T. Hayama

发表

Crystallographic Approach to Identification of Cyclin-dependent Kinase 4 (CDK4)-specific Inhibitors by Using CDK4 Mimic CDK2 Protein*

T Honma, H. Hirai, K. Fukasawa, 2001, The Journal of Biological Chemistry.

Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design.

K. Fukasawa, T. Machida, Y. Iwasawa, 2001, Journal of medicinal chemistry.

Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist.

T. Hayama, J. O'brien, S. Ozaki, 1999, The Journal of pharmacology and experimental therapeutics.

[IgD-lambda type multiple myeloma associated with IgG-kappa type benign monoclonal gammopathy].

T. Horie, T. Hayama, M. Hirano, 1995, Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.

[A case of Sjögren's syndrome complicated with cryoglobulinemia, nephrogenic diabetes insipidus, and renal tubular acidosis].

M. Takei, T. Hayama, S. Hashimoto, 1995, Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.

Successful child bearing during intravenous cyclophosphamide therapy in a patient with systemic lupus erythematosus.

T. Horie, T. Hayama, Y. Matsukawa, 1998, British journal of rheumatology.

Questionnaire surveys of cases of tick bite and Lyme borreliosis in hunters in Hokkaido with reference to detection of anti-Borrelia burgdorferi antibody.

T. Horie, S. Sawada, T. Hayama, 1992, Internal medicine.

Marked reduction of mortality in salt‐loaded Dahl salt‐ sensitive rats by the new, selective endothelin ETA receptor antagonist, J‐105859

T. Hayama, N. Ohtake, T. Ikeda, 2000, Journal of hypertension.

Patient with both lupus anticoagulant and acute disseminated encephalomyelitis

M. Takei, T. Horie, S. Sawada, 1996, Clinical Rheumatology.

Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists.

T. Hayama, T. Fukami, T. Saeki, 1995, Journal of medicinal chemistry.

A convenient synthetic method of a 5,7-diarylcyclopenteno-[1,2-b]pyridine-6-carboxylate: a key intermediate for potent endothelin receptor antagonists.

T. Hayama, T. Fukami, A. Naya, 2002, Bioorganic & Medicinal Chemistry.

Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon

T. Hayama, K. Matsuyama, T. Fukami, 1994 .

Suicide in Patients with Systemic Lupus Erythematosus: A Clinical Analysis of Seven Suicidal Patients

T. Horie, S. Sawada, T. Hayama, 1994, Lupus.

The effects of immunoglobulin preparations on human monocyte IL-1 production

K. Mitamura, S. Sawada, Hoil Kang, 1989 .

Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications.

T. Hayama, T. Fukami, M. Yano, 1992, Journal of medicinal chemistry.

Endothelin antagonistic peptide derivatives with high selectivity for ETA receptors

T. Hayama, T. Fukami, M. Yano, 1993 .

Antigen inhibition on antibody forming cells at the level of effector cell.

T. Hayama, 1976, The Tohoku journal of experimental medicine.

Trialkyl(2-nitro-1-alkenyl)silanes: synthesis and Diels-Alder reaction

S. Tomoda, T. Hayama, Y. Takeuchi, 1984 .

Asymmetric synthesis of α-amino acids by alkylation of N-[N-bis-(methylthio)methyleneglycyl]-2,5-bis(methoxymethoxymethyl)pyrrolidine and enantioselective synthesis of protected (2S,9S)-2-amino-8-oxo-9,10-epoxydecanoic acid

T. Hayama, T. Katsuki, M. Yamaguchi, 1988 .

A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues.

T Honma, K. Fukasawa, N. Kawanishi, 2001, Journal of medicinal chemistry.

