C. Fairchild

发表

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.

Punit Marathe, John S Tokarski, Toomas Mitt, 2002, Journal of medicinal chemistry.

Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

Ping Chen, A. Doweyko, Derek J. Norris, 2004, Journal of medicinal chemistry.

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression

P. Ross-Macdonald, S. Kirov, L. Schweizer, 2015, Molecular Cancer Therapeutics.

Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection.

Fei Huang, Xia Han, F. Huang, 2007, Cancer research.

Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase.

C. Fairchild, B. Long, Craig R. Fairchild, 1994, Cancer research.

Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol).

C. Fairchild, T. Lindel, P. Jensen, 1998, Cancer research.

IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines

Fei Huang, Dharmesh M. Patel, Han Chang, 2014, Molecular Cancer Therapeutics.

Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant

C. Croce, K. Huebner, C. Fairchild, 2004, British Journal of Cancer.

Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein.

K. Suzuki, T. Tsuruo, G. Yu, 1991, Cancer communications.

Identification of 5' and 3' sequences involved in the regulation of transcription of the human mdr1 gene in vivo.

K. Cowan, C. Fairchild, M. Nakagawa, 1993, The Journal of biological chemistry.

Diastereoselective addition of Grignard reagents to azetidine-2,3-dione: Synthesis of novel Taxol® analogues

Stella Huang, D. Langley, C. Fairchild, 1996 .

Novel strategies for the discovery of plant-derived anticancer agents

G. Cordell, J. Pezzuto, C. Fairchild, 1994 .

Preclinical pharmacology of BMS-275183, an orally active taxane.

C. Fairchild, J. Kadow, F. Lee, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-pi.

K. Cowan, C. Fairchild, J. Moscow, 1990, Molecular pharmacology.

Synthesis and antitumor evaluation of 2′-oxycarbonylpaclitaxels (paclitaxel-2′-carbonates)

C. Fairchild, W. Rose, E. Kerns, 1994 .

Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors.

H. Wieand, K. Cowan, C. Fairchild, 1989, Cancer research.

POTENTIAL CLINICAL APPLICATIONS OF NATURAL PRODUCTS OF MEDICINAL PLANTS AS ANTICANCER DRUGS – A REVIEW

C. Fairchild, S. Forenza, K. Lane, 2013 .

Biochemical and pharmacological characterization of MCF-7 drug-sensitive and AdrR multidrug-resistant human breast tumor xenografts in athymic nude mice.

C. Fairchild, E. Mimnaugh, J. Fruehauf, 1991, Biochemical pharmacology.

Cytotoxic Constituents of the Roots of Exostema acuminatum

G. Cordell, J. Pezzuto, A. Kinghorn, 2000 .

TAXOL STRUCTURE-ACTIVITY RELATIONSHIPS : SYNTHESIS AND BIOLOGICAL EVALUATION OF TAXOL ANALOGS MODIFIED AT C-7

Jianmei Wei, G. Roth, C. Fairchild, 1994 .

Stephacidin A and B: two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cells.

Stella Huang, Y. Shu, S. Klohr, 2002, Journal of the American Chemical Society.

Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.

J. Fargnoli, R. Talbott, J. Hunt, 2015, Experimental cell research.

Analysis of structure activity relationships for LPS-mimetic activities of taxane analogs in murine macrophages

C. Fairchild, S. Vogel, J. Kadow, 1999 .

Structure-activity relationships study at the 3′-N position of paclitaxel-part 1: Synthesis and biological evaluation of the 3′-(t)-butylaminocarbonyloxy bearing paclitaxel analogs

Stella Huang, C. Fairchild, J. Kadow, 1997 .

Advances in Brief Eleutherobin , a Novel Cytotoxic Agent That Induces Tubulin Polymerization , Is Similar to Paclitaxel ( TaxolÂ ® ) 1

Arthur, Laurie, J. Wasserman, 2006 .

SAR and pH stability of cyano-substituted epothilones.

Soong-Hoon Kim, Kenneth J. Leavitt, C. Fairchild, 2002, Organic letters.

Synthesis, structure proof, and biological activity of epothilone cyclopropanes.

