen, A. Coito, 2013 .

T Cells by Skin Grafts Via Direct + CD 8 ofPathway Is Required for Host Sensitization The CD 154-CD 40 T Cell Costimulation

F. Gao, Xiu‐da Shen, Y. Zhai, 2002 .

Role of novel T-cell costimulatory pathways in transplantation

M. Sayegh, D. Mandelbrot, 2003 .

Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.

M. Sayegh, W. Hancock, M. Russell, 1996, The Journal of clinical investigation.

Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.

K. Nadeau, M. Sayegh, W. Hancock, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens

L. Wen, M. Atkinson, R. Abdi, 2014, Diabetes.

Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses

J. Markmann, A. Secchi, A. Petrelli, 2011, Diabetes.

Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy.

S. Khoury, M. Sayegh, Wanjun Chen, 1998, Journal of immunology.

The arduous road to achieving an immunosuppression-free state in kidney transplant recipients

M. Sayegh, M. Ansari, 2007, Nature Clinical Practice Nephrology.

Induced costimulatory molecule-B7h costimulatory pathway in alloimmune regulation

M. Sayegh, I. Guleria, 2005 .

Role of the ICOS-B7h Costimulatory Pathway in the Pathophysiology of Chronic Allograft Rejection

M. Sayegh, H. Yagita, M. Sho, 2005, Transplantation.

Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection.

K. Nadeau, M. Sayegh, W. Hancock, 1998, The Journal of clinical investigation.

Comparative strategies to induce long-term graft acceptance in fully allogeneic renal versus cardiac allograft models by CD28-B7 T cell costimulatory blockade: role of thymus and spleen.

M. Sayegh, A. Chandraker, M. Schaub, 1998, Journal of the American Society of Nephrology : JASN.

T-cell costimulatory blockade in experimental chronic cardiac allograft rejection: effects of cyclosporine and donor antigen.

M. Sayegh, M. Russell, A. Chandraker, 1997, Transplantation.

T cell costimulatory pathways: promising novel targets for immunosuppression and tolerance induction.

M. Sayegh, L. Turka, 1995, Journal of the American Society of Nephrology : JASN.

Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat.

H. Weiner, S. Khoury, M. Sayegh, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Mechanisms of T cell recognition of alloantigen. The role of peptides.

M. Sayegh, C. Carpenter, B. Watschinger, 1994, Transplantation.

Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo.

S. Khoury, M. Sayegh, N. Najafian, 2001, The Journal of clinical investigation.

CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines.

W. Baldwin, J. Kupiec-Weglinski, M. Sayegh, 1993, Journal of immunology.

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.

S. Khoury, H. Auchincloss, M. Sayegh, 2000, The Journal of clinical investigation.

Regulation of Postsurgical Fibrosis by the Programmed Death-1 Inhibitory Pathway1

R. Bronson, T. Chitnis, M. Sayegh, 2004, The Journal of Immunology.

Endothelial Cells Modify the Costimulatory Capacity of Transmigrating Leukocytes and Promote Cd28-Mediated Cd4+ T Cell Alloactivation

S. Alexander, D. Briscoe, M. Sayegh, 1999, The Journal of experimental medicine.

Donor antigen and transplant tolerance strategies: it takes two to tango!

M. Sayegh, K. Womer, 2004, Journal of the American Society of Nephrology : JASN.

Immunologic tolerance to renal allografts after bone marrow transplants from the same donors.

H. Rennke, M. Sayegh, E. Milford, 1991, Annals of internal medicine.

Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation.

P. Linsley, M. Sayegh, L. Kobzik, 1998, International immunology.

Importance of hyperglycemia on the primary function of allogeneic islet transplants1

S. Bonner-Weir, G. Weir, M. Sayegh, 2003, Transplantation.

The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade.

H. Auchincloss, R. Abdi, M. Sayegh, 2002, Diabetes.

Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7

C. Ricordi, R. Abdi, A. Petrelli, 2013, Circulation.

A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice

M. Atkinson, S. Rodig, J. Markmann, 2010, Diabetes.

This information is current as via Programmed Death Ligand 1 Cells and Prolongs Islet Allograft Survival Mobilizes Autologous Hematopoietic Stem CXCL12 Axis - Targeting the CXCR4

S. Rodig, R. Abdi, M. Jurewicz, 2012 .

Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice.

G. Freeman, P. Fiorina, M. Sayegh, 2008, Clinical immunology.

Allorecognition and effector pathways of islet allograft rejection in normal versus nonobese diabetic mice.

H. Auchincloss, R. Abdi, M. Sayegh, 2003, Journal of the American Society of Nephrology : JASN.

Cells in Fetomaternal Tolerance A Link between PDL1 and T Regulatory

M. Jurewicz, M. Sayegh, A. Habicht, 2022 .

Characterization of Donor Dendritic Cells and Enhancement of Dendritic Cell Efflux With cc-Chemokine Ligand 21

R. Abdi, M. Jurewicz, P. Fiorina, 2007, Diabetes.

T-Cell Costimulatory Pathways in Allograft Rejection and Tolerance

M. Sayegh, M. Clarkson, 2005, Transplantation.

Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation.

A. Sharpe, H. Auchincloss, M. Sayegh, 2004, Journal of the American Society of Nephrology : JASN.

A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection1

C. Benjamin, A. Coito, M. Sayegh, 2002, Transplantation.

Challenges for the translation of T cell costimulatory blockade therapies to the clinic

M. Sayegh, A. Salama, 2002, Expert opinion on biological therapy.

Tolerance in Stringent Transplant Models Promotes Long Term Engraftment and Synergizes with CD40 Ligand Blockade and Targeting Signal 1 Through CD45RB

C. Ariyan, X. Zheng, M. Sayegh, 2000 .

Blocking costimulatory signals to induce transplantation tolerance and prevent autoimmune disease.

S. Khoury, M. Sayegh, L. Turka, 1999, International reviews of immunology.

Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients.

J. Kupiec-Weglinski, I. De Meester, M. Sayegh, 1997, Transplantation.

Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death1

L. Turka, A. Wells, M. Sykes, 2001, The Journal of Immunology.

Cell Death Activation-Induced Cell Death and Passive Blockade Has Features of Both Transplantation with Costimulatory Peripheral Deletion After Bone Marrow

L. Turka, A. Wells, M. Sykes, 2001 .

CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.

P. Linsley, S. Khoury, M. Sayegh, 1995, Journal of immunology.

The role of costimulatory molecules as targets for new immunosuppressives in transplantation.

M. Sayegh, K. Kishimoto, V. Dong, 2000, Current opinion in urology.

Divergent Function of Programmed Death-Ligand 1 in Donor Tissue versus Recipient Immune System in a Murine Model of Bronchiolitis Obliterans.

M. Sayegh, N. Najafian, O. Boenisch, 2017, The American journal of pathology.

Rat intestinal epithelial cells present major histocompatibility complex allopeptides to primed T cells.

