A. Otaka

发表

Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells.

M. Imamura, R. Hosotani, Y. Miyamoto, 2000, Cancer letters.

Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway

M. Matsuoka, A. Otaka, N. Fujii, 2007, Journal of Virology.

Photo-triggered fluorescent labelling of recombinant proteins in live cells.

Juyeon Jung, A. Otaka, Kohei Sato, 2015, Chemical communications.

HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus

Jindrich Cinatl, Akira Otaka, Shinji Amari, 2004, Biochemical and Biophysical Research Communications.

Structure-activity relationships of an anti-HIV peptide, T22.

A. Otaka, H. Tamamura, M. Waki, 1994, Biochemical and biophysical research communications.

Interaction of an anti-HIV peptide, T22, with gp120 and CD4.

A. Otaka, H. Tamamura, M. Waki, 1996, Biochemical and biophysical research communications.

Analysis of the interaction of an anti-HIV peptide, T22 ([Tyr5, 12, Lys7]-polyphemusin II), with gp120 and CD4 by surface plasmon resonance.

A. Otaka, H. Tamamura, M. Waki, 1996, Biochimica et biophysica acta.

Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr(5,12),Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection.

A. Otaka, H. Tamamura, R. Arakaki, 1998, Bioorganic & medicinal chemistry.

Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries.

Stephen C Peiper, Satoshi Ueda, Shinya Oishi, 2003, Angewandte Chemie.

Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System

A. Otaka, Kohei Sato, Akira Shigenaga, 2015, ChemistryOpen.

Formation of stable nanodiscs by bihelical apolipoprotein A‐I mimetic peptide

A. Otaka, H. Saito, Akira Shigenaga, 2016, Journal of peptide science : an official publication of the European Peptide Society.

Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells.

T. Saio, Kiyoe Kurahashi, H. Kosako, 2022, Cell Chemical Biology.

Preparation of fluoro- and hydroxy-4-(phosphonomethyl)-D,L-phenylalanine suitably protected for solid-phase synthesis of peptides containing hydrolytically stable analogs of O-phosphotyrosine

T. Burke, A. Otaka, M. Nomizu, 1993 .

T140 analogs as CXCR4 antagonists identified as anti‐metastatic agents in the treatment of breast cancer

A. Otaka, H. Tamamura, N. Fujii, 2003, FEBS letters.

Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats

H. Takagi, A. Otaka, M. Satoh, 1987, Brain Research.

Application of tri- and tetrasubstituted alkene dipeptide mimetics to conformational studies of cyclic RGD peptides

A. Asai, A. Otaka, H. Tamamura, 2006 .

Synthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity.

A. Otaka, H. Tamamura, M. Waki, 1995, Chemical & pharmaceutical bulletin.

Silver trifluoromethanesulphonate as an S-deprotecting reagent for the synthesis of cystine peptides

A. Otaka, H. Tamamura, N. Fujii, 1989 .

A Photo-Activatable Peptide Mimicking Functions of Apolipoprotein A-I.

A. Otaka, T. Ishida, Akira Shigenaga, 2019, Biological & pharmaceutical bulletin.

Investigation of the dimethylsulfoxide-trifluoroacetic acid oxidation system for the synthesis of cystine-containing peptides.

A. Otaka, T. Koide, N. Fujii, 1993, Chemical & pharmaceutical bulletin.

Application of dimethylsulphoxide(DMSO) / trifluoroacetic acid(TFA) oxidation to the synthesis of cystine-containing peptide

A. Otaka, T. Koide, N. Fujii, 1991 .

Electrostatically constrained alpha-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide.

M. Matsuoka, A. Otaka, Yuji Kobayashi, 2009, The international journal of biochemistry & cell biology.

14-3-3β Protein Associates with Insulin Receptor Substrate 1 and Decreases Insulin-stimulated Phosphatidylinositol 3′-Kinase Activity in 3T3L1 Adipocytes*

A. Kosaki, A. Otaka, K. Yamada, 1998, The Journal of Biological Chemistry.

Design and synthesis of a hydrogen peroxide-responsive amino acid that induces peptide bond cleavage after exposure to hydrogen peroxide

A. Otaka, K. Tsuchiya, Akira Shigenaga, 2015 .

Application of N-C- or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation.

T. Hara, A. Otaka, Kohei Sato, 2011, Bioorganic & medicinal chemistry.

Synthesis of potent β-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure–activity relationship studies

A. Otaka, H. Tamamura, N. Fujii, 2003 .

Specific Recognition of the Collagen Triple Helix by Chaperone HSP47

A. Otaka, T. Koide, K. Nagata, 2006, Journal of Biological Chemistry.

Rhemium-186-monoaminemonoamidedithiol-conjugated bisphosphonate derivatives for bone pain palliation.

Y. Magata, H. Saji, A. Otaka, 2006, Nuclear medicine and biology.

Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.

M. Matsuoka, A. Otaka, H. Tamamura, 2001, Bioorganic & medicinal chemistry letters.

Synthetic procedure for N-Fmoc amino acyl-N-sulfanylethylaniline linker as crypto-peptide thioester precursor with application to native chemical ligation.

A. Otaka, Kohei Sato, Akira Shigenaga, 2012, The Journal of organic chemistry.

Heptad repeat-derived peptides block the protease-mediated direct entry from cell surface of SARS coronavirus but not entry via endosomal pathway

M. Matsuoka, A. Otaka, N. Fujii, 2017 .

An N-sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins.

A. Otaka, D. Tsuji, Akira Shigenaga, 2016, Chemical communications.

Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins.

A. Otaka, H. Tamamura, A. Yamauchi, 2014, Organic & biomolecular chemistry.

Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker

A. Otaka, H. Tamamura, A. Yamauchi, 2014 .

α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.

K. Nakao, K. Hosoda, Tatsuya Hayashi, 2006, Metabolism: clinical and experimental.

Possible involvement of the alpha1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle.

