J. Shayman

发表

Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle

S. Cooper, J. Shayman, S. Cooper, 2001, Cellular and Molecular Life Sciences CMLS.

1-O-acylceramides are natural components of human and mouse epidermis[S]

H. Gröne, Dagmar Wachten, J. Shayman, 2013, Journal of Lipid Research.

Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues Published, JLR Papers in Press, August 16, 2005. DOI 10.1194/jlr.M500248-JLR200

A. Abe, J. Shayman, M. Hiraoka, 2005, Journal of Lipid Research.

THE T LYMPHOCYTE STRUCTURE CD60 CONTAINS A SIALYLATED CARBOHYDRATE EPITOPE THAT IS EXPRESSED ON BOTH GANGLIOSIDES AND GLYCOPROTEINS

A. Abe, J. Shayman, D. Fox, 2001, Immunological investigations.

The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases

J. Shayman, S. Larsen, 2014, Journal of Lipid Research.

Use of an Inhibitor of Glucosylceramide Synthesis, D-1-Phenyl-2-decanoylamino-3-morpholino-1 -propanol

N. Radin, J. Shayman, 1993 .

Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy

R. Scheule, J. Shayman, W. Chuang, 2010, Journal of Inherited Metabolic Disease.

Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis

Angela Lee, J. Shillingford, A. Abe, 2021, Journal of lipid research.

Lysosomal phospholipase A 2 and phospholipidosis

Xianlin Han, J. Shayman, Kui Yang, 2015 .

Drug induced phospholipidosis: an acquired lysosomal storage disorder.

A. Abe, J. Shayman, 2013, Biochimica et biophysica acta.

Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens.

J. Shayman, G. De Libero, L. Mori, 2016, Cell chemical biology.

Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease

J. M. Aerts, C. Hollak, J. Shayman, 2014, Kidney international.

Glycosphingolipid Mediated Caveolin-1 Oligomerization.

J. Shayman, L. Shu, 2012, Journal of glycomics & lipidomics.

α-galactosidase A deficiency promotes von Willebrand factor secretion in models of Fabry disease.

J. Shayman, P. Bodary, K. Desch, 2019, Kidney international.

Thinking about rare kidney diseases.

J. Shayman, 2005, Journal of the American Society of Nephrology : JASN.

Ceramide-1-phosphate in phagocytosis and calcium homeostasis.

J. Shayman, V. Hinkovska-Galcheva, 2010, Advances in experimental medicine and biology.

A Novel Enzyme That Catalyzes the Esterification of N-Acetylsphingosine

A. Abe, N. Radin, J. Shayman, 1996, The Journal of Biological Chemistry.

Enhanced Phagocytosis through Inhibition of de Novo Ceramide Synthesis*

J. Shayman, L. Boxer, A. Schreiber, 2003, The Journal of Biological Chemistry.

Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells.

M. Goligorsky, J. Shayman, O. Gealekman, 2008, American journal of physiology. Renal physiology.

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2[S]

K. Manthei, J. Shayman, A. Schwendeman, 2018, Journal of Lipid Research.

Lysosomal phospholipase A2.

J. Shayman, John J. G. Tesmer, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Developing novel chemical entities for the treatment of lysosomal storage disorders: an academic perspective.

J. Shayman, 2015, American journal of physiology. Renal physiology.

The design and clinical development of inhibitors of glycosphingolipid synthesis: will invention be the mother of necessity?

J. Shayman, 2013, Transactions of the American Clinical and Climatological Association.

Eliglustat tartrate, a prototypic glucosylceramide synthase inhibitor

J. Shayman, 2013, Expert review of endocrinology & metabolism.

Caveolin-associated Accumulation of Globotriaosylceramide in the Vascular Endothelium of α-Galactosidase A Null Mice*

J. Shayman, L. Shu, 2007, Journal of Biological Chemistry.

Sphingolipids: their role in intracellular signaling and renal growth.

J. Shayman, 1996, Journal of the American Society of Nephrology : JASN.

Purification and Characterization of 1-O-Acylceramide Synthase, a Novel Phospholipase A2 with Transacylase Activity*

A. Abe, J. Shayman, 1998, The Journal of Biological Chemistry.

The role of negatively charged lipids in lysosomal phospholipase A2 function

A. Abe, J. Shayman, 2009, Journal of Lipid Research.

Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice

J. Shayman, Seng H. Cheng, Canwen Jiang, 2009, Hepatology.

Decreased nitric oxide bioavailability in a mouse model of Fabry disease.

James L. Park, J. Shayman, S. Pennathur, 2009, Journal of the American Society of Nephrology : JASN.

