A. Pegg

L. Fong, V. Nguyen, A. Pegg, 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.

A. Pegg, K. Goodtzova, T. M. Crone, 1996, Mutation research.

A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.

A. Pegg, T. M. Crone, 1993, Cancer research.

Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide.

A. Pegg, Liping Liu, M. Xu-Welliver, 2002, Cancer research.

Studies of the ethylation of rat liver transfer ribonucleic acid after administration of L-ethionine.

A. Pegg, 1972, The Biochemical journal.

Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine.

A. Pegg, P. Magee, E. Farber, 1971, The Biochemical journal.

O6-benzylguanine and its role in chemotherapy.

M. Dolan, A. Pegg, Anthony E. Pegg, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

O6-Benzylguanine-mediated enhancement of nitrosourea activity in Mer− central nervous system tumor xenografts – implications for clinical trials

S. Keir, D. Bigner, H. Friedman, 2000, Cancer Chemotherapy and Pharmacology.

Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.

M. Dolan, A. Pegg, R. Moschel, 1990, Cancer communications.

Modulation of cyclophosphamide activity by O 6-alkylguanine-DNA alkyltransferase

M. Dolan, S. Keir, D. Bigner, 1999, Cancer Chemotherapy and Pharmacology.

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.

M. Dolan, T. Byers, A. Pegg, 1993, Biochemistry.

Polyamine depletion inhibits etoposide-induced NF-κB activation in transformed mouse fibroblasts

E. Fiumana, C. Caldarera, F. Flamigni, 2004, Amino Acids.

Alkylation of DNA in rat tissues following administration of streptozotocin.

A. Pegg, R. Bennett, 1981, Cancer research.

DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy.

J. Tainer, J. L. Tubbs, A. Pegg, 2007, DNA repair.

S-Adenosylmethionine decarboxylase.

A. Pegg, 2009, Essays in biochemistry.

Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase.

A. Pegg, C. Coleman, H. Huang, 1996, The Biochemical journal.

In vitro study of proteolytic degradation of rat histidine decarboxylase.

F. Sánchez-Jiménez, A. Pegg, M. Medina, 2000, European journal of biochemistry.

DNA Repair and Carcinogenesis by Alkylating Agents

A. Pegg, 1990 .

Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine.

A. Pegg, S. Kanugula, S. Edara, 1999, Carcinogenesis.

Transformation Translational Repression Is Associated with Neoplastic Overproduction of Ornithine Decarboxylase Caused by Relief of Updated

L. Shantz, A. Pegg, 2006 .

Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA.

Delshanee Kotandeniya, N. Tretyakova, A. Pegg, 2011, Chemical research in toxicology.

Cytosine Methylation Effects on the Repair of O6-Methylguanines within CG Dinucleotides*

A. Pegg, Q. Fang, R. Guza, 2009, The Journal of Biological Chemistry.

Mechanisms and regulation of polyamine and putrescine biosynthesis in male genital glands and other tissues of mammals.

A. Pegg, D. Lockwood, H. G. Williams-Ashman, 1969, Advances in enzyme regulation.

Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism

S. Schold, D. Kokkinakis, A. Pegg, 2000, Cancer Chemotherapy and Pharmacology.

O6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents.

A. Pegg, N. Loktionova, L. Peterson, 2005, Chemical research in toxicology.

Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine.

N. Tretyakova, A. Pegg, L. Peterson, 2004, Chemical research in toxicology.

The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.

A. Pegg, R. Moschel, L. Peterson, 2004, Chemical research in toxicology.

Synthesis of DNA oligonucleotides containing site-specifically incorporated O6-[4-oxo-4-(3-pyridyl)butyl]guanine and their reaction with O6-alkylguanine-DNA alkyltransferase.

A. Pegg, L. Peterson, T. Spratt, 1999, Chemical research in toxicology.

Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.

A. Pegg, N. Loktionova, 1996, Cancer research.

Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.

M. Dolan, A. Pegg, L. Erickson, 1989, Carcinogenesis.

Growth Hormone Action on Rat Liver RNA Polymerase

A. Pegg, A. Korner, A. E. PEGG, 1965, Nature.

Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents.

M. Dolan, A. Pegg, G. S. Young, 1986, Cancer research.

Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferase.

M. Dolan, A. Pegg, 1987, Pharmacology & therapeutics.

Effect of starvation on initiation of protein synthesis in skeletal muscle and heart.

L. Jefferson, A. Pegg, S. Rannels, 1978, The American journal of physiology.

Starvation results in decreased initiation factor activity in rat skeletal muscle.

A. Pegg, S. Rannels, D. Rannels, 1976, Biochemical and biophysical research communications.

Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells

C. Byus, A. Pegg, A. Bachmann, 2005, Oncogene.

Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.

M. Dolan, A. Pegg, D. Scicchitano, 1984, Cancer research.

Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin.

A. Pegg, S. Bettuzzi, A. Caporali, 2005, Carcinogenesis.

Mechanistic Studies of the Processing of Human S-Adenosylmethionine Decarboxylase Proenzyme

A. Pegg, Haishan Xiong, 1999, The Journal of Biological Chemistry.

Processing of Mammalian and PlantS-Adenosylmethionine Decarboxylase Proenzymes*

B. Tekwani, A. Pegg, H. Xiong, 1997, The Journal of Biological Chemistry.

Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine.

Y. Pommier, P. Pourquier, A. Pegg, 2001, Cancer research.

Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosin

L. Shantz, A. Pegg, B. Stanley, 1992, Biochemistry.

Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase.

S. Oredsson, L. Marton, D. Deen, 1984, European Journal of Cancer and Clinical Oncology.

Inhibition of spermidine formation in rat liver and kidney by methylglyoxal bis(guanylhydrazone).

A. Pegg, 1973, The Biochemical journal.

Effect of inhibition of spermidine formation on protein and nucleic acid synthesis during lymphocyte activation

A. Pegg, J. Kay, 1973, FEBS letters.

-deoxyguanosine and Bcnu ′ -benzyl-2 6 O Treatment of Human Brain Tumor Xenografts with Updated Version Citing Articles E-mail Alerts Treatment of Human Brain Tumor Xenografts with 06-benzyl-2'-deoxyguanosine and Bcnu1

S. Schold, D. Kokkinakis, A. Pegg, 2013 .

Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine.

A. Pegg, Xiaojing Wang, 2011, Methods in molecular biology.

Purification and characterization of some metabolic effects of S-neplanocylmethionine.

R. Borchardt, A. Pegg, R. Clark, 1985, Molecular pharmacology.

Studies on inhibitors of mammalian tRNA methylases

A. Pegg, 1971, FEBS letters.

The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.

T. Byers, A. Pegg, J. Coward, 1994, The Biochemical journal.

Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion.

B. Ganem, T. Byers, A. Pegg, 1992, The Biochemical journal.

2-amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase.

A. Pegg, R. Moschel, N. Loktionova, 2004, Journal of medicinal chemistry.

Colonic polyamine content and ornithine decarboxylase activity as markers for adenomas

A. Pegg, T. Mcgarrity, M. Bartholomew, 1990, Cancer.

Formation and subsequent repair of alkylation lesions in tissues of rodents treated with nitrosamines.

A. Pegg, 1980, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells

M. Wada, A. Pegg, A. Shirahata, 2011, Amino Acids.

Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine.

A. Pegg, A. Hawks, 1971, The Biochemical journal.

Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin.

A. Pegg, L. Persson, G. J. Sertich, 1987, The American journal of physiology.

In vivo effects of α-dl-Difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei

P. McCann, A. Sjoerdsma, A. Pegg, 1983 .

The effects ofO6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells

L. Marton, D. Deen, A. Pegg, 2004, Cancer Chemotherapy and Pharmacology.

Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.

A. Pegg, K. Goodtzova, S. Kanugula, 1996, Cancer research.

Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts.

A. Pegg, M. Dolan, C. Mummert, 1991, Carcinogenesis.

Kinins V

A. Pegg, K. Abe, S. Fujii, 1989, Advances in Experimental Medicine and Biology.

Effects of inhibitors of spermidine and spermine synthesis on polyamine concentrations and growth of transformed mouse fibroblasts.

R. Borchardt, A. Pegg, J. Coward, 1981, The Biochemical journal.

Advances in Brief Expression of an Ornithine Decarboxylase Dominant-Negative Mutant Reverses Eukaryotic Initiation Factor 4 E-induced Cell Transformation '

L. Shantz, A. Pegg, C. Coleman, 2006 .

POL Y AMINES AS TARGETS FOR THERAPEUTIC INTERVENTION

L. Marton, A. Pegg, 1995 .

Formationof 06-Methylguanineby Alkylationof Rat Liver, Colon, and Kidney DNA followingAdministrationof

A. Pegg, K. Rogers, 1977 .

Unique Characteristics of the Parasite Polyamine Pathway.

