P. Lavia

发表

E2F target genes and cell‐cycle checkpoint control

P. Jansen-Dürr, P. Lavia, 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

Spatial control of mitosis by the GTPase Ran

P. Lavia, R. Mangiacasale, M. Ciciarello, 2007, Cellular and Molecular Life Sciences.

Two E2F Sites Control Growth-regulated and Cell Cycle-regulated Transcription of the Htf9-a/RanBP1 Gene through Functionally Distinct Mechanisms*

R. Kerkhoven, P. Lavia, G. Guarguaglini, 1999, The Journal of Biological Chemistry.

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

C. Martini, A. Coluccia, R. Silvestri, 2018, European journal of medicinal chemistry.

Transcriptional control of the Htf9-A/RanBP-1 gene during the cell cycle.

P. Lavia, K. Zerfass, M. Tripodi, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Transcriptional Control of the Htf 9-A / RanBP-1 Gene during the Cell Cycle ’

P. Lavia, K. Zerfass, M. Tripodi, 2005 .

Emerging roles of DNA tumor viruses in cell proliferation: new insights into genomic instability

A. Giordano, M. G. Paggi, P. Lavia, 2003, Oncogene.

Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy

P. Visca, E. Gallo, S. Schenone, 2015, Oncotarget.

Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores

P. Lavia, A. Harel, M. Schininá, 2012, The Journal of cell biology.

Deregulated expression of the RanBP1 gene alters cell cycle progression in murine fibroblasts.

E. Cundari, P. Lavia, G. Guarguaglini, 1997, Journal of cell science.

E 1 A Deregulates the Centrosome Cycle in a Ran GTPase-dependent Manner 1

A. Baldi, A. Luca, M. G. Paggi, 2003 .

RANBP 2 ( RAN binding protein 2 )

P. Lavia, Erica Di Cesare, 2017 .

Transcription factors binding to the mouse HTF9 housekeeping promoter differ between cell types.

P. Lavia, M. P. Somma, I. Gambino, 1991, Nucleic acids research.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

Y. Ni, E. Novellino, B. Maresca, 2013, Journal of medicinal chemistry.

Subcellular localization of the five members of the human steroid 5α-reductase family

B. Vallone, F. Mancia, L. C. Montemiglio, 2017, Biochimie open.

New CRIME plots

P. Lavia, M. Ciciarello, 2005 .

New CRIME plots. Ran and transport factors regulate mitosis.

P. Lavia, M. Ciciarello, 2005, EMBO reports.

p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells

R. Silvestri, G. La Regina, A. Santoni, 2017, Oncoimmunology.

Coincident start sites for divergent transcripts at a randomly selected CpG‐rich island of mouse.

A. Bird, P. Lavia, D. Macleod, 1987, The EMBO journal.

Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region

P. Lavia, P. Rovella, L. Le Pera, 2019, Oncogene.

Regulated interactions of the SUMO ligase RANBP2 with the mitotic spindle and kinetochores during mitotic progression Dottorando

S. Soddu, P. Lavia, S. Bonaccorsi, 2017 .

p73 Is Regulated by Phosphorylation at the G2/M Transition*

G. Blandino, S. Strano, M. Levrero, 2003, Journal of Biological Chemistry.

Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells

D. Trisciuoglio, A. Mai, D. Del Bufalo, 2022, Cancer Gene Therapy.

Identification of small molecule inhibitors of the Aurora-A/TPX2 complex

A. Paiardini, P. Lavia, I. A. Asteriti, 2017, Oncotarget.

Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function

V. de Turris, P. Lavia, R. De Santis, 2017, Journal of Cell Science.

Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cells.

P. Lavia, G. Guarguaglini, M. De Luca, 2008, Molecular biology of the cell.

PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma

I. Screpanti, G. Giannini, A. Gulino, 2017, Oncogene.

Activation of human ribosomal genes by 5-azacytidine.