M. Sayegh, R. Blumberg, C. Carpenter, 1994, Gastroenterology.

Indirect Allorecognition of Mismatched Donor HLA Class II Peptides in Lung Transplant Recipients with Bronchiolitis Obliterans Syndrome

E. Trulock, T. Mohanakumar, A. Jaramillo, 2001, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Careers in immunology: the new reality

C. Ariyan, M. Sayegh, D. Rothstein, 2001, Nature Immunology.

AnergyApoptosis of Thymocytes and Peripheral T Cell Vivo: Intrathymic Injection of Antigen Induces Mechanisms of Acquired Thymic Tolerance In

S. Khoury, M. Sayegh, Wan-tao Chen, 1998 .

Clinical Transplantation Tolerance: Many Rivers to Cross

M. Sayegh, A. Salama, K. Womer, 2007, The Journal of Immunology.

Rivers to Cross Clinical Transplantation Tolerance : Many

M. Sayegh, A. Salama, K. Womer, 2007 .

Combination Treatment with Donor-Specific Transfusions and Cyclosporine A Induces Long-Term Survival of Cardiac Allografts in Miniature Swine

D. Sachs, J. Madsen, M. Sayegh, 2005, Transplantation.

The Novel Costimulatory Programmed Death Ligand 1/B7.1 Pathway Is Functional in Inhibiting Alloimmune Responses In Vivo

G. Freeman, A. Sharpe, S. Rodig, 2011, The Journal of Immunology.

Regulatory functions of alloreactive Th2 clones in human renal transplant recipients.

M. Sayegh, C. Geehan, N. Najafian, 2002, Kidney international.

Enzyme-linked immunosorbent spot assay analysis of peripheral blood lymphocyte reactivity to donor HLA-DR peptides: potential novel assay for prediction of outcomes for renal transplant recipients.

M. Sayegh, A. Salama, N. Najafian, 2002, Journal of the American Society of Nephrology : JASN.

Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy

J. Madsen, M. Sayegh, S. Houser, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Blockade of CD28-B7, But Not CD40-CD154, Prevents Costimulation of Allogeneic Porcine and Xenogeneic Human Anti-Porcine T Cell Responses1

D. Sachs, J. Madsen, M. Sayegh, 2000, The Journal of Immunology.

T-cell recognition of allograft target antigens

M. Sayegh, M. Nadim, K. Womer, 2000 .

Responses and Xenogeneic Human Anti-Porcine T Cell Prevents Costimulation of Allogeneic Porcine Blockade of CD28-B7, But Not CD40-CD154,

D. Sachs, J. Madsen, M. Sayegh, 2000 .

Xenogeneic Human Anti-Porcine T Cell Prevents Costimulation of Allogeneic Porcine Blockade of CD 28B 7 , But Not CD 40-CD 154 ,

D. Sachs, J. Madsen, M. Sayegh, 2000 .

Intrathymic tolerance in the Lewis-to-F344 chronic cardiac allograft rejection model.

D. Adams, M. Karnovsky, M. Sayegh, 1995, Transplantation.

Negative T-cell costimulatory pathways: their role in regulating alloimmune responses.

M. Sayegh, N. Najafian, O. Boenisch, 2008, Current opinion in organ transplantation.

Organ trafficking and transplant tourism and commercialism : the declaration of Istanbul

A. Levin, V. Jha, M. Alrukhaimi, 2008 .

Effects of leflunomide and deoxyspergualin in the guinea pig-->rat cardiac model of delayed xenograft rejection: suppression of B cell and C-C chemokine responses but not induction of macrophage lectin.

F. Bach, M. Sayegh, W. Hancock, 1997, Transplantation.

Costimulation couture: a designer approach to regulating autoimmunity.

M. Sayegh, M. Ansari, 2006, The Journal of clinical investigation.

Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance.

T. Strom, L. Turka, Yongsheng Li, 2002, The Journal of clinical investigation.

Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance.

M. Sykes, M. Sayegh, A. Chandraker, 1999, Transplantation.

Blockade of CD40L/CD40 costimulatory pathway in a DST presensitization model of islet allograft leads to a state of Allo-Ag specific tolerance and permits subsequent engraftment of donor strain islet or heart allografts.

P. Nickerson, T. Strom, M. Sayegh, 1998, Transplantation Proceedings.

Response to letter to the editor: Immunophenotyping of SARS-CoV-2 and vaccine design

M. Sayegh, R. Moghnieh, D. Abdallah, 2022, Vaccine.

A pilot study on the immunological effects of oral administration of donor major histocompatibility complex class II peptides in renal transplant recipients

M. Sayegh, E. Milford, N. Najafian, 2008, Clinical transplantation.

Mechanisms of Oral Tolerance by MHC Peptides

H. Weiner, S. Khoury, M. Sayegh, 1996, Annals of the New York Academy of Sciences.

a Reciprocal Cytokine Environment In Vivo Defining Th1 and Th2 Immune Responses in

S. Khoury, T. Chitnis, M. Sayegh, 2013 .

Defining Th1 and Th2 Immune Responses in a Reciprocal Cytokine Environment In Vivo1

S. Khoury, T. Chitnis, M. Sayegh, 2004, The Journal of Immunology.

The role of CD 154-CD 40 versus CD 28B 7 costimulatory pathways in regulating allogeneic Th 1 and Th 2 responses in vivo

S. Khoury, H. Auchincloss, M. Sayegh, 2000 .

Immunomodulatory functions of mesenchymal stem cells

M. Sayegh, M. Frank, 2004, The Lancet.

Programmed Death-1 Inhibitory Pathway Regulation of Postsurgical Fibrosis by the and

R. Bronson, T. Chitnis, M. Sayegh, 2004 .

T-cell response to cardiac myosin persists in the absence of an alloimmune response in recipients with chronic cardiac allograft rejection.

M. Sayegh, B. Illigens, M. Sho, 2002, Transplantation.

Mechanisms of indirect allorecognition: characterization of MHC class II allopeptide-specific T helper cell clones from animals undergoing acute allograft rejection.

S. Khoury, M. Sayegh, A. Chandraker, 1998, Transplantation.

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

L. Turka, M. Sayegh, W. Hancock, 1998, Nature Medicine.

Colchicine interferes with L-selectin and leukocyte function-associated antigen-1 expression on human T lymphocytes and inhibits T cell activation.

N. Perico, G. Remuzzi, M. Sayegh, 1996, Journal of the American Society of Nephrology : JASN.

Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients.

H. Volk, T. Strom, J. Kupiec-Weglinski, 1997, Journal of immunology.

Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes

M. Sayegh, L. Wicker, D. Greiner, 2014, PloS one.

Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation.

H. Weiner, M. Sayegh, W. Hancock, 1993, Transplantation.

CD 28B 7 Blockade after Alloantigenic Challenge In Vivo Inhibits Thl Cytokines but Spares Th 2 By

P. Linsley, L. Turka, M. Sayegh, 2003 .

Acquired thymic tolerance: role of CTLA4 in the initiation and maintenance of tolerance in a clinically relevant autoimmune disease model.

S. Khoury, M. Sayegh, M. Zhang, 1999, Journal of immunology.

Comparative studies of specific acquired systemic tolerance induced by intrathymic inoculation of a single synthetic Wistar-Furth (RT1U) allo-MHC class I (RT1.AU) peptide or WAG (RT1U)-derived class I peptide.