K. Nakao, K. Hosoda, Tatsuya Hayashi, 2004, American journal of physiology. Endocrinology and metabolism.

Liquid-phase synthesis of bridged peptides using olefin metathesis of a protected peptide with a long aliphatic chain anchor.

A. Otaka, Akira Shigenaga, D. Takahashi, 2015, Organic letters.

Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI2)-mediated reductive alkylation reaction

A. Otaka, N. Fujii, Akira Shigenaga, 2007 .

SmI2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized (Z)-Fluoroalkene-Type Dipeptide Isosteres

T. Kinoshita, A. Otaka, H. Tamamura, 2004 .

Application of samarium diiodide (SmI2)-induced reduction of γ-acetoxy-α,β-enoates with α-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives

A. Otaka, H. Tamamura, N. Fujii, 2003 .

Immuno-affinity purification of specific antibodies against human gastrin releasing peptide (h-GRP) by the h-GRP(1-8)-linked polydimethylacrylamide resin.

A. Otaka, N. Fujii, M. Takeyama, 2009, International journal of peptide and protein research.

Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells.

M. Matsuoka, S. Uchiyama, A. Otaka, 2002, Angewandte Chemie.

Binding sites of calcitonin gene-related peptide (CGRP): abundant occurrence in visceral organs.

H. Nakamuta, M. Koida, A. Otaka, 1986, Japanese journal of pharmacology.

Recent Progress in the Synthetic Methodologies of Peptide Thioesters

A. Otaka, Kohei Sato, Akira Shigenaga, 2011 .

Cysteine-derived s-protected oxazolidinones: potential chemical devices for the preparation of peptide thioesters.

A. Otaka, N. Fujii, Akira Shigenaga, 2006, Organic letters.

CXCL14 is a natural inhibitor of the CXCL12–CXCR4 signaling axis

T. Hara, A. Otaka, Y. Nakayama, 2013, FEBS letters.

Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives.

J. Trent, A. Otaka, H. Tamamura, 2003, Organic & biomolecular chemistry.

Corrigendum to “conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity”: [Bioorg. Med. Chem. Lett. 11 (2001) 359]

Y. Kan, A. Otaka, H. Tamamura, 2001 .

Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity.

Y. Kan, A. Otaka, H. Tamamura, 2001, Bioorganic & medicinal chemistry letters.

Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S‐cyanylation and hydrazinolysis

S. Futaki, A. Otaka, Akira Shigenaga, 2016, Biopolymers.

Heterodimer formation between the antimicrobial peptides magainin 2 and PGLa in lipid bilayers: a cross-linking study.

T. Tachi, T. Hara, H. Kodama, 2001, Biochemistry.

Human calcitonin gene-related peptide possesses weak inhibitory potency of bone resorptionin vitro

K. Torizuka, A. Otaka, N. Fujii, 1986, Calcified Tissue International.

Possible mechanisms of positive inotropic action of synthetic human calcitonin gene-related peptide in isolated rat atrium

H. Takagi, A. Otaka, M. Satoh, 1986, Peptides.

Gastrin releasing peptide-like immunoreactive substance in rat mammary glands during pregnancy.

A. Otaka, N. Fujii, M. Takeyama, 1991, Biochemical and biophysical research communications.

Induction of human leukocyte antigen (HLA)‐A2‐restricted and MAGE‐3‐gene‐derived peptide‐specific cytolytic T lymphocytes using cultured dendritic cells from an HLA‐A2 esophageal cancer patient

M. Kaneko, M. Imamura, A. Otaka, 1999, Journal of surgical oncology.

Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity.

J. Broach, A. Otaka, H. Tamamura, 2006, Bioorganic & medicinal chemistry letters.

Mutations Conferring Resistance to Human Immunodeficiency Virus Type 1 Fusion Inhibitors Are Restricted by gp41 and Rev-Responsive Element Functions

M. Matsuoka, A. Otaka, M. Ohno, 2005, Journal of Virology.

Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells

A. Otaka, A. Ishimoto, K. Takahashi, 1993, Journal of virology.

Certification of the critical importance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study.

A. Otaka, H. Tamamura, N. Fujii, 2002, Bioorganic & medicinal chemistry.

Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety.

A. Otaka, H. Tamamura, N. Fujii, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation.

A. Otaka, H. Tamamura, H. Nakashima, 2001, Bioorganic & medicinal chemistry.

Identification of Cell Binding Sequences in Mouse Laminin γ1 Chain by Systematic Peptide Screening*

H. Kleinman, Y. Kuratomi, S. Song, 1997, The Journal of Biological Chemistry.

Identification of Functional Domains of CXCL14 Involved in High-Affinity Binding and Intracellular Transport of CpG DNA

T. Hara, A. Otaka, R. Iwase, 2021, The Journal of Immunology.

CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity

T. Hara, A. Otaka, R. Iwase, 2017, EBioMedicine.

Design and synthesis of caged ceramide: UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O―N acyl transfer

K. Ogura, A. Otaka, D. Tsuji, 2011 .

Development of UV-responsive catch-and-release system of a cysteine protease model peptide

A. Otaka, Kohei Sato, Akira Shigenaga, 2011 .

Asymmetric Synthesis of α-Amino Phosphonic Acids Using Stable Imino Phosphonate as a Universal Precursor.

A. Otaka, Akira Shigenaga, Ken‐ichi Yamada, 2019, Chemistry.

Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein.

K. Ogura, A. Otaka, Akira Shigenaga, 2014, Bioorganic & medicinal chemistry.

Synthesis of fluorine-containing bioisosteres corresponding to phosphoamino acids and dipeptide units.