P. Lavia, M. Ferraro, 1983, Experimental cell research.

E2F transcription factors are differentially expressed in murine gametes and early embryos

P. Lavia, C. Spadafora, R. Mangiacasale, 2000, Mechanisms of Development.

An Epigenetic LINE-1-Based Mechanism in Cancer

P. Lavia, C. Spadafora, I. Sciamanna, 2022, International journal of molecular sciences.

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

Ettore Novellino, Andrea Brancale, Ilaria Granata, 2011, Journal of medicinal chemistry.

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

E. Novellino, L. Di Marcotullio, C. Martini, 2015, Journal of medicinal chemistry.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

Ettore Novellino, Andrea Brancale, Ruoli Bai, 2014, Journal of medicinal chemistry.

A role for endogenous reverse transcriptase in tumorigenesis and as a target in differentiating cancer therapy

P. Lavia, E. Garaci, C. Spadafora, 2006, Genes, chromosomes & cancer.

A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains enriched in retroposon DNA.

D. Cimini, G. Zaccagnini, P. Lavia, 1999, Journal of cell science.

Differential gene activity visualized on sister chromatids after replication in the presence of 5-azacytidine

P. Lavia, M. Ferraro, 2004, Chromosoma.

Clonal inheritance of rRNA gene activity: Cytological evidence in human cells

P. Lavia, M. Ferraro, F. Pelliccia, 2004, Chromosoma.

Effects of potassium cyanide on silver stainability of specific cell structures.

P. Lavia, M. Ferraro, F. Pelliccia, 1982, Stain technology.

Silver staining of the nucleolus organizer regions (NOR) requires clusters of sulfhydryl groups.

A. Finazzi-Agro’, P. Lavia, M. Ferraro, 1982, Journal of Histochemistry and Cytochemistry.

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential

P. Lavia, A. Verrico, V. Leaner, 2016, IUBMB life.

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces

P. Lavia, I. A. Asteriti, G. Guarguaglini, 2011, Molecular Cancer.

Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation

P. Lavia, C. Nervi, C. Barone, 2003, Oncogene.

Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells

G. Cuda, F. Costanzo, M. G. Paggi, 2013, Oncogene.

E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner.

A. Baldi, A. De Luca, M. G. Paggi, 2003, Cancer research.

The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?

Giulia Guarguaglini, P. Lavia, I. A. Asteriti, 2010, Biochimica et biophysica acta.

Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity

L. Brunetto, P. Lavia, I. A. Asteriti, 2008, Oncogene.

A Functional Interplay Between Aurora-A, Plk1 and TPX2 at Spindle Poles: Plk1 Controls Centrosomal Localization of Aurora-A and TPX2 Spindle Association

P. Lavia, G. Guarguaglini, M. Luca, 2006, Cell cycle.

p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells.

M. Kirsch‐Volders, E. Cundari, A. Elhajouji, 1999, Experimental cell research.

Characterization of the opposite-strand genes from the mouse bidirectionally transcribed HTF9 locus.

N. Copeland, D. Gilbert, N. Jenkins, 1991, Gene.

Mammalian Genes and Islands of Non-Methylated CpG-Rich DNA

A. Bird, P. Lavia, M. Taggart, 1987 .

Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium.

F. Tirone, M. Quarto, G. Corrente, 2000, Genomics.

Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules

E. Cundari, A. Coluccia, R. Silvestri, 2017, Oncotarget.

Control of Aurora-A stability through interaction with TPX2

P. Lavia, I. A. Asteriti, G. Guarguaglini, 2011, Journal of Cell Science.

The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy

B. Neumann, E. Cundari, P. Lavia, 2014, Oncotarget.

The GTPase Ran: regulation of cell life and potential roles in cell transformation.

P. Lavia, R. Mangiacasale, M. Ciciarello, 2008, Frontiers in bioscience : a journal and virtual library.

The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme

E. Gallo, F. Musumeci, S. Schenone, 2017, Oncotarget.

Normal and cancer‐prone human cells respond differently to extremely low frequency magnetic fields

E. Cundari, P. Lavia, I. Sciamanna, 2001, FEBS letters.

Expression of the murine RanBP1 and Htf9-c genes is regulated from a shared bidirectional promoter during cell cycle progression.

