S. Kozma

Á. Valverde, J. Muntané, Á. González-Rodríguez, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Detection of virus antigens in Swiss albino mice infected by milk-borne mouse mammary tumour virus: the effect of age, sex and reproductive status. I. Localization by immunofluorescence of four antigens in mammary tissues and other organs.

S. Kozma, C. Calberg‐Bacq, P. Osterrieth, 1979, The Journal of general virology.

Oncogenic MYC Induces the Impaired Ribosome Biogenesis Checkpoint and Stabilizes p53, Independent of Increased Ribosome Content.

S. Kozma, A. Gentilella, G. Thomas, 2019, Cancer research.

Phytohormones Participate in an S6 Kinase Signal Transduction Pathway in Arabidopsis1

F. Nagy, F. Turck, G. Thomas, 2004, Plant Physiology.

A Heat-Sensitive Arabidopsis thalianaKinase Substitutes for Human p70s6k Function In Vivo

F. Nagy, F. Turck, G. Thomas, 1998, Molecular and Cellular Biology.

S6K1 controls pancreatic β cell size independently of intrauterine growth restriction.

P. Pfluger, M. Tschöp, R. Adams, 2015, The Journal of clinical investigation.

MYCN concurrence with SAHA-induced cell death in human neuroblastoma cells

S. Ambrosio, S. Kozma, A. Tauler, 2015, Cellular Oncology.

The Search for Oncogenes in Breast Cancer

B. Groner, A. Andres, R. Jaggi, 1986 .

An Analysis of Three Proto-Oncogenes in Primary Human Breast Tumor DNAs: The c-mos, the c-erbB-2 and the Epidermal Growth Factor Receptor Genes

B. Groner, N. Hynes, S. Kozma, 1988 .

NewAcceptor CellforTransfected GenomicDNA:Oncogene Transfer into aMouseMammaryEpithelial CellLine

B. Groner, N. Hynes, R. Jaggi, 1985 .

New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line

B. Groner, R. Jaggi, S. Kozma, 1985 .

p70s6k/p85s6k: mechanism of activation and role in mitogenesis.

G. Thomas, S. Kozma, George Thomas, 1994, Seminars in cancer biology.

Mechanistic Target of Rapamycin (Mtor) Is Essential for Murine Embryonic Heart Development and Growth

G. Thomas, S. Kozma, E. Abel, 2013, PloS one.

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.

M. Siegmann, S. Ferrari, G. Thomas, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Therapeutics , Targets , and Chemical Biology Differential Expression of S 6 K 2 Dictates Tissue-Specific Requirement for S 6 K 1 in Mediating Aberrant mTORC 1 Signaling and Tumorigenesis

M. Loda, J. Clohessy, P. Pandolfi, 2011 .

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.

M. Loda, J. Clohessy, P. Pandolfi, 2011, Cancer research.

p70S6K Controls Selective mRNA Translation during Oocyte Maturation and Early Embryogenesis inXenopus laevis

M. Schwab, J. Maller, N. Terada, 1999, Molecular and Cellular Biology.

Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras

C. Heldin, J. Bos, B. Burgering, 1994, Nature.

hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling.

G. Thomas, S. Kozma, T. Nobukuni, 2007, Current Opinion in Cell Biology.

The Nuclear Receptor DHR3 Modulates dS6 Kinase–Dependent Growth in Drosophila

E. Hafen, G. Thomas, S. Kozma, 2010, PLoS genetics.

Deficiency of IL-6 versus IL-6 Receptor Differences in Wound Healing in Mice with

S. Kozma, M. Zhou, Molly M. McFarland-Mancini, 2015 .

A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis

J. Latorre, J. Moreno-Navarrete, F. Ortega, 2022, JCI insight.

S 6 K 1 controls pancreatic b cell size independently of intrauterine growth restriction

M. Tschöp, R. Adams, G. Thomas, 2018 .

K 1 controls pancreatic β cell size independently of intrauterine growth restriction

P. Pfluger, M. Tschöp, R. Adams, 2022 .

Immunological characterization of a mammary tumour virus from Swiss mice: multiple epitopes associated with the viral gene products.