A. Pegg, 2018, Structure.

Introduction to the Thematic Minireview Series: Sixty plus years of polyamine research

A. Pegg, 2018, The Journal of Biological Chemistry.

Properties of LI 210 Cells Resistant to a-Difluoromethylornithine1

A. Pegg, John A. Serrisi, 2006 .

Pegg and as a Target for Chemotherapy Polyamine Metabolism and Its Importance in Neoplastic Growth

A. Pegg, 2006 .

Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei

B. Tekwani, A. Pegg, C. Bacchi, 1992, Molecular and Cellular Biochemistry.

Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.

A. Pegg, C. Coleman, J. Sawicki, 2002, Carcinogenesis.

Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy.

L. Shantz, A. Pegg, D. Feith, 2000, The Biochemical journal.

Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents.

A. Pegg, J. Coward, 1993, Biochemical Pharmacology.

Regulation of polyamine transport in Chinese hamster ovary cells

T. Byers, A. Pegg, 1990, Journal of cellular physiology.

Properties of human and rodent S-adenosylmethionine decarboxylase.

O. Jänne, A. Crozat, A. Pegg, 1988, Advances in experimental medicine and biology.

Increase in S-adenosylmethionine decarboxylase in SV-3T3 cells treated with S-methyl-5'-methylthioadenosine.

A. Pegg, R. Wechter, A. Pajunen, 1987, The Biochemical journal.

Specific multisubstrate adduct inhibitors of aminopropyltransferases and their effect on polyamine biosynthesis in cultured cells.

A. Pegg, J. Coward, 1987, Advances in enzyme regulation.

S‐Adenosylmethionine decarboxylase: A brief review

A. Pegg, A. Pegg, Anthony E. Pegg, 1984, Cell biochemistry and function.

Autoradiographic localization of ornithine decarboxylase.

I. Zagon, A. Pegg, J. Seely, 1983, Methods in enzymology.

Regulation of polyamine content in cultured fibroblasts.

A. Pegg, H. Hibasami, D. Bethell, 1982, The American journal of physiology.

Effect of carbon tetrachloride on polyamine metabolism in rodent liver.

A. Pegg, H. Pösö, 1982, Archives of biochemistry and biophysics.

Effect of androgens on turnover of ornithine decarboxylase in mouse kidney. Studies using labeling of the enzyme by reaction with [14C] alpha-difluoromethylornithine.

A. Pegg, J. Seely, H. Pösö, 1982, The Journal of biological chemistry.

Purification of ornithine decarboxylase from kidneys of androgen-treated mice.

A. Pegg, J. Seely, H. Pösö, 1982, Biochemistry.

Autoradiographic identification of ornithine decarboxylase in mouse kidney by means of alpha-[5-14C]difluoromethylornithine.

I. Zagon, A. Pegg, J. Seely, 1982, Science.

Effect of alpha-difluoromethylornithine on polyamine and DNA synthesis in regenerating rat liver: reversal of inhibition of DNA synthesis by putrescine.

A. Pegg, H. Pösö, Anthony E. Pegg, 1982, Biochimica et biophysica acta.

Effect of inhibition of polyamine synthesis on the content of decarboxylated S-adenosylmethionine.

A. Pegg, R. Bennett, H. Pösö, 1982, The Biochemical journal.

Formation of putrescine in rat liver.

A. Pegg, J. Seely, H. Pösö, 1981, Medical biology.

Polyamines are needed for the differentiation of 3T3-L1 fibroblasts into adipose cells.

A. Pegg, D. Bethell, 1981, Biochemical and biophysical research communications.

Effect of alpha-difluoromethylornithine on cardiac polyamine content and hypertrophy.

A. Pegg, 1981, Journal of molecular and cellular cardiology.

Formation and interconversion of putrescine and spermidine in mammalian cells.

A. Pegg, H. Hibasami, D. Bethell, 1980, Advances in enzyme regulation.

Biosynthesis of putrescine in the prostate gland of the rat.

A. Pegg, H. G. Williams-Ashman, 1968, The Biochemical journal.

Tumor Cells to the Cytotoxic Effects of Alkylating Agents-Benzylguanine Analogues on Sensitivity of Human 6 O Effect of Updated

A. Pegg, R. B. Mitchell, C. Mummert, 2006 .

Effect of 06-Benzylguanine Analogues on Sensitivity of Human Tumor Cells to the Cytotoxic Effects of Alkylating Agents 1

A. Pegg, R. B. Mitchell, C. Mummert, 2006 .

Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice.

L. Shantz, A. Pegg, P. Welsh, 2006, The Biochemical journal.

Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

D. Koomoa, A. Pegg, A. Bachmann, 2009, Molecular Cancer Therapeutics.

Effect of polyamine analogues and inhibition of polyamine oxidase on spermidine/spermine N1-acetyltransferase activity and cell proliferation.

A. Pegg, R. Hu, 1995, Cancer letters.

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.

R. McLendon, A. Friedman, M. Dolan, 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide.

A. Pegg, Rebecca A. Hillary, 2003, Biochimica et biophysica acta.

Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation.

L. Shantz, A. Pegg, J. Sawicki, 2002, Carcinogenesis.

Nucleotide sequence of hamster S-adenosylmethionine decarboxylase cDNA.

B. Tekwani, A. Pegg, B. Stanley, 1992, Biochimica et biophysica acta.

Role of the carboxyl terminal MATEE sequence of spermidine/spermine N1-acetyltransferase in the activity and stabilization by the polyamine analog N1,N12-bis(ethyl)spermine.

A. Pegg, C. Coleman, H. Huang, 1995, Biochemistry.

Properties of spermidine N-acetyltransferase from livers of rats treated with carbon tetrachloride and its role in the conversion of spermidine into putrescine.

A. Pegg, I. Matsui, L. Wiegand, 1981, The Journal of biological chemistry.

Properties and Regulation of Human Spermidine/Spermine N 1-Acetyltransferase Stably Expressed in Chinese Hamster Ovary Cells*

A. Pegg, C. Coleman, D. McCloskey, 1999, The Journal of Biological Chemistry.

Mouse models to investigate the function of spermine

A. Pegg, Xiaojing Wang, 2009, Communicative & integrative biology.

High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.

A. Pegg, P. Celano, R. Casero, 1990, The Biochemical journal.

Ornithine decarboxylase (mouse kidney).

A. Pegg, J. Seely, 1983, Methods in enzymology.

Properties of the Spermidine/SpermineN 1-Acetyltransferase Mutant L156F That Decreases Cellular Sensitivity to the Polyamine AnalogueN 1,N 11-Bis(ethyl)norspermine*

A. Pegg, D. McCloskey, 2003, The Journal of Biological Chemistry.

Role of polyamines in differentiation of 3T3-L1 fibroblasts into adipocytes.

A. Pegg, B. Erwin, D. Bethell, 1984, The American journal of physiology.

Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine.

A. Pegg, S. Kanugula, T. M. Crone, 1995, Carcinogenesis.

Investigation of structure and rate of synthesis of ornithine decarboxylase protein in mouse kidney.

A. Pegg, J. Seely, L. Persson, 1984, Biochemistry.

Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites.

A. Pegg, P. Bey, R. Poulin, 1992, The Journal of biological chemistry.

Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase.

A. Pegg, R. Moschel, N. Loktionova, 2008, Biochemical pharmacology.

Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker.

A. Pegg, U. Choi, H. Malech, 2004, Experimental hematology.

Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1,N11-diethylnorspermine

E. Gabrielson, N. Davidson, A. Pegg, 2004, Cancer Chemotherapy and Pharmacology.

Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells

L. Loeb, M. Zago, D. Covas, 2006, Molecular Cancer Therapeutics.

The effects of diamines and polyamines on enzymic methylation of nucleic acid.

A. Pegg, 1971, Biochimica et biophysica acta.

Enzymic synthesis of spermine in rat prostate.

A. Pegg, H. G. Williams-Ashman, 1970, Archives of biochemistry and biophysics.

Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.

P. Kaldis, Suhwan Chang, A. Pegg, 2008, Cancer research.

Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.

P. Kaldis, Suhwan Chang, A. Pegg, 2008, Cancer research.

Degradation of BRCA 2 in Alkyltransferase-Mediated DNA Repair and Its Clinical Implications

P. Kaldis, Suhwan Chang, A. Pegg, 2008 .

Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA

A. Pegg, P. Swann, J. W. Nicoll, 1975, Nature.

Role of the 5'-untranslated region of mRNA in the synthesis of S-adenosylmethionine decarboxylase and its regulation by spermine.

L. Shantz, A. Pegg, R. Viswanath, 1994, The Biochemical journal.

Characterization of transgenic mice with widespread overexpression of spermine synthase.

L. Shantz, A. Pegg, C. Coleman, 2004, The Biochemical journal.

Overcoming Resistance to Alkylating Agents by Inhibitors of O 6-Alkylguanine-DNA Alkyltransferase

M. Dolan, A. Pegg, 2004 .

Comparison of inhibitors of S-adenosylmethionine decarboxylase from different species.