A. Otaka, N. Fujii, E. Mitsuyama, 2004, Biopolymers.

Development of new methodology for the synthesis of functionalized α-fluorophosphonates and its practical application to the preparation of phosphopeptide mimetics

A. Otaka, H. Tamamura, N. Fujii, 2000 .

Development of a Reduction‐Responsive Amino Acid that Induces Peptide Bond Cleavage in Hypoxic Cells

K. Ogura, A. Otaka, K. Tsuchiya, 2012, Chembiochem : a European journal of chemical biology.

Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides.

J. Trent, A. Otaka, H. Tamamura, 2004, Organic & biomolecular chemistry.

Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds.

Teppei Ogawa, J. Trent, A. Otaka, 2005, Organic & biomolecular chemistry.

Identification of a CXCR4 antagonist, a T140 analog, as an anti‐rheumatoid arthritis agent

A. Otaka, H. Tamamura, N. Fujii, 2004, FEBS letters.

Disulfide bond-forming reaction using a dimethyl sulfoxide/aqueous HCl system and its application to regioselective two disulfide bond formation.

A. Otaka, T. Koide, H. Tamamura, 2009, International journal of peptide and protein research.

Two-step hard acid deprotection/cleavage procedure for solid phase peptide synthesis.

P. Roller, A. Otaka, M. Nomizu, 2009, International journal of peptide and protein research.

Solid phase peptide synthesis of human endothelin precursor peptides using two-step hard acid deprotection/cleavage methods.

P. Roller, A. Iwamatsu, A. Otaka, 2009, International journal of peptide and protein research.

Microenzyme immunoassay for the measurement of brain natriuretic peptide (BNP)-like immunoreactivity in porcine plasma.

A. Otaka, N. Fujii, M. Takeyama, 1990, Journal of immunological methods.

Lymphocytes and promonocytes attach to the synthetic [Tyr5,12, Lys7]- polyphemusin II peptide.

A. Otaka, H. Tamamura, M. Nomizu, 1994, Biochemical and biophysical research communications.

Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1.

A. Otaka, N. Fujii, S. Oishi, 2006, Organic letters.

Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.

T. Hirokawa, Y. Urano, M. Setou, 2016, The Journal of clinical investigation.

Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and their biological evaluation.

T. Hara, A. Otaka, Kohei Sato, 2015, Bioorganic & Medicinal Chemistry.

Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system

K. Ogura, A. Otaka, Akira Shigenaga, 2010 .

Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I

A. Otaka, T. Shimanouchi, H. Saito, 2018, Scientific Reports.

Notch receptor cleavage depends on but is not directly executed by presenilins

U. Lendahl, T. Honjo, T. Mizutani, 2002, Proceedings of the National Academy of Sciences of the United States of America.

N‐Sulfanylethylanilide Peptide as a Crypto‐Thioester Peptide

A. Otaka, Kohei Sato, Akira Shigenaga, 2011, Chembiochem : a European journal of chemical biology.

Invention of stimulus‐responsive peptide‐bond‐cleaving residue (Spr) and its application to chemical biology tools

A. Otaka, Akira Shigenaga, T. Inokuma, 2017, Journal of peptide science : an official publication of the European Peptide Society.

Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent

A. Otaka, D. Tsuji, A. Nakayama, 2020, Communications Chemistry.

Labelling of endogenous target protein via N-S acyl transfer-mediated activation of N-sulfanylethylanilide.

A. Otaka, Kohei Sato, A. Yamauchi, 2016, Organic & biomolecular chemistry.

Sequential native chemical ligation utilizing peptide thioacids derived from newly developed Fmoc-based synthetic method

A. Otaka, Kohei Sato, Akira Shigenaga, 2010 .

Deprotection of S-acetamidomethyl cysteine with copper(II) and 1,2-aminothiols under aerobic conditions.

A. Otaka, Akira Shigenaga, Masaya Denda, 2020, Organic & biomolecular chemistry.

Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in Peptide/Protein Synthesis.

M. Kanai, A. Otaka, K. Yamatsugu, 2020, Organic letters.

Copper-mediated deprotection of thiazolidine and selenazolidine derivatives applied to native chemical ligation.

A. Otaka, Akira Shigenaga, Naoto Naruse, 2020, The Journal of organic chemistry.

Chemical synthesis of proteins using N-sulfanylethylanilide peptides, based on N-S acyl transfer chemistry.

A. Otaka, Kohei Sato, Akira Shigenaga, 2015, Topics in current chemistry.

Cysteine-Free Intramolecular Ligation of N-Sulfanylethylanilide Peptide Using 4-Mercaptobenzylphosphonic Acid: Synthesis of Cyclic Peptide Trichamide

Fei-xue Fu, D. Hutchins, A. Otaka, 2017 .

An anti-HIV peptide, T22, forms a highly active complex with Zn(II).

A. Otaka, H. Tamamura, M. Waki, 1996, Biochemical and biophysical research communications.

Heparin promotes fibril formation by the N‐terminal fragment of amyloidogenic apolipoprotein A‐I

A. Otaka, T. Shimanouchi, H. Saito, 2016, FEBS letters.

Preparation of Nα-Boc 4-O-Diethylphospho-L-azatyrosine, a Regent Potentially Useful for the Synthesis of Signal Transduction Related Peptides

T. Burke, A. Otaka, B. Ye, 1996 .

Synthesis and application of N-Boc-L-2-amino-4-(diethylphosphono)-4,4-difluorobutanoic acid for solid-phase synthesis of nonhydrolyzable phosphoserine peptide analogues

P. Roller, T. Burke, A. Otaka, 1995 .

Studies on peptides CLVIII. Model experiments for the synthesis of open-chain unsymmetrical cystine-peptides

A. Otaka, H. Yajima, S. Funakoshi, 1988, Journal of protein chemistry.

Palladium-catalyzed reductive ring opening with formic acid of aziridines bearing an α,β-unsaturated ester group