S. Kozma, C. Calberg‐Bacq, P. Osterrieth, 1981, The Journal of general virology.

S6K1 deficiency protects against apoptosis in hepatocytes

Á. Valverde, Á. González-Rodríguez, Javier Alba, 2009, Hepatology.

Phosphorylation Sites in the Autoinhibitory Domain Participate in p70s6k Activation Loop Phosphorylation*

R. Pearson, S. Kozma, P. Dennis, 1998, The Journal of Biological Chemistry.

S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy.

G. Thomas, S. Kozma, Jian-Kang Chen, 2009, American journal of physiology. Renal physiology.

Year : 2003 Insulin activation of Rheb , a mediator of mTOR / S 6 K / 4 EBP signaling , is inhibited by TSC 1 and 2

E. Hafen, J. Bos, G. Thomas, 2006 .

Expression of the p70s6k / p85s6k Isoforms from a Single Gene and Activation Following Mitogenic Stimulation

G. Thomas, S. Kozma, C. Reinhard, 1993 .

The Drosophila p 70 s 6 k homolog exhibits conserved regulatory elements and rapamycin sensitivity ( signal transduction / phosphorylation / Schneider cells )

C. A. Berry, G. Thomas, S. Kozma, 2005 .

The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity.

G. Thomas, S. Kozma, C. O. Berry, 1996, Proceedings of the National Academy of Sciences of the United States of America.

A stimulated S6 kinase from rat liver: identity with the mitogen activated S6 kinase of 3T3 cells.

M. Siegmann, S. Ferrari, G. Thomas, 1989, The EMBO journal.

Rapamycin impacts positively on longevity, despite glucose intolerance induction.

S. Kozma, A. Piguet, P. Martins, 2012, Journal of hepatology.

Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences.

B. Groner, S. Kozma, N. Hynes, 1988, The EMBO journal.

Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin.

J. Dumont, R. Stein, F. Vandeput, 2000, The Biochemical journal.

Oncogenic activation of the human trk proto‐oncogene by recombination with the ribosomal large subunit protein L7a.

S. Kozma, A. Ziemiecki, N. Hynes, 1990, The EMBO journal.

Phytohormones Participate in an S6 Kinase Signal Transduction Pathway in Arabidopsis1

F. Nagy, F. Turck, G. Thomas, 2004, Plant Physiology.

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

G. Thomas, S. Kozma, C. Reinhard, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Identification and early activation of a Xenopus laevis p70s6k following progesterone‐induced meiotic maturation.

M. Dorée, G. Thomas, S. Kozma, 1992, The EMBO journal.

- S6K: Ribosomal protein S6 kinase (vertebrates) p70S6 kinaseαI andαII (p70S6Kp85S6K)

G. Thomas, S. Kozma, 1995 .

Unmasking a growth factor/oncogene-activated S6 phosphorylation cascade.

S. Ferrari, S. Kozma, G. Thomas, 1989, Cellular signalling.

Active baculovirus recombinant p70s6k and p85s6k produced as a function of the infectious response.

M. Siegmann, S. Ferrari, S. Kozma, 1993, The Journal of biological chemistry.

New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line

B. Groner, N. Hynes, R. Jaggi, 1985, Molecular and cellular biology.

Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis

Yi Zheng, J. Cancelas, G. Thomas, 2013, Haematologica.

The ganglioside content of the milk fat-globule membrane and the mouse mammary-tumour virus isolated from the milk of infected mice. Partial characterization of a new disialoganglioside.

S. Kozma, C. Calberg‐Bacq, G. V. Van Dessel, 1980, European journal of biochemistry.

Drosophila S6 kinase: a regulator of cell size.

E. Hafen, G. Thomas, S. Kozma, 1999, Science.

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

N. Sonenberg, T. Alain, O. Larsson, 2010, Science.

A guide to analysis of mouse energy metabolism

Robert V Farese, E. Ravussin, R. Eckel, 2011, Nature Methods.

Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

F. Natt, G. Thomas, S. Kozma, 2008, Cell metabolism.

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

G. Thomas, S. Kozma, N. Pullen, 1996, Molecular and cellular biology.

Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice

R. Burcelin, B. Thorens, M. Pende, 2000, Nature.

Among the human antibodies reacting with intracytoplasmic a particles of mouse mammary tumor virus, some react with MMTV p14, the nucleic‐acid‐binding protein, and others with MMTV p28, the main core protein

P. Hainaut, S. Kozma, S. Zotter, 1983, International journal of cancer.

Effect of low doses of actinomycin D on neuroblastoma cell lines

George Thomas, J. Hernández-Losa, S. Ambrosio, 2016, Molecular Cancer.

P1.14A Dose Escalation Single Arm Phase Ib Combination Study of BEZ235 with Everolimus in Patients with Advanced Solid Malignancies

G. Thomas, S. Kozma, T. Wise-Draper, 2015 .

Differences in Wound Healing in Mice with Deficiency of IL-6 versus IL-6 Receptor

S. Kozma, C. Mercer, M. Zhou, 2010, The Journal of Immunology.

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6.

L. Terracciano, M. Grompe, S. Volarevic, 2000, Science.

Identification, partial purification and biochemical characterization of gamma-glutamyltranspeptidase present as a membrane component in skimmed milk and milk fat-globule membranes, and in mammary-tumour virus from the milk of infected mice.

S. Kozma, C. Calberg‐Bacq, P. Osterrieth, 1979, Biochimica et biophysica acta.

Radioimmunoassay for glycoprotein gp47 of murine mammary tumor virus in organs and serum of mice and search for related antigens in human sera.

S. Kozma, P. Franchimont, C. Calberg‐Bacq, 1977, Cancer research.

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

E. Hafen, J. Bos, G. Thomas, 2003, Molecular cell.

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.

G. Thomas, S. Kozma, C. Reinhard, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

B. Viollet, S. Kim, N. Bardeesy, 2010, Cell metabolism.

Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

H. Lane, N. Ratner, J. Perentesis, 2008, Molecular Cancer Therapeutics.

S6K1 plays a critical role in early adipocyte differentiation.

N. Sonenberg, G. Thomas, S. Kozma, 2010, Developmental cell.

Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

G. Thomas, S. Kozma, E. Brown, 2004, Molecular and Cellular Biology.

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K

George Thomas, G. Thomas, S. Kozma, 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

Mammalian TOR: A Homeostatic ATP Sensor

A. Jaeschke, S. Kozma, George Thomas, 2001, Science.

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

J. Clohessy, P. Pandolfi, H. Scher, 2010, The Journal of clinical investigation.

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

S. Kozma, Wei Huang, M. Costa-Mattioli, 2011, Proceedings of the National Academy of Sciences.

Identification of oncogenes in breast tumors and their effects on growth and differentiation.

B. Groner, N. Hynes, A. Andres, 1988, Cancer treatment and research.

Corrigendum: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

J. Auwerx, S. Fumagalli, S. Kozma, 2004, Nature.

Tumour suppressors in liver carcinogenesis.

J. Dufour, Xin Lu, S. Kozma, 2007, Journal of hepatology.

Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activity*

G. Rena, P. Lochhead, C. Sutherland, 2002, The Journal of Biological Chemistry.

The PI3K-mTOR Pathway

G. Thomas, S. Kozma, H. Thomas, 2016 .

Targeting mTOR Signaling Pathways in Liver Disease

S. Kozma, H. Thomas, 2010 .

Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

R. Marcos, N. Agell, G. Thomas, 2020, EMBO Journal.

Phosphorylation and activation of p70s6k by PDK1.

M. Andjelkovic, B. Hemmings, G. Thomas, 1998, Science.

Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis

M. Loda, J. Clohessy, P. Pandolfi, 2009, Science Signaling.

mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma

S. Thorgeirsson, P. Mischel, B. Aronow, 2012, Science Translational Medicine.

Thomas and Autophagy in Hepatocellular Carcinoma mTOR Inhibitors Synergize on Regression , Reversal of Gene Expression

S. Thorgeirsson, P. Mischel, B. Aronow, 2012 .

EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice

Alka A. Potdar, J. M. Brown, S. Kozma, 2017, Nature.

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Janet M. Thornton, David Carling, Linda Partridge, 2009, Science.

S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis.

Min Gyu Lee, J. You, Sang-Jin Lee, 2016, Molecular cell.