A. Pegg, G. Jacobs, 1983, The Biochemical journal.

Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosine.

F. Della Ragione, A. Pegg, 1983, The Biochemical journal.

Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice.

Hong Zhang, L. Kopelovich, Xiuwei Tang, 2004, The Journal of clinical investigation.

Inhibition of polyamine metabolism

P. McCann, A. Sjoerdsma, A. Pegg, 1988, Plant Growth Regulation.

Enhancing Human Spermine Synthase Activity by Engineered Mutations

Zhe Zhang, Emil Alexov, Yueli Zheng, 2013, PLoS Comput. Biol..

Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase.

M. Dolan, A. Pegg, M. Mcdougall, 1992, Journal of medicinal chemistry.

Phosphate-stimulated breakdown of 5'-methylthioadenosine by rat ventral prostate.

A. Pegg, H. G. Williams-Ashman, 1969, The Biochemical journal.

Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.

M. Dolan, A. Pegg, J. Mccormick, 1984, Carcinogenesis.

8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.

M. Dolan, A. Pegg, M. Chae, 1995, Journal of medicinal chemistry.

Conversion of exogenous spermidine into putrescine after administration to rats.

A. Pegg, H. Pösö, I. Matsui, 1982, Biochimica et biophysica acta.

Pharmacologic interference with enzymes of polyamine biosynthesis and of 5'-Methylthioadenosine metabolism

A. Pegg, 1987 .

The decarboxylation of S-adenosylmethionine by detergent-treated extracts of rat liver.

A. Pegg, H. G. Williams-Ashman, A. Corti, 1979, The Biochemical journal.

Differential inhibition of mammalian aminopropyltransferase activities.

A. Pegg, H. Hibasami, 1978, Biochemical and biophysical research communications.

On the role of S-adenosyl-L-methionine in the biosynthesis of spermidine by rat prostate.

A. Pegg, A E Pegg, H G Williams-Ashman, 1969, The Journal of biological chemistry.

Effects of certain 5'-substituted adenosines on polyamine synthesis: selective inhibitors of spermine synthase.

A. Pegg, J. Coward, J. Secrist, 1986, Biochemistry.

Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase.

R. Wu, P. Woster, A. Pegg, 1996, Bioorganic & medicinal chemistry.

Effects of Inhibition of O6‐Alkylguanine‐DNA Alkyltransferase in Rats on Carcinogenesis by Methylnitrosourea and Ethylnitrosourea

M. Anver, A. Pegg, R. Moschel, 1994, Japanese journal of cancer research : Gann.

Polyamine metabolism and cancer: treatments, challenges and opportunities

A. Pegg, R. Casero, R. Casero, 2018, Nature Reviews Cancer.

Current status of the polyamine research field.

A. Pegg, R. Casero, 2011, Methods in molecular biology.

Production of N1-acetyl spermidine by renal cell tumors.

A. Pegg, R. Huben, M. Pine, 1989, The Journal of urology.

Induction of Spermidine A/1-Acetyltransferase by Dialkylnitrosamines1

A. Pegg, I. Matsui, 1982 .

Effect of α-difluoromethylornithine on cardiac polyamine content and hypertrophy

A. Pegg, 1981 .

Effects of growth hormone and glucagon on ornithine decarboxylase activity and adenosine 3',5'-monophosphate levels in isolated rat hepatocytes.

L. Jefferson, A. Pegg, M. Klingensmith, 1980, Endocrinology.

Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells.

C. Caldarera, F. Flamigni, B. Tantini, 2001, The Biochemical journal.

Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents.

A. Pegg, A. Pegg, Anthony E. Pegg, 1977, Advances in cancer research.

Induction of spermidine/spermine N1-acetyltransferase by methylglyoxal bis(guanylhydrazone).

A. Pegg, B. Erwin, L. Persson, 1985, Biochimica et biophysica acta.

Polyamines as targets for therapeutic intervention.

L. Marton, A. Pegg, L J Marton, 1995, Annual review of pharmacology and toxicology.

Progress in Polyamine Research

A. Pegg, V. Zappia, 1988, Advances in Experimental Medicine and Biology.

Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells.

A. Pegg, G. Pelletier, R. Poulin, 1995, The Biochemical journal.

Recent advances in the biochemistry of polyamines in eukaryotes.

A. Pegg, 1986, The Biochemical journal.

Structural Basis of O6-Alkylguanine Recognition by a Bacterial Alkyltransferase-like DNA Repair Protein*

Mei Jiang, John A Tainer, Ta-Tsen Soong, 2010, The Journal of Biological Chemistry.

Regulation of ornithine decarboxylase expression by anisosmotic shock in alpha-difluoromethylornithine-resistant L1210 cells.

A. Pegg, R. Poulin, 1990, The Journal of biological chemistry.

Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.

M. Dolan, A. Pegg, M. Chae, 1995, Biochemical pharmacology.

Possible factors in the potentiation of 1-(2-chloroethyl)-3-trans-4-methylcyclohexyl-1-nitrosourea cytotoxicity by alpha-difluoromethylornithine in 9L rat brain tumor cells.

S. Oredsson, L. Marton, D. Deen, 1984, European journal of cancer & clinical oncology.

Function of domains of human O6-alkylguanine-DNA alkyltransferase.

A. Pegg, Q. Fang, S. Kanugula, 2005, Biochemistry.

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

J. Tainer, C. Mol, A. Pegg, 2000, The EMBO journal.

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

A. Pegg, A E Pegg, A. Pegg, 1988, Cancer research.

DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells.

N. Tretyakova, A. Pegg, C. Campbell, 2013, Biochemistry.

O6-Alkylguanine-DNA Alkyltransferase

A. Pegg, N. Loktionova, S. Kanugula, 2011 .

Repair of O4-Alkylthymine by O6-Alkylguanine-DNA Alkyltransferases*

J. Tainer, J. L. Tubbs, A. Pegg, 2009, The Journal of Biological Chemistry.

Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.

J. Tainer, F. Guengerich, A. Noronha, 2008, Biochemistry.

Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide.

A. Pegg, N. Loktionova, Aley G. Kalapila, 2008, Chemical research in toxicology.

Interactions of Human O6-Alkylguanine-DNA Alkyltransferase (AGT) with Short Single-stranded DNAs*

M. Fried, A. Pegg, J. Rasimas, 2007, Journal of Biological Chemistry.

Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts.

A. Pegg, Anthony E. Pegg, 1978, Biochemical and biophysical research communications.

Removal of methylated purines from rat liver DNA after administration of dimethylnitrosamine.

A. Pegg, G. Hui, 1978, Cancer research.

Bioditribution ofO6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL

M. Grever, M. Dolan, H. Friedman, 2004, Cancer Chemotherapy and Pharmacology.

Effect ofO6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer

A. Pegg, R. Moschel, M. Dolan, 2004, Cancer Chemotherapy and Pharmacology.

Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.

M. Dolan, H. Friedman, A. Pegg, 1994, Cancer research.

Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

M. Dolan, A. Pegg, R. Moschel, 1993, Biochemical pharmacology.

Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.

M. Dolan, D. Bigner, G. Felker, 1992, Journal of the National Cancer Institute.

12 – INHIBITION OF POLYAMINE BIOSYNTHESIS AND FUNCTION AS AN APPROACH TO DRUG DESIGN

A. Pegg, 1989 .

Mammalian polyamine metabolism and function

A. Pegg, 2009, IUBMB life.

Molecular Mechanisms of Chemical Carcinogenesis

A. Pegg, P. Magee, P. Swann, 1975 .

Role of pyridoxal phosphate in mammalian polyamine biosynthesis. Lack of requirement for mammalian S-adenosylmethionine decarboxylase activity.

A. Pegg, 1977, The Biochemical journal.

Stereochemistry of the decarboxylation of l-ornithine with ornithine decarboxylase from mouse kidney

A. Pegg, S. Gould, J. Seely, 1984 .

Effect of mutations at active site residues on the activity of ornithine decarboxylase and its inhibition by active site-directed irreversible inhibitors.

A. Pegg, C. Coleman, B. Stanley, 1993, The Journal of biological chemistry.

Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.

M. Dolan, A. Pegg, D. Scicchitano, 1985, Environmental health perspectives.

Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome).

R. Stevenson, C. Schwartz, A. Pegg, 2011, Methods in molecular biology.

Aminopropyltransferases: function, structure and genetics.

M. Bewley, A. Pegg, Yoshihiko Ikeguchi, 2006, Journal of biochemistry.

Primary structure of rat spermidine synthase: an example of refining the cDNA-derived amino acid sequence.

M. Wada, A. Pegg, A. Shirahata, 1999, Biological & pharmaceutical bulletin.

Purification of rat liver S-adenosyl-L-methionine decarboxylase.

A. Pegg, A. Pegg, 1974, The Biochemical journal.

Induction of spermidine/spermine N1-acetyltransferase in rat tissues by polyamines.