M. Sayegh, A. Chandraker, A. Waaga, 1998, Transplantation.

Autoimmune Disease Model Tolerance in a Clinically Relevant in the Initiation and Maintenance of Acquired Thymic Tolerance : Role of CTLA 4 and

S. Khoury, M. Sayegh, S. Issazadeh, 1998 .

In vivo mechanisms of acquired thymic tolerance.

S. Khoury, M. Sayegh, W. Chen, 1997, Cellular immunology.

Mechanisms of Acquired Thymic Tolerance in Experimental Autoimmtme Encephalomyelitis: Thymic Dendritic-enriched Cells Induce Specific Peripheral T Cell Unresponsiveness In Vivo By Samia J. Khoury,* Lorenzo Gallon, Wanjun Chen,*

H. Weiner, S. Khoury, M. Sayegh, 1995 .

H. Weiner, M. Sayegh, W. Hancock, 1995 .

Differential effects of oral versus intrathymic administration of polymorphic major histocompatibility complex class II peptides on mononuclear and endothelial cell activation and cytokine expression during a delayed-type hypersensitivity response.

S. Khoury, M. Sayegh, W. Hancock, 1994, The American journal of pathology.

Blocking of mononuclear cell accumulation, cytokine production, and endothelial activation within rat cardiac allografts by CD4 monoclonal antibody therapy.

T. Sablinski, J. Kupiec-Weglinski, M. Sayegh, 1992, Transplantation.

A Novel Clinically Relevant Approach to Tip the Balance Toward Regulation in Stringent Transplant Model

L. Turka, M. Sayegh, A. Habicht, 2010, Transplantation.

Cutting Edge: Recipient MHC Class II Expression Is Required to Achieve Long-Term Survival of Murine Cardiac Allografts After Costimulatory Blockade1

H. Auchincloss, A. Gerth, M. Sayegh, 2001, The Journal of Immunology.

Alternative T‐Cell Costimulatory Pathways in Transplant Rejection and Tolerance Induction: Hierarchy or Redundancy?

M. Sayegh, A. Salama, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

T cell costimulatory blockade as a novel immune intervention in autoimmune diseases.

S. Khoury, M. Sayegh, N. Najafian, 2001, Clinics in dermatology.

CD28-B7 T-cell co-stimulatory blockade potentiates the effects of intrathymic immunomodulation in sensitized graft recipients.

J. Kupiec-Weglinski, M. Sayegh, K. Onodera, 1997, Transplantation.

Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis.

S. Khoury, T. Chitnis, A. Wells, 2000, The Journal of clinical investigation.

Clinical transplantation tolerance: the promise and challenges.

M. Sayegh, M. Ansari, 2004, Kidney international.

Achieving clinical transplant tolerance: what are the hurdles?

M. Sayegh, A. Salamam, 2001, Transplantation proceedings.

Challenges to achieving clinical transplantation tolerance.

G. Remuzzi, M. Sayegh, A. Salama, 2001, The Journal of clinical investigation.

Chronic Rejection in Experimental Cardiac Transplantation: Studies in the Lewis‐F344 Model

D. Adams, M. Karnovsky, M. Sayegh, 1993, Immunological reviews.

Endothelin in organ transplantation.

M. Sayegh, B. Watschinger, Mohamed H. Sayegh, 1996, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Effect of hepatocyte growth factor on chronic rejection in rat renal allografts.

S. Suzuki, M. Sayegh, S. Takahara, 1999, Transplantation proceedings.

Differential Role of CCR2 in Islet and Heart Allograft Rejection: Tissue Specificity of Chemokine/Chemokine Receptor Function In Vivo1

H. Auchincloss, R. Abdi, M. Jurewicz, 2004, The Journal of Immunology.

VivoChemokine/Chemokine Receptor Function In Allograft Rejection: Tissue Specificity of Differential Role of CCR2 in Islet and Heart

H. Auchincloss, R. Abdi, M. Jurewicz, 2003 .

Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats.

M. Taal, M. Sayegh, M. Wilhelm, 2002, Journal of the American Society of Nephrology : JASN.

The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.

L. Turka, M. Sayegh, A. Habicht, 2008, The Journal of clinical investigation.

New Insights Into the Interactions Between T-Cell Costimulatory Blockade and Conventional Immunosuppressive Drugs

M. Sayegh, A. Salama, M. Sho, 2002, Annals of surgery.

Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

M. Sykes, M. Sayegh, Hiroshi Ito, 2000, Nature Medicine.

CTLA 4 Ig graduates to the clinic

M. Sayegh, 1999 .

CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival

G. Freeman, P. Fiorina, M. Sayegh, 2013, PloS one.

Critical Role of Proinflammatory Cytokine IL‐6 in Allograft Rejection and Tolerance

Sunmi Yang, M. Sayegh, J. Iacomini, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells

G. Freeman, L. Glimcher, L. Turka, 2009, Proceedings of the National Academy of Sciences.

New therapies Maintenance pharmacological immunosuppressive strategies in renal transplantation

M. Sayegh, J. Vella, 2003 .

Maintenance pharmacological immunosuppressive strategies in renal transplantation.

M. Sayegh, J. Vella, 1997, Postgraduate medical journal.

Detection of cardiac myosin-specific autoimmunity in a model of chronic heart allograft rejection.

M. Sayegh, B. Illigens, H. Rolls, 2001, Transplantation proceedings.

CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis.

R. Peach, M. Sayegh, M. Denton, 2001, The American journal of pathology.

Critical Role of OX40 in CD28 and CD154-Independent Rejection1

T. Strom, X. Li, M. Sayegh, 2004, The Journal of Immunology.

The Role of the CD134-CD134 Ligand Costimulatory Pathway in Alloimmune Responses In Vivo 1

M. Sayegh, A. Salama, H. Yagita, 2003, The Journal of Immunology.

Modulation of Tissue-Specific Immune Response to Cardiac Myosin Can Prolong Survival of Allogeneic Heart Transplants1

M. Sayegh, B. Illigens, A. Valujskikh, 2002, The Journal of Immunology.

Survival of Allogeneic Heart Transplants Response to Cardiac Myosin Can Prolong Modulation of Tissue-Specific Immune

M. Sayegh, A. Valujskikh, H. Rolls, 2002 .

Different Costimulatory and Growth Factor Requirements for CD4+ and CD8+ T Cell-Mediated Rejection 1

X. Li, Yongsheng Li, M. Sayegh, 2004, The Journal of Immunology.

Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.

P. Linsley, S. Khoury, R. Peach, 1996, Journal of immunology.

Thromboxane A2 receptor blocking abrogates donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides

N. Perico, G. Remuzzi, A. Benigni, 1994, The Journal of experimental medicine.

Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis.

