S. Rabindran

发表

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.

C. Moskaluk, J. Herman, S. Baylin, 1997, Cancer research.

Regulation of heat shock factor trimer formation: role of a conserved leucine zipper.

J. Wiśniewski, Carl Wu, S. Rabindran, 1993, Science.

Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo

J. Wiśniewski, G. Li, S. Rabindran, 1994, Molecular and cellular biology.

4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4 (CDK4).

R. Nilakantan, M. B. Floyd, S. Rabindran, 2008, Journal of medicinal chemistry.

Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.

S. Rabindran, N. Campobasso, V. Sudakin, 2011, Journal of medicinal chemistry.

Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer.

K. Syrigos, K. O'Byrne, Keunchil Park, 2019, The New England journal of medicine.

Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata.

M. K. Harper, C. Ireland, S. Rabindran, 2002, Journal of natural products.

Discovery of Novel AKT Inhibitors with Enhanced Anti-Tumor Effects in Combination with the MEK Inhibitor

Ming-Chih Crouthamel, Rakesh Kumar, S. Rabindran, 2014, PloS one.

Induction temperature of human heat shock factor is reprogrammed in a Drosophila cell environment

Carl Wu, S. Rabindran, J. Clos, 1993, Nature.

Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as anti-proliferative agents.

D. Powell, Biqi Wu, C. Discafani, 2009, Bioorganic & medicinal chemistry.

Glucocorticoid-resistant lymphoma cell variants that contain functional glucocorticoid receptors

M. Stallcup, S. Rabindran, M. Danielsen, 1987, Molecular and cellular biology.

Stimulation of the DNA-dependent Protein Kinase by RNA Polymerase II Transcriptional Activator Proteins (*)

Carl Wu, A. Dvir, S. Peterson, 1995, The Journal of Biological Chemistry.

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: exploration of core and headpiece structure-activity relationships.

D. Powell, N. Zhang, S. Rabindran, 2007, Bioorganic & medicinal chemistry letters.

Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells.

C. Discafani, S. Rabindran, G. Krishnamurthy, 2005, Bioorganic & medicinal chemistry letters.

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region.

D. Powell, N. Zhang, S. Rabindran, 2005, Bioorganic & medicinal chemistry letters.

A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma.

S. Rabindran, C. Wu, W. Powell, 2000, The American journal of pathology.

Displacement of sequence-specific transcription factors from mitotic chromatin

K. Ozato, Carl Wu, S. Rabindran, 1995, Cell.

CheckMate 384: Phase IIIb/IV trial of nivolumab (nivo) 480 mg Q4W versus 240 mg Q2W after ≤ 12 months of nivo in previously treated advanced NSCLC.

N. Reinmuth, K. O'Byrne, S. Rabindran, 2019, Journal of Clinical Oncology.

Inhibition of tumor cell proliferation by thieno[2,3-d]pyrimidin-4(1H)-one-based analogs.

D. Powell, S. Rabindran, J. McGinnis, 2005, Bioorganic & medicinal chemistry letters.

Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.

S. Rabindran, T. Mansour, H. Tsou, 2009, Journal of medicinal chemistry.

Pyrazolo[1,5-a]pyrimidin-7-yl Phenyl Amides as Novel Antiproliferative Agents: Parallel Synthesis for Lead Optimization of Amide Region.

N. Zhang, D. Powell, S. Rabindran, 2005 .

Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.

S. Rabindran, L. Greenberger, Eileen Brown, 1998, Cancer research.

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).

L. Shewchuk, S. Rabindran, A. Hassell, 2012, Journal of medicinal chemistry.

Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.

L. Doyle, D. Ross, Weidong Yang, 2000, Cancer research.

Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)

Ramaswamy Nilakantan, Fei Ye, Allan Wissner, 2003 .

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib.

Patricia L. Harris, Allan Wissner, Thomas J Lynch, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression

S. Rabindran, E. Rosfjord, M. Bott, 2005, Breast Cancer Research and Treatment.

Heat shock-regulated transcription in vitro from a reconstituted chromatin template.

S. Rabindran, P. Becker, C. Wu, 1991, Proceedings of the National Academy of Sciences of the United States of America.

16 Structure and Regulation of Heat Shock Transcription Factor

Carl Wu, Soon-jong Kim, S. Rabindran, 1994 .

Molecular cloning and expression of a human heat shock factor, HSF1.

S. Rabindran, C. Wu, J. Clos, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Antitumor Activity of HKI-272, an Orally Active, Irreversible Inhibitor of the HER-2 Tyrosine Kinase

Ramaswamy Nilakantan, Allan Wissner, William A. Hallett, 2004, Cancer Research.

Two point mutations in the hormone-binding domain of the mouse glucocorticoid receptor that dramatically reduce its function.

M. Garabedian, M. Stallcup, S. Rabindran, 1991, Molecular endocrinology.

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors

M. Meyerson, A. Protopopov, Xiaojun Zhao, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of oligosaccharide chains on mouse mammary tumor virus envelope proteins and the implications for the mechanism of their glucocorticoid regulated processing.

M. Stallcup, L. Snider, S. Rabindran, 1990, Molecular endocrinology.

Mouse lymphoma cell variants with genetically dominant alterations in the maturation of viral glycoproteins.

M. Stallcup, S. Rabindran, 1987, Molecular endocrinology.

Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.

Ramaswamy Nilakantan, Allan Wissner, R. Nilakantan, 2005, Journal of medicinal chemistry.

GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers

P. Sabbatini, R. Kruger, Rakesh Kumar, 2009, Molecular Cancer Therapeutics.

Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase

P. Sabbatini, Rakesh Kumar, S. Rabindran, 2009, Clinical Cancer Research.

Molecular cloning and expression of a human heat shock factor , HSF 1

S. Rabindran, J. Clos, W. Carl, 2022 .

Antitumor activity of HER-2 inhibitors.

S. Rabindran, 2005, Cancer letters.

Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents.

R. Nilakantan, A. Wissner, S. Rabindran, 2002, Bioorganic & medicinal chemistry letters.

AntitumorActivity of GSK 1904529 A , a Small-molecule Inhibitor of the Insulin-like Growth Factor-IReceptorTyrosine Kinase

P. Sabbatini, Rakesh Kumar, S. Rabindran, 2009 .

4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors.

D. Powell, Biqi Wu, A. Wissner, 2002, Bioorganic & Medicinal Chemistry Letters.

4‐Anilino‐3‐cyanobenzo[g]quinolines as Kinase Inhibitors.

N. Zhang, D. Powell, Biqi Wu, 2002 .

Glucocorticoid-dependent maturation of viral proteins in mouse lymphoma cells: Isolation of defective and hormone-independent cell variants

G. Firestone, M. Stallcup, S. Rabindran, 1987, Somatic cell and molecular genetics.

GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers

P. Sabbatini, R. Kruger, S. Rabindran, 2009, Molecular Cancer Therapeutics.

Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase

Brian J. Wilson, P. Sabbatini, S. Rabindran, 2009, Clinical Cancer Research.