A. Pegg, B. Erwin, 1985, The Biochemical journal.

Effect of putrescine on the synthesis of S-adenosylmethionine decarboxylase.

A. Pegg, T. Kameji, 1987, The Biochemical journal.

Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant.

W. Tolbert, A. Pegg, S. Ealick, 2001, Biochemistry.

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor

Aled Edwards, Cheryl Arrowsmith, Steven Beasley, 2002, Nature Structural Biology.

Progress in polyamine research : novel biochemical, pharmacological, and clinical aspects

A. Pegg, V. Zappia, 1988 .

Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism.

A. Pegg, J. Coward, K. Tang, 1982, Biochemistry.

Acetylation of decarboxylated S-adenosylmethionine by mammalian cells.

A. Pegg, R. Wechter, R. Clark, 1986, Biochemistry.

Growth of mammalian cells in the absence of the accumulation of spermine.

A. Pegg, J. Coward, 1985, Biochemical and biophysical research communications.

Determination of cellular decarboxylated S-adenosylmethionine content.

A. Pegg, R. Bennett, 1983, Methods in enzymology.

Decarboxylated S-adenosylmethionine in mammalian cells.

A. Pegg, H. Hibasami, J. L. Hoffman, 1980, The Journal of biological chemistry.

Inhibition of cytomegalovirus-stimulated human cell ornithine decarboxylase by alpha-difluoromethylornithine.

A. Pegg, H. Isom, 1979, Biochimica et biophysica acta.

The accumulation of O6-methylguanine in the liver and kidney DNA of rats treated with dimethylinitrosamine for a short or a long period.

A. Pegg, P. Swann, J. W. Nicoll, 1977, Chemico-biological interactions.

Stimulation of the decarboxylation of S-adenosylmethionine by putrescine in mammalian tissues.

A. Pegg, H. G. Williams-Ashman, 1968, Biochemical and biophysical research communications.

Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.

E. Gabrielson, A. Pegg, R. Casero, 1994, Cancer research.

Methylation of rat liver mitochondrial deoxyribonucleic acid by chemical carcinogens and associated alterations in physical properties.

A. Pegg, R. Wilkinson, A. Hawks, 1975, Chemico-biological interactions.

Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2-dimethylhydrazine by aminoacetonitrile.

A. Pegg, A. E. Pegg, Anthony E. Pegg, 1978, Chemico-biological interactions.

BIOSYNTHESIS OF PUTRESCINE AND POLYAMINES IN MAMMALIAN TISSUES *

A. Pegg, 1970 .

Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen.

J. Swenberg, A. Pegg, M. Bedell, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Alkylation of rat liver DNA by dimethylnitrosamine: effect of dosage on O6-methylguanine levels.

A. Pegg, 1977, Journal of the National Cancer Institute.

Alkylation of intracellular and extracellular DNA by dimethylnitrosamine following activation by isolated rat hepatocytes.

A. Pegg, D. Umbenhauer, 1981, Cancer research.

Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA

A. Pegg, Anthony E. Pegg, 1978, Nature.

Effects of aliphatic diamines on rat liver ornithine decarboxylase activity.

C. Conover, A. Pegg, A. Wrona, 1978, The Biochemical journal.

Occurrence and induction of spermidine-N1-acetyltransferase in Escherichia coli.

S. Otani, A. Pegg, M. Kamei, 1982, Biochemical and biophysical research communications.

Studies on ornithine decarboxylase activity in the isolated perfused rat liver.

L. Jefferson, A. Pegg, 1977, Biochimica et biophysica acta.

Differential inhibition of histone and polyamine acetylases by multisubstrate analogues.

A. Pegg, B. Erwin, L. Persson, 1984, Biochemistry.

Changes in tRNA methylase activity of rat kidney following administration of the carcinogen, dimethylnitrosamine.

B. Stewart, A. Pegg, 1972, Biochimica et biophysica acta.

Rapid effects of testosterone in prostatic polyamine-synthesizing enzyme systems.

A. Pegg, H. G. Williams-Ashman, 1968, The Biochemical journal.

Polyamine metabolism and cancer: treatments, challenges and opportunities

A. Pegg, R. Casero, T. Murray Stewart, 2018, Nature Reviews Cancer.

Depletion of O6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine.

M. Dolan, A. Pegg, J. Mccormick, 1985, Carcinogenesis.

Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.

M. Dolan, A. Pegg, K. Morimoto, 1985, Cancer research.

Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents.

M. Dolan, A. Pegg, C. Corsico, 1985, Biochemical and biophysical research communications.

Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.

S. Schold, D. Bocangel, D. Kokkinakis, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea.

S. Schold, D. Kokkinakis, A. Pegg, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase synthesis by antisense oligodeoxynucleotides

R. Madhubala, A. Pegg, 1992, Molecular and Cellular Biochemistry.

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.

M M Haglund, T Kerby, R. McLendon, 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea

R. McLendon, D. Bigner, S. Kurpad, 1997, Cancer Chemotherapy and Pharmacology.

Mechanism of depletion of O6-methylguanine-DNA methyltransferase activity in rat tissues by O6-Benzyl-2'-deoxyguanosine. Role of metabolism.

S. Schold, D. Kokkinakis, A. Pegg, 1996, In Vivo.

Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats.

M. Dolan, S. Schold, D. Kokkinakis, 1994, Chemical Research in Toxicology.

O6-alkylguanine-DNA alkyltransferase activity in human brain and brain tumors.

P. Kleihues, O. Wiestler, A. Pegg, 1984, Carcinogenesis.

Structure and regulation of mammalian S-adenosylmethionine decarboxylase.

R. Madhubala, O. Jänne, A. Crozat, 1988, The Journal of biological chemistry.

Properties of L1210 cells resistant to α-difluoromethylornithine

R. Madhubala, A. Pegg, J. Secrist, 1988 .

Properties of L1210 cells resistant to alpha-difluoromethylornithine.

R. Madhubala, A. Pegg, J. Secrist, 1988, Cancer Research.

Inhibition of translation of mRNAs for ornithine decarboxylase and S-adenosylmethionine decarboxylase by polyamines.

A. Pegg, T. Kameji, 1987, The Journal of biological chemistry.

Regulation of S-adenosylmethionine decarboxylase activity in rat liver and prostate.

A. Pegg, A. Shirahata, 1985, The Journal of biological chemistry.

Escherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action.

F. Ragione, F. Della Ragione, A. Pegg, 1985, The Biochemical journal.

Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase.

M. Dolan, A. Pegg, R. Moschel, 1995, Progress in nucleic acid research and molecular biology.

Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase.

M. Dolan, A. Pegg, M. Mcdougall, 1994, Journal of medicinal chemistry.

A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities.

A. Pegg, R. Moschel, G. Pauly, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Inactivation of human O(6)-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O(6)-benzylguanine.

A. Pegg, R. Moschel, N. Loktionova, 2001, The Journal of pharmacology and experimental therapeutics.

Reaction ofO 6-Benzylguanine-resistant Mutants of Human O 6-Alkylguanine-DNA Alkyltransferase with O 6-Benzylguanine in Oligodeoxyribonucleotides*

A. Pegg, R. Moschel, G. Pauly, 1998, The Journal of Biological Chemistry.

O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.

M. Dolan, A. Pegg, S. Roy, 1998, Biochemical pharmacology.

Repair of O6-alkylguanine by alkyltransferases

A. Pegg, 2000 .

Leukocyte O 6-Alkylguanine-DNA Alkyltransferase from Human Donors Is Uniformly Sensitive to O 6-Benzylguanine 1

Lili Liu, A. Pegg, S. Gerson, 1999 .

Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine.

A. Pegg, M. Xu-Welliver, S. Kanugula, 1998, Cancer research.

Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.

A. Pegg, K. Goodtzova, S. Edara, 1994, Cancer research.

Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine.

M. Dolan, A. Pegg, R. Moschel, 1991, Carcinogenesis.

Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.

M. Dolan, A. Pegg, L. Erickson, 1988, Cancer research.

Repair of O-alkylpyrimidines in mammalian cells: a present consensus.

H. Fraenkel-conrat, M. Dolan, G. Margison, 1988, Proceedings of the National Academy of Sciences of the United States of America.

O6-alkylguanine-DNA alkyltransferase activity in normal human tissues and cells.

C. Harris, B. Trump, A. Pegg, 1984, Cancer research.

New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine†

W. Guida, A. Pegg, S. Ealick, 2009, Journal of medicinal chemistry.

S-adenosylmethionine decarboxylase: structure, function and regulation by polyamines.

L. Shantz, A. Pegg, H. Xiong, 1998, Biochemical Society transactions.

Control of ornithine decarboxylase activity in alpha-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues.

R. Madhubala, R. Bergeron, A. Pegg, 1988, The Journal of biological chemistry.

The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine.