Glucosylceramide synthase: assay and properties.

A. Abe, J. Shayman, 2000, Methods in enzymology.

Inhibitors of glucosylceramide synthase.

A. Abe, J. Shayman, L. Shu, 2000, Methods in enzymology.

Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells.

T. Essington, J. Shayman, D. Yule, 1993, The Journal of biological chemistry.

Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes.

J. Shayman, L. Boxer, P. Mansfield, 2004, Blood.

Increased Hepatic Insulin Action in Diet-Induced Obese Mice Following Inhibition of Glucosylceramide Synthase

J. Shayman, Seng H. Cheng, Canwen Jiang, 2010, PloS one.

Induction of lysosomal phospholipase A 2 through the retinoid X receptor in THP-1 cells

J. Shayman, Akira Abe, M. Hiraoka, 2004 .

B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals

J. Shayman, G. Kass, M. Wright, 2017, Toxicology.

Improved Inhibitors of Glucosylceramide Synthase*

A. Abe, J. Shayman, Lihsueh C. Lee, 1999, The Journal of Biological Chemistry.

The Formation of Ceramide-1-phosphate during Neutrophil Phagocytosis and Its Role in Liposome Fusion*

J. Shayman, L. Boxer, P. Mansfield, 1998, The Journal of Biological Chemistry.

Thematic review series: Recent advances in the treatment of lysosomal storage diseases

J. Shayman, 2014, Journal of Lipid Research.

Ethylenedioxy-PIP2 Oxalate Reduces Ganglioside Storage in Juvenile Sandhoff Disease Mice

J. R. Arthur, J. Shayman, T. Seyfried, 2013, Neurochemical Research.

Phagocytic signaling molecules in lipid rafts of COS-1 cells transfected with FcgammaRIIA.

J. Shayman, L. Boxer, P. Mansfield, 2005, Biochemical and biophysical research communications.

Ceramide 1-Phosphate, a Mediator of Phagocytosis*

S. Spiegel, H. Petty, J. Shayman, 2005, Journal of Biological Chemistry.

Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

L. Kjeldsen, J. Shayman, L. Boxer, 1998 .

Activation of a plasma membrane-associated neutral sphingomyelinase and concomitant ceramide accumulation during IgG-dependent phagocytosis in human polymorphonuclear leukocytes.

L. Kjeldsen, J. Shayman, L. Boxer, 1998, Blood.

Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells.

R. Schnellmann, J. Shayman, J. Arthur, 2015, American journal of physiology. Renal physiology.

The separation of myo-inositol phosphates by ion-pair chromatography.

J. Shayman, D. Bement, 1988, Biochemical and biophysical research communications.

Substrate Reduction Augments the Efficacy of Enzyme Therapy in a Mouse Model of Fabry Disease

R. Desnick, R. Scheule, J. Shayman, 2010, PloS one.

Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D.

J. Shayman, L. Boxer, P. Mansfield, 2002, Blood.

Dissociation of endogenous cellular ceramide from NF-kappa B activation.

G. Nabel, Jonathan C. Betts, A. B. Agranoff, 1994, The Journal of biological chemistry.

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

V. Dixit, M. Jäättelä, J. Shayman, 1995, Oncogene.

α-Galactosidase A in Vascular Disease

J. Shayman, P. Bodary, D. Eitzman, 2007 .

Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells.

R. Schiffmann, J. Shayman, C. Kaneski, 2008, Molecular genetics and metabolism.

Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.

N. Radin, J. Shayman, T. Thomas, 1991, The Journal of biological chemistry.

Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition

Jelena S. Bezbradica, P. Cresswell, G. Besra, 2013, Proceedings of the National Academy of Sciences.

Phosphorylation‐Dephosphorylation of Retinoblastoma Protein Not Necessary for Passage through the Mammalian Cell Division Cycle

S. Cooper, J. Shayman, C. Yu, 1999, IUBMB life.

An in vitro model of Fabry disease.

J. Shayman, L. Shu, L. Cooling, 2005, Journal of the American Society of Nephrology : JASN.

Src Kinase Mediates the Regulation of Phospholipase C-γ Activity by Glycosphingolipids*

J. Shayman, L. Shu, 2003, Journal of Biological Chemistry.

Src kinase mediates the regulation of phospholipase C-gamma activity by glycosphingolipids.

J. Shayman, L. Shu, 2003, The Journal of biological chemistry.

Regulation of Phospholipase C-γ Activity by Glycosphingolipids*

J. Shayman, L. Shu, Lihsueh C. Lee, 2002, The Journal of Biological Chemistry.

Regulation of phospholipase C-gamma activity by glycosphingolipids.