J. Tokarski, C. Fairchild, F. Lee, 2000, Organic letters.

Microtubule Functions during Anaphase and Telephase Interference with Spindle Formation without Affecting Other Phase by 1 Paclitaxel Inhibits Progression of Mitotic Cells to G Updated

C. Fairchild, B. Long, 4361. Augusl, 2006 .

Eleutherobin, a New Cytotoxin that Mimics Paclitaxel (Taxol) by Stabilizing Microtubules

C. Fairchild, T. Lindel, P. Jensen, 1997 .

Cytotoxic constituents of the roots of Ekmanianthe longiflora.

G. Cordell, J. Pezzuto, A. Kinghorn, 2000, Journal of natural products.

Synthesis and antitumor activity of novel C-7 paclitaxel ethers: discovery of BMS-184476.

C. Fairchild, J. Kadow, F. Lee, 2001, Journal of medicinal chemistry.

Enhanced cytotoxicity with methotrexate in conjunction with hypoxanthine in L1210 cells in culture

J. Maybaum, C. Fairchild, J. Straw, 2004, Cancer Chemotherapy and Pharmacology.

Concurrent unilateral chromatid damage and DNA strand breakage in response to 6-thioguanine treatment.

J. Maybaum, C. Fairchild, K. A. Kennedy, 1986, Biochemical pharmacology.

Preclinical antitumor activity of two novel taxanes

F. Lee, C. Fairchild, W. Rose, 2000, Cancer Chemotherapy and Pharmacology.

Ecological leads for natural product discovery: Novel sesquiterpene hydroquinones from the red macroalga Peyssonnelia sp.

Amy L. Lane, K. L. Le Roch, J. Prudhomme, 2010, Tetrahedron.

Structure-activity relationships of taxol®: synthesis and biological evaluation of C2 taxol analogs

Jianmei Wei, C. Fairchild, J. Kadow, 1994 .

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).

P. Giannakakou, D. Kingston, C. Fairchild, 1998, Journal of medicinal chemistry.

Taxol structure-activity relationships : synthesis and biological evaluation of 10-deoxytaxol

C. Fairchild, V. Farina, S. Mamber, 1993 .

Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.

G. Cordell, J. Pezzuto, A. Kinghorn, 2004, The Journal of organic chemistry.

BMS-354825 potently inhibits multiple selected oncogenic tyrosine kinases and possesses broad-spectrum antitumor activities in vitro and in vivo

F. Lee, C. Fairchild, R. Borzilleri, 2005 .

Discovery of anticancer agents of diverse natural origin

A. Kinghorn, D. Jarjoura, S. Emanuel, 2009, Pure and applied chemistry. Chimie pure et appliquee.

Botryllamides A-D, new brominated tyrosine derivatives from styelid ascidians of the genus Botryllus

A. Carroll, C. Ireland, C. Fairchild, 1995 .

Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.

D. Langley, C. Fairchild, R. Kramer, 2005, Journal of medicinal chemistry.

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activit

C. Fairchild, M. Deshpande, R. Kramer, 2004 .

Naamidine A is an antagonist of the epidermal growth factor receptor and an in vivo active antitumor agent.

S. Robinson, C. Ireland, C. Fairchild, 1998, Journal of medicinal chemistry.

Isolation and Structure of Caribenolide I, a Highly Potent Antitumor Macrolide from a Cultured Free-Swimming Caribbean Dinoflagellate, Amphidinium sp. S1-36-5

I. Bauer, Lucie Maranda, K. A. Young, 1995 .

Synthesis and biological activity of novel epothilone aziridines.

C. Fairchild, R. Borzilleri, F. Lee, 2001, Organic letters.

Scleritodermin A, a cytotoxic cyclic peptide from the lithistid sponge Scleritoderma nodosum.

C. Fairchild, E. Schmidt, D. Faulkner, 2004, Journal of natural products.

Novel 3',6'-anhydro and N12,N13-bridged glycosylated fluoroindolo[2,3-a]carbazoles as topoisomerase I inhibitors. Fluorine as a leaving group from sp3 carbon.

Stella Huang, D. Langley, C. Fairchild, 2005, Organic letters.