A. Otaka, H. Tamamura, N. Fujii, 1997 .

A simple synthesis of Ω[(E)CHCH]gly dipeptide isosteres via reductive elimination of γ-oxygenated α,β-enoates with alkenylcopper reagents

A. Otaka, Yoshinori Yamamoto, H. Habashita, 1991 .

A highly stereoselective synthesis of (E)-alkene dipeptide isosteres via organocyanocopper-Lewis acid mediated reaction

A. Otaka, N. Fujii, Yoshinori Yamamoto, 1991 .

Safe Removal of the Allyl Protecting Groups of Allyl Esters using a Recyclable, Low-Leaching and Ligand-Free Palladium Nanoparticle Catalyst

S. Shuto, A. Otaka, H. Fukuda, 2015 .

Synthesis of 4-phosphono(difluoromethyl)-D,L-phenylalanine and N-boc and N-Fmoc derivatives suitably protected for solid-phase synthesis of nonhydrolyzable phosphotyrosyl peptide analogues

P. Roller, A. Otaka, T. Burke, 1993 .

Molecular complex composed of β-cyclodextrin-grafted Chitosan and pH-sensitive amphipathic peptide for enhancing cellular cholesterol efflux under acidic pH.

A. Otaka, H. Izawa, K. Kawakami, 2015, Bioconjugate chemistry.

Development of copper-mediated allylation of γ-activated-α,β-unsaturated lactam toward peptide mimetic synthesis

A. Otaka, N. Fujii, Akira Shigenaga, 2007 .

Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131.

J. Trent, A. Otaka, H. Tamamura, 2005, Journal of medicinal chemistry.

Diastereoselective synthesis of new psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type alkene dipeptide isosteres by organocopper reagents and application to conformationally restricted cyclic RGD peptidomimetics.

A. Otaka, H. Tamamura, N. Fujii, 2002, The Journal of organic chemistry.

Regio- and stereoselective ring-opening of chiral 1,3-oxazolidin-2-one derivatives by organocopper reagents provides novel access to di-, tri- and tetra-substituted alkene dipeptide isosteres

A. Otaka, Y. Miwa, H. Tamamura, 2002 .

Stereoselective synthesis of a set of two functionalized (E)-alkene dipeptide isosteres of L-amino acid-L-Glu and L-amino acid-D-Glu

A. Otaka, H. Tamamura, N. Fujii, 2001 .

Regiospecific ring-opening reactions of β-aziridinyl α,β-enoates with acids: application to the stereoselective synthesis of a couple of diastereoisomeric (E)-alkene dipeptide isosteres from a single β-aziridinyl α,β-enoate and to the convenient preparation of amino alcohols bearing α,β-unsaturated

A. Otaka, H. Tamamura, N. Fujii, 2000 .

Palladium-Catalyzed Reductive Ring Opening with Formic Acid of Aziridines Bearing an α,β-Unsaturated Ester Group.

A. Otaka, H. Tamamura, N. Fujii, 1998 .

Synthesis of optically pure 2-aziridinemethanols: versatile synthetic building blocks

A. Otaka, H. Tamamura, N. Fujii, 1994 .

Enantioselective synthesis of stimulus-responsive amino acid via asymmetric α-amination of aldehyde

A. Otaka, Akira Shigenaga, N. Nishioka, 2010 .

AZA-PAYNE REARRANGEMENT OF ACTIVATED 2-AZIRIDINEMETHANOLS AND 2,3-EPOXY AMINES UNDER BASIC CONDITIONS

A. Otaka, Y. Miwa, H. Tamamura, 1995 .

Regio- and Stereoselective Synthesis of (E)-Alkene trans-Xaa-Pro Dipeptide Mimetics Utilizing Organocopper-Mediated Anti-SN2‘ Reactions

T. Kinoshita, A. Otaka, H. Tamamura, 2002 .

Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors.

S. Shoelson, P. Roller, T. Burke, 1994, Biochemistry.

Synthetic study on selenocystine-containing peptides.

K. Soda, A. Otaka, T. Koide, 1993, Chemical & pharmaceutical bulletin.

Diastereoselective synthesis of psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-S(N)2' reaction.

A. Otaka, H. Tamamura, N. Fujii, 2002, Organic letters.

SN2′ Ring opening of aziridines bearing an α,β-unsaturated ester group with organocopper reagents. A new stereoselective synthetic route to (E)-alkene dipeptide isosteres

A. Otaka, Y. Miwa, H. Tamamura, 1995 .

A one-pot aza-Payne rearrangement-epoxide ring opening reaction of 2-aziridinemethanols: A regio- and stereoselective synthetic route to diastereomerically pure 1,2-amino alcohols

A. Otaka, H. Tamamura, N. Fujii, 1995 .

Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.

H. Mitsuya, K. Maeda, A. Otaka, 2003, Journal of medicinal chemistry.

Regio- and stereoselectivity in reactions of 2,3-cis- and trans-3-alkyl-2-vinylaziridines with organocopper reagents: Importance of 2,3-cis-stereochemistry in controlling selectivity

A. Otaka, H. Tamamura, N. Fujii, 1997 .

(E)-stereoselective synthesis of vinylglycines from (R)-serine via organocopper–BF3 and related reagents

A. Otaka, Y. Miwa, H. Tamamura, 1994 .

A Simple Synthesis of ψ((E)CH=CH)Gly Dipeptide Isosteres via Reductive Elimination of γ‐Oxygenated α,β‐Enoates with Alkenylcopper Reagents.

A. Otaka, H. Habashita, T. Ibuka, 2010 .

Diastereoselective synthesis of psi[(E)-CMe=CH]- and psi[(E)-CMe=CMe]- type dipeptide isosteres based on organocopper-mediated anti-S(N)2' reaction.

