Chiehying Y Chang

发表

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.

Punit Marathe, John S Tokarski, Toomas Mitt, 2002, Journal of medicinal chemistry.

X‐Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

D. Xie, J. Sack, Chiehying Y Chang, 2011, Chemical biology & drug design.

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.

Chiehying Y Chang, M. Gottardis, R. Attar, 2005, Journal of medicinal chemistry.

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).

D. Langley, J. Sack, Chiehying Y Chang, 2007, Bioorganic & medicinal chemistry letters.

Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

G. Trainor, A. Mathur, D. Langley, 2009, Journal of medicinal chemistry.

Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway: in vitro and in vivo studies

Wen-Sen Lee, Chiehying Y Chang, C. Kuo, 2015, Scientific Reports.

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

M. Blanar, Rongan Zhang, S. Krystek, 2016, ACS medicinal chemistry letters.

Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

Wei Wang, Jonathan Lippy, Arthur M Doweyko, 2009, Bioorganic & medicinal chemistry letters.

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

D. Shuster, J. Macor, J. Yanchunas, 2020, Journal of medicinal chemistry.

Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.

Chiehying Y Chang, M. Gottardis, R. Attar, 2007, Bioorganic & medicinal chemistry letters.

Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.

J. Macor, Chiehying Y Chang, M. Ahlijanian, 2016, Bioorganic & medicinal chemistry letters.

Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.

J. Macor, H. Lewis, Chiehying Y Chang, 2016, Journal of medicinal chemistry.

The Crystal Structure of Abl Kinase with BMS-354825, a Dual SRC/ABL Kinase Inhibitor.

J. Tokarski, K. Kish, H. Klei, 2004 .

Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.

J. Sack, Chiehying Y Chang, A. Greer, 2010, Bioorganic & medicinal chemistry letters.

Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.

R. Moquin, James Lin, E. Iwanowicz, 2002, Bioorganic & medicinal chemistry letters.

Crystallographic determination of the structures of human α‐thrombin complexed with BMS‐186282 and BMS‐189090

Lydia Tabernero, L. Tabernero, J. Sack, 1996 .

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked

Michael A. Galella, K. McIntyre, J. Barrish, 2016, Journal of medicinal chemistry.

Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple α-helical coiled-coil

S. Sheriff, Chiehying Y Chang, R. Ezekowitz, 1994, Nature Structural Biology.

The X-ray structure of an anti-tumour antibody in complex with antigen

J. Bajorath, P. Jeffrey, S. Sheriff, 1995, Nature Structural Biology.

The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants.

M. Wittekind, J. Tokarski, K. Kish, 2006, Cancer research.

Kinetic and crystallographic studies of Escherichia coli UDP‐N‐acetylmuramate:L‐alanine ligase

J. Villafranca, Chiehying Y Chang, H. Einspahr, 1996, Protein science : a publication of the Protein Society.

Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).

P. M. Davis, K. McIntyre, J. Barrish, 2010, Journal of medicinal chemistry.

Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).

Zheng Yang, Neha Surti, Jonathan S Lippy, 2015, Bioorganic & medicinal chemistry letters.

Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.

Andrew Tebben, Qian Ruan, Neha Surti, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Daniel Meyers, Jonathan Lippy, Rongan Zhang, 2010, Bioorganic & medicinal chemistry letters.

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.

Andrea Mcclure, J. Macor, H. Lewis, 2016, ACS medicinal chemistry letters.

Structure and specificity of the anti-digoxin antibody 40-50.

J. Schildbach, M. N. Margolies, P. Jeffrey, 1995, Journal of molecular biology.

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.

Andrea Mcclure, J. Macor, H. Lewis, 2016, ACS medicinal chemistry letters.

X‐Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

D. Xie, J. Sack, Chiehying Y Chang, 2011, Chemical biology & drug design.