E. Gabrielson, A. Pegg, R. Casero, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

The Upstream Open Reading Frame of the mRNA Encoding S-Adenosylmethionine Decarboxylase Is a Polyamine-responsive Translational Control Element*

D. Morris, L. Shantz, A. Pegg, 1996, The Journal of Biological Chemistry.

S-adenosylmethionine decarboxylase as an enzyme target for therapy.

P. McCann, A. Pegg, 1992, Pharmacology & therapeutics.

Detection of proenzyme form of S-adenosylmethionine decarboxylase in extracts from rat prostate.

A. Pegg, L. Wiest, A. Pajunen, 1988, Biochemical and biophysical research communications.

5 – The Use of Inhibitors to Study the Biochemistry and Molecular Biology of Polyamine Biosynthesis and Uptake

A. Pegg, 1987 .

The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold.

I. Mathews, A. Pegg, S. Ealick, 1999, Structure.

Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway.

L. Shantz, A. Pegg, 1999, The international journal of biochemistry & cell biology.

Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase.

A. Pegg, P. Celano, R. Casero, 1991, Biochemical and biophysical research communications.

Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.

M. Dolan, D. Bigner, H. Friedman, 2004, Molecular cancer therapeutics.

Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model

F. Balis, B. Widemann, A. Pegg, 2011, Cancer Chemotherapy and Pharmacology.

Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.

A. Pegg, R. Moschel, N. Loktionova, 2007, Journal of medicinal chemistry.

Interaction of mammalian O6-alkylguanine-DNA alkyltransferases with O6-benzylguanine

A. Pegg, N. Loktionova, 2002 .

Effect of DNA on the inactivation of O6-alkylguanine-DNA alkyltransferase by 9-substituted O6-benzylguanine derivatives.

A. Pegg, R. Moschel, L. Chung, 1997, Biochemical pharmacology.

Specific labeling of O6-alkylguanine-DNA alkyltransferase by reaction with O6-(p-hydroxy[3H]methylbenzyl)guanine.

I. Zagon, P. McLaughlin, A. Pegg, 1995, Cancer research.

Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine

M. Dolan, G. Larkin, A. Pegg, 2004, Cancer Chemotherapy and Pharmacology.

Kinetic Analysis of Steps in the Repair of Damaged DNA by Human O6-Alkylguanine-DNA Alkyltransferase*

F. Guengerich, A. Pegg, Q. Fang, 2005, Journal of Biological Chemistry.

Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.

A. Pegg, N. Loktionova, M. Xu-Welliver, 1999, Biochemical pharmacology.

Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.

A. Pegg, M. Xu-Welliver, S. Kanugula, 1999, Cancer research.

DNA binding mechanism of O6-alkylguanine-DNA alkyltransferase: stoichiometry and effects of DNA base composition and secondary structure on complex stability.

M. Fried, A. Pegg, J. Bromberg, 1996, Biochemistry.

Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine.

A. Pegg, K. Goodtzova, S. Kanugula, 1995, Biochemistry.

Activation of human O6-alkylguanine-DNA alkyltransferase by DNA.

A. Pegg, K. Goodtzova, T. M. Crone, 1994, Biochemistry.

Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.

M. Dolan, A. Pegg, S. Gerson, 1991, Carcinogenesis.

Kinetics of repair of O6-methylguanine in dna by O6-methylguanine-DNA methyltransferase in vitro and in vivo.

A. Pegg, D. Scicchitano, 1982, Biochemical and biophysical research communications.

Alkylated DNA damage flipping bridges base and nucleotide excision repair

John A Tainer, Oliver Fleck, J. Tainer, 2009, Nature.

Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase.

A. Pegg, M. Xu-Welliver, 2002, Carcinogenesis.

Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.

Sai Lakshmana Vankayala, W. Guida, S. L. Vankayala, 2008, Journal of medicinal chemistry.

Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.

A. Pegg, N. Loktionova, M. Xu-Welliver, 2000, The Biochemical journal.

Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.

A. Pegg, M. Xu-Welliver, 2000, The Biochemical journal.

Repair of O(6)-alkylguanine by alkyltransferases.

A. Pegg, 2000, Mutation research.

Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase.

A. Pegg, T. Spratt, D. Levy, 1999, Biochemistry.

Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts.

A. Pegg, M. Dolan, J. Mccormick, 1991, Mutation research.

Sequence specificity of guanine alkylation and repair.

M. Dolan, A. Pegg, A. Pegg, 1988, Carcinogenesis.

Inhibition of O6-alkylguanine-DNA-alkyltransferase by metals.

A. Pegg, D. Scicchitano, 1987, Mutation research.

Repair of oligodeoxynucleotides containing O6-methylguanine by O6-alkylguanine-DNA-alkyltransferase.

B. Gaffney, J. Essigmann, A. Pegg, 1986, Carcinogenesis.

Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli.

M. Dolan, A. Pegg, D. Scicchitano, 1985, Carcinogenesis.

Characterization of a Mutagenic DNA Adduct Formed from 1,2-Dibromoethane by O6-Alkylguanine-DNA Alkyltransferase*

F. Guengerich, A. Pegg, N. Loktionova, 2004, Journal of Biological Chemistry.

Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus.

A. Pegg, S. Kanugula, 2003, The Biochemical journal.

DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability.

M. Fried, A. Pegg, J. Rasimas, 2003, The Journal of biological chemistry.

Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.

M. Dolan, M. Wu, A. Pegg, 2000, Cancer research.

Effect of O 6-Benzylguanine on Alkylating Agent-induced Toxicity and Mutagenicity in Chinese Hamster Ovary Cells Expressing Wild-Type and Mutant O 6-Alkylguanine-DNA Alkyltransferases 1

M. Dolan, A. Pegg, Yingna Cai, 2000 .

Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.

A. Pegg, W. Meehan, M. Xu-Welliver, 1999, Biochemical pharmacology.

Synthesis and characterization of an O(6)-2'-deoxyguanosine-alkyl-O(6)-2'-deoxyguanosine interstrand cross-link in a 5'-GNC motif and repair by human O(6)-alkylguanine-DNA alkyltransferase.

A. Noronha, C. Wilds, A. Pegg, 2010, Organic & biomolecular chemistry.

Novel DNA repair alkyltransferase from Caenorhabditis elegans

A. Pegg, S. Kanugula, 2001, Environmental and molecular mutagenesis.

Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine.

J. Swenberg, A. Pegg, S. O'Toole, 1993, Cancer research.

Properties of mammalian O6-alkylguanine-DNA transferases.

A. Pegg, 1990, Mutation research.

Investigation of Sequence Specificity in DNA Alkylation and Repair Using Oligodeoxynucleotide Substrates

M. Dolan, A. Pegg, 1989 .

Activity of temozolomide in the treatment of central nervous system tumor xenografts.

M. Dolan, S. Keir, D. Bigner, 1995, Cancer research.

Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins.

A. Pegg, W. Perry, 1981, Carcinogenesis.

Enzymatic release of 7-methylguanine from methylated DNA by rodent liver extracts.

G. Margison, A. Pegg, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli.

M. Dolan, A. Pegg, D. Scicchitano, 1984, Biochemical and biophysical research communications.

Metabolism of dimethylnitrosamine and subsequent removal of O6-methylguanine from DNA by isolated rat hepatocytes.

A. Pegg, D. Umbenhauer, 1981, Chemico-biological interactions.

Measurement of the amount of ornithine decarboxylase in Saccharomyces cerevisiae and Saccharomyces uvarum by using alpha-[5-14C]difluoromethylornithine.

A. Pegg, H. Pösö, 1983, Biochimica et biophysica acta.

Ornithine decarboxylase from hepatoma cells and a variant cell line in which the enzyme is more stable.

L. Jefferson, A. Pegg, M. L. Pritchard, 1982, The Journal of biological chemistry.

Mechanism of stimulation of ornithine decarboxylase activity in transformed mouse fibroblasts.

A. Pegg, J. Seely, B. Erwin, 1983, Biochemistry.

[23] Ornithine Decarboxylase (Mouse Kidney)

A. Pegg, J. Seely, 1983 .

Alkylation of transfer RNA by N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea.

A. Pegg, Anthony E. Pegg, 1973, Chemico-biological interactions.

Effect of 06-Alkylguanine Pretreatment on the Sensitivity of Human Colon Tumor Cells to the Cytotoxic Effects of Chloroethy lating Agents1

M. Dolan, A. Pegg, G. S. Young, 2006 .

The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.

S E Ealick, I. Mathews, W. Tolbert, 2001, Biochemistry.

Studies of the base composition of transfer rna and the specificity of transfer rna methylases of hamster liver

A. Pegg, A. Jackson, 1975 .

Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells.

R. Bergeron, A. Pegg, R. Pakala, 1989, The Journal of biological chemistry.

Increase in acetylation of spermidine in rat liver extracts brought about by treatment with carbon tetrachloride.

A. Pegg, I. Matsui, 1980, Biochemical and biophysical research communications.

Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity.