A. Otaka, H. Tamamura, N. Fujii, 2002, Organic letters.

Stereoselective synthesis of two type (E)-alkene dipeptide isosteres from a single substrate of β-aziridinyl- α,β-enoate

A. Otaka, H. Tamamura, M. Yamashita, 1999 .

A Highly Stereoselective Synthesis of E-Alkene Dipeptide Isosters via Organocyanocopper - Lewis Acid-Mediated Reaction.

A. Otaka, H. Habashita, T. Ibuka, 1991 .

Photolabile Protection for One‐Pot Sequential Native Chemical Ligation

A. Otaka, H. Tamamura, N. Fujii, 2005, Chembiochem : a European journal of chemical biology.

Safe Removal of the Allyl Protecting Groups of Allyl Esters Using a Recyclable, Low‐Leaching and Ligand‐Free Palladium Nanoparticle Catalyst.

S. Shuto, A. Otaka, H. Fukuda, 2015 .

Trimethylsilyl trifluoromethanesulphonate as a useful deprotecting reagent in both solution and solid phase peptide syntheses

A. Otaka, N. Fujii, Y. Hayashi, 1987 .

Phospho-Azatyrosine, a less effective protein-tyrosine phosphatase substrate than phosphotyrosine.

L. Wu, T. Burke, A. Otaka, 2001, Bioorganic & medicinal chemistry letters.

Why is phosphonodifluoromethyl phenylalanine a more potent inhibitory moiety than phosphonomethyl phenylalanine toward protein-tyrosine phosphatases?

L. Wu, P. Roller, J. den Hertog, 1995, Biochemical and biophysical research communications.

A Recyclable Hydrophobic Anchor‐Tagged Asymmetric Amino Thiourea Catalyst

A. Otaka, Akira Shigenaga, Ken‐ichi Yamada, 2018, ChemCatChem.

Studies on peptides. CLV. Evaluation of trimethylsilyl bromide as a hard-acid deprotecting reagent in peptide synthesis.

A. Otaka, H. Yajima, N. Fujii, 1987, Chemical & pharmaceutical bulletin.

Ca2+-independent activity of Ca2+/calmodulin-dependent protein kinase II involved in stimulation of neurite outgrowth in neuroblastoma cells

A. Otaka, Y. Sogawa, T. Yamauchi, 2000, Brain Research.

N-Sulfanylethylaminooxybutyramide (SEAoxy): A Crypto-Thioester Compatible with Fmoc Solid-Phase Peptide Synthesis.

A. Otaka, Taku Yoshiya, Masaya Denda, 2016, Organic letters.

Development of an Anilide-Type Scaffold for the Thioester Precursor N-Sulfanylethylcoumarinyl Amide.

A. Otaka, Kohei Sato, Akira Shigenaga, 2016, Organic letters.

Facile synthesis of C-terminal peptide thioacids under mild conditions from N-sulfanylethylanilide peptides

A. Otaka, Kohei Sato, Akira Shigenaga, 2016 .

One-pot/sequential native chemical ligation using N-sulfanylethylanilide peptide.

A. Otaka, Kohei Sato, Akira Shigenaga, 2012, Chemical record.

Development of Organic and Bio-organic Methodologies for the Synthesis of Proteins

A. Otaka, 2012 .

Syntheses and Biological Activities of Selenium Analogs of α-Rat Atrial Natriuretic Peptide

A. Otaka, T. Koide, M. Furuya, 1993 .

Syntheses and biological activities of selenium analogs of alpha-rat atrial natriuretic peptide.

A. Otaka, T. Koide, M. Furuya, 1993, Chemical and pharmaceutical bulletin.

Studies on peptides. CLI. Syntheses of cystine-peptides by oxidation of S-protected cysteine-peptides with thallium(III) trifluoroacetate.

A. Otaka, A Otaka, N Fujii, 1987, Chemical & pharmaceutical bulletin.

Active site peptides with CXXC motif on map-resin can mimic protein disulfide isomerase activity.

A. Otaka, H. Kim, N. Fujii, 1995, Biochemical and biophysical research communications.

N-->S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives.

A. Otaka, Akira Shigenaga, Shugo Tsuda, 2009, Organic letters.

Dual kinetically controlled native chemical ligation using a combination of sulfanylproline and sulfanylethylanilide peptide.

A. Otaka, Kohei Sato, Akira Shigenaga, 2011, Organic letters.

One-Pot/Sequential Native Chemical Ligation Using Photocaged Crypto-thioester.

A. Otaka, Akira Shigenaga, T. Inokuma, 2016, Organic letters.

Chemical synthesis of biologically active monoglycosylated GM2-activator protein analogue using N-sulfanylethylanilide peptide.

A. Otaka, Kohei Sato, D. Tsuji, 2013, Angewandte Chemie.

Synthesis of a Stimulus‐Responsive Processing Device and Its Application to a Nucleocytoplasmic Shuttle Peptide

A. Otaka, D. Tsuji, Akira Shigenaga, 2007, Chembiochem : a European journal of chemical biology.

The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate.

A. Otaka, Kohei Sato, D. Tsuji, 2015, Chemical communications.

ProteoFind : A script for finding proteins that are suitable for chemical synthesis

A. Otaka, Akira Shigenaga, Naoto Naruse, 2018 .

Elucidation of inhibitor-binding pockets of d-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology.

A. Otaka, Y. Kato, Akira Shigenaga, 2017, Organic & biomolecular chemistry.

Examination of native chemical ligation using peptidyl prolyl thioesters.

A. Otaka, Kohei Sato, Akira Shigenaga, 2014, Chemical communications.

One‐Pot/Sequential Native Chemical Ligation Using N‐Sulfanylethylanilide Peptide

A. Otaka, Kohei Sato, Akira Shigenaga, 2013 .

Syntheses and Biological Activities of Selenium Analogues of α- Rat Atrial Natriuretic Peptide.

A. Otaka, T. Koide, M. Furuya, 1994 .

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.