A. Sharpe, M. Sayegh, M. Keir, 2011, Clinical immunology.

Regulation of Alloimmune Responses In Vivo Role of the Programmed Death-1 Pathway in Turka and

L. Turka, M. Sayegh, A. Habicht, 2005 .

CD28: beyond just T-cell costimulation

X. Li, M. Sayegh, 2007 .

Cell-Mediated Rejection T + and CD 8 + Requirements for CD 4 Different Costimulatory and Growth Factor

X. Li, Yongsheng Li, M. Sayegh, 2004 .

in Alloimmune Responses CD28-independent Costimulation of T Cells

A. Sharpe, H. Auchincloss, L. Turka, 2001 .

CD 28-independent Costimulation of T Cells in Alloimmune Responses 1

A. Sharpe, L. Turka, M. Sayegh, 2001 .

Up-regulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and arteriosclerosis.

M. Sayegh, W. Hancock, M. Russell, 1995, The American journal of pathology.

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

D. Scott, David Steven Scott, S. Khoury, 2012, Journal of Clinical Immunology.

Novel Insights into the Mechanism of Action of FTY720 in a Transgenic Model of Allograft Rejection: Implications for Therapy of Chronic Rejection1

S. Fernandes, M. Jurewicz, M. Sayegh, 2006, The Journal of Immunology.

The antagonism of calcineurin inhibitors and costimulatory blockers: fact or fiction?

M. Sayegh, A. Chandraker, A. Izawa, 2004, Transplantation proceedings.

CD 154-Independent Rejection Critical Role of OX 40 in CD 28 and Sayegh and

T. Strom, X. Li, M. Sayegh, 2004 .

Cutting Edge: Transplantation Tolerance through Enhanced CTLA-4 Expression 1

C. Ariyan, A. Sharpe, P. Salvalaggio, 2003, The Journal of Immunology.

through Enhanced CTLA-4 Expression Cutting Edge: Transplantation Tolerance

C. Ariyan, A. Sharpe, P. Salvalaggio, 2003 .

Responses In Vivo Costimulatory Pathway in Alloimmune The Role of the CD 134-CD 134 Ligand Yagita and

M. Sayegh, A. Salama, H. Yagita, 2003 .

Mechanisms of targeting cd28 by a signaling monoclonal antibody in acute and chronic allograft rejection1

A. Coito, M. Sayegh, Xueli Yuan, 2002, Transplantation.

Costimulatory signal blockade in murine relapsing experimental autoimmune encephalomyelitis

S. Khoury, R. Peach, M. Sayegh, 1999, Journal of Neuroimmunology.

Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.

Megan E. McNerney, M. McNerney, A. Sharpe, 2006, Blood.

CD45RB-targeting strategies for promoting long-term allograft survival and preventingchronic allograft vasculopathy1

M. Sayegh, M. Sho, D. Rothstein, 2003, Transplantation.

CD28-independent induction of experimental autoimmune encephalomyelitis.

S. Khoury, T. Chitnis, M. Sayegh, 2001, The Journal of clinical investigation.

CD 28-independent induction of experimental autoimmune encephalomyelitis

S. Khoury, T. Chitnis, M. Sayegh, 2001 .

Phenotypic and Functional Differences Between Wild-Type and CCR2−/− Dendritic Cells: Implications for Islet Transplantation

R. Abdi, M. Jurewicz, P. Fiorina, 2008, Transplantation.

ABCB5 Identifies Immunoregulatory Dermal Cells.

A. Sharpe, T. Kupper, Q. Zhan, 2015, Cell reports.

Induction of transplantation tolerance by combining non-myeloablative conditioning with delivery of alloantigen by T cells.

J. Bagley, M. Sayegh, J. Iacomini, 2008, Clinical immunology.

Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection.

D. Adams, N. Sibinga, M. Karnovsky, 1995, Transplantation.

Allograft Rejection in a New Allospecific CD4+ TCR Transgenic Mouse

R. Mitchell, E. Palmer, L. Turka, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

MECHANISMS OF INDIRECT ALLORECOGNITION

S. Khoury, M. Sayegh, A. Chandraker, 1998 .

The indirect pathway of allorecognition. The occurrence of self-restricted T cell recognition of allo-MHC peptides early in acute renal allograft rejection and its inhibition by conventional immunosuppression.

M. Sayegh, E. Akalin, C. Carpenter, 1995, Transplantation.

Thymic recognition of class II major histocompatibility complex allopeptides induces donor-specific unresponsiveness to renal allografts.

N. Perico, G. Remuzzi, M. Sayegh, 1993, Transplantation.

Use of polyclonal/monoclonal antibody therapies in transplantation

M. Sayegh, M. Yeung, S. Gabardi, 2017, Expert opinion on biological therapy.

DOWN‐REGULATION OF THE IMMUNE RESPONSE TO HISTOCOMPATIBILITY ANTIGENS AND PREVENTION OF SENSITIZATION BY SKIN ALLOGRAFTS BY ORALLY ADMINISTERED ALLOANTIGEN1

H. Weiner, M. Sayegh, W. Hancock, 1992, Transplantation.

Paradoxical Functions of B7: CD28 Costimulation in a MHC Class II‐Mismatched Cardiac Transplant Model

M. Sayegh, L. Riella, O. Boenisch, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

TolerancePathway and Th17 in Fetomaternal The Link between the PDL1 Costimulatory

M. Sayegh, M. Azuma, H. Yagita, 2011 .

Inhibiting Alloimmune Responses In Vivo Ligand 1/B7.1 Pathway Is Functional in The Novel Costimulatory Programmed Death

Toshihiko, G. Freeman, S. Rodig, 2011 .

Anti-CD4 monoclonal antibody effects cellular hyporesponsiveness and prolongs renal allograft survival in the rat.

M. Sayegh, E. Milford, J. P. Kut, 1989, Human immunology.

Function in Alloimmunity Regulatory T Cell + CD25+ Specificity of CD4

T. Strom, L. Turka, M. Sayegh, 2022 .

TNF:TNF-R T-Cell costimulatory pathways in transplantation.

H. Auchincloss, M. Sayegh, A. Salama, 2001, Transplantation proceedings.

Th2-type cytokines in the "infectious" tolerance pathway.

H. Volk, J. Kupiec-Weglinski, M. Sayegh, 1997, Transplantation proceedings.

The effects of nondepleting CD4 targeted therapy in presensitized rat recipients of cardiac allografts.

H. Volk, J. Kupiec-Weglinski, M. Sayegh, 1996, Transplantation.

Characterization of donor dendritic cells and enhancement of dc efflux with cc-chemokine ligand 21 : a novel strategy to prolong islet allograft survival

R. Abdi, M. Jurewicz, P. Fiorina, 2007 .

The Novel Role of SERPINB9 in Cytotoxic Protection of Human Mesenchymal Stem Cells

M. Atkinson, J. Azzi, Robert Moore, 2011, The Journal of Immunology.

CellsProtection of Human Mesenchymal Stem The Novel Role of SERPINB9 in Cytotoxic

J. Azzi, Robert Moore, R. Abdi, 2011 .

ABCB 5 Identifies Immunoregulatory Dermal Cells Graphical Abstract Highlights

A. Sharpe, T. Kupper, R. Abdi, 2018 .

Mesenchymal stem cells express serine protease inhibitor to evade the host immune response.