P. Lavia, G. Guarguaglini, G. Di Matteo, 1997, The Biochemical journal.

Mammalian RanBP1 regulates centrosome cohesion during mitosis

E. Cundari, A. Tassin, P. Lavia, 2003, Journal of Cell Science.

A Role of p73 in Mitotic Exit*

G. Blandino, S. Strano, M. Levrero, 2005, Journal of Biological Chemistry.

p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.

E. Cundari, S. Soddu, E. Oricchio, 2004, Molecular biology of the cell.

The GTPase RAN regulates multiple steps of the centrosome life cycle

P. Lavia, 2016, Chromosome Research.

Interactions with Single-stranded and Double-stranded DNA-binding Factors and Alternative Promoter Conformation upon Transcriptional Activation of the Htf9-a/RanBP1 andHtf9-c Genes*

P. Lavia, G. Guarguaglini, F. Palitti, 1998, The Journal of Biological Chemistry.

The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases

P. Lavia, F. Degrassi, Michela Damizia, 2019, Cells.

Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors.

A. Mai, G. Sbardella, P. Lavia, 2011, Journal of medicinal chemistry.

Reverse transcriptase inhibitors promote the remodeling of nuclear architecture and induce autophagy in prostate cancer cells.

D. Trisciuoglio, G. Sbardella, P. Lavia, 2020, Cancer letters.

Segmental chromosome aberrations converge on overexpression of mitotic spindle regulatory genes in high‐risk neuroblastoma

G. Tonini, Viktoryia Sidarovich, N. Arseni, 2012, Genes, chromosomes & cancer.

Mitotic Functions of the Ran GTPase Network: the Importance of Being in the Right Place at the Right Time

P. Lavia, M. Ciciarello, B. D. Fiore, 2004, Cell cycle.

Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity

I. Bozzoni, M. Fanciulli, P. Lavia, 2021, Molecular cell.

Aurora B SUMOylation Is Restricted to Centromeres in Early Mitosis and Requires RANBP2

A. Musacchio, P. Lavia, V. Krenn, 2023, Cells.

p53 Displacement from Centrosomes and p53-mediated G1 Arrest following Transient Inhibition of the Mitotic Spindle*

E. Cundari, S. Soddu, P. Lavia, 2001, The Journal of Biological Chemistry.

The housekeeping promoter from the mouse CpG island HTF9 contains multiple protein-binding elements that are functionally redundant.

P. Lavia, M. P. Somma, C. Pisano, 1991, Nucleic acids research.

Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells

P. Lavia, A. Harel, R. Mangiacasale, 2010, Chromosoma.

RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner

A. Tedeschi, P. Lavia, R. Mangiacasale, 2009, Oncogene.

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells

A. Tedeschi, P. Lavia, R. Mangiacasale, 2007, Journal of Cell Science.

Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo.

E. Cundari, P. Lavia, G. Guarguaglini, 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

RAN (RAN, member RAS oncogene family)

P. Lavia, W. Rensen, 2011 .

Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.

M. Bornens, A. Tassin, C. Celati, 2003, Molecular biology of the cell.

Importin β is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells

P. Lavia, G. Guarguaglini, R. Mangiacasale, 2004, Journal of Cell Science.

Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays

P. Lavia, I. A. Asteriti, G. Guarguaglini, 2018, Scientific Reports.

Immunofluorescence methods in studies of the GTPase RAN and its effectors in interphase and in mitotic cells.

V. de Turris, P. Lavia, G. Guarguaglini, 2014, Methods in molecular biology.

Ran control of mitosis in human cells: gradients and local signals.

P. Lavia, G. Guarguaglini, A. Bolognesi, 2010, Biochemical Society transactions.