J. Shayman, L. Shu, Lihsueh C. Lee, 2002, The Journal of biological chemistry.

Positional specificity of lysosomal phospholipase A2 Published, JLR Papers in Press, July 12, 2006.

A. Abe, J. Shayman, M. Hiraoka, 2006, Journal of Lipid Research.

Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2

J. Shayman, H. Ohguro, Akira Abe, 2016, Journal of Lipid Research.

Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP‐Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth

J. Shayman, M. Momany, S. Levery, 2002, FEBS letters.

Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

J. Shayman, L. Boxer, P. Mansfield, 1997 .

Lysosomal phospholipase A2: A novel player in host immunity to Mycobacterium tuberculosis

U. Schaible, J. Shayman, N. Harmel, 2014, European journal of immunology.

Fabry disease in mice is associated with age-dependent susceptibility to vascular thrombosis.

A. Abe, J. Shayman, P. Bodary, 2003, Journal of the American Society of Nephrology : JASN.

Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways.

Cullen B. Owens, P. Ward, J. Shayman, 1992, The American journal of physiology.

Differential involvement of COX1 and COX2 in the vasculopathy associated with the alpha-galactosidase A-knockout mouse.

James L. Park, J. Shayman, L. Shu, 2009, American journal of physiology. Heart and circulatory physiology.

The riddle of the sphinx redux.

J. Shayman, 2010, Kidney international.

Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion.

J. Shayman, L. Holzman, L. Shu, 2000, Archives of biochemistry and biophysics.

Globoside (Gb4) promotes activation of ERK by interaction with the epidermal growth factor receptor

J. Shayman, Seung-Yeol Park, Jung Hoe Kim, 2013 .

The Use of Cerebroside Synthase Inhibitors as Probes for Assessing the Metabolism and Function of Sphingolipids

N. Radin, J. Shayman, 1997 .

α-Galactosidase A Deficiency Leads to Increased Tissue Fibrin Deposition and Thrombosis in Mice Homozygous for the Factor V Leiden Mutation

J. Shayman, P. Bodary, Yue-chun Shen, 2006 .

Experimental Studies in Mice on the Vasculopathy of Fabry Disease

J. Shayman, 2010 .

&agr;-Galactosidase A Deficiency Accelerates Atherosclerosis in Mice With Apolipoprotein E Deficiency

J. Shayman, P. Bodary, Yue-chun Shen, 2005, Circulation.

(cid:1) -Galactosidase A Deficiency Accelerates Atherosclerosis in Mice With Apolipoprotein E Deficiency Molecular Cardiology

J. Shayman, P. Bodary, Yue-chun Shen, 2005 .

Endothelial nitric oxide synthase uncoupling and microvascular dysfunction in the mesentery of mice deficient in α-galactosidase A.

James L. Park, J. Shayman, P. Bodary, 2014, American journal of physiology. Gastrointestinal and liver physiology.

The measurement of lysosomal phospholipase A2 activity in plasma

A. Abe, J. Shayman, Robert Kelly, 2010, Journal of Lipid Research.

Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation

L. Kjeldsen, J. Shayman, L. Boxer, 1999 .

Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation.

L. Kjeldsen, J. Shayman, L. Boxer, 1999, Blood.

Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes.

J. Shayman, L. Boxer, P. Mansfield, 1997, Blood.

VASCULAR DYSFUNCTION IN THE α‐GALACTOSIDASE A‐KNOCKOUT MOUSE IS AN ENDOTHELIAL CELL‐, PLASMA MEMBRANE‐BASED DEFECT

James L. Park, J. Shayman, S. Whitesall, 2008, Clinical and experimental pharmacology & physiology.

A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity

A. Abe, J. Shayman, M. Hiraoka, 2003, Glycoconjugate Journal.

The acylation of lipophilic alcohols by lysosomal phospholipase A2 Published, JLR Papers in Press, July 12, 2007.

A. Abe, J. Shayman, M. Hiraoka, 2007, Journal of Lipid Research.

A hemolytic anti‐LKE associated with a rare LKE‐negative, “weak P” red blood cell phenotype: alloanti‐LKE and alloanti‐P recognize galactosylgloboside and monosialogalactosylgloboside (LKE) antigens

J. Shayman, L. Cooling, W. Judd, 2015, Transfusion.

Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide.