M. Atkinson, Jeng-Shin Lee, J. Azzi, 2011, Blood.

Experimental Autoimmune Type 1 Diabetes Marrow-Derived Mesenchymal Stem Cells in Immunomodulatory Function of Bone

M. Selig, M. Atkinson, S. Rodig, 2009 .

Mechanisms of acquired thymic unresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy.

N. Perico, G. Remuzzi, M. Sayegh, 1994, Transplantation.

Clinical update: immunosuppression minimisation

G. Remuzzi, M. Sayegh, 2007, The Lancet.

Mechanisms of indirect allorecognition in graft rejection: class II MHC allopeptide-specific T cell clones transfer delayed-type hypersensitivity responses in vivo.

S. Khoury, M. Sayegh, M. Russell, 1996, Transplantation.

Further Analysis of the T‐Cell Subsets and Pathways of Murine Cardiac Allograft Rejection

R. Colvin, H. Auchincloss, A. Gerth, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The alloantibody network following intrathymic immunomodulation of sensitized rat recipients of cardiac allografts.

J. Kupiec-Weglinski, M. Sayegh, W. Hancock, 1995, Transplantation.

Differential role of CD4+ cells in the sensitization and effector phases of accelerated graft rejection.

T. Sablinski, J. Kupiec-Weglinski, M. Sayegh, 1991, Transplantation.

Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients.

H. Volk, J. Kupiec-Weglinski, M. Sayegh, 1996, Journal of immunology.

Immunogenicity and Effectiveness of Primary and Booster Vaccine Combination Strategies during Periods of SARS-CoV-2 Delta and Omicron Variants

M. Sayegh, Nayla Jbeily, R. Moghnieh, 2022, Vaccines.

Regulatory T Cells Maintain Peripheral Tolerance to Islet Allografts Induced by Intrathymic Injection of MHC Class I Allopeptides1

M. Sayegh, A. Chandraker, S. Oluwole, 1999 .

Avoidance of cyclosporine in renal transplantation: effects of daclizumab, mycophenolate mofetil, and steroids.

H. Auchincloss, M. Sayegh, E. Milford, 2000, Journal of the American Society of Nephrology : JASN.

Immunomodulatory functions of low-molecular weight hyaluronate in an acute rat renal allograft rejection model.

M. Sayegh, M. Denton, C. Magee, 1999, Journal of the American Society of Nephrology : JASN.

Promotion of altruistic donation.

M. Sarwal, F. Delmonico, G. Danovitch, 2009, Transplantation.

Chronic allograft dysfunction: mechanisms and new approaches to therapy.

M. Sayegh, K. Womer, J. Vella, 2000, Seminars in nephrology.

The relative contribution of direct and indirect antigen recognition pathways to the alloresponse and graft rejection depends upon the nature of the transplant.

B. Boehm, M. Sayegh, B. Illigens, 2002, Human immunology.

Allografts After Costimulatory Blockade Long-Term Survival of Murine Cardiac Expression Is Required to Achieve Cutting Edge: Recipient MHC Class II

Gerth, H. Auchincloss, M. Sayegh, 2001 .

Intrathymic immunomodulation in sensitized rat recipients of cardiac allografts: requirements for allorecognition pathways.

J. Kupiec-Weglinski, M. Sayegh, M. Schaub, 1997, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Peptide mediated immunosuppression: new developments.

M. Sayegh, C. Magee, 1998, Transplantation proceedings.

Intrathymic immunomodulation of sensitized rat recipients of cardiac allografts: requirements for allorecognition pathways.

J. Kupiec-Weglinski, M. Sayegh, K. Onodera, 2000, Transplantation proceedings.

Induction of transplant tolerance by intrathymic inoculation of synthetic MHC class I allopeptides.

M. Sayegh, B. Murphy, M. Hardy, 1997, Transplantation proceedings.

In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

D. Scott, S. Khoury, W. Elyaman, 2012, Journal of Clinical Immunology.

Assessment by flow cytometry of intracellular cytokine production in the peripheral blood cells of renal transplant recipients

S. Khoury, M. Sayegh, M. Denton, 2004, Clinical transplantation.

CD4+ T Cells Regulate Surgical and Postinfectious Adhesion Formation

D. Kasper, T. Chitnis, M. Sayegh, 2002, The Journal of experimental medicine.

Effect of gonadectomy on epidermal growth factor values in the gastrointestinal tract of male and female CD-1 mice.

M. Sayegh, J. Elder, 1995, Gut.

ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.

W. Sadee, Ying Huang, M. Sayegh, 2005, Cancer research.

Chapter 88 – Diagnosis and Management of Renal Allograft Dysfunction

M. Sayegh, J. Vella, 2008 .

Identification of cells initiating human melanomas

Mohamed H. Sayegh, George F. Murphy, T. Kupper, 2008, Nature.

Regulation of Progenitor Cell Fusion by ABCB5 P-glycoprotein, a Novel Human ATP-binding Cassette Transporter*

M. Sayegh, M. Frank, S. Pendse, 2003, Journal of Biological Chemistry.

Costimulatory pathways in transplantation: challenges and new developments

X. Li, M. Sayegh, D. Rothstein, 2009, Immunological reviews.

Transplantation tolerance in pediatric recipients: Lessons and challenges

M. Sayegh, K. Tinckam, 2005, Pediatric transplantation.

Nocardial infection in a renal transplant recipient on tacrolimus and mycophenolate mofetil.

M. Sayegh, E. Milford, C. Magee, 1999, Clinical nephrology.

Indirect allorecognition promotes the development of cardiac allograft vasculopathy.

J. Madsen, M. Sayegh, S. Houser, 2001, Transplantation proceedings.

Cellular and humoral mechanisms of vascularized allograft rejection induced by indirect recognition of donor MHC allopeptides.

H. Rennke, M. Sayegh, W. Hancock, 1999, Transplantation.

Role of indirect allorecognition in experimental late acute rejection.

M. Sayegh, C. Carpenter, J. Vella, 1997, Transplantation.

Class II MHC allopeptide-specific T-cell clones transfer delayed type hypersensitivity responses in vivo.

S. Khoury, M. Sayegh, A. Waaga, 1997, Transplantation proceedings.

Why do we reject a graft? Mechanisms of recognition of transplantation antigens

M. Sayegh, B. Murphy, 1996 .

Tissue expression of PD-L1 mediates peripheral T cell tolerance

G. Freeman, A. Sharpe, M. Sayegh, 2006, The Journal of experimental medicine.

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

Xueli Yuan, Raghu Kalluri, Erika Gustafsson, 2007, Nature Medicine.

The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo

G. Freeman, A. Sharpe, M. Sayegh, 2011, The Journal of Immunology.

Blocking cell microtubule assembly inhibits the alloimmune response in vitro and prolongs renal allograft survival by inhibition of Th1 and sparing of Th2 cell function in vivo.

N. Perico, G. Remuzzi, M. Sayegh, 1995, Journal of the American Society of Nephrology : JASN.

Differential Role of Programmed Death-Ligand 1 and Programmed Death-Ligand 2 in Regulating the Susceptibility and Chronic Progression of Experimental Autoimmune Encephalomyelitis1

S. Khoury, T. Chitnis, M. Sayegh, 2006, The Journal of Immunology.

Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis.

