L. Qian

发表

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.

Punit Marathe, John S Tokarski, Toomas Mitt, 2002, Journal of medicinal chemistry.

Improved method for the preparation of guanidines

K. Kim, L. Qian, 1993 .

Design, synthesis, and evaluation of orally active 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 inhibitors.

J. Fargnoli, J. Barrish, J. Tokarski, 2005, Journal of medicinal chemistry.

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.

Punit Marathe, Ravindra Tejwani, Arvind Mathur, 2008, Bioorganic & medicinal chemistry letters.

Metabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus Monkey

Y. Shu, Donna D Wei, L. Qian, 2008, Drug Metabolism and Disposition.

Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215)

J. Fargnoli, G. Derbin, J. Barrish, 2008, Journal of medicinal chemistry.

Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.

J. Tokarski, B. Koplowitz, J. Hunt, 2005, Bioorganic & medicinal chemistry letters.

Structural Aspects of the Dephosphorylation of Adenosine Triphosphate Catalyzed by Polyammonium Macrocycles

L. Qian, Zhong‐Ming Sun, B. Movassagh, 1991 .

Synthesis, biological properties, and structure-activity relationships of quinoxaline angiotensin II receptor antagonists

T. Waldron, S. Moreland, K. Dickinson, 1993 .

Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships.

T. Waldron, S. Moreland, K. Dickinson, 1993, Journal of medicinal chemistry.

Synthesis of 4,4-difluoro-L-arginine

L. Qian, S. KimKyoung, 1993 .

Synthesis of macrocyclic ligands incorporating sulfur and furan subunits

L. Qian, Zhong‐Ming Sun, K. Bowman-James, 1996 .

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

Punit Marathe, John S Tokarski, J. Tokarski, 2004, Journal of medicinal chemistry.

A total synthesis of (±)-huperzine A

L. Qian, R. Ji, 1989 .

Synthesis of polyaza macropolycyclic ligands

L. Qian, Zhong‐Ming Sun, K. Bowman-James, 1996 .

Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.

J. Fargnoli, G. Derbin, J. Barrish, 2006, Journal of medicinal chemistry.

Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors.

J. Fargnoli, J. Tokarski, J. Hunt, 2005, Bioorganic & medicinal chemistry letters.

Preparation of enantiopure (R)-flurbiprofen catalyzed by a newly isolated Bacillus cereus C71

L. Qian, Shaoxin Chen, Bing-zhao Shi, 2007 .

Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.

W. Humphreys, J. Tokarski, L. Leith, 2000, Journal of medicinal chemistry.

Quinoxaline N‐Oxide Containing Potent Angiotensin II Receptor Antagonists: Synthesis, Biological Properties, and Structure‐Activity Relationships.

T. Waldron, S. Moreland, K. Dickinson, 1993 .

Synthesis of selectively protected polyaza macrocycles

L. Qian, Zhong‐Ming Sun, K. B. Mertes, 1991 .

Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2.

J. Fargnoli, G. Derbin, J. Barrish, 2006, Journal of medicinal chemistry.

J. Fargnoli, G. Derbin, J. Barrish, 2008, Bioorganic & medicinal chemistry letters.

Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors.

J. Fargnoli, J. Tokarski, J. Hunt, 2008, Bioorganic & medicinal chemistry letters.

Y. Shu, L. Qian, A. Kamath, 2008, Drug Metabolism and Disposition.