A. Constantinou

C. Neophytou, A. Vasincu, A. Constantinou, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Isolation of isoflavones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea

A. Constantinou, J. Weber, K. Schram, 1997, Applied Microbiology and Biotechnology.

Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells.

E. Huberman, A. Constantinou, K. Kiguchi, 1990, Cancer communications.

Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27-dependent G1/S cell cycle arrest in conjunction with NF-B activation

Panagiotis, Christoforos Thomas, A. Constantinou, 2020 .

A novel use for the comet assay: detection of topoisomerase II inhibitors.

G. Salti, T. K. Das Gupta, A. Constantinou, 2000, Anticancer Research.

Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo

A. Husband, M. Dimopoulos, O. Tsitsilonis, 2009, Journal of cellular and molecular medicine.

Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex.

A. Husband, A. Constantinou, 2002, Anticancer research.

Separation of the complexes formed between the regulatory and catalytic subunits of cyclic adenosine monophosphate-dependent protein kinase and topoisomerase I activity in preovulatory follicle-enriched immature rat ovaries.

E. Maizels, M. Hunzicker-Dunn, A. Constantinou, 1989, Molecular endocrinology.

D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells.

P. Papageorgis, C. Neophytou, A. Constantinou, 2014, Biochemical pharmacology.

Reduction in Topoisomerase II Activity Differentiation of Human Leukemia Cells Associated with a Novobiocin-and Phorbol-12-myristate-13-acetate-induced Updated

E. Huberman, A. Constantinou, C. Henning-Chubb, 2006 .

Novobiocin- and phorbol-12-myristate-13-acetate-induced differentiation of human leukemia cells associated with a reduction in topoisomerase II activity.

E. Huberman, A. Constantinou, C. Henning-Chubb, 1989, Cancer research.

Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells.

G. Salti, R. Mehta, T. K. Das Gupta, 2000, European journal of cancer.

Regulation of Lactate Dehydrogenase Gene Expression by AMP‐dependent Protein Kinase Subunits a

A. Constantinou, J. Kwast-Welfeld, S. Squinto, 1986, Annals of the New York Academy of Sciences.

The phosphoform of the regulatory subunit RII of cyclic AMP-dependent protein kinase possesses intrinsic topoisomerase activity

A. Constantinou, S. Squinto, R. Jungmann, 1985, Cell.

Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.

J. Pezzuto, J. Bolton, A. Constantinou, 2002, Journal of agricultural and food chemistry.

Drug Delivery Innovations for Enhancing the Anticancer Potential of Vitamin E Isoforms and Their Derivatives

C. Neophytou, A. Constantinou, 2015, BioMed research international.

Vernonia kotschyana Roots: Therapeutic Potential via Antioxidant Activity

A. Vasincu, A. Constantinou, B. Paulsen, 2014, Molecules.

Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol.

A. Skaltsounis, A. Constantinou, E. M. Odiatou, 2013, Cancer letters.

Carob and its Components in the Management of Gastrointestinal Disorders

A. Kakas, C. Neophytou, A. Constantinou, 2017 .

Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage.

J. Pezzuto, R. Mehta, R. Moriarty, 1995, Carcinogenesis.

Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase

J. Pezzuto, A. Kinghorn, R. Mehta, 1995, Nature Medicine.

Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture.

J. Pezzuto, R. Mehta, R. Moriarty, 1994, Anticancer research.

Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1alpha-hydroxyvitamin D5.

R. Mehta, R. Mehta, R. Moriarty, 1997, Journal of the National Cancer Institute.

Inhibition of topoisomerase II activity in repair-proficient CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065)

N. Shigematsu, A. Constantinou, D. Grdina, 1992 .

The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells.

E. Huberman, A. Constantinou, K. Kiguchi, 1992, Experimental cell research.

To explore the program of cell differentiation in Friend murine eryth roleukemia (MEL) cells, we used three clonal variants: phorbol 12-my

H. Yamasaki, A. Vaughan, A. Constantinou, 2006 .

In vitro study on the antioxidant activity of a polyphenol-rich extract from Pinus brutia bark and its fractions.