S. Khoury, T. Chitnis, M. Sayegh, 2006, Journal of immunology.

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

S. Khoury, T. Chitnis, M. Sayegh, 2003, The Journal of experimental medicine.

The role of T-cell costimulatory activation pathways in transplant rejection.

L. Turka, M. Sayegh, L. Turka, 1998, The New England journal of medicine.

Delayed graft function in kidney transplantation

Giuseppe Remuzzi, Dario Cattaneo, Norberto Perico, 2004, The Lancet.

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1–PD-L1 pathway

J. Bluestone, M. G. Gubbels Bupp, M. Sayegh, 2006, The Journal of experimental medicine.

The cell cycle associated protein, HTm4, is expressed in differentiating cellsof the hematopoietic and central nervous system in mice

J. Kutok, R. Folkerth, D. Scadden, 2005, Journal of Molecular Histology.

Safety and efficacy of a calcineurin inhibitor avoidance regimen in pediatric renal transplantation.

J. Ingelfinger, M. Sayegh, C. Geehan, 2006, Journal of the American Society of Nephrology : JASN.

The Limits of Linked Suppression for Regulatory T Cells

M. Sayegh, T. Ueno, Toshiro Ito, 2016, Front. Immunol..

The Link between the PDL1 Costimulatory Pathway and Th17 in Fetomaternal Tolerance

M. Sayegh, M. Azuma, H. Yagita, 2011, The Journal of Immunology.

A Link between PDL1 and T Regulatory Cells in Fetomaternal Tolerance1

M. Jurewicz, M. Sayegh, A. Habicht, 2007, The Journal of Immunology.

A critical role for the programmed death ligand 1 in fetomaternal tolerance

S. Khoury, M. Sayegh, A. Habicht, 2005, The Journal of experimental medicine.

Neural stem/progenitor cells express costimulatory molecules that are differentially regulated by inflammatory and apoptotic stimuli.

E. Snyder, S. Khoury, M. Comabella, 2004, The American journal of pathology.

Memory T cells: a hurdle to immunologic tolerance.

M. Sayegh, Fadi G Lakkis, 2003, Journal of the American Society of Nephrology : JASN.

Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question1

E. Palmer, L. Turka, A. Wells, 2001, The Journal of Immunology.

Proinflammatory functions of vascular endothelial growth factor in alloimmunity.

D. Mukhopadhyay, D. Briscoe, M. Sayegh, 2003, The Journal of clinical investigation.

Mechanisms Underlying Blockade of Allograft Acceptance by TLR Ligands1

Wenda Gao, T. Strom, L. Turka, 2008, The Journal of Immunology.

Specificity of CD4+CD25+ Regulatory T Cell Function in Alloimmunity1

T. Strom, L. Turka, X. Zheng, 2006, The Journal of Immunology.

Immunosuppressive strategies in transplantation

M. Sayegh, M. Denton, C. Magee, 1999, The Lancet.

Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy.

N. Greenspan, D. Hricik, M. Sayegh, 2004, Journal of the American Society of Nephrology : JASN.

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

L. Glimcher, M. Sayegh, A. Habicht, 2008, The Journal of experimental medicine.

Overcoming cardiac allograft vasculopathy (CAV) by inducing tolerance.

J. Madsen, M. Sayegh, D. Johnston, 2002, Frontiers in bioscience : a journal and virtual library.

Intact B7‐H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses

G. Freeman, Sunmi Yang, M. Sayegh, 2012, European journal of immunology.

Activation In Vitro Inhibits Human Alloimmune T Cell Specific MDR1 P-Glycoprotein Blockade

S. Khoury, S. Alexander, M. Sayegh, 2013 .

Specific MDR1 P-Glycoprotein Blockade Inhibits Human Alloimmune T Cell Activation In Vitro1

S. Khoury, S. Alexander, D. Briscoe, 2001, The Journal of Immunology.

This information is current as Activation In Vitro Inhibits Human Alloimmune T Cell Specific MDR 1 P-Glycoprotein Blockade Briscoe

S. Khoury, S. Alexander, D. Briscoe, 2001 .

Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation‐05 Study

P S Heeger, M. Bhasin, T. Strom, 2016, American Journal of Transplantation.

Immune profile of pediatric renal transplant recipients following alemtuzumab induction.

M. Sayegh, N. Najafian, C. Magee, 2012, Journal of the American Society of Nephrology : JASN.

Measuring T cell alloreactivity to predict kidney transplant outcomes: are we there yet?

M. Sayegh, J. Iacomini, 2006, Journal of the American Society of Nephrology : JASN.

Dual effects of the alloresponse by Th1 and Th2 cells on acute and chronic rejection of allotransplants

M. Sayegh, B. Illigens, G. Benichou, 2009, European journal of immunology.

Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes

M. Atkinson, J. Azzi, Robert Moore, 2010, Diabetes.

Tolerance: Is it time to Move to the Clinic?

M. Sayegh, M. Frank, 2001 .

Transplantation tolerance: The concept and its applicability

M. Sayegh, V. Dong, K. Womer, 1999, Pediatric transplantation.

Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo.

S. Khoury, M. Sayegh, M. Schaub, 1998, Journal of immunology.

Activation of Alloreactive CD8+ T Cells Operates Via CD4-Dependent and CD4-Independent Mechanisms and Is CD154 Blockade Sensitive 1

Y. Zhai, R. Busuttil, J. Kupiec-Weglinski, 2003, The Journal of Immunology.

Regulatory T cells in transplantation: what we know and what we do not know.

M. Sayegh, M. Yeung, 2009, Transplantation proceedings.

Chapter 32 – Transplantation Immunobiology

M. Sayegh, N. Najafian, 2010 .

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

M. Sayegh, R. Noelle, I. Guleria, 2008, Proceedings of the National Academy of Sciences.

Inhibition of allorecognition by a human class II MHC-derived peptide through the induction of apoptosis.

H. Snoeck, S. Alexander, M. Sayegh, 1999, The Journal of clinical investigation.

Peptide-mediated immunosuppression.

M. Sayegh, C. Magee, 1997, Current opinion in immunology.

Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction.

B Murphy, S. Alexander, M. Sayegh, 1997, Transplantation.

Cytokine analysis of human renal allograft aspiration biopsy cultures supernatants predicts acute rejection.

M. Sayegh, B. Murphy, P. Xavier, 1998, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Donor-specific transplantation unresponsiveness in sensitized rats following treatment with a nondepleting anti-CD4 MAb is associated with selective intragraft sparing of Th2-like cells.

H. Volk, J. Kupiec-Weglinski, M. Sayegh, 1995, Transplantation proceedings.

Novel Strategies Using MHC Peptides

M. Sayegh, C. Magee, 2001 .

The T Cell Response to Transplantation Antigens

M. Sayegh, D. Mandelbrot, B. Burrell, 2012 .

Matrix adherence of endothelial cells attenuates immune reactivity: induction of hyporesponsiveness in allo‐ and xenogeneic models

E. Edelman, A. Groothuis, H. Methe, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

T cell recognition of xeno-MHC peptides during concordant xenograft rejection.