A. Pegg, S. Ealick, S. Bale, 2010, Acta crystallographica. Section D, Biological crystallography.

Evolutionary Links as Revealed by the Structure of Thermotoga maritima S-Adenosylmethionine Decarboxylase*

C. Kinsland, A. Pegg, S. Ealick, 2004, Journal of Biological Chemistry.

X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome

C. Skinner, R. Stevenson, C. Schwartz, 2003, European Journal of Human Genetics.

Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea.

A. Pegg, C. Mackintosh, 2000, The Biochemical journal.

Altered Spermidine/SpermineN 1-Acetyltransferase Activity as a Mechanism of Cellular Resistance to Bis(ethyl)polyamine Analogues*

A. Pegg, D. McCloskey, 2000, The Journal of Biological Chemistry.

alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.

A. Pegg, J. Coward, J. R. Lakanen, 1992, Journal of medicinal chemistry.

Ornithine decarboxylase as an enzyme target for therapy.

P. McCann, A. Pegg, P P McCann, 1992, Pharmacology & therapeutics.

Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator.

A. Pegg, Anthony E Pegg, 2008, American journal of physiology. Endocrinology and metabolism.

Spermidine N-acetyltransferase.

F. Della Ragione, A. Pegg, 1983, Methods in enzymology.

Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver.

F. Ragione, A. Pegg, 1982, Biochemistry.

Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine.

R. Bergeron, C. Porter, A. Pegg, 1990, The Biochemical journal.

Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function.

A. Pegg, J. Coward, R. Poulin, 1995, The international journal of biochemistry & cell biology.

Spermine synthase

A. Pegg, A. Michael, 2009, Cellular and Molecular Life Sciences.

Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermine (corrected) and related compounds.

R. Bergeron, A. Pegg, R. Pakala, 1990, The Biochemical journal.

Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine.

R. Bergeron, A. Pegg, L. Albanese, 1993, The Biochemical journal.

Expression of a human gene for polyamine transport in Chinese-hamster ovary cells.

T. Byers, A. Pegg, R. Wechter, 1989, The Biochemical journal.

Multiple pathways for uptake of paraquat, methylglyoxal bis(guanylhydrazone), and polyamines.

T. Byers, A. Pegg, D. Rannels, 1987, The American journal of physiology.

Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine.

R. Bergeron, C. Porter, A. Pegg, 1987, The Biochemical journal.

Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress.

A. Pegg, J. Coward, R. Poulin, 1993, The Journal of biological chemistry.

S-adenosylmethionine decarboxylase (rat liver).

A. Pegg, H. Pösö, 1983, Methods in enzymology.

Increased content of mRNA for a precursor of S-adenosylmethionine decarboxylase in rat prostate after treatment with 2-difluoromethylornithine.

A. Pegg, A. Shirahata, 1986, The Journal of biological chemistry.

Quantitation of S-adenosylmethionine decarboxylase protein.

A. Pegg, K. Christman, A. Shirahata, 1985, Biochemistry.

Evidence for the presence of pyruvate in rat liver S‐adenosylmethionine decarboxylase

A. Pegg, A. Pegg, Anthony E. Pegg, 1977, FEBS letters.

Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase.

A. Pegg, H. Xiong, B. Stanley, 1999, Biochemistry.

[40] Inhibitors of S-adenosylmethionine decarboxylase

A. Pegg, 1983 .

Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues.

B. Tekwani, A. Pegg, C. Bacchi, 1992, Biochemical pharmacology.

Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney.

A. Pegg, J. Seely, L. Persson, 1985, The Biochemical journal.

Studies of mammalian ornithine decarboxylase using a monoclonal antibody.

M. Herlyn, A. Pegg, J. Seely, 1984, The Biochemical journal.

Effect of 1,3-diaminopropane on ornithine decarboxylase enzyme protein in thioacetamide-treated rat liver.

A. Pegg, J. Seely, 1983, The Biochemical journal.

Measurement of the number of ornithine decarboxylase molecules in rat and mouse tissues under various physiological conditions by binding of radiolabelled alpha-difluoromethylornithine.

A. Pegg, J. Seely, H. Pösö, 1982, The Biochemical journal.

Binding of radioactive α-difluoromethylorithine to rat liver ornithine decarboxylase

L. Jefferson, A. Pegg, J. Seely, 1981 .

Investigation of the turnover of rat liver S-adenosylmethionine decarboxylase using a specific antibody.

A. Pegg, 1979, The Journal of biological chemistry.

Amino acid residues necessary for putrescine stimulation of human S-adenosylmethionine decarboxylase proenzyme processing and catalytic activity.

A. Pegg, B. Stanley, 1991, The Journal of biological chemistry.

Site of pyruvate formation and processing of mammalian S-adenosylmethionine decarboxylase proenzyme.

A. Pegg, I. Holm, B. Stanley, 1989, The Journal of biological chemistry.

Effects of S-adenosyl-1,8-diamino-3-thio-octane and S-methyl-5'-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells.

A. Pegg, I. Holm, L. Persson, 1989, The Biochemical journal.

Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells.

D. Jones, A. Pegg, J. Secrist, 1988, Biochemistry.

Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane.

A. Pegg, J. Coward, K. Tang, 1980, Biochemical and biophysical research communications.

Rapid and convenient method for the assay of aminopropyltransferases.

A. Pegg, H. Hibasami, 1978, The Biochemical journal.

Inhibition of mammalian S-adenosylmethionine decarboxylase activity by 1,1'-((methylethanediylidene)-dinitrilo)bis(3-aminoguanidine).

A. Pegg, 1978, The Journal of biological chemistry.

Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells.

R. Madhubala, A. Pegg, J. Secrist, 1988, The Biochemical journal.

Abstract 2483: Transgenic mice to evaluate the role of S-adenosylmethionine decarboxylase in skin carcinogenesis

A. Pegg, D. Feith, D. McCloskey, 2010 .

Structure and mechanism of spermidine synthases.

J. Min, A. Pegg, A. Plotnikov, 2007, Biochemistry.

Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis.

L. Shantz, A. Pegg, D. Feith, 2001, Cancer research.

Ornithine decarboxylase induction in transformation by H-Ras and RhoA.

L. Shantz, A. Pegg, A E Pegg, 1998, Cancer research.

Assay of spermidine and spermine synthases.

A. Pegg, A E Pegg, L Wiest, 1998, Methods in molecular biology.

Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells.

S. Kar, B. Carr, A. Pegg, 1997, The Biochemical journal.

Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content.

O. Jänne, L. Shantz, A. Pegg, 1992, The Biochemical journal.

Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase.

P. Woster, A. Pegg, J. Coward, 1989, Journal of medicinal chemistry.

Ornithine decarboxylase: structure, function and translational regulation.

L. Shantz, A. Pegg, C. Coleman, 1994, Biochemical Society transactions.

Expression of mammalian S-adenosylmethionine decarboxylase in Escherichia coli. Determination of sites for putrescine activation of activity and processing.

L. Shantz, A. Pegg, B. Stanley, 1994, The Journal of biological chemistry.

Nucleotide sequence of hamster spermidine/spermine-N1-acetyltransferase cDNA.

A. Pegg, R. Casero, B. Stanley, 1992, Biochimica et biophysica acta.

Regulation of spermidine/spermine N1-acetyltransferase in L6 cells by polyamines and related compounds.

A. Pegg, B. Erwin, 1986, The Biochemical journal.

Studies of the induction of spermidine/spermine N1-acetyltransferase using a specific antiserum.

A. Pegg, L. Persson, 1984, The Journal of biological chemistry.

Studies of the specificity and kinetics of rat liver spermidine/spermine N1-acetyltransferase.

F. Della Ragione, A. Pegg, 1983, The Biochemical journal.

Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.

A. Pegg, R. Moschel, N. Loktionova, 2005, Journal of medicinal chemistry.

The effect of trypsin digestion and ionic strength on RNA polymerase of rat liver.

A. Pegg, A. Korner, 1967, Archives of biochemistry and biophysics.

Use of a dodecadeoxynucleotide to study repair of the O4-methylthymine lesion.

M. Dolan, A. Pegg, M. Oplinger, 1988, Mutation research.

Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine.

A. Pegg, A E Pegg, G Hui, 1978, The Biochemical journal.

Metabolism of O6-alkyldeoxyguanosines and their effect on removal of O6-methylguanine from rat liver DNA.

A. Pegg, P. Swann, 1979, Biochimica et biophysica acta.

Regulation of O 6-Methylguanine-DNA Methyltransferase Levels in Rat Liver and Kidney 1

A. Pegg, Wiest, 2006 .

Regulation of O6-methylguanine-DNA methyltransferase levels in rat liver and kidney.

A. Pegg, L. Wiest, 1983, Cancer research.

Methylation of yeast aspartic acid transfer RNA by rat liver extracts

A. Pegg, 1972, FEBS letters.

Studies of inhibition of rat spermidine synthase and spermine synthase.