A chemoselective approach to functionalize the C-10 position of 10-deacetylbaccatin III. Synthesis and biological properties of novel C-10 Taxol® analogues

C. Fairchild, J. Kadow, K. Johnston, 1994 .

Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus.

C. Fairchild, J. Kubanek, T. Snell, 2005, Organic letters.

A Novel Application of a Pd(0)-Catalyzed Nucleophilic Substitution Reaction to the Regio- and Stereoselective Synthesis of Lactam Analogues of the Epothilone Natural Products

Soong-Hoon Kim, C. Fairchild, R. Borzilleri, 2000 .

Synthesis and Biological Activity of C-6 and C-7 Modified Paclitaxels

D. Kingston, C. Fairchild, Xian Liang, 2000 .

Preclinical discovery of ixabepilone, a highly active antineoplastic agent

F. Lee, A. Kamath, C. Fairchild, 2008, Cancer Chemotherapy and Pharmacology.

Synthesis of 7β-Sulfur Analogues of Paclitaxel Utilizing a Novel Epimerization of the 7α-Thiol Group

C. Fairchild, D. Vyas, H. Mastalerz, 2001 .

Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum.

D. Pirnik, S. Klohr, S. Huang, 1993, The Journal of antibiotics.

A new EGF-active polymeric pyridinium alkaloid from the sponge Callyspongia fibrosa

G. Roth, C. Fairchild, C. Polson, 1993 .

Bromophycoic acids: bioactive natural products from a Fijian red alga Callophycus sp.

Jacques Prudhomme, Sebastian Engel, Julia Kubanek, 2012, The Journal of organic chemistry.

Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus.

E. P. Stout, K. L. Le Roch, J. Prudhomme, 2010, Journal of natural products.

Bromophycolides C-I from the Fijian red alga Callophycus serratus.

C. Fairchild, J. Kubanek, T. Snell, 2006, Journal of natural products.

Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.

Stella Huang, D. Kingston, C. Fairchild, 2008, Journal of natural products.

Structure and biological evaluation of novel cytotoxic sterol glycosides from the marine red alga Peyssonnelia sp.

C. Fairchild, J. Kubanek, W. Aalbersberg, 2010, Bioorganic & medicinal chemistry.

Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.

A. Kinghorn, C. Fairchild, N. Oberlies, 2002, Journal of natural products.

Ecological leads for natural product discovery: Novel sesquiterpene hydroquinones from the red macroalga Peyssonnelia sp.

Amy L. Lane, K. L. Le Roch, J. Prudhomme, 2010, Tetrahedron.

Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus.

E. P. Stout, Amy L. Lane, K. L. Le Roch, 2009, The Journal of organic chemistry.

BMS-536924 Reverses IGF-IR-Induced Transformation of Mammary Epithelial Cells and Causes Growth Inhibition and Polarization of MCF7 Cells

Adrian V. Lee, B. Litzenburger, C. Fairchild, 2009, Clinical Cancer Research.

BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.

F. Lee, Soong-Hoon Kim, C. Fairchild, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo.

G. Cordell, G. Tan, J. Pezzuto, 2003, Journal of natural products.

Erratum: Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris (Journal of Organic Chemistry (2004) 69 (3350-3357))

G. Cordell, J. Pezzuto, A. Kinghorn, 2004 .

Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.

G. Cordell, J. Pezzuto, A. Kinghorn, 2004, The Journal of organic chemistry.

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

T. Rushmore, K. Cowan, C. Fairchild, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum.

A. Kinghorn, C. Fairchild, H. Navarro, 2002, Journal of natural products.

Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.

Wayne Vaccaro, Steven Sheriff, Neil Burford, 2006, Bioorganic & medicinal chemistry letters.

Paclitaxel (Taxol): mechanisms of Resistance.

C. Fairchild, A. Casazza, 1996, Cancer treatment and research.

Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor.

F. Lee, V. Manne, M. Lynch, 2001, Cancer research.

Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces.

C. Fairchild, P. Jensen, W. Fenical, 2007, Journal of natural products.

Novel fluoro-substituted camptothecins: in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization

P. Marathe, C. Fairchild, T. Monticello, 2006, Cancer Chemotherapy and Pharmacology.

Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.