Detection of virus antigens in Swiss albino mice infected by milk-borne mouse mammary tumour virus: the effect of age, sex and reproductive status. II. Radioimmunoassay of two virus components, gp47 and p28 in serum and organ extracts.

S. Kozma, P. Franchimont, C. Calberg‐Bacq, 1979, The Journal of general virology.

Radioimmunoassay for protein p28 of murine mammary tumor virus in organs and serum of mice and search for related antigens in human sera and breast cancer extracts.

S. Kozma, P. Franchimont, C. Calberg‐Bacq, 1978, Cancer research.

Distribution of mouse mammary tumour virus antigens in RIII mice as detected by immunofluorescence on tissue sections and by immunoassays in sera and organ extracts.

S. Kozma, C. Calberg‐Bacq, P. Osterrieth, 1980, The Journal of general virology.

Radioimmunoassay for Glycoprotein gp 47 of Murine Mammary Tumor Virus in Organs and Serum of Mice and Search for Related Antigens in Human Sera 1

S. Kozma, P. Franchimont, C. Calberg‐Bacq, 2006 .

Metabolic Control by S6 Kinases Depends on Dietary Lipids

P. Pfluger, M. Tschöp, D. Clegg, 2012, PLoS ONE.

Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes.

G. Thomas, S. Kozma, A. Gentilella, 2017, Molecular cell.

Dual requirement for a newly identified phosphorylation site in p70s6k

R. Pearson, G. Thomas, S. Kozma, 1997, Molecular and cellular biology.

S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

M. Diamond, N. Sonenberg, T. Alain, 2016, Nature Immunology.

S 6 K 1 Phosphorylation of H 2 B Mediates EZH 2 Trimethylation of H 3 : A Determinant of Early Adipogenesis Graphical Abstract Highlights

Min Gyu Lee, J. You, Sang-Jin Lee, 2022 .

Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.

R. Pearson, S. Peddigari, G. Thomas, 2021, Blood.

Serine/threonine kinases in the propagation of the early mitogenic response.

S. Kozma, G. Thomas, George Thomas, 1992, Reviews of physiology, biochemistry and pharmacology.

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

B. Pulendran, N. Sonenberg, T. Alain, 2010, Proceedings of the National Academy of Sciences.

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

L. Schaeffer, J. Tanti, D. Freyssenet, 2009, The Journal of cell biology.

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.

E. Klann, M. Merhav, K. Rosenblum, 2008, Learning & memory.

The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

R. Pearson, G. Thomas, S. Kozma, 1995, The EMBO journal.

mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells

B. Zingarelli, Jian Li, S. Kozma, 2013, Leukemia.

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR

A. Zorzano, S. Ramón y. Cajal, J. Hernández-Losa, 2018, Clinical Cancer Research.

Mitochondrial Complex I Activity Is Required for Maximal Autophagy

G. Thomas, S. Kozma, Jonathan A Stefely, 2018, Cell reports.

A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies

George Thomas, Carol A. Mercer, John C. Morris, 2017, Targeted Oncology.

Interferon-Dependent Engagement of Eukaryotic Initiation Factor 4B via S6 Kinase (S6K)- and Ribosomal Protein S6K-Mediated Signals

L. Platanias, S. Kozma, E. Fish, 2009, Molecular and Cellular Biology.

Effect of low doses of actinomycin D on neuroblastoma cell lines

J. Hernández-Losa, S. Ambrosio, G. Thomas, 2016, Molecular Cancer.

cDNA sequence of the human ribosomal large subunit protein L7a.

N. Hynes, S. Kozma, A. Ziemiecki, 1988, Nucleic acids research.

Mitochondrial Complex I Activity Is Required for Maximal Autophagy

G. Thomas, S. Kozma, Jonathan A Stefely, 2018, Cell reports.

MYCN concurrence with SAHA-induced cell death in human neuroblastoma cells

S. Ambrosio, S. Kozma, A. Tauler, 2015, Cellular Oncology.

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

P. Pandolfi, L. Salmena, J. Teruya-Feldstein, 2008, The Journal of clinical investigation.

A liaison between mTOR signaling, ribosome biogenesis and cancer.

G. Thomas, S. Kozma, A. Gentilella, 2015, Biochimica et biophysica acta.