J. Shayman, L. Boxer, P. Mansfield, 1997, Journal of immunology.

Synthesis inhibition therapy for Gaucher disease

J. Shayman, 2013 .

Role of diradylglycerol formation in H2O2 and lactoferrin release in adherent human polymorphonuclear leukocytes

J. Shayman, T. Nakamura, L. Boxer, 1994, Journal of leukocyte biology.

Lowering Glycosphingolipid Levels in CD4+ T Cells Attenuates T Cell Receptor Signaling, Cytokine Production, and Differentiation to the Th17 Lineage*

J. Shayman, W. Chuang, Seng H. Cheng, 2011, The Journal of Biological Chemistry.

Studies on morpholinosphingolipids: Potent inhibitors of glucosylceramide synthase

B. Ganem, N. Radin, J. Shayman, 1994 .

ELIGLUSTAT TARTRATE: Glucosylceramide Synthase Inhibitor Treatment of Type 1 Gaucher Disease.

J. Shayman, Shayman Ja, 2010, Drugs of the future.

Targeting Glucosylceramide Synthesis in the Treatment of Rare and Common Renal Disease.

J. Shayman, 2018, Seminars in nephrology.

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

Laurie A. Smith, O. Ibraghimov-Beskrovnaya, B. Wang, 2010, Nature Medicine.

A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease.

J. Shayman, W. Chuang, J. Marshall, 2007, Molecular genetics and metabolism.

Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release.

J. Shayman, L. Boxer, P. Mansfield, 2002, The Journal of laboratory and clinical medicine.

Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.

J. Shayman, L. Boxer, P. Mansfield, 1999, Journal of immunology.

Glucosphingolipid dependence of hormone-stimulated inositol trisphosphate formation.

N. Radin, J. Shayman, J. Inokuchi, 1990, The Journal of biological chemistry.

Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain[S]

A. Abe, R. Keep, J. Shayman, 2012, Journal of Lipid Research.

1-O-acylceramide synthase.

A. Abe, J. Shayman, 2000, Methods in Enzymology.

Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase

C. Rani, A. Abe, Y. Chang, 1995, The Journal of Biological Chemistry.

Optimization of Eliglustat-Based Glucosylceramide Synthase Inhibitors as Substrate Reduction Therapy for Gaucher Disease Type 3.

A. Abe, J. Shayman, Yafei Jin, 2020, ACS chemical neuroscience.

Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor.

J. Shayman, Seung-Yeol Park, Jung Hoe Kim, 2012, Biochimica et biophysica acta.

(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase (*)

A. Bielawska, Y. Hannun, J. Shayman, 1996, The Journal of Biological Chemistry.

Effect of an Inhibitor of Glucosylceramide Synthesis on Cultured Human Keratinocytes

A. Abe, N. Radin, J. Shayman, 1998, The Journal of dermatology.

by Alveolar Macrophages 2 Phospholipase A The Secretion and Uptake of Lysosomal

J. Shayman, Akira Abe, M. Hiraoka, 2017 .

Group XV phospholipase A₂, a lysosomal phospholipase A₂.

Y. He, J. Shayman, Akira Abe, 2011, Progress in lipid research.

The Secretion and Uptake of Lysosomal Phospholipase A2 by Alveolar Macrophages1

A. Abe, J. Shayman, M. Hiraoka, 2008, The Journal of Immunology.

Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils.

J. Shayman, T. Nakamura, L. Boxer, 1994, The Journal of biological chemistry.

Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cellss⃞

F. Lanni, H. Petty, J. Shayman, 2008, Journal of Lipid Research.

Lysosomal Phospholipase A2 and Phospholipidosis

Xianlin Han, J. Shayman, Kui Yang, 2006, Molecular and Cellular Biology.

Moving the Needle: Accelerating Drug Discovery in Nephrology.

J. Shayman, 2023, Journal of the American Society of Nephrology : JASN.

Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells Published, JLR Papers in Press, February 1, 2004. DOI 10.1194/jlr.M300342-JLR200

A. Abe, J. Shayman, M. Hiraoka, 2004, Journal of Lipid Research.

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

A. Bielawska, Y. Hannun, L. Obeid, 2017, Journal of Lipid Research.

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.

P. Meikle, K. Sigmundsson, Mei Wang, 2016, Cell metabolism.

Calcium-Independent Phospholipase A2β Is Dispensable in Inflammasome Activation and Its Inhibition by Bromoenol Lactone

G. Dubyak, G. Núñez, J. Shayman, 2009, Journal of Innate Immunity.

Ganglioside-Linked Terminal Sialic Acid Moieties on Murine Macrophages Function as Attachment Receptors for Murine Noroviruses

Kristen D Yetming, J. Shayman, C. Wobus, 2009, Journal of Virology.