M. Akamatsu, J. Trent, A. Otaka, 2003, Organic & biomolecular chemistry.

A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

X Zhang, A. Otaka, H. Tamamura, 1998, Biochemical and biophysical research communications.

Peptide Cyclization Mediated by Metal-Free S-Arylation: S-Protected Cysteine Sulfoxide as an Umpolung of Cysteine Nucleophile.

T. Fujiwara, T. Sugiki, A. Otaka, 2021, Chemistry.

Calcitonin gene-related peptide increases in the dorsal root ganglia of adjuvant arthritic rat

A. Otaka, N. Fujii, H. Ohno, 1989, Peptides.

A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP47.

A. Otaka, T. Koide, Akira Shigenaga, 2010, Bioorganic & medicinal chemistry.

Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and their use in the preparation of low-molecule CXCR4 antagonists.

K. Kitaura, A. Otaka, H. Tamamura, 2006, The Journal of organic chemistry.

Electrostatically constrained alpha-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide.

M. Matsuoka, A. Otaka, Yuji Kobayashi, 2009, The international journal of biochemistry & cell biology.

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.

P. Zhan, Yukihiro Itoh, Miki Suzuki, 2016, Journal of medicinal chemistry.

Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.

Stephen C Peiper, Satoshi Ueda, Shinya Oishi, 2005, Journal of medicinal chemistry.

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

Fa Liu, Marc C. Nicklaus, Dong-Hee Lee, 2009, Nature Structural &Molecular Biology.

Stereoselective synthesis of CF(2)-substituted phosphothreonine mimetics and their incorporation into peptides using newly developed deprotection procedures.

T. Kinoshita, A. Otaka, H. Tamamura, 2000, The Journal of organic chemistry.

Identification of Cell Binding Sites in the Laminin α5-Chain G Domain

A. Otaka, M. Nomizu, N. Nishi, 2002 .

Cell Adhesive Sequences in Mouse Laminin β1 Chain

H. Kleinman, Y. Kuratomi, A. Otaka, 2000 .

Cell Binding Sequences in Mouse Laminin α1 Chain*

H. Kleinman, Y. Kuratomi, A. Otaka, 1998, The Journal of Biological Chemistry.

A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide, T22 ([Tyr5,12, Lys7]-polyphemusin II), determined by nuclear magnetic resonance.

D. Kohda, A. Otaka, H. Tamamura, 1993, Biochimica et biophysica acta.

Trojan p16 peptide suppresses pancreatic cancer growth and prolongs survival in mice.

M. Imamura, R. Hosotani, Y. Miyamoto, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

New strategy for the chemical synthesis of proteins

A. Otaka, N. Fujii, Toshihiro Watanabe, 1988 .

Preparation of Nα‐Boc 4‐O‐Diethylphospho‐L‐azatyrosine, a Reagent Potentially Useful for the Synthesis of Signal Transduction Related Peptides.

T. Burke, A. Otaka, B. Ye, 1996 .

F(Pmp)-TAM, a Novel Competitive Inhibitor of the Binding of ZAP-70 to the T Cell Antigen Receptor, Blocks Early T Cell Signaling (*)

R. Aebersold, J. Watts, P. Roller, 1995, The Journal of Biological Chemistry.

Dimeric peptides of the C‐terminal region of CXCL14 function as CXCL12 inhibitors

T. Hara, A. Otaka, Akira Shigenaga, 2013, FEBS letters.

Interactions between local anesthetics and Na+ channel inactivation gate peptides in phosphatidylserine suspensions as studied by 1H-NMR spectroscopy.

A. Otaka, T. Nakagawa, N. Fujii, 2000, Chemical & pharmaceutical bulletin.

Disulfide bond formation in S-Acetamidomethyl cysteine-containing peptides by the combination of silver trifluoromethanesulfonate and dimethylsulfoxide / aqueous HCl

A. Otaka, T. Koide, H. Tamamura, 1993 .

Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation.

A. Otaka, H. Tamamura, N. Fujii, 2004, Chemical communications.

Development and photo-responsive peptide bond cleavage reaction of two-photon near-infrared excitation-responsive peptide

A. Otaka, T. Furuta, Akira Shigenaga, 2010 .

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

Fa Liu, Dong-Hee Lee, Jung-Eun Park, 2009, Nature Structural &Molecular Biology.

Peptide probes containing a non‐hydrolyzable phosphotyrosine‐mimetic residue for enrichment of protein tyrosine phosphatases

Y. Ishihama, A. Otaka, Kazuya Tsumagari, 2021, Proteomics.

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

T. Katagiri, Y. Miyoshi, S. Toyokuni, 2017, Scientific Reports.

Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics.

A. Otaka, N. Fujii, Akira Shigenaga, 2006, The Journal of organic chemistry.

Identification of Cell Binding Sites in the Laminin α1 Chain Carboxyl-terminal Globular Domain by Systematic Screening of Synthetic Peptides (*)

A. Utani, H. Kleinman, P. Roller, 1995, The Journal of Biological Chemistry.

Light-induced propulsion of a giant liposome driven by peptide nanofibre growth

Akihito Uemura, Akira Otaka, Kazunori Matsuura, 2018, Scientific Reports.

Development of an Intein-Inspired Amide Cleavage Chemical Device.

A. Otaka, Akira Shigenaga, T. Inokuma, 2016, The Journal of organic chemistry.

FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides : influence of amino acid sequence on reaction kinetics

A. Otaka, Akira Shigenaga, Jun Yamamoto, 2009 .

Cyclic peptide inhibitors of phosphatidylinositol 3-kinase p85 SH2 domain binding.