Reaction of trimethyl-(2-nitrovinyl)silane with organometallic compounds. An example of reactivity umpolung of 1-alkenylsilane

S. Tomoda, T. Hayama, Y. Takeuchi, 1983 .

Asymmetric synthesis of α-amino acids by alkylation of a glycine amide derivative bearing chiral 2,5-disubstituted pyrrolidine as an amine component

T. Hayama, T. Katsuki, M. Yamaguchi, 1986 .

Cleavage of t-butyldimethylsilyl ether with t-butyl hydroperoxide and dioxobis(2,4-pentanedionato)molybdenum(VI) system

T. Hanamoto, T. Hayama, T. Katsuki, 1987 .

Synthesis of conjugated nitroalkenes via nitroselenenylation of alkenes

S. Tomoda, T. Hayama, Y. Takeuchi, 1983 .

Synthesis of 2-nitroalkyl phenyl selenides and their conversion to nitroalkenes.

S. Tomoda, T. Hayama, Y. Takeuchi, 1982 .

Endothelin Receptor Antagonists with Various Subtype-Specificity: Their Discovery and Use as Pharmacological Tools

T. Hayama, S. Ozaki, T. Fukami, 1995, European Journal of Medicinal Chemistry.

[Cultured human monocytes activated by cytokines or lipopolysaccharide induce fibronectin].

T. Horie, T. Hayama, N. Kitamura, 1995, Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology.

Increased soluble CD4 and decreased soluble CD8 molecules in patients with Sjögren's syndrome.

M. Takei, T. Horie, S. Sawada, 1992, The American journal of medicine.

Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder

N. Matoba, A. Takata, M. Ikeda, 2021, Nature Communications.

Production of auto-anti-idiotypic antibody during the normal immune response. VI. Hapten augmentation of plaque formation and hapten-reversible inhibition of plaque formation as assays for anti-idiotype antibody.

T. Hayama, G. Thorbecke, G. Shepherd, 1983, Journal of immunological methods.

Mechanism of Calcium Ionophore and Phorbol Ester‐Induced T‐cell Activation

T. Horie, S. Sawada, Y. Takahashi, 1991, Scandinavian journal of immunology.

Convenient synthesis of 2-alkylamino-6-carboxy-5,7-diarylcyclopenteno[1,2-b]pyridines via direct acylamination with imidoyl chlorides

T. Hayama, T. Fukami, T. Nishimura, 2005 .

Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines.

N. Kawanishi, T. Hayama, S. Ozaki, 2004, Bioorganic & medicinal chemistry letters.

Ia-restricted interaction between normal lymphoid cells and SJL lymphoma (RCS) leading to lymphokine production. I. Enhancement and suppression of antibody formation to TI antigens by supernatants and cells from cocultures of RCS and lymphoid cells.

D. Umetsu, T. Hayama, G. Thorbecke, 1983, Cellular immunology.

Potent and orally active ET(A) selective antagonists with 5,7-diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acid structures.

T. Hayama, S. Ozaki, Y. Shibata, 2004, Bioorganic & medicinal chemistry.

[AUTOPSY CASE OF CHONDRO-OSTEOIDSARCOMA ORIGINATING IN THE LUNG].

T. Kiyota, T. Hayama, T. Yamashita, 1964, Showa Igakkai zasshi = The Journal of the Showa Medical Association.

6-Carboxy-5,7-diarylcyclopenteno[1,2-b]pyridine derivatives: a novel class of endothelin receptor antagonists.

T. Hayama, S. Ito, S. Ozaki, 2002, Bioorganic & medicinal chemistry.

Detection of HIV antigen on acid and heat treated sera from HIV antibodies positive patients

S. Sawada, T. Hayama, H. Kawahira, 1992 .

Correlations between IL-2 enhancing activity and clinical parameters in patients with rheumatoid arthritis and systemic lupus erythematosus.

M. Takei, K. Mitamura, T. Horie, 1991, The Tohoku journal of experimental medicine.

Functional T cell subpopulations responsible for hyposecretion of IL-2 in patients with systemic lupus erythematosus

T. Horie, S. Sawada, H. Hashimoto, 1991, Clinical Rheumatology.