A. Constantinou, J. Salminen, C. Mircea, 2013, Journal of medicinal food.

6‐O‐(3″, 4″‐di‐O‐trans‐cinnamoyl)‐α‐l‐rhamnopyranosylcatalpol and verbascoside: Cytotoxicity, cell cycle kinetics, apoptosis, and ROS production evaluation in tumor cells

C. Neophytou, A. Vasincu, A. Constantinou, 2020, Journal of biochemical and molecular toxicology.

Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms.

H H Fong, J M Pezzuto, J. Pezzuto, 2001, Journal of agricultural and food chemistry.

Induction of Apoptosis by Genistein: Potential Applications in Cancer Prevention and Treatment

A. Wu, A. Constantinou, L. Thompson, 2002 .

Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs

Andreas I Constantinou, A. Constantinou, A. Papas, 2008, International journal of cancer.

Natural colonization and adaptation of a mosquito species in Galápagos and its implications for disease threats to endemic wildlife

L. Kramer, S. Goodman, A. Constantinou, 2009, Proceedings of the National Academy of Sciences.

Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent

J. Pezzuto, G. Salti, J. Kichina, 2001, Melanoma research.

Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.

P. Papageorgis, A. Constantinou, Christiana Charalambous, 2013, Cancer letters.

d-a-Tocopheryl Polyethylene Glycol 1000 Succinate and a small-molecule Survivin suppressant synergistically induce apoptosis in SKBR3 breast cancer cells

G. Gregoriou, C. Neophytou, A. Constantinou, 2019, Scientific Reports.

Genistein as an Inducer of Tumor Cell Differentiation: Possible Mechanisms of Action

E. Huberman, A. Constantinou, A Constantinou, 1995, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

WR‐1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells

A. Constantinou, J. Murley, D. Grdina, 1997, Cell proliferation.

Inhibition of topoisomerase IIα activity in CHO K1 cells by 2- [(aminopropyl)amino]ethanethiol (WR-1065)

N. Shigematsu, A. Constantinou, J. Murley, 1994 .

Inhibition of topoisomerase II alpha activity in CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065).

N. Shigematsu, A. Constantinou, J. Murley, 1994, Radiation research.

Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis

A. Constantinou, R. Moon, 1997, Breast Cancer Research and Treatment.

Breast Cancer Epigenetics

A. Constantinou, C. A. Pitta, 2015 .

Therapeutic monitoring of continuous infusion etoposide in small-cell lung cancer.

P. Ellis, K. O'Byrne, S. Joel, 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis

A. Tzatsos, S. Thiagalingam, P. Papageorgis, 2015, Breast Cancer Research.

Pro-apoptotic Properties of Chemopreventive Agents

C. Neophytou, Yiota Gregoriou, A. Constantinou, 2020 .

Nitrogen mustard up-regulates Bcl-2 and GSH and increases NTP and PCr in HT-29 colon cancer cells.

A. Constantinou, C. Williams, A. Boddie, 1998, British Journal of Cancer.

Involvement of host DNA gyrase in growth of bacteriophage T5

R. Sternglanz, A. Constantinou, D. McCorquodale, 1986, Journal of virology.

Monoclonal antibodies to bull sperm surface antigens

A. Constantinou, J. Chakraborty, M. McCorquodale, 1985 .

Survivin : Transcriptional Regulation and Protein Function in Cancer

C. Neophytou, A. Constantinou, 2017 .

Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis

A. Tzatsos, S. Thiagalingam, P. Papageorgis, 2015, Breast Cancer Research.

VL30 retrotransposition is associated with induced EMT, CSC generation and tumorigenesis in HC11 mouse mammary stem-like epithelial cells

G. Vartholomatos, A. Charchanti, P. Papageorgis, 2020, Oncology reports.

Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity.

V. Steele, J. Pezzuto, G. Kelloff, 2000, European journal of cancer.

Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells.

A. Evdokiou, A. Skaltsounis, A. Constantinou, 2012, Biochemical and biophysical research communications.

GPCR receptor phosphorylation and endocytosis are not necessary to switch polarized growth between internal cues during pheromone response in S. cerevisiae

A. Colman-Lerner, A. Constantinou, Gustavo Vasen, 2020, Communicative & integrative biology.

Helping cells jump to conclusions.

A. Constantinou, 2014 .

Comparison of two different doses of ondansetron plus dexamethasone in the prophylaxis of cisplatin-induced emesis.

A. Constantinou, D. Pectasides, M. Kostopoulou, 1997, Oncology.

Caspase-independent pathways of programmed cell death: the unraveling of new targets of cancer therapy?