S. Shoelson, P. Roller, T. Burke, 1994, Biochemical and biophysical research communications.

Synthesis and structure activity studies of phosphatase resistant SH2 domain inhibiting peptides: D-amino acid effects

S. Shoelson, P. Roller, T. Burke, 1995 .

Synthesis and structure-activity studies of SH2 binding peptides containing hydrolytically stable analogs of O -phosphotyrosine

S. Shoelson, P. Roller, T. Burke, 1994 .

New access to α-substituted (Z)-fluoroalkene dipeptide isosteres utilizing organocopper reagents under ‘reduction–oxidative alkylation (R–OA)’ conditions

A. Otaka, H. Tamamura, N. Fujii, 2001 .

Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organometallic Reagents

A. Otaka, H. Tamamura, N. Fujii, 2001 .

Conformational analysis of cyclic hexapeptides designed as constrained ligands for the SH2 domain of the p85 subunit of phosphatidylinositol-3-OH kinase.

P. Roller, T. Burke, A. Otaka, 1996, Biopolymers.

Norleucine as a replacement for methionine in phosphatase-resistant linear and cyclic peptides which bind to p85 SH2 domains

S. Shoelson, P. Roller, T. Burke, 1994 .

Cell adhesive sequences in mouse laminin beta1 chain.

H. Kleinman, A. Otaka, Y. Yamada, 2000, Archives of biochemistry and biophysics.

Studies on Peptides. CXLIII. : Evaluation of β-Methylaspartate for Peptide Synthesis

S. Futaki, A. Otaka, N. Fujii, 1986 .

Studies on Peptides. CXXXII. : Evaluation of Two β-Carboxyl Protecting Groups of Aspartic Acid, Cycloheptyl and Cyclooctyl, for Peptide Synthesis

S. Futaki, A. Otaka, N. Fujii, 1986 .

Proline cis/trans-Isomerase Pin1 Regulates Peroxisome Proliferator-activated Receptor γ Activity through the Direct Binding to the Activation Function-1 Domain*

K. Morikawa, A. Otaka, Tsuyoshi Waku, 2009, The Journal of Biological Chemistry.

Role of disulfide linkages in tachyplesin-lipid interactions.

A. Otaka, N. Fujii, K. Miyajima, 1993, Biochemistry.

Studies on peptides. CLII. Hard acid deprotecting procedure for peptide synthesis.

A. Otaka, H. Yajima, S. Funakoshi, 1987, Chemical & pharmaceutical bulletin.

Structural study of the sodium channel inactivation gate peptide including an isoleucine-phenylalanine-methionine motif and its analogous peptide (phenylalanine/glutamine) in trifluoroethanol solutions and SDS micelles.

K. Kanaori, A. Otaka, T. Nakagawa, 2000, The journal of peptide research : official journal of the American Peptide Society.

Synthesis of phosphonomethyl-phenylalanine and phosphotyrosine containing cyclic peptides as inhibitors of protein tyrosine kinase/SH2 interactions

P. Roller, A. Otaka, M. Nomizu, 1994 .

A novel anti-HIV synthetic peptide, T-22 ([Tyr5,12,Lys7]-polyphemusin II).

T Ueda, A. Otaka, H. Tamamura, 1992, Biochemical and biophysical research communications.

Discovery of a Macropinocytosis‐Inducing Peptide Potentiated by Medium‐Mediated Intramolecular Disulfide Formation

S. Futaki, A. Otaka, K. Sonomura, 2021, Angewandte Chemie.

Discovery of a Macropinocytosis-Inducing Peptide Potentiated by Medium-Mediated Intramolecular Disulfide Formation.

S. Futaki, A. Otaka, K. Sonomura, 2021, Angewandte Chemie.

Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II).

A. Otaka, H. Tamamura, R. Arakaki, 1998, Bioorganic & medicinal chemistry.

The synthetic [Tyr5,12,Lys7]-polyphemusin II peptide (T22) binds to the CD4 cell surface molecule.

A. Otaka, H. Tamamura, M. Nomizu, 1995, Biochemical and biophysical research communications.

Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes.

A. Otaka, H. Tamamura, N. Fujii, 2000, Bioorganic & medicinal chemistry letters.

Downsizing of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II), with the maintenance of anti-HIV activity and solution structure.

A. Otaka, H. Tamamura, H. Nakashima, 1998, Bioorganic & medicinal chemistry.

HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II), and its related compounds

A. Otaka, H. Tamamura, H. Nakashima, 1999 .

Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides.

T. Kawakami, A. Otaka, K. Kawakami, 2016, Biochimica et biophysica acta.

Copper(II)-mediated C-H sulphenylation or selenylation of tryptophan enabling macrocyclization of peptides.

A. Otaka, K. Tsuchiya, Masaya Denda, 2021, Chemical communications.

A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres.

T. Narumi, A. Otaka, N. Fujii, 2006, Chemical communications.

Synthesis of amide-type fluoroalkene dipeptide isosteres by an intramolecular redox reaction.

Y. Shimohigashi, A. Otaka, Akira Shigenaga, 2009, The Journal of organic chemistry.

A Novel One‐Pot Reaction Involving Organocopper‐Mediated Reduction/Transmetalation/Asymmetric Alkylation, Leading to the Diastereoselective Synthesis of Functionalized (Z)‐Fluoroalkene Dipeptide Isosteres.

T. Narumi, A. Otaka, N. Fujii, 2007 .

Synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing organocopper-mediated reduction of γ,γ-difluoro-α,β-enoates

A. Otaka, H. Tamamura, N. Fujii, 2001 .

An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gαs.

Tomoaki Koga, A. Otaka, Y. Sugimoto, 2017, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.

Glycosylation of the active sequence ser-ile-lys-val-ala-val from the α1 chain of laminin reduces tumor cell attachment activity

A. Otaka, M. Nomizu, Yoshihiko Yamada, 1995 .

Molecular parameters for the anti-human immunodeficiency virus activity of T22 ([Tyr5,12, Lys7]-polyphemusin II).