H. Auchincloss, M. Sayegh, C. Carpenter, 1996, Transplantation.

Overcome It T Cell Depletion and Approaches to Accelerated Memory Cell Homeostasis during

J. Markmann, L. Turka, M. Sayegh, 2006 .

Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function

V. Kuchroo, R. Sobel, S. Khoury, 2007, The Journal of experimental medicine.

Diff erential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and eff ector function

V. Kuchroo, R. Sobel, S. Khoury, 2007 .

Thymic Dendritic Cells Express Inducible Nitric Oxide Synthase and Generate Nitric Oxide in Response to Self- and Alloantigens1

G. Remuzzi, M. Sayegh, M. Noris, 2000, The Journal of Immunology.

Oxide in Response to Self- and Alloantigens Nitric Oxide Synthase and Generate Nitric Thymic Dendritic Cells Express Inducible

M. Sayegh, M. Noris, F. Casiraghi, 2000 .

The role of indirect recognition of donor MHC class II peptides in cardiac transplantation in miniature swine.

J. Madsen, M. Sayegh, S. Houser, 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Chronic Rejection Rejection: Implications for Therapy of Allograft of FTY720 in a Transgenic Model of Novel Insights into the Mechanism of Action

S. Fernandes, M. Jurewicz, M. Sayegh, 2005 .

Role of podocyte B7-1 in diabetic nephropathy.

M. Rastaldi, A. Krolewski, P. Fiorina, 2014, Journal of the American Society of Nephrology : JASN.

Immunosuppressive drugs and Tregs: a critical evaluation!

M. Sayegh, N. Najafian, S. D. De Serres, 2009, Clinical journal of the American Society of Nephrology : CJASN.

Regulatory CD25+ T cells in human kidney transplant recipients.

M. Sayegh, A. Salama, M. Clarkson, 2003, Journal of the American Society of Nephrology : JASN.

CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo.

M. Sayegh, W. Hancock, M. Russell, 1996, Transplantation.

T-cell co-stimulatory blockade in transplantation: two steps forward one step back!

M. Sayegh, L. Riella, 2013, Expert opinion on biological therapy.

Coichicine Interferes with L-Selectin and Leukocyte Function-Associated Antigen-i Expression on Human I Lymphocytes a nd Inhibits I Cell

N. Perico, G. Remuzzi, M. Sayegh, 1996 .

Effects of BWH-4 anti-CD4 monoclonal antibody on rat vascularized cardiac allografts before and after engraftment.

T. Sablinski, J. Kupiec-Weglinski, M. Sayegh, 1991, Transplantation.

Mixed lymphocyte response-generated suppressor cell specificity in humans is major histocompatibility complex-restricted.

M. Sayegh, E. Milford, C. Carpenter, 1989, Human immunology.

Current and Future Immunosuppressive Therapies Following Transplantation

G. Remuzzi, M. Sayegh, 2001, Springer Netherlands.

Synthetic MHC class I peptide prolongs cardiac survival and attenuates transplant arteriosclerosis in the Lewis-->Fischer 344 model of chronic allograft rejection.

B Murphy, M. Sayegh, W. Hancock, 1997, Transplantation.

Chronic Kidney Disease, Dialysis, and Transplantation: A Companion to Brenner and Rector's The Kidney

B. Pereira, M. Sayegh, P. Blake, 2019 .

Core concepts in renal transplantation

Ajay K. Singh, M. Sayegh, A. Chandraker, 2012 .

The in vivo mechanism of action of CTLA4Ig.

L. Spain, L. Turka, M. Sayegh, 1996, Journal of immunology.

Regulatory T cells maintain peripheral tolerance to islet allografts induced by intrathymic injection of MHC class I allopeptides.

M. Sayegh, A. Chandraker, S. Oluwole, 1998, Cell transplantation.

CTLA4Ig and donor-specific transfusion prolongs cardiac allograft survival in the miniature swine.

J. Madsen, M. Sayegh, S. Houser, 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Case record of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 8-2003. A 35-year-old man with early dysfunction of a second renal transplant.

R. Colvin, M. Sayegh, 2003, The New England journal of medicine.

Recurrence of glomerulonephritis following renal transplantation

M. Sayegh, M. Denton, 1999 .

Dialysis and Transplantation: A Companion to Brenner & Rector's The Kidney

W. Owen, B. Pereira, M. Sayegh, 2000 .

Membranous nephropathy in a patient with renal cell carcinoma.

M. Cudkowicz, H. Rennke, M. Sayegh, 1991, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Anaritide in Acute Tubular Necrosis

R. Lafayette, R. Sweet, M. Sayegh, 1997 .

The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury.

K. Nadeau, M. Sayegh, A. Chandraker, 1997, The Journal of clinical investigation.

Understanding how Tregs are regulated: therapeutic implications.

M. Sayegh, J. Iacomini, Xueli Yuan, 2009, Transplantation.

Is the administration of dopamine associated with adverse or favorable outcomes in acute renal failure? Auriculin Anaritide Acute Renal Failure Study Group.

G. Chertow, M. Sayegh, J. Lazarus, 1996, The American journal of medicine.

Immunogenicity and reactogenicity of BNT162b2 booster in BBIBP-CorV-vaccinated individuals compared with homologous BNT162b2 vaccination: Results of a pilot prospective cohort study from Lebanon

M. Sayegh, T. Jisr, R. Moghnieh, 2021, Vaccine.

Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients.

D. Rader, R. Starling, A. Javaheri, 2016, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection.

D. Adams, N. Sibinga, M. Karnovsky, 1995, Transplantation.

Regulating rejection with cell therapy

H. Weiner, M. Sayegh, 2008, Nature Biotechnology.

Alloreactive T Cell Clone Size Cells, and the + CTLA-4, CD25 Regulating Alloimmunity: Cytokines, Physiological Mechanisms of

Mohamed H. Sayegh, Terry B. Strom, Xin Xiao Zheng, 2010 .

Differential role of programmed death-1 ligand and programmed death-2 ligand in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis

S. Khoury, T. Chitnis, M. Sayegh, 2006, Journal of Immunology.

Immunomodulatory functions of hyaluronate in the LEW-to-F344 model of chronic cardiac allograft rejection.

M. Sayegh, M. Denton, W. Hancock, 1999, Transplantation.

Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.

V. Kuchroo, P. Kivisäkk, S. Khoury, 2008, The American journal of pathology.

CD4-targeted therapy and CD28-B7 costimulatory blockage may independently induce tolerance in sensitized allograft recipients.

H. Volk, J. Kupiec-Weglinski, M. Sayegh, 1998, Transplantation proceedings.

Faculty Opinions recommendation of Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy.

J. Bagley, M. Sayegh, 2008 .

Predictors of mortality and the provision of dialysis in patients with acute tubular necrosis. The Auriculin Anaritide Acute Renal Failure Study Group.