M. Israel, N. Rosen, K. Cowan, 1987, Cancer research.

Synergistic Antitumor Activity of Ixabepilone (BMS-247550) Plus Bevacizumab in Multiple In vivo Tumor Models

J. Fargnoli, F. Lee, C. Fairchild, 2008, Clinical Cancer Research.

Synergistic AntitumorActivity of Ixabepilone ( BMS-247550 ) Plus Bevacizumab inMultiple In vivo TumorModels

J. Fargnoli, F. Lee, C. Fairchild, 2008 .

Synthesis and Antitumor Evaluation of 2′-Oxycarbonylpaclitaxels ( Paclitaxel-2′-carbonates).

C. Fairchild, W. Rose, E. Kerns, 1995 .

Structures and absolute configurations of sulfate-conjugated triterpenoids including an antifungal chemical defense of the green macroalga Tydemania expeditionis.

Amy L. Lane, C. Fairchild, J. Kubanek, 2008, Journal of natural products.

Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.

E. P. Stout, Amy L. Lane, K. L. Le Roch, 2007, The Journal of organic chemistry.

Antineoplastic unsaturated fatty acids from Fijian macroalgae.

K. Roch, J. Prudhomme, C. Fairchild, 2008, Phytochemistry.

Unusual antimalarial meroditerpenes from tropical red macroalgae.

E. P. Stout, K. Roch, J. Prudhomme, 2010, Bioorganic & medicinal chemistry letters.

Patient Selection Sensitivity in Solid Tumors to Dasatinib : Rationale for Identification of Candidate Molecular Markers Predicting

Peter Shaw, Xia Han, F. Huang, 2007 .

Adriamycin-resistant Human Breast Cancer Cells Isolation of Amplified and Overexpressed DNA Sequences from

M. Israel, N. Rosen, K. Cowan, 1987 .

Antitumor and Antiangiogenic Activities of BMS-690514, an Inhibitor of Human EGF and VEGF Receptor Kinase Families

J. Fargnoli, Derek J. Norris, J. Hunt, 2011, Clinical Cancer Research.

Development of Farnesyltransferase Inhibitors as Potential Antitumor Agents

F. Lee, V. Manne, C. Fairchild, 2001 .

Apoptotic and Cytostatic Farnesyltransferase Inhibitors Have Distinct Pharmacology and Efficacy Profiles in Tumor Models

J. Hunt, F. Lee, V. Manne, 2004, Cancer Research.

Preclinical efficacy spectrum and pharmacokinetics of ixabepilone

F. Lee, C. Fairchild, R. Kramer, 2008, Cancer Chemotherapy and Pharmacology.

The multidrug resistance phenotype: 31P nuclear magnetic resonance characterization and 2-deoxyglucose toxicity.

M. Gottesman, C. Fairchild, J. Jaroszewski, 1991, Cancer research.

Synthesis and biological evaluation of analogs of altohyrtin C (spongistatin 2)

C. Fairchild, A. Melamed, R. Wild, 2008 .

Synthesis and antitumor properties of novel 14-β-hydroxytaxol and related analogues

D. Langley, C. Fairchild, J. Kadow, 1994 .

Structure-activity relationships study at the 3'-N position of paclitaxel. Part 2: synthesis and biological evaluation of 3'-N-thiourea- and 3'-N-thiocarbamate-bearing paclitaxel analogues.

C. Fairchild, J. Kadow, K. Johnston, 2000, Bioorganic & medicinal chemistry letters.

Stereospecific synthesis of 7-deoxy-6-hydroxy paclitaxel

C. Fairchild, J. Kadow, M. Wittman, 1999 .

Studies in Sugar Chemistry VII1). Glucuronides of Podophyllum Derivatives

H. Gottlieb, C. Fairchild, A. Nudelman, 1997 .

NOVEL C-4 PACLITAXEL (TAXOL) ANALOGS : POTENT ANTITUMOR AGENTS

Jianmei Wei, C. Fairchild, J. Kadow, 1995 .