A. Otaka, H. Tamamura, K. Miyajima, 1994, Biological & pharmaceutical bulletin.

An anti-HIV peptide T22 is confirmed to be a selective CXCR4/fusin inhibitor by comparative inhibition study of a chemokine SDF-1, synthesized by regioselective disulfide bond formation

A. Otaka, H. Tamamura, H. Nakashima, 1999 .

Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes*

A. Otaka, T. Shimanouchi, H. Saito, 2015, The Journal of Biological Chemistry.

Studies on peptides. CXXXVI. Solution-phase synthesis of a 37-residue peptide amide corresponding to the entire amino acid sequence of human calcitonin gene-related peptide (hCGRP).

K. Torizuka, A. Otaka, N. Fujii, 1986, Chemical & pharmaceutical bulletin.

Studies on peptides. CXXXV. Preparation of seven peptide fragments for the synthesis of human calcitonin gene-related peptide (hCGRP).

A. Otaka, M. Nomizu, H. Yajima, 1986, Chemical & pharmaceutical bulletin.

Application of S-1-adamantylcysteine to the synthesis of a 37-residue peptide amide corresponding to human calcitonin gene-related peptide (hCGRP)

K. Torizuka, A. Otaka, N. Fujii, 1985 .

Tailored Synthesis of 162‐Residue S‐Monoglycosylated GM2‐Activator Protein (GM2AP) Analogues that Allows Facile Access to a Protein Library

T. Hirokawa, A. Otaka, Kohei Sato, 2016, Chembiochem : a European journal of chemical biology.

Anti-HIV activity and conformational analysis of a novel synthetic peptide, T22 ([Tyr5,12, Lys7]-Polyphemusin II)

A. Otaka, H. Tamamura, H. Nakashima, 1994 .

Mechanism of laminin chain assembly into a triple-stranded coiled-coil structure.

A. Utani, P. Roller, K. Beck, 1996, Biochemistry.

1H-NMR and circular dichroism spectroscopic studies on changes in secondary structures of the sodium channel inactivation gate peptides as caused by the pentapeptide KIFMK.

K. Kanaori, A. Otaka, T. Nakagawa, 1999, Biophysical journal.

Facile access to (Z)-alkene-containing diketopiperazine mimetics utilizing organocopper-mediated anti-SN2′ reactions

A. Otaka, H. Tamamura, N. Fujii, 2005 .

Synthesis of lactam-bridged cyclic peptides using sequential olefin metathesis and diimide reduction reactions

A. Otaka, Akira Shigenaga, T. Inokuma, 2015 .

Development of a novel tocopheryl ester for suppression of lipid accumulation without cytotoxicity by optimization of dicarboxylic ester moiety

A. Otaka, K. Kogure, Mizune Ozono, 2022, Biochemistry and Biophysics Reports.

Solution-phase synthesis of an anti-human immunodeficiency virus peptide, T22 ([Tyr5,12,Lys7]-polyphemusin II), and the modification of Trp by the p-methoxybenzyl group of Cys during trimethylsilyl trifluoromethanesulfonate deprotection.

A. Otaka, H. Tamamura, H. Yoshizawa, 1995, Chemical & pharmaceutical bulletin.

Unambiguous synthesis of stromal cell-derived factor-1 by regioselective disulfide bond formation using a DMSO–aqueous HCl system

A. Otaka, H. Tamamura, F. Matsumoto, 1998 .

S-Protected Cysteine Sulfoxide-Enabled Tryptophan-Selective Modification with Application to Peptide Lipidation.

A. Otaka, N. Inagaki, N. Harada, 2022, ACS medicinal chemistry letters.

A photoinduced growth system of peptide nanofibres addressed by DNA hybridization.

A. Otaka, M. Furutani, K. Matsuura, 2015, Chemical communications.

Cell binding sequences in mouse laminin alpha1 chain.

H. Kleinman, A. Otaka, Y. Yamada, 1998, The Journal of biological chemistry.

HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus

H. Doerr, J. Cinatl, A. Otaka, 2004, Biochemical and Biophysical Research Communications.

Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides.

T. Kawakami, A. Otaka, K. Kawakami, 2016, Biochimica et biophysica acta.

Synthesis of fluoroalkene dipeptide isosteres by an intramolecular redox reaction utilizing N-heteorocyclic carbenes (NHCs).

T. Narumi, A. Otaka, N. Fujii, 2009, The Journal of organic chemistry.

Synthesis of (Z)-alkene and (E)-fluoroalkene-containing diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations.

K. Kitaura, T. Narumi, A. Otaka, 2006, The Journal of organic chemistry.

Deprotection and cleavage methods for protected peptide resins containing 4-[(diethylphosphono)difluoromethyl]-D,L-phenylalanine residues

P. Roller, T. Burke, A. Otaka, 1993 .

Identification of minimal sequence for HIV-1 fusion inhibitors.

M. Matsuoka, A. Otaka, N. Fujii, 2008, Bioorganic & medicinal chemistry.

Chemical synthesis of biologically active monoglycosylated GM2-activator protein analogue using N-sulfanylethylanilide peptide.

A. Otaka, Kohei Sato, D. Tsuji, 2013, Angewandte Chemie.

Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S‐cyanylation and hydrazinolysis

S. Futaki, A. Otaka, Akira Shigenaga, 2016, Biopolymers.

Convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins and its application to the synthesis of bifunctional anti-HIV compounds

A. Otaka, H. Tamamura, T. Ishihara, 1999 .

Convenient one-pot synthesis of cystine-containing peptides using the trimethylsilyl chloride–dimethyl sulfoxide/trifluoroacetic acid system and its application to the synthesis of bifunctional anti-HIV compounds1

A. Otaka, H. Tamamura, N. Fujii, 1998 .

A convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins using the trimethylsilyl chloride–dimethyl sulfoxide–trifluoroacetic acid system

A. Otaka, T. Koide, H. Tamamura, 1996 .