R. Lafayette, G. Chertow, M. Sayegh, 1998, Journal of the American Society of Nephrology : JASN.

IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response

W. Leonard, P. Hwu, J. Markmann, 2011, Diabetes.

Matrix Embedding Alters the Immune Response Against Endothelial Cells In Vitro and In Vivo

E. Edelman, P. Seifert, A. Groothuis, 2005, Circulation.

The role of T-cell costimulatory pathways in ischemia—reperfusion injury

M. Sayegh, A. Chandraker, 1998 .

P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes

L. Potena, R. Starling, G. Zuccotti, 2018, The Journal of clinical investigation.

Chronic Kidney Disease, Dialysis, and Transplantation

J. Himmelfarb, M. Sayegh, 2010 .

I m m u n o s u p p ressive strategies in transplantation

M. Sayegh, M. Denton, C. Magee, 1999 .

Complement dances with T cells.

M. Sayegh, M. Ansari, 2008, Blood.

Does belatacept provide equivalent suppression of acute renal transplant rejection to ciclosporin?

M. Sayegh, A. Chandraker, 2006, Nature Clinical Practice Nephrology.

Zeisberg, E.M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952-961

W. Pu, A. Roberts, R. Kalluri, 2007 .

Novel immunotherapeutic strategies using MHC derived peptides.

A. Krensky, M. Sayegh, 1996, Kidney international. Supplement.

Anaritide in acute tubular necrosis. Auriculin Anaritide Acute Renal Failure Study Group.

R. Lafayette, R. Sweet, M. Sayegh, 1997, The New England journal of medicine.

Minimisation of immunosuppression in transplantation – Authors' reply

G. Remuzzi, M. Sayegh, 2007, The Lancet.

INTRATHYMIC INJECTION OF DONOR‐SPECIFIC X‐IRRADIATION-SENSITIVE SPLEEN CELLS ABROGATES ACCELERATED REJECTION OF CARDIAC ALLOGRAFTS IN SENSITIZED RATS1

J. Kupiec-Weglinski, M. Sayegh, W. Hancock, 1994, Transplantation.

Key role of the alternate complement pathway in hyperacute rejection of rat hearts transplanted into fetal sheep.

M. Sayegh, F. Hanley, W. Hancock, 1996, Transplantation.

LONG-TERM SURVIVAL OF CARDIAC ALLOGRAFTS INDUCED BY COSTIMULATORY BLOCKADE MAY REQUIRE INDIRECT RECOGNITION

H. Auchincloss, M. Sayegh, A. Yamada, 1999 .

Inhibition of the alloimmune response with synthetic nonpolymorphic class II MHC peptides.

M. Sayegh, E. Akalin, C. Carpenter, 1995, Transplantation proceedings.

Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.

P. Linsley, S. Khoury, R. Peach, 1997, Journal of immunology.

Developments in the clinical science of transplantation during the 20th century.

M. Sayegh, J. Vella, L. Turka, 1998, Pediatric transplantation.

Current and future immunosuppressive therapies: impact on chronic allograft dysfunction.

M. Sayegh, J. Vella, 1997, Journal of nephrology.

Requirements for the induction of allospecific CD8+ suppressor T cells in the rat primary mixed lymphocyte response. CD4+, CD45R+ T cells, or supernatant factor.

M. Sayegh, E. Milford, D. Rothstein, 1989, Transplantation.

P‐Glycoprotein Functions as a Differentiation Switch in Antigen Presenting Cell Maturation

M. Sayegh, A. Izawa, M. H. Sayegh, 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Transplantation tolerance. A complex scenario awaiting clinical applicability.

N. Perico, G. Remuzzi, M. Sayegh, 2005, Contributions to Nephrology.

P-glycoprotein--a novel therapeutic target for immunomodulation in clinical transplantation and autoimmunity?

M. Sayegh, M. Frank, S. Pendse, 2003, Current drug targets.

Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade.

M. Sykes, M. Sayegh, A. Chandraker, 1999, Transplantation Proceedings.

Schizophrenia: new pathological insights and therapies.

J. Lieberman, M. Clarke, R. Strieter, 2007, Annual review of medicine.

Role of regulatory T cells in the "infectious" tolerance pathway in transplant recipients.

H. Volk, J. Kupiec-Weglinski, M. Sayegh, 1998, Transplantation proceedings.

Striking Dichotomy of PD‐L1 and PD‐L2 Pathways in Regulating Alloreactive CD4+ and CD8+ T Cells In Vivo

X. Li, M. Sayegh, A. Habicht, 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The Prevalence and Risk Factors of Acute Kidney Injury during Colistin Therapy: A Retrospective Cohort Study from Lebanon

M. Sayegh, R. Moghnieh, D. Abdallah, 2023, Antibiotics.

CTLA4Ig: effects on cellular and humoral immunity and macrophage activation.

M. Sayegh, M. Schaub, T. Stadlbauer, 1997, Experimental nephrology.

Costimulation and Autoimmune Diabetes in BB Rats

C. Benjamin, H. Drexhage, M. Sayegh, 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2

P. Linsley, L. Turka, M. Sayegh, 1995, The Journal of experimental medicine.

New Insights in CD28‐Independent Allograft Rejection

M. Sayegh, A. Habicht, H. Yagita, 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Critical Role of Proinflammatory Cytokine IL‐6 in Allograft Rejection and Tolerance

Sunmi Yang, M. Sayegh, J. Iacomini, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Erratum: Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4 +CD25+ T cells (The Journal of Immunology (2005) 174 (3741-3748))

S. Schenk, K. Fukamachi, L. Turka, 2005 .

Chronic rejection in experimental cardiac transplantation in a rat model.

D. Adams, M. Karnovsky, M. Sayegh, 1994, Clinical transplantation.

Dual effects of the alloresponse by Th1 and Th2 cells on acute and chronic rejection of allotransplants

M. Sayegh, B. Illigens, G. Benichou, 2009, European journal of immunology.

A critical role for the programmed death ligand 1 in fetomaternal tolerance

S. Khoury, M. Sayegh, A. Habicht, 2005, The Journal of experimental medicine.

Critical Role of Donor Tissue Expression of Programmed Death Ligand-1 in Regulating Cardiac Allograft Rejection and Vasculopathy

M. Sayegh, M. Azuma, H. Yagita, 2008, Circulation.

Tissue expression of PD-L1 mediates peripheral T cell tolerance

A. Sharpe, M. Sayegh, M. Keir, 2006, The Journal of experimental medicine.

Donor Antioxidant Strategy Prolongs Cardiac Allograft Survival by Attenuating Tissue Dendritic Cell Immunogenicity†

J. Azzi, R. Abdi, Sunmi Yang, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The Link between the PDL1 Costimulatory Pathway and Th17 in Fetomaternal Tolerance

M. Sayegh, M. Azuma, H. Yagita, 2011, The Journal of Immunology.

REPLY: DISCREPANCY IN PEPTIDES SERIOUSLY DAMAGES STUDY

M. Sayegh, S. Oluwole, N. Chowdhury, 1997 .

Immunomodulatory function of major histocompatibility complex-derived peptides.

M. Sayegh, B. Murphy, 1996, Current opinion in nephrology and hypertension.

ABCB5 Identifies Immunoregulatory Dermal Cells.

A. Sharpe, T. Kupper, Q. Zhan, 2015, Cell reports.