A. Constantinou, C. Constantinou, K. Papas, 2009, Current cancer drug targets.

Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells.

A. Constantinou, R. Ganapathi, D. Grabowski, 1991, Biochemical pharmacology.

Automated Scientific Assistant for Cancer and Chemoprevention

Antonis C. Kakas, Andreas Constantinou, Sotiris Lazarou, 2013, AIAI.

Update on the Anti-Cancer Potency of Tocotrienols and α-Tocopheryl Polyethylene Glycol 1000 Succinate on Leukemic Cell Lines

A. Constantinou, O. Kolokotroni, Christiana Charalambous, 2020, Nutrition and cancer.

Induction of DNA Damage and Caspase-Independent Programmed Cell Death by Vitamin E

C. Neophytou, A. Constantinou, C. Constantinou, 2012, Nutrition and cancer.

Resveratrol loaded polymeric micelles for theranostic targeting of breast cancer cells

M. Prokopi, G. Gregoriou, Yiota Gregoriou, 2021, Nanotheranostics.

Lycopene, a Dietary Cancer Chemopreventive Agent

A. Constantinou, R. Breemen, 2004 .

Resistance to etoposide in human leukemia HL-60 cells: reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides.

G. Dubyak, A. Constantinou, R. Ganapathi, 1996, Molecular pharmacology.

Altered phosphorylation, biosynthesis and degradation of the 170 kDa isoform of topoisomerase II in amsacrine-resistant human leukemia cells.

L. Zwelling, A. Constantinou, R. Ganapathi, 1993, Biochemical and biophysical research communications.

Induction of Caspase-Independent Programmed Cell Death by Vitamin E Natural Homologs and Synthetic Derivatives

A. Constantinou, A. Papas, C. Constantinou, 2009, Nutrition and cancer.

Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats.

A. Husband, R. Mehta, A. Constantinou, 2003, European journal of cancer.

Evidence that a metabolite of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro.

J. Bolton, A. Constantinou, E. Pisha, 2001, Chemical research in toxicology.

A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines.

J. Bolton, A. Constantinou, R. V. van Breemen, 2000, Chemical research in toxicology.

Equol enhances tamoxifen’s anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells

A. Constantinou, Christiana Charalambous, C. A. Pitta, 2013, BMC Cancer.

A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.

J. Pezzuto, J. Bolton, A. Constantinou, 2002, Phytomedicine : international journal of phytotherapy and phytopharmacology.

The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours.

A. Constantinou, R. V. van Breemen, D. Tonetti, 2005, European journal of cancer.

Dynamic monitoring of PD‐L1 and Ki67 in circulating tumor cells of metastatic non‐small cell lung cancer patients treated with pembrolizumab

M. Spiliotaki, C. Deltas, G. Gregoriou, 2022, Molecular oncology.

Chemopreventive Effects of Soy Protein and Purified Soy Isoflavones on DMBA-Induced Mammary Tumors in Female Sprague-Dawley Rats

J. Pezzuto, A. Constantinou, R. V. van Breemen, 2001, Nutrition and cancer.

In Vitro Antioxidant Activity and Phenolic Content of Cedrus brevifolia Bark

A. Constantinou, J. Salminen, M. Karonen, 2014, Natural Product Communications.

Application of topoisomerase assays in the evaluation of natural products as antitumor agents.

G. Salti, A. Constantinou, 1999, Journal of medicinal food.

LiSIs: An Online Scientific Workflow System for Virtual Screening.

Christos C. Kannas, Ioanna Kalvari, Constantinos S Pattichis, 2015, Combinatorial chemistry & high throughput screening.

Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis

A. Tzatsos, S. Thiagalingam, P. Papageorgis, 2015, Breast Cancer Research.

Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs

A. Constantinou, A. Papas, C. Constantinou, 2008, International journal of cancer.

Production and study of polysialylated antibodies for improved cancer therapy.

A. Constantinou, 2006 .

Molecular clustering via knowledge mining from biomedical scientific corpora

Constantinos S. Pattichis, Athos Antoniades, Christos Georgousopoulos, 2013, 13th IEEE International Conference on BioInformatics and BioEngineering.

Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIalpha.

G. Dubyak, I. Hickson, R. Bukowski, 1998, The Biochemical journal.