R. Borchardt, A. Pegg, J. Coward, 1980, The Biochemical journal.

The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

D. Geerts, R. Versteeg, H. Caron, 2010, International journal of cancer.

Proteasomal Degradation of Spermidine/Spermine N 1-Acetyltransferase Requires the Carboxyl-terminal Glutamic Acid Residues*

A. Pegg, C. Coleman, 1997, The Journal of Biological Chemistry.

Formation and removal of methylated nucleosides in nucleic acids of mammalian cells.

A. Pegg, 1983, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase.

J. Koopmeiners, N. Tretyakova, A. Pegg, 2013, Biochemistry.

Polyamine metabolism during cardiac hypertrophy.

A. Pegg, A E Pegg, H Hibasami, 1980, The American journal of physiology.

Topologies of complexes containing O6-alkylguanine-DNA alkyltransferase and DNA.

M. Fried, D. Rodgers, A. Pegg, 2009, Journal of molecular biology.

Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.

M. Dolan, S. Paikoff, A. Pegg, 2007, DNA repair.

O6-benzylguanine-mediated enhancement of chemotherapy.

Peter J Houghton, M Eileen Dolan, M. Dolan, 2002, Molecular cancer therapeutics.

Structure/function relationship studies on the T/S residues 173-177 of rat ODC.

F. Sánchez-Jiménez, A. Pegg, C. Coleman, 1998, Biochimica et biophysica acta.

Effect of thioacetamide, growth hormone or partial hepatectomy on spermidine acetylase activity of rat liver cytosol.

A. Pegg, I. Matsui, Anthony E. Pegg, 1980, Biochimica et biophysica acta.

Further investigation of the increased transfer ribonucleic acid methylase activity in tumours of the mouse colon.

A. Pegg, A. Hawks, 1974, The Biochemical journal.

α-Difluoromethylornithine Inhibits N-Nitrosomethylbenzylamine-induced Esophageal Carcinogenesis in Zinc-deficient Rats: Effects on Esophageal Cell Proliferation and Apoptosis

L. Fong, A. Pegg, P. Magee, 1998 .

Brain infarction correlates more closely with acrolein than with reactive oxygen species.

S. Kojima, K. Kashiwagi, A. Pegg, 2011, Biochemical and biophysical research communications.

Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.

L. Shantz, A. Pegg, A. Pegg, 1994, Cancer research.

A reappraisal of the effects of adenosine 3':5'-cyclic monophosphate on the function and morphology of the rat prostate gland.

A. Pegg, F. Mangan, I. P. Mainwaring, 1973, The Biochemical journal.

Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.

F. Guengerich, A. Pegg, G. Chowdhury, 2013, Angewandte Chemie.

Polyamine biosynthesis and interconversion in rodent tissues.

F. Della Ragione, A. Pegg, J. Seely, 1982, Federation proceedings.

Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.

P. Woster, A. Pegg, R. Wechter, 1989, Biochemistry.

Effects of inhibitors of S-adenosylmethionine decarboxylase and ornithine decarboxylase on DNA synthesis in rat liver after partial hepatectomy.

A. Pegg, L. Wiegand, 1978, Biochimica et biophysica acta.

O(6)-methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes.

J. Cairncross, C. Nutt, A. Chambers, 1999, Carcinogenesis.

Specificity of mammalian spermidine synthase and spermine synthase.

A. Pegg, H. Hibasami, K. Shuttleworth, 1981, Biochemical Journal.

Inhibition of diamine oxidase by 1,1-[(methylethanediylidene)-dinitrilo]-bis-(3-aminoguanidine) and 1,1'-[(methylethanediylidene)-dinitrilo]-diguanidine.

A. Pegg, S. McGill, 1978, Biochemical pharmacology.

Nitric Oxide Inhibits Ornithine Decarboxylase viaS-Nitrosylation of Cysteine 360 in the Active Site of the Enzyme*

L. Ignarro, A. Pegg, J. Fukuto, 2001, The Journal of Biological Chemistry.

Polyamine administration reduces ornithine decarboxylase activity without affecting its mRNA content.

A. Pegg, G. J. Sertich, 1987, Biochemical and biophysical research communications.

Caspase activation in etoposide‐treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion

C. Caldarera, F. Flamigni, B. Tantini, 2002, FEBS letters.

Spermidine/spermine N 1-acetyltransferase specifically binds to the integrin α9 subunit cytoplasmic domain and enhances cell migration

D. Sheppard, A. Pegg, C. Coleman, 2004, The Journal of cell biology.

Effects of the S-adenosylmethionine decarboxylase inhibitor, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures.

T. Byers, A. Pegg, R. Wechter, 1994, The Biochemical journal.

Drugs affecting the cell cycle via actions on the polyamine metabolic pathway.

A. Pegg, D. McCloskey, J. M. Ackermann, 2003, Progress in cell cycle research.

Carrier-mediated uptake of methylglyoxal bis(guanylhydrazone) by rat lungs perfused in situ.

A. Pegg, D. Rannels, J. L. Addison, 1985, The American journal of physiology.

DNA binding and nucleotide flipping by the human DNA repair protein AGT

J. Tainer, A. Pegg, Tammy T. Woo, 2004, Nature Structural &Molecular Biology.

The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with alpha-difluoromethylornithine.

A. Pegg, 1984, The Biochemical journal.

Uptake of α-difluoromethylornithine by mouse fibroblasts

A. Pegg, B. Erwin, 1982 .

Characterization of transgenic mice with overexpression of spermidine synthase

A. Pegg, P. Welsh, D. Feith, 2012, Amino Acids.

Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover.

A. Pegg, B. Stanley, A E Pegg, 1991, The Biochemical journal.

Effects of diamines on ornithine decarboxylase activity in control and virally transformed mouse fibroblasts.

A. Pegg, D. Bethell, 1979, The Biochemical journal.

Effect of partial hepatectomy on removal of O6-methylguanine from alkylated DNA by rat liver extracts.

A. Pegg, R. Bennett, W. Perry, 1981, The Biochemical journal.

Effects of inhibitors of ornithine and S‐adenosylmethionine decarboxylases on L6 myoblast proliferation

A. Pegg, C. Stoscheck, J. Florini, 1982, Journal of cellular physiology.

Spermidine uptake by type II pneumocytes: interactions of amine uptake pathways.

A. Pegg, S. Rannels, D. Rannels, 1989, The American journal of physiology.

Interaction of paraquat and amine uptake by rat lungs perfused in situ.

A. Pegg, R. Clark, D. Rannels, 1985, The American journal of physiology.

Sites of methylation of purified transfer ribonucleic acid preparations by enzymes from normal tissues and from tumours induced by dimethylnitrosamine and 1,2-dimethylhydrazine.

A. Pegg, 1974, The Biochemical journal.

Alkylation of DMA in Rat Tissues following Administration of Streptozotocin 1

A. Pegg, R. Bennett, 2004 .

Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences.

N. Tretyakova, A. Pegg, Q. Fang, 2006, Chemical research in toxicology.

Spermidine uptake by type II pulmonary epithelial cells in primary culture.

A. Pegg, S. Rannels, D. Rannels, 1989, The American journal of physiology.

Effect of pretreatment with other dialkylnitrosamines on excision from hepatic DNA of O6-methylguanine produced by dimethylnitrosamine.

A. Pegg, 1978, Chemico-biological interactions.

Alkylation of nucleic acids and metabolism of small doses of dimethylnitrosamine in the rat.

A. Pegg, W. Perry, 1981, Cancer research.

Metabolism of N-nitrosodimethylamine.

A. Pegg, 1980, IARC scientific publications.

Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase.

M. Fried, A. Pegg, J. Rasimas, 2003, Biochemistry.

Repair of alkylated DNA by cell extracts from various organs and species.

A. Pegg, 1983, Basic life sciences.

Alkylating intermediates in nitrosamine metabolism.

A. Pegg, P. Magee, P. Swann, 1975, Biochemical Society transactions.

Expression of arginase II in prostate cancer.

W. Grody, D. Seligson, S. Cederbaum, 2008, International journal of oncology.

Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy

Xueqian Zhang, J. Cheung, C. Caldarera, 2012, Amino Acids.

Effect of hypophysectomy on persistence of methylated purines in rat liver deoxyribonucleic acid after administration of dimethylnitrosamine.

A. Pegg, K. Rogers, G. Hui, 1978, Biochimica et biophysica acta.

Use of oligodeoxynucleotides containing O6-alkylguanine for the assay of O6-alkylguanine-DNA-alkyltransferase activity.

M. Dolan, A. Pegg, D. Scicchitano, 1988, Cancer research.

Saturation of repair system for O6-methylguanine in rat liver DNA by pretreatment with cyclic nitrosamines.

A. Pegg, W. Lijinsky, 1984, Chemico-biological interactions.

Properties of the O6-alkylguanine-DNA repair system of mammalian cells.