Studies toward structure-activity relationships of taxol®: synthesis and cytotoxicity of taxol® analogues with C-2′ modified phenylisoserine side chains☆

Stella Huang, C. Fairchild, H. Wong, 1993 .

Keynote address: multidrug resistance: a pleiotropic response to cytotoxic drugs.

K. Cowan, C. Fairchild, 1991, International journal of radiation oncology, biology, physics.

Carcinogenicity Risk Assessment Supports the Chronic Safety of Dapagliflozin, an Inhibitor of Sodium–Glucose Co-Transporter 2, in the Treatment of Type 2 Diabetes Mellitus

F. Lee, E. Janovitz, C. Fairchild, 2014, Diabetes Therapy.

Synthesis and biological activity of macrocyclic taxane analogues.

James G. Tarrant, C. Fairchild, J. Kadow, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of C-13 Amide-Linked Paclitaxel (Taxol†) Analogs

C. Fairchild, T. Doyle, V. Farina, 1996 .

Paclitaxel analogs modified in ring C: Synthesis and biological evaluation

D. Kingston, C. Fairchild, K. Johnston, 1997 .

Synthesis, structure elucidation and biological evaluation of C-norpaclitaxel

D. Kingston, C. Fairchild, Xian Liang, 1995 .

Altered regulation of P-450IA1 expression in a multidrug-resistant MCF-7 human breast cancer cell line.

A. Tulpule, D. Nebert, K. Cowan, 1988, The Journal of biological chemistry.

Synthesis and Biological Evaluation of 1-Deoxypaclitaxel Analogues.

D. Kingston, C. Fairchild, M. Chordia, 1999, The Journal of organic chemistry.

IRS 2 Copy Number Gain , KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1 R / IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines

Dharmesh M. Patel, Han Chang, F. Huang, 2015 .

Copy Number Gain , KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1 R / IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines

Dharmesh M. Patel, Han Chang, F. Huang, 2015 .

Eleutherobin, a New Cytotoxin that Mimics Paclitaxel (Taxol) by Stabilizing Microtubules.

C. Fairchild, T. Lindel, P. Jensen, 1997 .

New Anticancer Drugs from Cultured and Collected Marine Organisms

Eric J. Kantorowski, Y. Shimizu, C. Fairchild, 2003 .

The discovery of BMS-275183: an orally efficacious novel taxane.

James G. Tarrant, C. Fairchild, J. Kadow, 2003, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of analogues of cryptolepine, an alkaloid isolated from the Suriname rainforest.

D. Kingston, I. Bursuker, C. Fairchild, 1999, Journal of natural products.

SYNTHESIS AND BIOLOGICAL EVALUATION OF C-1 AND RING MODIFIED A-NORPACLITAXELS

D. Kingston, C. Fairchild, K. Johnston, 1999 .

Synthesis and bioactivity of 2,4-diacyl analogues of paclitaxel.

D. Kingston, C. Fairchild, M. Chordia, 2001, Bioorganic & medicinal chemistry.

Novel C-4 Paclitaxel (Taxol) Analogues: Potent Antitumor Agents

Jianmei Wei, C. Fairchild, J. Kadow, 1996 .

Synthesis and biological evaluation of novel C-4 aziridine-bearing paclitaxel (taxol) analogs.

C. Fairchild, S. Chen, B. Long, 1995, Journal of medicinal chemistry.

First Syntheses of Novel Paclitaxel(Taxol) Analogs Modified at the C4-Position

C. Fairchild, J. Kadow, K. Johnston, 1994 .

First Syntheses of Novel Paclitaxel(Taxol) Analogues (I) Modified at the C-4-Position.

C. Fairchild, J. Kadow, K. Johnston, 1995 .

Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia.

E. P. Stout, Amy L. Lane, K. L. Le Roch, 2009, Organic letters.

Highly cytotoxic metabolites from the culture supernatant of the temperate dinoflagellate Protoceratium cf. reticulatum.

Y. Shimizu, C. Fairchild, M. Konishi, 2004, Journal of natural products.

Analysis of structure activity relationships for LPS-mimetic activities of taxane analogs in murine macrophages

C. Fairchild, S. Vogel, J. Kadow, 1999 .