Serine Palmitoyltransferase Controls Stemness of Intestinal Progenitors

H. Clevers, P. Meikle, J. Rutter, 2020, bioRxiv.

Ceramides and Glucosylceramides Are Independent Antagonists of Insulin Signaling*

J. Shayman, S. Summers, J. Chavez, 2013, The Journal of Biological Chemistry.

Cloning and Characterization of a Lysosomal Phospholipase A2, 1-O-Acylceramide Synthase*

A. Abe, J. Shayman, M. Hiraoka, 2002, The Journal of Biological Chemistry.

Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase

A. Abe, J. Shayman, A. Glukhova, 2015, Nature Communications.

Glucosylceramide and Galactosylceramide Synthase

J. Shayman, 2006 .

Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells.

J. Shayman, J. Holoshitz, Liqun Xiao, 2006, Arthritis and rheumatism.

Voluntary wheel running activates Akt/AMPK/eNOS signaling cascades without improving profound endothelial dysfunction in mice deficient in α-galactosidase A

J. Shayman, P. Bodary, Taylour A. Treadwell, 2019, PloS one.

Globoside ( Gb 4 ) promotes activation of ERK by interaction with the epidermal growth factor receptor

J. Shayman, Seung-Yeol Park, Jung Hoe Kim, 2013 .

Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase.

J. Shayman, L. Boxer, P. Mansfield, 2000, Blood.

chain kinase after activation of mitogen-activated protein kinase Regulation of polymorphonuclear leukocyte phagocytosis by myosin light

J. Shayman, L. Boxer, P. Mansfield, 2000 .

A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I

K. Manthei, C. Larkin, J. Shayman, 2017, The Journal of Biological Chemistry.

Prolonged Ocular Inflammation in Endotoxin-Induced Uveitis in Lysosomal Phospholipase A2-Deficient Mice

J. Shayman, H. Ohguro, Akira Abe, 2017, Current eye research.

Myo-inositol does not modulate PI turnover in MDCK cells under hyperosmolar conditions.

J. Shayman, D. Wu, 1990, The American journal of physiology.

Lysosomal Phospholipase A2 Is Selectively Expressed in Alveolar Macrophages*

A. Abe, J. Shayman, R. Paine, 2004, Journal of Biological Chemistry.

A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity.

A. Abe, J. Shayman, P. Rzepecki, 2013, Analytical Biochemistry.

A fluorometric assay for lysosomal phospholipase A2 activity using fluorescence-labeled truncated oxidized phospholipid.

A. Abe, J. Shayman, H. Ohguro, 2018, Analytical biochemistry.

A role for lysosomal phospholipase A2 in drug induced phospholipidosis.

Akira Abe, A. Abe, J. Shayman, 2007, Drug metabolism letters.

Targeting Glycosphingolipid Metabolism to Treat Kidney Disease

J. Shayman, 2016, Nephron.

Dissociation of globotriaosylceramide and impaired endothelial function in α-galactosidase-A deficient EA.hy926 cells.

J. Shayman, L. Shu, M. Ferraz, 2018, Molecular genetics and metabolism.

Chapter 13 – Fabry Disease

J. Shayman, P. Killen, 2008 .

Challenges and opportunities in the development of therapeutics for chronic kidney disease.

J. Shayman, 2015, Translational research : the journal of laboratory and clinical medicine.

Establishing a role for sphingolipids in renal injury and stress responses.

J. Shayman, 1998, Kidney international.

Adding Lyso-Lipids to Arachidonate Metabolism Sets the Stage for New Biology.

J. Shayman, 2016, Cell chemical biology.

Ethylenedioxy-PIP2 Oxalate Reduces Ganglioside Storage in Juvenile Sandhoff Disease Mice

J. R. Arthur, J. Shayman, T. Seyfried, 2013, Neurochemical Research.

Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation.

A. Kulkarni, R. Brady, S. Gregory, 2000, The Journal of clinical investigation.

Structural Basis of Lysosomal Phospholipase A2 Inhibition by Zn2.

J. Shayman, J. Tesmer, R. Bouley, 2019, Biochemistry.

Improved inhibitors of glucosylceramide synthase.

A. Abe, N. Radin, J. Shayman, 1992, The Journal of biological chemistry.

Targeting Glycosphingolipid Metabolism to Treat Kidney Disease

D. Warnock, J. Shayman, 2016, Nephron.

Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.

B. Ganem, A. Abe, N. Radin, 1995, Journal of lipid research.

Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription.

A. Abe, J. Shayman, J. Shayman, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.

K. Sigmundsson, Mei Wang, J. Shayman, 2016, Cell metabolism.

Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D.

J. Shayman, L. Boxer, V. Hinkovska-Galcheva, 2002, Blood.

Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells.

R. Schnellmann, J. Shayman, J. Arthur, 2015, American journal of physiology. Renal physiology.