A. Pegg, 1984, IARC scientific publications.

Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase.

M. Dolan, A. Pegg, K. Morimoto, 1988, Chemico-biological interactions.

Formation and subsequent excision of O6-ethylguanine from DNA of rat liver following administration of diethylnitrosamine.

A. Pegg, B. Balog, 1979, Cancer research.

Effects of androgens on incorporation of labeled amino acids into proteins by prostate mitochondria.

A. Pegg, H. G. Williams-Ashman, 1968, Endocrinology.

Repair of O6-alkylguanine in cellular DNA: significance for tumour induction and chemotherapy

P. Kleihues, O. Wiestler, A. Pegg, 1984 .

Experimental evidence for structure-activity features in common between mammalian histidine decarboxylase and ornithine decarboxylase.

F. Sánchez-Jiménez, A. Pegg, M. Medina, 1996, The Biochemical journal.

Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase.

A. Pegg, R. Moschel, L. Peterson, 2007, Chemical research in toxicology.

O6-alkylguanine-DNA alkyltransferases repair O6-methylguanine in DNA with Michaelis-Menten-like kinetics.

A. Pegg, Q. Fang, T. Spratt, 2003, Chemical research in toxicology.

Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards.

N. Tretyakova, A. Pegg, Q. Fang, 2008, Chemical research in toxicology.

Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.

Kengo Watanabe, F. Guengerich, A. Pegg, 2007, Chemical research in toxicology.

New SMS mutation leads to a striking reduction in spermine synthase protein function and a severe form of Snyder–Robinson X-linked recessive mental retardation syndrome

C. Schwartz, M. Passos-Bueno, A. Pegg, 2008, Journal of Medical Genetics.

Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.

A. Pegg, C. Coleman, Anthony E. Pegg, 2001, The Biochemical journal.

Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine.

A. Pegg, R. Balaña Fouce, L. Parry, 1995, The Biochemical journal.

Effect of spermine synthase on the sensitivity of cells to anti-tumour agents.

A. Pegg, Yoshihiko Ikeguchi, C. Mackintosh, 2003, The Biochemical journal.

Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target

Maria C. Bewley, F. William Studier, Anthony E. Pegg, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Crystal Structure of Human Spermine Synthase

Peter Loppnau, Jinrong Min, J. Min, 2008, Journal of Biological Chemistry.

Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine

J. Min, C. Arrowsmith, J. Weigelt, 2008 .

Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii

C. Kinsland, A. Pegg, S. Ealick, 2008, Acta crystallographica. Section D, Biological crystallography.

Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant.

W. Tolbert, A. Pegg, S. Ealick, 2003, Biochemistry.

Effect of inhibitors of protein synthesis on rat liver spermidine N-acetyltransferase.

A. Pegg, I. Matsui, 1981, Biochimica et biophysica acta.

Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells

M. Wada, A. Pegg, A. Shirahata, 2011, Amino Acids.

Determination of Cellular Aminopropyltransferase Activity Using Precolumn Fluorescent Etheno-Derivatization with High-Performance Liquid Chromatography

A. Pegg, A. Shirahata, Yoshihiko Ikeguchi, 2012, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

Polyamine depletion inhibits the differentiation of L6 myoblast cells.

A. Pegg, J. Florini, D. Ewton, 1983, Biochemical and biophysical research communications.

In Silico Chemical Library Screening and Experimental Validation of a Novel 9-Aminoacridine Based Lead-Inhibitor of Human S-Adenosylmethionine Decarboxylase

Kenyon G. Daniel, Wayne C. Guida, Wesley H. Brooks, 2007, J. Chem. Inf. Model..

Effect of 06-Methylguanine on DNA Interstrand Chloroethylnitrosoureas and Z-ChloroethyKmethylsulfonyOmethanesulfonate1

M. Dolan, A. Pegg, L. Erickson, 2006 .

Differences between tissues in response of S-adenosylmethionine decarboxylase to administration of polyamines.

A. Pegg, H. Pösö, 1981, The Biochemical journal.

Absence of inactivation or phosphorylation of ornithine decarboxylase by nuclear protein kinase NII and of immunological cross-reactivity between RNA polymerase I and ornithine decarboxylase.

S. Jacob, A. Pegg, J. Seely, 1984, Biochemical and Biophysical Research Communications - BBRC.

Assay of mammalian S-adenosylmethionine decarboxylase activity.

L. Shantz, A. Pegg, 1998, Methods in molecular biology.

Inhibition of bacterial aminopropyltransferases by S‐adenosyl‐1,8‐diamino‐3‐thiooctane and by dicyclohexylamine

A. Bitonti, P. McCann, A. Pegg, 1983, FEBS letters.

Induction of spermidine N1-acetyltransferase by sodium n-butyrate and phytohemagglutinin in bovine lymphocytes.

S. Otani, A. Pegg, A. Kuramoto, 1983, Journal of biochemistry.

Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis.

A. Pegg, K. Goodtzova, S. Kanugula, 1998, The Biochemical journal.

Effects of glucocorticoids on peptide chain initiation in heart and skeletal muscle.

L. Jefferson, A. Pegg, H. E. Morgan, 1980, Advances in myocardiology.

Effect of expression of human spermidine/spermine N1-acetyltransferase in Escherichia coli.

A. Pegg, L. Wiest, J. López-Ballester, 1995, Biochemistry.

Paramecium bursaria Chlorella Virus-1 Encodes an Unusual Arginine Decarboxylase That Is a Close Homolog of Eukaryotic Ornithine Decarboxylases*

N. Grishin, J. V. Van Etten, J. Baldwin, 2004, Journal of Biological Chemistry.

Inhibition of aminopropyltransferases.

A. Pegg, 1983, Methods in enzymology.

Assay of aminopropyltransferases.

A. Pegg, 1983, Methods in enzymology.

Involvement of polyamines in the progestin-induced stimulation of endometrial glycogen synthesis during organ culture.

A. Pegg, L. Demers, C. Bardin, 1977, Biochemical and biophysical research communications.

Irreversible inhibition of mamalian and yeast S-adenosylmethionine decarboxylase by 1,1'- (methylethanediylidenedinitrilo)-bis (3-aminoguanidine).

C. Conover, A. Pegg, 1976, Biochemical and biophysical research communications.

Inhibition of aminopropyltransferases by S‐adenosylmethionine

A. Pegg, M. Tanaka, J. Nagai, 1980, FEBS letters.

The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity.

A. Pegg, K. Goodtzova, S. Edara, 1995, Carcinogenesis.

Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase.

S. Mitra, A. Pegg, R. Roy, 1997, Biochemistry.

Current status of the polyamine research field.

A. Pegg, R. Casero, 2011, Methods in molecular biology.

Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

D. Koomoa, A. Pegg, A. Bachmann, 2009, Molecular Cancer Therapeutics.

Spermidine/spermine N 1 -acetyltransferase speciﬁcally binds to the integrin (cid:1) 9 subunit cytoplasmic domain and enhances cell migration

D. Sheppard, A. Pegg, C. Coleman, 2004 .

Spermidine/spermine N 1 -acetyltransferase speciﬁcally binds to the integrin (cid:1) 9 subunit cytoplasmic domain and enhances cell migration

D. Sheppard, A. Pegg, C. Coleman, 2004 .

Alpha-difluoromethylornithine inhibits N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in zinc-deficient rats: effects on esophageal cell proliferation and apoptosis.

L. Fong, A. Pegg, P. Magee, 1998, Cancer research.

Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation.

A. Pegg, S. Ealick, E. Bennett, 2002, Biochemistry.

Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase.

A. Pegg, R. Moschel, G. Pauly, 2002, Biochemistry.

Formationand Lossof Alkylated Purines from DNA of Hamster Liver after Administrationof Dimethylnitrosamine '

R. Montesano, A. Pegg, R. Stumpf, 2006 .

Studies of the acetyl-CoA-binding site of rat liver spermidine/spermine N1-acetyltransferase.

F. Della Ragione, A. Pegg, B. Erwin, 1983, The Biochemical journal.

Properties and physiological function of the polyamine transport system.

T. Byers, A. Pegg, 1989, American Journal of Physiology.

Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome).

R. Stevenson, C. Schwartz, A. Pegg, 2011, Methods in molecular biology.

Methylation of purified transfer RNA preparations by extracts derived from rat kidney and kidney tumours.

A. Pegg, 1972, Biochimica et biophysica acta.

DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells.

N. Tretyakova, A. Pegg, C. Campbell, 2013, Biochemistry.

Toxicity of polyamines and their metabolic products.

A. Pegg, 2013, Chemical research in toxicology.

Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards.

N. Tretyakova, A. Pegg, Q. Fang, 2008, Chemical research in toxicology.

Administration of Ethylnitrosourea to Neonate Hamsters Increases Growth and Frequency of SV40-Induced Fibrosarcomas

A. Pegg, J. Kreider, M. Howett, 1989, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.