W. Han

发表

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.

Punit Marathe, John S Tokarski, Toomas Mitt, 2002, Journal of medicinal chemistry.

Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists.

J. Chen, L. Schweizer, M. Salvati, 2010, Bioorganic & medicinal chemistry letters.

Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity.

James Lin, E. Iwanowicz, S. D. Kimball, 2002, Bioorganic & medicinal chemistry letters.

Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists.

O. Kocy, J. Barrish, R. Misra, 1993, Journal of medicinal chemistry.

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.

Vijay T. Ahuja, Derek J. Norris, J. Tokarski, 2021, Journal of medicinal chemistry.

Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2 antagonists. Semicarbazone omega-chains.

M. Webb, R. Misra, W. Han, 1991, Journal of medicinal chemistry.

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

Discovery of the pyrrolo[2,1-f][1,2,4]triazine nucleus as a new kinase inhibitor template.

J. Fargnoli, J. Hunt, B. Fink, 2004, Journal of medicinal chemistry.

Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.

R. Moquin, James Lin, E. Iwanowicz, 2002, Bioorganic & medicinal chemistry letters.

Regiospecific cleavage of strained tri- and tetraquinane .beta.-diketones via retro-Claisen reaction

W. Han, J. Cook, K. Takahashi, 1982 .

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

Punit Marathe, John S Tokarski, J. Tokarski, 2004, Journal of medicinal chemistry.

Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

J. Fargnoli, Derek J. Norris, J. Tokarski, 2009, Journal of medicinal chemistry.

Reaction of dicarbonyl compounds with dimethyl 3-ketoglutarate. Influence of steric effects on success of the condensation

W. Han, J. Cook, K. Avasthi, 1982 .

9,11-Epoxy-9-homo-14-oxaprosta-5-enoic acid derivatives. Novel inhibitors of fatty acid cyclooxygenase.

W. Han, S. Hall, M. Ogletree, 1986, Journal of medicinal chemistry.

Thromboxane receptor antagonist BMS-180291: A new pre-clinical lead

J. Barrish, P. Sprague, R. Morrison, 1992 .

General approach for the synthesis of polyquinenes via the Weiss reaction XV. Synthesis of the [5.5.5.5]fenestrane system via the aldol approach and studies directed toward the [5.5.6.6]fenestranes

Weijiang Zhang, W. Han, A. Gupta, 1993 .

Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.

J S Sack, E. Iwanowicz, L. Tabernero, 1995, Journal of molecular biology.

7-Oxabicyclo[2.2.1]heptyl carboxylic acids as thromboxane A2 antagonists: aza omega-chain analogues.

J. Das, W. Han, M. Ogletree, 1990, Journal of medicinal chemistry.

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.

Derek J. Norris, D. Shen, G. Trainor, 2015, Bioorganic & medicinal chemistry letters.

Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.

Derek J. Norris, J. Tokarski, S. D. Kimball, 2006, Bioorganic & medicinal chemistry letters.

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

Derek J. Norris, D. Shen, G. Trainor, 2015, ACS medicinal chemistry letters.

Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

R. Parker, W. Han, W. Harte, 1990, Journal of medicinal chemistry.

5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.